Growth hormone receptor promotes breast cancer progression via the BRAF/MEK/ERK signaling pathway.


:Growth hormone receptor (GHR), a member of the class I cytokine receptor family, plays key roles in cancer progression. Recently, GHR has been reported to be associated with breast cancer development, but the molecular mechanism of GHR in this malignancy is not fully understood. To investigate this issue, we stably inhibited GHR in breast cancer cell lines, which were observed to reduce cell proliferation, tumor growth and induction of apoptosis, and arrest the cell-cycle arrest at the G1-S phase transition. In addition, GHR silencing suppressed the protein levels of B-Raf proto-oncogene, serine/threonine kinase (BRAF), Mitogen-activated protein kinase kinase (MEK) and Extracellular regulated protein kinases (ERK). These findings suggest that GHR may mediate breast cell progression and apoptosis through control of the cell cycle via the BRAF/MEK/ERK signaling pathway.


FEBS Open Bio


FEBS open bio


Zhu X,Li Y,Xu G,Fu C




Has Abstract


2020-06-01 00:00:00










  • CDR3 sequences in IgA nephropathy are shorter and exhibit reduced diversity.

    abstract::Immunoglobulin (Ig) A nephropathy (IgAN) is the most common glomerulonephritis, which is characterized by the deposition of IgA antibody in the glomerulus. Systematic dissection of immune composition may contribute to a better understanding of the alternations in the immune system in IgAN. To this end, here we applied...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Zhang X,Zeng J,Tong Y,Zhang L,Lu X,Zhu S,Li Z

    更新日期:2020-12-01 00:00:00

  • Cyclophilin D-dependent mitochondrial permeability transition amplifies inflammatory reprogramming in endotoxemia.

    abstract::Microorganisms or LPS (lipopolysaccharide), an outer membrane component of Gram-negative bacteria, can induce a systemic inflammatory response that leads to sepsis, multiple organ dysfunction, and mortality. Here, we investigated the role of cyclophilin D (CypD)-dependent mitochondrial permeability transition (mPT) in...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Veres B,Eros K,Antus C,Kalman N,Fonai F,Jakus PB,Boros E,Hegedus Z,Nagy I,Tretter L,Gallyas F Jr,Sumegi B

    更新日期:2021-01-20 00:00:00

  • Rosiglitazone suppresses RANKL-induced NFATc1 autoamplification by disrupting the physical interaction between NFATc1 and PPARγ.

    abstract::Receptor activator of nuclear factor-κB ligand (RANKL) is required for initiation of osteoclastogenesis, with the signaling pathway including the NF-kB, c-Fos, and nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) transcription factors. Because NFATc1 expression is autoamplified, we investigated the molecula...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Park KL,Oh DG,Kim YO,Song KS,Ahn DW

    更新日期:2018-09-10 00:00:00

  • Knockout of cytochrome P450 1A1 enhances lipopolysaccharide-induced acute lung injury in mice by targeting NF-κB activation.

    abstract::Acute lung injury (ALI) is accompanied by overactivation of multiple pro-inflammatory factors. Cytochrome P450 1A1 (CYP1A1) has been shown to aggravate lung injury in response to hyperoxia. However, the relationship between CYP1A1 and lipopolysaccharide (LPS)-induced ALI is unknown. In this study, CYP1A1 was shown to ...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Tian LX,Tang X,Ma W,Wang J,Zhang W,Liu K,Chen T,Zhu JY,Liang HP

    更新日期:2020-09-15 00:00:00

  • DNA-induced unfolding of the thyroid hormone receptor α A/B domain through allostery.

    abstract::The A/B domains of nuclear receptors such as thyroid receptor α (TRα) are considered to be conformationally flexible and can potentially adopt multiple structural conformations. We used intrinsic tryptophan fluorescence quenching and circular dichroism spectroscopy to characterize the unfolding of this A/B domain upon...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Fernandez EJ,Gahlot V,Rodriguez C,Amburn J

    更新日期:2017-05-15 00:00:00

  • Survey and analysis of simple sequence repeats (SSRs) present in the genomes of plant viroids.

    abstract::Extensive simple sequence repeat (SSR) surveys have been performed for eukaryotic prokaryotic and viral genomes, but information regarding SSRs in viroids is limited. We undertook a survey to examine the presence of SSRs in viroid genomes. Our results show that the distribution of SSRs in viroids may influence seconda...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Qin L,Zhang Z,Zhao X,Wu X,Chen Y,Tan Z,Li S

    更新日期:2014-02-07 00:00:00

  • Inhibition of glycolysis disrupts cellular antioxidant defense and sensitizes HepG2 cells to doxorubicin treatment.

    abstract::Increased glucose consumption is a known hallmark of cancer cells. Increased glycolysis provides ATP, reducing agents and substrates for macromolecular synthesis in intensely dividing cells. Therefore, inhibition of glycolysis is one strategy in anticancer therapy as well as in improved efficacy of conventional antica...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Korga A,Ostrowska M,Iwan M,Herbet M,Dudka J

    更新日期:2019-05-01 00:00:00

  • Sex-specific effects of leptin administration to pregnant mice on the placentae and the metabolic phenotypes of offspring.

    abstract::Obesity during pregnancy has been shown to increase the risk of metabolic diseases in the offspring. However, the factors within the maternal milieu which affect offspring phenotypes and the underlying mechanisms remain unknown. The adipocyte hormone leptin plays a key role in regulating energy homeostasis and is know...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Denisova EI,Kozhevnikova VV,Bazhan NM,Makarova EN

    更新日期:2020-01-01 00:00:00

  • Interaction of Carthamus tinctorius lignan arctigenin with the binding site of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase.

    abstract::Mediterranean Carthamus tinctorius (Safflower) is used for treatment of inflammatory conditions and neuropsychiatric disorders. Recently C. tinctorius lignans arctigenin and trachelogenin but not matairesinol were described to interfere with the activity of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO)...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Temml V,Kuehnl S,Schuster D,Schwaiger S,Stuppner H,Fuchs D

    更新日期:2013-09-07 00:00:00

  • Different evolutionary patterns of hypoxia-inducible factor α (HIF-α) isoforms in the basal branches of Actinopterygii and Sarcopterygii.

    abstract::Hypoxia-inducible factor (HIF) is a crucial regulator of cellular and systemic responses to low oxygen levels. Here we firstly cloned three HIF-α isoforms from the basal branches of Osteichthyes and used computational tools to characterise the molecular change underlying the functional divergence of HIF-α isoforms in ...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Chi W,Gan X,Xiao W,Wang W,He S

    更新日期:2013-09-19 00:00:00

  • Secretory prostate apoptosis response (Par)-4 sensitizes multicellular spheroids (MCS) of glioblastoma multiforme cells to tamoxifen-induced cell death.

    abstract::Glioblastoma multiforme (GBM) is the most malignant form of brain tumor and is associated with resistance to conventional therapy and poor patient survival. Prostate apoptosis response (Par)-4, a tumor suppressor, is expressed as both an intracellular and secretory/extracellular protein. Though secretory Par-4 induces...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Jagtap JC,Parveen D,Shah RD,Desai A,Bhosale D,Chugh A,Ranade D,Karnik S,Khedkar B,Mathur A,Natesh K,Chandrika G,Shastry P

    更新日期:2014-11-21 00:00:00

  • In vivo assay to monitor flavonoid uptake across plant cell membranes.

    abstract::Flavonoids represent one of the most important molecules of plant secondary metabolism, playing many different biochemical and physiological roles. Although their essential role in plant life and human health has been elucidated by many studies, their subcellular transport and accumulation in plant tissues remains unc...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Filippi A,Petrussa E,Peresson C,Bertolini A,Vianello A,Braidot E

    更新日期:2015-08-29 00:00:00

  • Arachidonic acid suppresses hepatic cell growth through ROS-mediated activation of transglutaminase.

    abstract::We previously reported a profound augmentation in the hepatic levels of a pro-inflammatory precursor, arachidonic acid (AA), during liver tumorigenesis. Here, we report a critical role of the induced reactive oxygen species (ROS)-mediated cellular activation of a protein cross-linking enzyme, transglutaminase 2 (TG2),...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Qin XY,Lu J,Cai M,Kojima S

    更新日期:2018-09-11 00:00:00

  • Bioinformatic analysis of the fold type I PLP-dependent enzymes reveals determinants of reaction specificity in l-threonine aldolase from Aeromonas jandaei.

    abstract::Understanding the role of specific amino acid residues in the molecular mechanism of a protein's function is one of the most challenging problems in modern biology. A systematic bioinformatic analysis of protein families and superfamilies can help in the study of structure-function relationships and in the design of i...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Fesko K,Suplatov D,Švedas V

    更新日期:2018-05-21 00:00:00

  • Tropomyosin isoforms have specific effects on the transcriptome of undifferentiated and differentiated B35 neuroblastoma cells.

    abstract::Tropomyosins, a family of actin-associated proteins, bestow actin filaments with distinct biochemical and physical properties which are important for determining cell shape and regulating many cellular processes in eukaryotic cells. Here, we used RNA-seq to investigate the effect of four tropomyosin isoforms on gene e...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Stefen H,Suchowerska AK,Chen BJ,Brettle M,Kuschelewski J,Gunning PW,Janitz M,Fath T

    更新日期:2018-02-19 00:00:00

  • Dimerization facilitates the conformational transitions for bacterial phosphotransferase enzyme I autophosphorylation in an allosteric manner.

    abstract::The bacterial phosphotransferase system is central to sugar uptake and phosphorylation. Enzyme I (EI), the first enzyme of the system, autophosphorylates as a dimer using phosphoenolpyruvate (PEP), but it is not clearly understood how dimerization activates the enzyme activity. Here, we show that EI dimerization is im...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Lee KO,Yun YJ,Kim I,Suh JY

    更新日期:2017-07-17 00:00:00

  • The E144 residue of Scherffelia dubia centrin discriminates between the DNA repair protein XPC and the centrosomal protein Sfi1.

    abstract::Centrins are members of the EF-hand family of calcium-binding proteins, which are highly conserved among eukaryotes. Centrins bind to several cellular targets, through a hydrophobic triad. However, the W(1)xxL(4)xxxL(8) triad in XPC (Xeroderma Pigmentosum Group C protein) is found in the reverse orientation, as in the...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Grecu D,Blouquit Y,Assairi L

    更新日期:2013-12-05 00:00:00

  • Glucocorticoids induce femoral head necrosis in rats through the ROS/JNK/c-Jun pathway.

    abstract::Osteonecrosis of the femoral head (ONFH) is a common clinical disease with a high disability rate. Apoptosis of osteoblasts caused by high-dose short-term or low-dose long-term glucocorticoid (GC) administration is the biological basis of steroid-induced avascular necrosis of the femoral head (SANFH). The pathogenesis...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Peng P,Nie Z,Sun F,Peng H

    更新日期:2020-11-15 00:00:00

  • An autophagy-related long non-coding RNA signature for glioma.

    abstract::Glioma is one of the most common types of malignant primary central nervous system tumor, and prognosis for this disease is poor. As autophagic drugs have been reported to induce glioma cell death, we investigated the potential prognostic role of autophagy-associated long non-coding RNA (lncRNA) in glioma patients. In...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Luan F,Chen W,Chen M,Yan J,Chen H,Yu H,Liu T,Mo L

    更新日期:2019-03-05 00:00:00

  • Inhibition of cyclophilin A suppresses H2O2-enhanced replication of HCMV through the p38 MAPK signaling pathway.

    abstract::Human cytomegalovirus (HCMV) infection can be accelerated by intracellular and extracellular hydrogen peroxide (H2O2) stimulation, mediated by the activation of the p38 mitogen-activated protein kinase (MAPK) pathway. However, it remains unknown whether host gene expression is involved in H2O2-upregulated HCMV replica...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Xiao J,Song X,Deng J,Lv L,Ma P,Gao B,Zhou X,Zhang Y,Xu J

    更新日期:2016-08-15 00:00:00

  • Identification of a novel lactose oxidase in Myrmecridium flexuosum NUK-21.

    abstract::Lactobionic acid (O-β-galactosyl-(1-4)-gluconic acid) (LBA) is a high-value lactose derivative, produced via oxidation of the reducing terminal of lactose. LBA can be produced by fermentation using certain microorganisms, although subsequent purification is challenging. Therefore, we have attempted to identify an enzy...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Lin SF,Li CK,Chung YP

    更新日期:2019-01-16 00:00:00

  • MiR-409-3p regulates cell proliferation and tumor growth by targeting E74-like factor 2 in osteosarcoma.

    abstract::Recent evidence has shown that miR-409-3p was down-regulated in several types of cancer, including osteosarcoma. However, the potential role of miR-409-3p in osteosarcoma remains largely unknown. In the present study, we showed that overexpression of miR-409-3p in osteosarcoma cells inhibited cell proliferation in vit...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Zhang J,Hou W,Jia J,Zhao Y,Zhao B

    更新日期:2017-01-27 00:00:00

  • The Hsp90 inhibitor 17-AAG represses calcium-induced cytokeratin 1 and 10 expression in HaCaT keratinocytes.

    abstract::Hsp90 is essential for maintaining the activity of numerous signaling factors, and plays a key role in cellular signal transduction networks. 17-Allylamino-17-demethoxygeldanamycin (17-AAG) is an ansamycin antibiotic that binds to Hsp90 and inhibits its function. HaCaT human keratinocytes were used to investigate the ...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Miyoshi S,Yamazaki S,Uchiumi A,Katagata Y

    更新日期:2012-03-25 00:00:00

  • Development of a novel murine heart failure model overexpressing human renin and angiotensinogen.

    abstract::Renin is the rate-limiting enzyme of the renin-angiotensin system cascade, which drives the pathophysiological progression of heart failure. Species differences in the amino acid sequence of the catalytic domain of renin limit evaluations of the potency and efficacy of human renin inhibitors in animal models, and a hi...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Hara T,Yamamura T,Murakami-Asahina M,Matsumoto H,Takeyama M,Kanagawa R,Nishimoto T

    更新日期:2020-05-01 00:00:00

  • Comparison of a new nanoform of the photosensitizer chlorin e6, based on plant phospholipids, with its free form.

    abstract::Photodynamic therapy is an advanced method of treating cancer and various benign diseases, including infections. It uses light-activated molecules [photosensitizers (PSs)] to generate reactive oxygen species (ROS) when irradiated with light of a specific wavelength. This study examined the photophysical and photosensi...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Kostryukova LV,Prozorovskiy VN,Medvedeva NV,Ipatova OM

    更新日期:2018-01-02 00:00:00

  • Fluoride resistance capacity in mammalian cells involves complex global gene expression changes.

    abstract::Fluorine is a bone-seeking element ubiquitously present in the environment and widely used in many oral hygiene products. In humans, excessive intake of fluoride may cause dental and skeletal fluorosis. However, endemic fluorosis does not appear to develop in a proportion of individuals exposed to the same levels of f...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Ran S,Sun N,Liu Y,Zhang W,Li Y,Wei L,Wang J,Liu B

    更新日期:2017-06-05 00:00:00

  • Kinetic and thermodynamic analysis of the conformational folding process of SS-reduced bovine pancreatic ribonuclease A using a selenoxide reagent with high oxidizing ability.

    abstract::Redox-coupled folding pathways of bovine pancreatic ribonuclease A (RNase A) with four intramolecular disulfide (SS) bonds comprise three phases: (I) SS formation to generate partially oxidized intermediate ensembles with no rigid folded structure; (II) SS rearrangement from the three SS intermediate ensemble (3S) to ...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Arai K,Kumakura F,Iwaoka M

    更新日期:2012-04-16 00:00:00

  • In vitro characterization of the RS motif in N-terminal head domain of goldfish germinal vesicle lamin B3 necessary for phosphorylation of the p34cdc2 target serine by SRPK1.

    abstract::The nuclear envelopes surrounding the oocyte germinal vesicles of lower vertebrates (fish and frog) are supported by the lamina, which consists of the protein lamin B3 encoded by a gene found also in birds but lost in the lineage leading to mammals. Like other members of the lamin family, goldfish lamin B3 (gfLB3) con...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Yamaguchi A,Iwatani M,Ogawa M,Kitano H,Matsuyama M

    更新日期:2013-03-29 00:00:00

  • Discovery of novel interacting partners of PSMD9, a proteasomal chaperone: Role of an Atypical and versatile PDZ-domain motif interaction and identification of putative functional modules.

    abstract::PSMD9 (Proteasome Macropain non-ATPase subunit 9), a proteasomal assembly chaperone, harbors an uncharacterized PDZ-like domain. Here we report the identification of five novel interacting partners of PSMD9 and provide the first glimpse at the structure of the PDZ-domain, including the molecular details of the interac...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Sangith N,Srinivasaraghavan K,Sahu I,Desai A,Medipally S,Somavarappu AK,Verma C,Venkatraman P

    更新日期:2014-06-06 00:00:00

  • Structure of the C-terminal domain of AspA (antigen I/II-family) protein from Streptococcus pyogenes.

    abstract::The pathogenic bacteria Streptococcus pyogenes can cause an array of diseases in humans, including moderate infections such as pharyngitis (strep throat) as well as life threatening conditions such as necrotizing fasciitis and puerperal fever. The antigen I/II family proteins are cell wall anchored adhesin proteins fo...

    journal_title:FEBS open bio

    pub_type: 杂志文章


    authors: Hall M,Nylander S,Jenkinson HF,Persson K

    更新日期:2014-03-12 00:00:00