Abstract：
:Rho family GTPases belong to the Ras GTPase superfamily and transduce intracellular signals known to regulate a variety of cellular processes, including cell polarity, morphogenesis, migration, apoptosis, vesicle trafficking, viral transport and cellular transformation. The three best-characterized Rho family members are Cdc42, RhoA and Rac1. Cdc42 regulates endocytosis, the transport between the endoplasmic reticulum and Golgi apparatus, post-Golgi transport and exocytosis. Cdc42 influences trafficking through interaction with Wiskott-Aldrich syndrome protein (N-WASP) and the Arp2/3 complex, leading to changes in actin dynamics. Rac1 mediates endocytic and exocytic vesicle trafficking by interaction with its effectors, PI3kinase, synaptojanin 2, IQGAP1 and phospholipase D1. RhoA participates in the regulation of endocytosis through controlling its downstream target, Rho kinase. Interestingly, these GTPases play important roles at different stages of viral protein and genome transport in infected host cells. Importantly, dysregulation of Cdc42, Rac1 and RhoA leads to numerous disorders, including malignant transformation. In some cases, hyperactivation of Rho GTPases is required for cellular transformation. In this article, we review a number of findings related to Rho GTPase function in intracellular transport and cellular transformation.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Chi X,Wang S,Huang Y,Stamnes M,Chen JLdoi
10.3390/ijms14047089subject
Has Abstractpub_date
2013-03-28 00:00:00pages
7089-108issue
4issn
1422-0067pii
ijms14047089journal_volume
14pub_type
杂志文章,评审abstract：:Overdose of acetaminophen (APAP), an antipyretic drug, is an important cause of liver injury. However, the mechanism in the rat model remains undetermined. We analyzed APAP-induced hepatotoxicity using rats based on M1/M2-macrophage functions in relation to damage-associated molecular patterns (DAMPs) and autophagy. L...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21238998
更新日期：2020-11-26 00:00:00
abstract：:Endothelial cells (ECs) that line the lumen of blood vessels are important players in blood vessel formation, and EC migration is a key component of the angiogenic process. Thus, identification of genes that are specifically or preferentially expressed in vascular ECs and in-depth understanding of their biological fun...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13044920
更新日期：2012-01-01 00:00:00
abstract：:Estrogen is believed to be pre-initiator in the risk of breast cancer. The BRCA1 is a tumor suppressor gene associated with breast and ovarian cancer risk. This report describes functional analysis of two BRCA1 missense mutations (Asp67Glu and Thr1051Ser) observed in the familial breast/ovarian cancer patients in Thai...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms10094187
更新日期：2009-09-24 00:00:00
abstract：:Two mesenchymal zinc transporters, ZIP7 and ZIP13, play critical roles in dermal development. ZIP7 and ZIP13 are the closest among the conserved mammalian zinc transporters. However, whether their functions are complementary remains a controversial issue. In the present study, we found that the expression of ZIP13, bu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20163941
更新日期：2019-08-13 00:00:00
abstract：:Urinary tract infections (UTIs) and catheter-associated UTIs (CAUTIs) are the principal hospital-acquired infections. Proteus mirabilis is characterized by several virulence factors able to promote adhesion and biofilm formation and ameliorate the colonization of urinary tract and the formation of crystalline biofilms...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020414
更新日期：2017-02-15 00:00:00
abstract：:Psoriasis is a chronic inflammatory cutaneous disease, characterized by activated plasmacytoid dendritic cells, myeloid dendritic cells, Th17 cells, and hyperproliferating keratinocytes. Recent studies revealed skin-resident cells have pivotal roles in developing psoriatic skin lesions. The balance in effector T cells...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21072582
更新日期：2020-04-08 00:00:00
abstract：:Many studies have provided evidence suggesting that caspases not only contribute to the neurodegeneration associated with Alzheimer's disease (AD) but also play essential roles in promoting the underlying pathology of this disease. Studies regarding the caspase inhibition draw researchers' attention through time due t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20194850
更新日期：2019-09-29 00:00:00
abstract：:Thrombospondin-1 (TSP-1) is a potent endogenous inhibitor of both physiological and pathological angiogenesis, widely studied as a target in drug development for treating cancer. Several studies performed in the cardiovascular field on TSP-1 are contradictory, the role of TSP-1 in the physiopathology of cardiovascular...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020348
更新日期：2017-02-07 00:00:00
abstract：:Integrins are important regulators of cell survival, proliferation, adhesion and migration. Once activated, integrins establish a regulated link between the extracellular matrix and the cytoskeleton. Integrins have well-established functions in cancer, such as in controlling cell survival by engagement of many specifi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18010189
更新日期：2017-01-18 00:00:00
abstract：:Actomyosin-mediated contractility is required for the majority of force-driven cellular events such as cell division, adhesion, and migration. Under pathological conditions, the role of actomyosin contractility in malignant phenotypes of various solid tumors has been extensively discussed, but the pathophysiological r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103460
更新日期：2020-05-14 00:00:00
abstract：:Plant architecture is critical for enhancing the adaptability and productivity of crop plants. Mutants with an altered plant architecture allow researchers to elucidate the genetic network and the underlying mechanisms. In this study, we characterized a novel nal1 rice mutant with short height, small panicle, and narr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218106
更新日期：2020-10-30 00:00:00
abstract：:High dietary salt intake has been listed among the top ten risk factors for disability-adjusted life years. We discuss the role of endogenous cardiotonic steroids in mediating the dietary salt-induced hypertension and organ damage. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20030590
更新日期：2019-01-30 00:00:00
abstract：:We have been made aware that text, figures and experimental data reported in the title paper [1] are duplicated in another publication by Zihan Xu et al. [2].[...]. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,撤回出版物
doi：10.3390/ijms17050768
更新日期：2016-05-20 00:00:00
abstract：:The authors wish to make the following corrections to this paper [...]. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,已发布勘误
doi：10.3390/ijms21124560
更新日期：2020-06-26 00:00:00
abstract：:As the majority of experimental studies suggest cadmium being metalloestrogen, we examined cadmium/breast cancer (BC) association by histological and tumor receptor subtype in 509 invasive BC patients and 1170 controls. Urinary cadmium was determined by atomic absorption spectrometry, and categorized using tertiles of...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20123029
更新日期：2019-06-21 00:00:00
abstract：:Bacterial exopolysaccharides produced by lactic acid bacteria are of increasing interest in the food industry, since they might enhance the technological and functional properties of some edible matrices. In this work, Pediococcus parvulus 2.6, which produces an O2-substituted (1,3)-β-d-glucan exopolysaccharide only s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18071588
更新日期：2017-07-21 00:00:00
abstract：:Dietary salt uptake and inflammation promote sodium accumulation in tissues, thereby modulating cells like macrophages and fibroblasts. Previous studies showed salt effects on periodontal ligament fibroblasts and on bone metabolism by expression of nuclear factor of activated T-cells-5 (NFAT-5). Here, we investigated ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020596
更新日期：2021-01-09 00:00:00
abstract：:Polysaccharides from Morchella esculenta have been proven to be functional and helpful for humans. The purpose of this study was to investigate the chemical structure and anti-proliferating and antitumor activities of a Morchella esculenta polysaccharide (MEP) extracted by pulsed electric field (PEF) in submerged ferm...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17060986
更新日期：2016-06-22 00:00:00
abstract：:Estrogen-receptor-mediated signaling has been suggested to decrease the inflammatory response in monocyte macrophages. Previously, we showed that a novel selective estrogen receptor modulator (SERM2) promotes anti-inflammatory phenotype of monocytes in vitro. In this study, we demonstrate the potential of SERM2 in ame...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20123007
更新日期：2019-06-20 00:00:00
abstract：:Left ventricular remodeling (LVR) occurring after ST-segment elevation myocardial infarction (STEMI) is frequent and severe. We present a metabolomic approach as an attempt to reveal unknown biomarkers associated with post-STEMI LVR. Out of 192 consecutive patients with successfully revascularized STEMI, 32 presented ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20020289
更新日期：2019-01-12 00:00:00
abstract：:Few studies have been conducted regarding the biological function and regulation role of gga-miR-221-5p in the liver. We compared the conservation of miR-221-5p among species and investigated the expression pattern of gga-miR-221-5p, validating the direct target genes of gga-miR-221-5p by dual luciferase reporter assa...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051624
更新日期：2020-02-27 00:00:00
abstract：:Interleukin (IL)-4 and -13 are structurally and functionally related cytokines sharing common receptor subunits. They regulate immune responses and, moreover, are involved in the pathogenesis of a variety of human neoplasms. Three different receptors have been described for IL-4, but only IL-4 receptor type II (IL-4Rα...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22020727
更新日期：2021-01-13 00:00:00
abstract：:The S-Allyl-L-cysteine (SAC) component of aged garlic extract (AGE) is proven to have anticancer, antihepatotoxic, neuroprotective and neurotrophic properties. -Cystathionase (CTH), cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (MPST) are involved in H2S/sulfane sulfur endogenous formation ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21031090
更新日期：2020-02-06 00:00:00
abstract：:Diabetic cardiomyopathy (DCM) has emerged as a relevant cause of heart failure among the diabetic population. Defined as a cardiac dysfunction that develops in diabetic patients independently of other major cardiovascular risks factors, such as high blood pressure and coronary artery disease, the underlying cause of D...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20112833
更新日期：2019-06-11 00:00:00
abstract：:Renal proximal tubular epithelial cells are significantly damaged during acute kidney injury. Renal proximal tubular cell-specific autophagy-deficient mice show increased sensitivity against renal injury, while showing few pathological defects under normal fed conditions. Considering that autophagy protects the proxim...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21010155
更新日期：2019-12-25 00:00:00
abstract：:The synergistic anticancer effect of docetaxel (DTX) and curcumin (CCM) has emerged as an attractive therapeutic candidate for lung cancer treatment. However, the lack of optimal bioavailability because of high toxicity, low stability, and poor solubility has limited their clinical success. Given this, an aerosolized ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124357
更新日期：2020-06-19 00:00:00
abstract：:In general, a drug candidate is evaluated using 2D-cultured cancer cells followed by an animal model. Despite successful preclinical testing, however, most drugs that enter human clinical trials fail. The high failure rates are mainly caused by incompatibility between the responses of the current models and humans. He...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18112348
更新日期：2017-11-07 00:00:00
abstract：:Multidrug resistance (MDR), of the innate and acquired types, is one of major problems in treating tumor diseases with a good chance of success. In this review, we examine the key role of nuclear factor-kappa B (NF-κB) to induce MDR in three tumor models characterized precisely by innate or acquired MDR, in particular...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21093070
更新日期：2020-04-27 00:00:00
abstract：:Eggplant cultivation is limited by numerous diseases, including the devastating bacterial wilt (BW) caused by the Ralstonia solanacearum species complex (RSSC). Within the RSSC, Ralstonia pseudosolanacearum (including phylotypes I and III) causes severe damage to all solanaceous crops, including eggplant. Therefore, t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19020357
更新日期：2018-01-25 00:00:00
abstract：:The dimension of the plants largest organelle-the vacuole-plays a major role in defining cellular elongation rates. The morphology of the vacuole is controlled by the actin cytoskeleton, but molecular players remain largely unknown. Recently, the Networked (NET) family of membrane-associated, actin-binding proteins ha...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20194752
更新日期：2019-09-25 00:00:00
