Growth hormone receptor promotes breast cancer progression via the BRAF/MEK/ERK signaling pathway.

Abstract:

:Growth hormone receptor (GHR), a member of the class I cytokine receptor family, plays key roles in cancer progression. Recently, GHR has been reported to be associated with breast cancer development, but the molecular mechanism of GHR in this malignancy is not fully understood. To investigate this issue, we stably inhibited GHR in breast cancer cell lines, which were observed to reduce cell proliferation, tumor growth and induction of apoptosis, and arrest the cell-cycle arrest at the G1-S phase transition. In addition, GHR silencing suppressed the protein levels of B-Raf proto-oncogene, serine/threonine kinase (BRAF), Mitogen-activated protein kinase kinase (MEK) and Extracellular regulated protein kinases (ERK). These findings suggest that GHR may mediate breast cell progression and apoptosis through control of the cell cycle via the BRAF/MEK/ERK signaling pathway.

journal_name

FEBS Open Bio

journal_title

FEBS open bio

authors

Zhu X,Li Y,Xu G,Fu C

doi

10.1002/2211-5463.12816

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

1013-1020

issue

6

issn

2211-5463

journal_volume

10

pub_type

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