Lithium chloride ameliorates cognition dysfunction induced by sevoflurane anesthesia in rats.

abstract：:Prostate cancer (PCa) is the most frequently diagnosed male cancer. An earlier study of a cohort of 333 primary prostate carcinomas showed that 74% of these tumors fell into one of seven subtypes of a molecular taxonomy defined by specific gene fusions (ERG, ETV1/4 and FLI1) or mutations (SPOP, FOXA1 and IDH1). Molecu...

journal_title：FEBS open bio

authors： Tang L,Zhang L,Liu L,Dong L,Dong Y,Zhu W,Wang H

更新日期：2020-12-01 00:00:00

abstract：:Hypoxia-inducible factor (HIF) is a crucial regulator of cellular and systemic responses to low oxygen levels. Here we firstly cloned three HIF-α isoforms from the basal branches of Osteichthyes and used computational tools to characterise the molecular change underlying the functional divergence of HIF-α isoforms in ...

journal_title：FEBS open bio

authors： Chi W,Gan X,Xiao W,Wang W,He S

更新日期：2013-09-19 00:00:00

abstract：:Understanding the role of specific amino acid residues in the molecular mechanism of a protein's function is one of the most challenging problems in modern biology. A systematic bioinformatic analysis of protein families and superfamilies can help in the study of structure-function relationships and in the design of i...

journal_title：FEBS open bio

authors： Fesko K,Suplatov D,Švedas V

更新日期：2018-05-21 00:00:00

abstract：:Neointimal hyperplasia (NIH) is a complicated inflammatory process contributing to vascular restenosis. The present study aimed to explore whether chemokine-like factor 1 (CKLF1) aggravates NIH via the nuclear factor-kappa B (NF-κB)/vascular cell adhesion molecule-1 (VCAM-1) pathway. We found the expression of CKLF1 a...

journal_title：FEBS open bio

authors： Liu X,Qu C,Zhang Y,Fang J,Teng L,Zhang R,Zhang X,Shen C

更新日期：2020-09-01 00:00:00

abstract：:Arbutin, a glycoside extracted from the plant Arctostaphylos uva-ursi, has been previously reported to possess antioxidant, anti-inflammatory and anticancer effects. Here, we investigated whether arbutin affects the proliferation of the cells of the osteosarcoma (OS) cell lines MG-63 and SW1353. Arbutin suppressed OS ...

journal_title：FEBS open bio

authors： Wang CQ,Wang XM,Li BL,Zhang YM,Wang L

更新日期：2020-11-03 00:00:00

abstract：:l-Ornithine cyclodeaminase (OCD) is involved in l-proline biosynthesis and catalyzes the unique deaminating cyclization of l-ornithine to l-proline via a Δ(1)-pyrroline-2-carboxyrate (Pyr2C) intermediate. Although this pathway functions in only a few bacteria, many archaea possess OCD-like genes (proteins), among whic...

journal_title：FEBS open bio

authors： Watanabe S,Tozawa Y,Watanabe Y

更新日期：2014-07-10 00:00:00

abstract：:Flavin adenine dinucleotide (FAD), synthesized from riboflavin, is redox cofactor in energy production and plays an important role in cell survival. More recently, riboflavin deficiency has been linked to developmental disorders, but its role in stem cell differentiation remains unclear. Here, we show that FAD treatme...

journal_title：FEBS open bio

authors： Hirano K,Namihira M

更新日期：2017-10-17 00:00:00

abstract：:Lactobionic acid (O-β-galactosyl-(1-4)-gluconic acid) (LBA) is a high-value lactose derivative, produced via oxidation of the reducing terminal of lactose. LBA can be produced by fermentation using certain microorganisms, although subsequent purification is challenging. Therefore, we have attempted to identify an enzy...

journal_title：FEBS open bio

authors： Lin SF,Li CK,Chung YP

更新日期：2019-01-16 00:00:00

abstract：:Flavonoids represent one of the most important molecules of plant secondary metabolism, playing many different biochemical and physiological roles. Although their essential role in plant life and human health has been elucidated by many studies, their subcellular transport and accumulation in plant tissues remains unc...

journal_title：FEBS open bio

authors： Filippi A,Petrussa E,Peresson C,Bertolini A,Vianello A,Braidot E

更新日期：2015-08-29 00:00:00

abstract：:Micro-exons are a set of ultrashort exons with lengths ≤ 51 nucleotides. Our previous study revealed that micro-exons were enriched in AP2 domains and K-box domains, which are crucial components of AP2/ERF (APETALA2/ethylene-responsive element-binding protein) and MADS-box (an acronym of MCM1, AGAMOUS, DEFICIENS and S...

journal_title：FEBS open bio

authors： Song Q,Bari A,Li H,Chen LL

更新日期：2020-12-01 00:00:00

abstract：:Dedifferentiation of adipocytes contributes to the generation of a proliferative cell population that could be useful in cellular therapy or tissue engineering. Adipocytes can dedifferentiate into precursor cells to acquire a fibroblast-like phenotype using ceiling culture, in which the buoyancy of fat cells is exploi...

journal_title：FEBS open bio

authors： Côté JA,Lessard J,Pelletier M,Marceau S,Lescelleur O,Fradette J,Tchernof A

更新日期：2017-07-10 00:00:00

abstract：:Amino acids are known to play a key role in gene expression regulation, and in mammalian cells, amino acid signaling is mainly mediated via two pathways, the mammalian target of rapamycin complex 1 (mTORC1) pathway and the amino acid responsive (AAR) pathway. It is vital for cells to have a system to sense amino acid ...

journal_title：FEBS open bio

authors： Hellsten SV,Lekholm E,Ahmad T,Fredriksson R

更新日期：2017-01-11 00:00:00

abstract：:Previous studies have proposed that the human papillomavirus (HPV) E6 oncoproteins modify the transcriptional activity of eIF4E through mechanisms dependent on p53 degradation. However, the effect of these oncoproteins on pathways regulating the activity of the eIF4E protein remains poorly understood. Hence, we invest...

journal_title：FEBS open bio

authors： Morales-Garcia V,Contreras-Paredes A,Martinez-Abundis E,Gomez-Crisostomo NP,Lizano M,Hernandez-Landero F,de la Cruz-Hernandez E

更新日期：2020-12-01 00:00:00

abstract：:The tumour microenvironment comprises a diverse range of cells, including fibroblasts, immune cells and endothelial cells, along with extracellular matrix. In particular, fibroblasts are of significant interest as these cells are reprogrammed during tumorigenesis to become cancer-associated fibroblasts (CAFs), which i...

journal_title：FEBS open bio

authors： Aguilera-Rojas M,Sharbati S,Stein T,Einspanier R

更新日期：2020-05-01 00:00:00

abstract：:An imbalance of branched-chain amino acids (BCAAs) in the brain may result in neuropathological conditions, such as autism spectrum disorders. The L-type amino acid transporter 1 (LAT1), encoded by the solute carrier transporter 7a5 (Slc7a5) gene, is critical for maintaining normal levels of BCAAs in the brain. Howeve...

journal_title：FEBS open bio

authors： Onishi Y,Hiraiwa M,Kamada H,Iezaki T,Yamada T,Kaneda K,Hinoi E

更新日期：2019-01-07 00:00:00

abstract：:Baicalin (5,6-dihydroxy-7-o-glucuronide flavone) is an extract from the roots of Chinese herb Huang Qin (Scutellaria baicalensis Georgi) and is reported to have antioxidative, antiproliferative, anti-inflammatory, and anticancer activities. This study aimed to investigate the inhibitory effect of baicalin on human hep...

journal_title：FEBS open bio

authors： Yu Z,Luo X,Wang C,Ye J,Liu S,Xie L,Wang F,Bao J

更新日期：2016-10-24 00:00:00

abstract：:Angiotensin converting enzyme (ACE) is a zinc-dependent dipeptidyl carboxypeptidase with an essential role in blood pressure homeostasis in mammals. ACE has long been targeted in the treatment of hypertension through ACE inhibitors, however current inhibitors are known to cause severe side effects. Therefore, there is...

journal_title：FEBS open bio

authors： Harrison C,Acharya KR

更新日期：2015-08-11 00:00:00

abstract：:Acute lung injury (ALI) is accompanied by overactivation of multiple pro-inflammatory factors. Cytochrome P450 1A1 (CYP1A1) has been shown to aggravate lung injury in response to hyperoxia. However, the relationship between CYP1A1 and lipopolysaccharide (LPS)-induced ALI is unknown. In this study, CYP1A1 was shown to ...

journal_title：FEBS open bio

authors： Tian LX,Tang X,Ma W,Wang J,Zhang W,Liu K,Chen T,Zhu JY,Liang HP

更新日期：2020-09-15 00:00:00

abstract：:Human type 2 diabetes is associated with β-cell apoptosis, and human islets from diabetic donors are ∼80% deficient in PAK1 protein. Toward addressing linkage of PAK1 to β-cell survival, PAK1-siRNA targeted MIN6 pancreatic β-cells were found to exhibit increased caspase-3 cleavage, cytosolic cytochrome-C and the pro-a...

journal_title：FEBS open bio

authors： Wang Z,Thurmond DC

更新日期：2012-09-08 00:00:00

abstract：:Identifying conserved binding motifs is an efficient way to study protein-ligand recognition. Most 3D binding motifs only contain information from the protein side, and so motifs that combine information from both protein and ligand sides are desired. Here, we propose an algorithm called LibME (Ligand-binding Motif Ex...

journal_title：FEBS open bio

authors： He W,Liang Z,Teng M,Niu L

更新日期：2016-11-30 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma coactivator-1β (PGC-1β) is a transcriptional regulator whose increased expression activates energy expenditure-related genes in skeletal muscles. However, how PGC-1β is regulated remains largely unclear. Here, we show that PGC-1β gene expression is negatively correlated...

journal_title：FEBS open bio

authors： Nakai S,Oyabu M,Hatazawa Y,Akashi S,Kitamura T,Miura S,Kamei Y

更新日期：2020-07-01 00:00:00

abstract：:Insulin signaling plays a central role in the regulation of facilitative glucose transporters (GLUTs) in humans. To establish Caenorhabditis elegans (C. elegans) as a model to study the mechanism underlying insulin regulation of GLUT, we identified that FGT-1 is most likely the only functional GLUT homolog in C. elega...

journal_title：FEBS open bio

authors： Kitaoka S,Morielli AD,Zhao FQ

更新日期：2016-04-21 00:00:00

abstract：:IL-1 family cytokines act as apical initiators of inflammation in many settings and can promote the production of a battery of inflammatory cytokines, chemokines and other inflammatory mediators in diverse cell types. IL-36α, IL-36β and IL-36γ, which belong to the extended IL-1 family, have been implicated as key init...

journal_title：FEBS open bio

authors： Sullivan GP,Davidovich PB,Sura-Trueba S,Belotcerkovskaya E,Henry CM,Clancy DM,Zinoveva A,Mametnabiev T,Garabadzhiu AV,Martin SJ

更新日期：2018-03-25 00:00:00

abstract：:Abdominal arterial aneurysm (AAA) shares many features with autoimmune diseases and appears to be a T-cell-mediated process. In addition, certain epigenetic changes, including DNA methylation, are associated with AAA. In this study, we investigated epigenetic modifications in regulatory T cells (Tregs) from AAA patien...

journal_title：FEBS open bio

authors： Xia Q,Zhang J,Han Y,Zhang X,Jiang H,Lun Y,Wu X,Gang Q,Liu Z,Böckler D,Duan Z,Xin S

更新日期：2019-06-01 00:00:00

abstract：:The identification of biomarkers for early diagnosis of Parkinson's disease (PD) prior to the onset of symptoms may improve the effectiveness of therapy. To identify potential biomarkers, we downloaded microarray datasets of PD from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) between PD...

journal_title：FEBS open bio

authors： Jiang F,Wu Q,Sun S,Bi G,Guo L

更新日期：2019-08-01 00:00:00

abstract：:The extreme halophile Halococcus morrhuae (ATCC® 17082) contains a 108-nucleotide insertion in its 5S rRNA. Large rRNA expansions in Archaea are rare. This one almost doubles the length of the 5S rRNA. In order to understand how such an insertion is accommodated in the ribosome, we obtained a cryo-electron microscopy ...

journal_title：FEBS open bio

authors： Tirumalai MR,Kaelber JT,Park DR,Tran Q,Fox GE

更新日期：2020-10-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease with increased risk of cardiovascular events and mortality that can be attributed to accelerated atherosclerosis. This pilot study aimed to investigate if changes in blood parameters were compatible with atherosclerotic events in RA patients. To this aim, 45 ...

journal_title：FEBS open bio

authors： Vona R,Di Franco M,Gambardella L,Di Lollo AC,Iannuccelli C,Valesini G,Malorni W,Straface E

更新日期：2018-11-06 00:00:00

abstract：:Nisin is the most prominent and applied bacteriocin that serves as a model for class I lantibiotics. The nisin leader peptide importantly determines interactions between precursor nisin and its modification enzymes NisB and NisC that mature nisin posttranslationally. NisB dehydrates serines and threonines, while NisC ...

journal_title：FEBS open bio

authors： Khusainov R,Moll GN,Kuipers OP

更新日期：2013-05-30 00:00:00

abstract：:Shiga toxin (Stx) causes fatal systemic complications. Stx induces apoptosis, but the mechanism of which is unclear. We report that Stx induced rapid reduction of short-lived anti-apoptotic proteins followed by activation of caspase 9 and the progression of apoptosis. Proteasome inhibitors prevented the reduction of a...

journal_title：FEBS open bio

authors： Hattori T,Watanabe-Takahashi M,Ohoka N,Hamabata T,Furukawa K,Nishikawa K,Naito M

更新日期：2015-06-12 00:00:00

abstract：:Synthetic biology circuits are often constructed with multiple gene expression units assembled in close proximity, and they can be used to perform complex functions in embryonic stem cells (ESCs). However, mutual interference between transcriptional units has not been well studied in mouse ESCs. To assess the efficien...

journal_title：FEBS open bio

authors： Lu XB,Guo YH,Huang W

更新日期：2020-04-01 00:00:00