Abstract：
:Genome stability requires tight regulation of DNA replication to ensure that the entire genome of the cell is duplicated once and only once per cell cycle. In mammalian cells, origin activation is controlled in space and time by a cell-specific and robust program called replication timing. About 100,000 potential replication origins form on the chromatin in the gap 1 (G1) phase but only 20⁻30% of them are active during the DNA replication of a given cell in the synthesis (S) phase. When the progress of replication forks is slowed by exogenous or endogenous impediments, the cell must activate some of the inactive or "dormant" origins to complete replication on time. Thus, the many origins that may be activated are probably key to protect the genome against replication stress. This review aims to discuss the role of these dormant origins as safeguards of the human genome during replicative stress.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Courtot L,Hoffmann JS,Bergoglio Vdoi
10.3390/ijms19113569subject
Has Abstractpub_date
2018-11-12 00:00:00issue
11issn
1422-0067pii
ijms19113569journal_volume
19pub_type
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