Abstract:
:Arbutin, a glycoside extracted from the plant Arctostaphylos uva-ursi, has been previously reported to possess antioxidant, anti-inflammatory and anticancer effects. Here, we investigated whether arbutin affects the proliferation of the cells of the osteosarcoma (OS) cell lines MG-63 and SW1353. Arbutin suppressed OS cell viability in a dose- and time-dependent manner, as shown by Cell Counting Kit-8 assay. Furthermore, arbutin exposure decreased the protein levels of MTHFD1L, CCND1 and phosphorylated-protein kinase B (AKT)/phosphorylated-mammalian target of rapamycin (mTOR). Potential upstream miRNAs of MTHFD1L were predicted using TargetScan, PICTAR5, miRanda and miRWalk. We performed luciferase activity assays to show that miR-338-3p directly targets and negatively regulates the expression of MTHFD1L. Knockdown of miR-338-3p promoted cell invasion, migration and proliferation in arbutin-treated OS cells via MTHFD1L. In summary, our data suggest that arbutin inhibits OS cell proliferation, migration and invasion via miR-338-3p/MTHFD1L and by inactivating the AKT/mTOR pathway.
journal_name
FEBS Open Biojournal_title
FEBS open bioauthors
Wang CQ,Wang XM,Li BL,Zhang YM,Wang Ldoi
10.1002/2211-5463.13024subject
Has Abstractpub_date
2020-11-03 00:00:00issn
2211-5463pub_type
杂志文章相关文献
FEBS Open Bio文献大全abstract::Lactobionic acid (O-β-galactosyl-(1-4)-gluconic acid) (LBA) is a high-value lactose derivative, produced via oxidation of the reducing terminal of lactose. LBA can be produced by fermentation using certain microorganisms, although subsequent purification is challenging. Therefore, we have attempted to identify an enzy...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12582
更新日期:2019-01-16 00:00:00
abstract::The Malayan pangolin (Manis javanica) is a mammal that feeds primarily on ants and termites, which contain the energy-rich carbohydrate chitin. Chitin is digestible by endogenous enzymes of the typical mammalian gastrointestinal tract, especially the acidic mammalian chitinase (AMCase). The objective of this research ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12461
更新日期:2018-07-04 00:00:00
abstract::Baicalin (5,6-dihydroxy-7-o-glucuronide flavone) is an extract from the roots of Chinese herb Huang Qin (Scutellaria baicalensis Georgi) and is reported to have antioxidative, antiproliferative, anti-inflammatory, and anticancer activities. This study aimed to investigate the inhibitory effect of baicalin on human hep...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12130
更新日期:2016-10-24 00:00:00
abstract::Growth hormone receptor (GHR), a member of the class I cytokine receptor family, plays key roles in cancer progression. Recently, GHR has been reported to be associated with breast cancer development, but the molecular mechanism of GHR in this malignancy is not fully understood. To investigate this issue, we stably in...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12816
更新日期:2020-06-01 00:00:00
abstract::Soft cheese with white rind lacks essential fatty acids (EFAs), and as a result its long-term consumption may lead to various kinds of cardiovascular and cerebrovascular diseases, such as hyperlipidemia, hypertension, and atherosclerosis. Geotrichum candidum is a dimorphic yeast that plays an important role in the rip...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12553
更新日期:2018-12-06 00:00:00
abstract::Despite progress in the treatment of hepatocellular carcinoma (HCC), 5-year survival rates remain low. Thus, a more comprehensive approach to explore the mechanism of HCC is needed to provide new leads for targeted therapy. We performed an integrated analysis to discover the relationship between DNA methylation and ge...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12433
更新日期:2018-05-30 00:00:00
abstract::The nuclear envelopes surrounding the oocyte germinal vesicles of lower vertebrates (fish and frog) are supported by the lamina, which consists of the protein lamin B3 encoded by a gene found also in birds but lost in the lineage leading to mammals. Like other members of the lamin family, goldfish lamin B3 (gfLB3) con...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2013.03.003
更新日期:2013-03-29 00:00:00
abstract::Understanding the role of specific amino acid residues in the molecular mechanism of a protein's function is one of the most challenging problems in modern biology. A systematic bioinformatic analysis of protein families and superfamilies can help in the study of structure-function relationships and in the design of i...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12441
更新日期:2018-05-21 00:00:00
abstract::Osteosarcoma, one of the most common malignant bone tumors, is characterized by a high rate of metastasis, and the survival rate of patients with metastatic osteosarcoma is poor. Previous studies have reported that miRNAs often regulate the occurrence and development of various tumors. In this work, we identified miRN...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12824
更新日期:2020-04-01 00:00:00
abstract::Peroxisome proliferator-activated receptor-gamma coactivator-1β (PGC-1β) is a transcriptional regulator whose increased expression activates energy expenditure-related genes in skeletal muscles. However, how PGC-1β is regulated remains largely unclear. Here, we show that PGC-1β gene expression is negatively correlated...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12898
更新日期:2020-07-01 00:00:00
abstract::Despite significant advances in understanding of the causes of and treatment of myocardial infarction (MI) in recent years, morbidity and mortality is still high. The aim of this study was to identify miRNA and genes potentially associated with MI. mRNA and miRNA expression datasets were downloaded from the Gene Expre...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12423
更新日期:2018-04-19 00:00:00
abstract::Previous studies have proposed that the human papillomavirus (HPV) E6 oncoproteins modify the transcriptional activity of eIF4E through mechanisms dependent on p53 degradation. However, the effect of these oncoproteins on pathways regulating the activity of the eIF4E protein remains poorly understood. Hence, we invest...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12987
更新日期:2020-12-01 00:00:00
abstract::The antipsychotic drug olanzapine is widely prescribed to treat schizophrenia and other psychotic disorders. However, it often causes unwanted side effects, including diabetes, due to disruption of insulin-dependant glucose metabolism through a mechanism yet to be elucidated. To determine if olanzapine can affect the ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2015.04.006
更新日期:2015-04-15 00:00:00
abstract::Sorafenib, the first-line agent for treatment of advanced hepatocellular carcinoma (HCC), improves median overall survival by approximately 3 months. In the present study, we investigated whether sorafenib combined with cucurbitacin B (CuB), a natural tetracyclic triterpenoid isolated from Cucurbitaceae, exerts enhanc...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.13035
更新日期:2020-11-11 00:00:00
abstract::Sorafenib is an inhibitor of a variety of tyrosine kinase receptors used to treat various cancers including hepatocellular, renal cell and thyroid carcinoma. It has been shown to change various targets associated with osteosarcoma, but the detailed mechanism remains unclear. In order to identify key genes, enriched pa...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12428
更新日期:2018-04-24 00:00:00
abstract::Human STIL (SCL/TAL1 interrupting locus) protein maintains centriole stability and spindle pole localisation. It helps in recruitment of CENPJ (Centromere protein J)/CPAP (centrosomal P4.1-associated protein) and other centrosomal proteins. Mutations in STIL protein are reported in several disorders, especially in der...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2012.09.003
更新日期:2012-09-25 00:00:00
abstract::Inovirus XacF1 (7325 nucleotides) is integrated into the genome of Xanthomonas citri pv. citri (Xcc) strains at the host dif site (attB) by the host XerC/D recombination system. The XacF1 attP sequence is located within the coding region of ORF12, a possible phage regulator. After integration, this open reading frame ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12312
更新日期:2017-09-19 00:00:00
abstract::IL-1 family cytokines act as apical initiators of inflammation in many settings and can promote the production of a battery of inflammatory cytokines, chemokines and other inflammatory mediators in diverse cell types. IL-36α, IL-36β and IL-36γ, which belong to the extended IL-1 family, have been implicated as key init...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12406
更新日期:2018-03-25 00:00:00
abstract::Osteosarcoma is the most common primary solid malignancy of the bone, and its high mortality usually correlates with early metastasis. In this study, we developed a risk score model to help predict metastasis at the time of diagnosis. We downloaded and mined four expression profile datasets associated with osteosarcom...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12592
更新日期:2019-02-02 00:00:00
abstract::As a small fruit rich in anthocyanins, blueberry (Vaccinium corymbosum × angustifolium) has become a focus of research in recent years for identifying genes related to anthocyanin transport and stress resistance mechanisms based on transcriptome sequencing. However, the lack of validated, stably expressed reference ge...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12903
更新日期:2020-08-01 00:00:00
abstract::Neointimal hyperplasia (NIH) is a complicated inflammatory process contributing to vascular restenosis. The present study aimed to explore whether chemokine-like factor 1 (CKLF1) aggravates NIH via the nuclear factor-kappa B (NF-κB)/vascular cell adhesion molecule-1 (VCAM-1) pathway. We found the expression of CKLF1 a...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12942
更新日期:2020-09-01 00:00:00
abstract::Tight regulation of the eukaryotic cell cycle is paramount to ensure genomic integrity throughout life. Cell cycle checkpoints are present in each phase of the cell cycle and prevent cell cycle progression when genomic integrity is compromised. The G2 checkpoint is an intricate signaling network that regulates the pro...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12206
更新日期:2017-03-04 00:00:00
abstract::Abscisic acid (ABA) response elements (ABREs) are a group of cis-acting DNA elements that have been identified from promoter analysis of many ABA-regulated genes in plants. We are interested in understanding the mechanism of binding specificity between ABREs and a class of bZIP transcription factors known as ABRE bind...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2013.01.006
更新日期:2013-01-22 00:00:00
abstract::An imbalance of branched-chain amino acids (BCAAs) in the brain may result in neuropathological conditions, such as autism spectrum disorders. The L-type amino acid transporter 1 (LAT1), encoded by the solute carrier transporter 7a5 (Slc7a5) gene, is critical for maintaining normal levels of BCAAs in the brain. Howeve...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12559
更新日期:2019-01-07 00:00:00
abstract::Inorganic polyphosphate (polyP) is a linear polymer containing tens to hundreds of orthophosphate residues linked by high-energy phosphoanhydride bonds. PolyP promotes osteocalcification and bone mineralization in both mouse and human osteoblastic cells. In the present study, we examined the molecular mechanism by whi...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12703
更新日期:2019-09-01 00:00:00
abstract::Prostate cancer (PCa) is the most frequently diagnosed male cancer. An earlier study of a cohort of 333 primary prostate carcinomas showed that 74% of these tumors fell into one of seven subtypes of a molecular taxonomy defined by specific gene fusions (ERG, ETV1/4 and FLI1) or mutations (SPOP, FOXA1 and IDH1). Molecu...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.13004
更新日期:2020-12-01 00:00:00
abstract::Cisplatin-based chemotherapy is the standard treatment of choice for head and neck squamous cell carcinoma (HNSCC). The efficiency of platinum-based therapies is directly influenced by the development of tumor resistance. Multiple signaling pathways have been linked to tumor resistance, including activation of nuclear...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2013.12.003
更新日期:2013-12-30 00:00:00
abstract::Glioma is one of the most common types of malignant primary central nervous system tumor, and prognosis for this disease is poor. As autophagic drugs have been reported to induce glioma cell death, we investigated the potential prognostic role of autophagy-associated long non-coding RNA (lncRNA) in glioma patients. In...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12601
更新日期:2019-03-05 00:00:00
abstract::Recent evidence has shown that miR-409-3p was down-regulated in several types of cancer, including osteosarcoma. However, the potential role of miR-409-3p in osteosarcoma remains largely unknown. In the present study, we showed that overexpression of miR-409-3p in osteosarcoma cells inhibited cell proliferation in vit...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12177
更新日期:2017-01-27 00:00:00
abstract::The A/B domains of nuclear receptors such as thyroid receptor α (TRα) are considered to be conformationally flexible and can potentially adopt multiple structural conformations. We used intrinsic tryptophan fluorescence quenching and circular dichroism spectroscopy to characterize the unfolding of this A/B domain upon...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12229
更新日期:2017-05-15 00:00:00