Growth hormone receptor promotes breast cancer progression via the BRAF/MEK/ERK signaling pathway.


:Growth hormone receptor (GHR), a member of the class I cytokine receptor family, plays key roles in cancer progression. Recently, GHR has been reported to be associated with breast cancer development, but the molecular mechanism of GHR in this malignancy is not fully understood. To investigate this issue, we stably inhibited GHR in breast cancer cell lines, which were observed to reduce cell proliferation, tumor growth and induction of apoptosis, and arrest the cell-cycle arrest at the G1-S phase transition. In addition, GHR silencing suppressed the protein levels of B-Raf proto-oncogene, serine/threonine kinase (BRAF), Mitogen-activated protein kinase kinase (MEK) and Extracellular regulated protein kinases (ERK). These findings suggest that GHR may mediate breast cell progression and apoptosis through control of the cell cycle via the BRAF/MEK/ERK signaling pathway.


FEBS Open Bio


FEBS open bio


Zhu X,Li Y,Xu G,Fu C




Has Abstract


2020-06-01 00:00:00










  • Cryo-electron microscopy visualization of a large insertion in the 5S ribosomal RNA of the extremely halophilic archaeon Halococcus morrhuae.

    abstract::The extreme halophile Halococcus morrhuae (ATCC® 17082) contains a 108-nucleotide insertion in its 5S rRNA. Large rRNA expansions in Archaea are rare. This one almost doubles the length of the 5S rRNA. In order to understand how such an insertion is accommodated in the ribosome, we obtained a cryo-electron microscopy ...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Tirumalai MR,Kaelber JT,Park DR,Tran Q,Fox GE

    更新日期:2020-10-01 00:00:00

  • Bioinformatic analysis of the fold type I PLP-dependent enzymes reveals determinants of reaction specificity in l-threonine aldolase from Aeromonas jandaei.

    abstract::Understanding the role of specific amino acid residues in the molecular mechanism of a protein's function is one of the most challenging problems in modern biology. A systematic bioinformatic analysis of protein families and superfamilies can help in the study of structure-function relationships and in the design of i...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Fesko K,Suplatov D,Švedas V

    更新日期:2018-05-21 00:00:00

  • PCBP2 post-transcriptionally regulates sortilin expression by binding to a C-rich element in its 3' UTR.

    abstract::Post-transcriptional regulation of cytokine production is crucial to ensure appropriate immune responses. We previously demonstrated that poly-rC-binding protein-1 (PCBP1) can act as a trans-acting factor to stabilize transcripts encoding sortilin, which mediates cytokine trafficking. Here, we report that PCBP2, which...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Yabe-Wada T,Philpott CC,Onai N

    更新日期:2020-03-01 00:00:00

  • Identification of potential diagnostic biomarkers for Parkinson's disease.

    abstract::The identification of biomarkers for early diagnosis of Parkinson's disease (PD) prior to the onset of symptoms may improve the effectiveness of therapy. To identify potential biomarkers, we downloaded microarray datasets of PD from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) between PD...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Jiang F,Wu Q,Sun S,Bi G,Guo L

    更新日期:2019-08-01 00:00:00

  • Seasonal variations in photoperiod affect hepatic metabolism of medaka (Oryzias latipes).

    abstract::Organisms living in temperate regions are sensitive to seasonal variations in the environment; they are known to accumulate energy as fat in their livers during the winter when days are shorter, temperatures are lower, and food is scarce. However, the effect of variations in photoperiod alone on hepatic lipid metaboli...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Fujisawa K,Takami T,Shintani H,Sasai N,Matsumoto T,Yamamoto N,Sakaida I

    更新日期:2021-01-21 00:00:00

  • Identification of distinctive interdomain interactions among ZP-N, ZP-C and other domains of zona pellucida glycoproteins underlying association of chicken egg-coat matrix.

    abstract::The vertebrate egg coat, including mammalian zona pellucida, is an oocyte-specific extracellular matrix comprising two to six zona pellucida (ZP) glycoproteins. The egg coat plays important roles in fertilization, especially in species-specific interactions with sperm to induce the sperm acrosome reaction and to form ...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Okumura H,Sato T,Sakuma R,Fukushima H,Matsuda T,Ujita M

    更新日期:2015-05-27 00:00:00

  • Bioinformatic screening for key miRNAs and genes associated with myocardial infarction.

    abstract::Despite significant advances in understanding of the causes of and treatment of myocardial infarction (MI) in recent years, morbidity and mortality is still high. The aim of this study was to identify miRNA and genes potentially associated with MI. mRNA and miRNA expression datasets were downloaded from the Gene Expre...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Wu K,Zhao Q,Li Z,Li N,Xiao Q,Li X,Zhao Q

    更新日期:2018-04-19 00:00:00

  • Transcriptome analysis of roots from resistant and susceptible rice varieties infected with Hirschmanniella mucronata.

    abstract::Hirschmanniella mucronata is a plant-parasitic nematode that is widespread in rice production areas and causes 10-25% yield losses a year on average. Here, we investigated the mechanism of resistance to this nematode by comparing the transcriptomes of roots from resistant (Jiabali) and susceptible (Bawangbian) varieti...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Sun X,Zhang L,Tang Z,Shi X,Ma J,Cui R

    更新日期:2019-11-01 00:00:00

  • miR-21-5p promotes cell proliferation and G1/S transition in melanoma by targeting CDKN2C.

    abstract::Human melanoma is a highly malignant tumor originating from cutaneous melanocytes. The noncoding RNA microRNA (miR)-21-5p has been reported to be expressed at high levels in malignant melanocytic skin tissues, but its potential functional role in melanoma remains poorly understood. Here, we explored the cellular effec...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Yang Z,Liao B,Xiang X,Ke S

    更新日期:2020-05-01 00:00:00

  • A cataract-causing connexin 50 mutant is mislocalized to the ER due to loss of the fourth transmembrane domain and cytoplasmic domain.

    abstract::Mutations in the eye lens gap junction protein connexin 50 cause cataract. Earlier we identified a frameshift mutant of connexin 50 (c.670insA; p.Thr203AsnfsX47) in a family with autosomal recessive cataract. The mutant protein is smaller and contains 46 aberrant amino acids at the C-terminus after amino acid 202. Her...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Somaraju Chalasani ML,Muppirala M,G Ponnam SP,Kannabiran C,Swarup G

    更新日期:2012-11-27 00:00:00

  • Angiotensin II type 1 receptor blocker telmisartan induces apoptosis and autophagy in adult T-cell leukemia cells.

    abstract::Adult T-cell leukemia/lymphoma (ATL), an aggressive T-cell malignancy that develops after long-term infection with human T-cell leukemia virus (HTLV-1), requires new treatments. Drug repositioning, reuse of a drug previously approved for the treatment of another condition to treat ATL, offers the possibility of reduce...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Kozako T,Soeda S,Yoshimitsu M,Arima N,Kuroki A,Hirata S,Tanaka H,Imakyure O,Tone N,Honda S,Soeda S

    更新日期:2016-04-13 00:00:00

  • Spatiotemporal immunolocalisation of REST in the brain of healthy ageing and Alzheimer's disease rats.

    abstract::In the brain, REST (Repressor Element-1 Silencing Transcription factor) is a key regulator of neuron cell-specific gene expression. Nuclear translocation of neuronal REST has been shown to be neuroprotective in a healthy ageing context. In contrast, inability to upregulate nuclear REST is thought to leave ageing neuro...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Mampay M,Velasco-Estevez M,Rolle SO,Chaney AM,Boutin H,Dev KK,Moeendarbary E,Sheridan GK

    更新日期:2020-11-13 00:00:00

  • Identification of distinct nisin leader peptide regions that determine interactions with the modification enzymes NisB and NisC.

    abstract::Nisin is the most prominent and applied bacteriocin that serves as a model for class I lantibiotics. The nisin leader peptide importantly determines interactions between precursor nisin and its modification enzymes NisB and NisC that mature nisin posttranslationally. NisB dehydrates serines and threonines, while NisC ...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Khusainov R,Moll GN,Kuipers OP

    更新日期:2013-05-30 00:00:00

  • Oligomer-dependent and -independent chaperone activity of sHsps in different stressed conditions.

    abstract::A great number of studies have proven that sHsps protect cells by inhibiting protein aggregation under heat stress, while little is known about their function to protect cells under acid stress. In this work, we show that Hsp20.1 and Hsp14.1 oligomers dissociated to smaller oligomeric species or even dimer/monomer at ...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Liu L,Chen J,Yang B,Wang Y

    更新日期:2015-03-05 00:00:00

  • Different evolutionary patterns of hypoxia-inducible factor α (HIF-α) isoforms in the basal branches of Actinopterygii and Sarcopterygii.

    abstract::Hypoxia-inducible factor (HIF) is a crucial regulator of cellular and systemic responses to low oxygen levels. Here we firstly cloned three HIF-α isoforms from the basal branches of Osteichthyes and used computational tools to characterise the molecular change underlying the functional divergence of HIF-α isoforms in ...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Chi W,Gan X,Xiao W,Wang W,He S

    更新日期:2013-09-19 00:00:00

  • Identification of a novel lactose oxidase in Myrmecridium flexuosum NUK-21.

    abstract::Lactobionic acid (O-β-galactosyl-(1-4)-gluconic acid) (LBA) is a high-value lactose derivative, produced via oxidation of the reducing terminal of lactose. LBA can be produced by fermentation using certain microorganisms, although subsequent purification is challenging. Therefore, we have attempted to identify an enzy...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Lin SF,Li CK,Chung YP

    更新日期:2019-01-16 00:00:00

  • Mass spectrometry-based analysis of macromolecular complexes of Staphylococcus aureus uracil-DNA glycosylase and its inhibitor reveals specific variations due to naturally occurring mutations.

    abstract::The base excision repair pathway plays an important role in correcting damage induced by either physiological or external effects. This repair pathway removes incorrect bases from the DNA. The uracil base is among the most frequently occurring erroneous bases in DNA, and is cut out from the phosphodiester backbone via...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Papp-Kádár V,Balázs Z,Vékey K,Ozohanics O,Vértessy BG

    更新日期:2019-02-09 00:00:00

  • Both Ser361 phosphorylation and the C-arrestin domain of thioredoxin interacting protein are important for cell cycle blockade at the G1/S checkpoint.

    abstract::Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor that is down-regulated in several cancer tissues and tumor cell lines. Overexpression of TXNIP causes cell cycle arrest at the G1/S checkpoint in the hepatocellular carcinoma cell line HuH-7. TXNIP contains putative phosphorylation sites, but the effe...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Kamitori K,Yamaguchi F,Dong Y,Hossain A,Katagi A,Noguchi C,Hirata Y,Tsukamoto I,Hatano N,Tokuda M

    更新日期:2018-10-01 00:00:00

  • TSLP induces a proinflammatory phenotype in circulating innate cells and predicts prognosis in sepsis patients.

    abstract::Thymic stromal lymphopoietin (TSLP) has been identified as a crucial inflammatory cytokine in immune homeostasis. Previous studies have reported conflicting effects of TSLP on sepsis in mice, and the effect of TSLP on sepsis in humans has not been investigated. In this study, we used the ELISA to measure serum levels ...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Yu Q,Li Y,Wang H,Xiong H

    更新日期:2019-12-01 00:00:00

  • A dodecylamine derivative of cyanocobalamin potently inhibits the activities of cobalamin-dependent methylmalonyl-CoA mutase and methionine synthase of Caenorhabditis elegans.

    abstract::In this study, we showed that cyanocobalamin dodecylamine, a ribose 5'-carbamate derivative of cyanocobalamin, was absorbed and accumulated to significant levels by Caenorhabditis elegans and was not further metabolized. The levels of methylmalonic acid and homocysteine, which serve as indicators of cobalamin deficien...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Bito T,Yabuta Y,Ichiyanagi T,Kawano T,Watanabe F

    更新日期:2014-08-01 00:00:00

  • Niclosamide and its derivative DK-520 inhibit RANKL-induced osteoclastogenesis.

    abstract::Niclosamide is a potent inhibitor of osteoclastogenesis and bone remodeling. DK-520 is an acyl derivative of Niclosamide and significantly increased both the plasma concentration and the duration of exposure of Niclosamide when dosed orally. However, at present the effect of DK-520 on osteoclastogenesis has not been r...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Jiao Y,Chen C,Hu X,Feng X,Shi Z,Cao J,Li Q,Zhu Y

    更新日期:2020-08-01 00:00:00

  • Hypoxia affects Slc7a5 expression through HIF-2α in differentiated neuronal cells.

    abstract::An imbalance of branched-chain amino acids (BCAAs) in the brain may result in neuropathological conditions, such as autism spectrum disorders. The L-type amino acid transporter 1 (LAT1), encoded by the solute carrier transporter 7a5 (Slc7a5) gene, is critical for maintaining normal levels of BCAAs in the brain. Howeve...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Onishi Y,Hiraiwa M,Kamada H,Iezaki T,Yamada T,Kaneda K,Hinoi E

    更新日期:2019-01-07 00:00:00

  • Structural evidence for Arabidopsis glutathione transferase AtGSTF2 functioning as a transporter of small organic ligands.

    abstract::Glutathione transferases (GSTs) are involved in many processes in plant biochemistry, with their best characterised role being the detoxification of xenobiotics through their conjugation with glutathione. GSTs have also been implicated in noncatalytic roles, including the binding and transport of small heterocyclic li...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Ahmad L,Rylott EL,Bruce NC,Edwards R,Grogan G

    更新日期:2016-12-22 00:00:00

  • Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes.

    abstract::A local tissue-specific renin-angiotensin system (local RAS) has been identified in many organs. However, no report has described the role of a local RAS in the hypertrophic differentiation of chondrocytes. To examine the role of a local RAS in the hypertrophic differentiation, we activated angiotensin II type 1 recep...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Tsukamoto I,Inoue S,Teramura T,Takehara T,Ohtani K,Akagi M

    更新日期:2013-07-04 00:00:00

  • Suppression of a single pair of mushroom body output neurons in Drosophila triggers aversive associations.

    abstract::Memory includes the processes of acquisition, consolidation and retrieval. In the study of aversive olfactory memory in Drosophila melanogaster, flies are first exposed to an odor (conditioned stimulus, CS+) that is associated with an electric shock (unconditioned stimulus, US), then to another odor (CS-) without the ...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Ueoka Y,Hiroi M,Abe T,Tabata T

    更新日期:2017-02-22 00:00:00

  • Specificity determinants for the abscisic acid response element.

    abstract::Abscisic acid (ABA) response elements (ABREs) are a group of cis-acting DNA elements that have been identified from promoter analysis of many ABA-regulated genes in plants. We are interested in understanding the mechanism of binding specificity between ABREs and a class of bZIP transcription factors known as ABRE bind...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Sarkar AK,Lahiri A

    更新日期:2013-01-22 00:00:00

  • Presence of O-glycosidically linked oligosaccharides in the cell wall mannan of Candida krusei purified with Benanomicin A.

    abstract::Cell wall mannan of the pathogenic yeast Candida krusei was prepared using the antibiotic Benanomicin A, which has a lectin-like function. The chemical structure of this molecule was found to be similar to that of mannan prepared from the same yeast by the conventional method using Fehling reagent. Only a few degradat...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Kuraoka T,Ishiyama A,Oyamada H,Ogawa Y,Kobayashi H

    更新日期:2018-12-10 00:00:00

  • A risk score model for the prediction of osteosarcoma metastasis.

    abstract::Osteosarcoma is the most common primary solid malignancy of the bone, and its high mortality usually correlates with early metastasis. In this study, we developed a risk score model to help predict metastasis at the time of diagnosis. We downloaded and mined four expression profile datasets associated with osteosarcom...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Dong S,Huo H,Mao Y,Li X,Dong L

    更新日期:2019-02-02 00:00:00

  • Iron overload inhibits self-renewal of human pluripotent stem cells via DNA damage and generation of reactive oxygen species.

    abstract::Iron overload affects the cell cycle of various cell types, but the effect of iron overload on human pluripotent stem cells has not yet been reported. Here, we show that the proliferation capacities of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) were significantly inhibited by ...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Han Z,Xu Z,Chen L,Ye D,Yu Y,Zhang Y,Cao Y,Djibril B,Guo X,Gao X,Zhang W,Yu M,Liu S,Yan G,Jin M,Huang Q,Wang X,Hua B,Feng C,Yang F,Ma W,Liu Y

    更新日期:2020-05-01 00:00:00

  • Aspergillus nidulans Pmts form heterodimers in all pairwise combinations.

    abstract::Eukaryotic protein O-mannosyltransferases (Pmts) are divided into three subfamilies (Pmt1, Pmt2, and Pmt4) and activity of Pmts in yeasts and animals requires assembly into complexes. In Saccharomyces cerevisiae, Pmt1 and Pmt2 form a heteromeric complex and Pmt 4 forms a homomeric complex. The filamentous fungus Asper...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Kriangkripipat T,Momany M

    更新日期:2014-03-19 00:00:00