Abstract:
:The last few years have witnessed significant changes in Pfam (https://pfam.xfam.org). The number of families has grown substantially to a total of 17,929 in release 32.0. New additions have been coupled with efforts to improve existing families, including refinement of domain boundaries, their classification into Pfam clans, as well as their functional annotation. We recently began to collaborate with the RepeatsDB resource to improve the definition of tandem repeat families within Pfam. We carried out a significant comparison to the structural classification database, namely the Evolutionary Classification of Protein Domains (ECOD) that led to the creation of 825 new families based on their set of uncharacterized families (EUFs). Furthermore, we also connected Pfam entries to the Sequence Ontology (SO) through mapping of the Pfam type definitions to SO terms. Since Pfam has many community contributors, we recently enabled the linking between authorship of all Pfam entries with the corresponding authors' ORCID identifiers. This effectively permits authors to claim credit for their Pfam curation and link them to their ORCID record.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
El-Gebali S,Mistry J,Bateman A,Eddy SR,Luciani A,Potter SC,Qureshi M,Richardson LJ,Salazar GA,Smart A,Sonnhammer ELL,Hirsh L,Paladin L,Piovesan D,Tosatto SCE,Finn RDdoi
10.1093/nar/gky995subject
Has Abstractpub_date
2019-01-08 00:00:00pages
D427-D432issue
D1eissn
0305-1048issn
1362-4962pii
5144153journal_volume
47pub_type
杂志文章abstract::Digital PCR provides high sensitivity and unprecedented accuracy in DNA quantification, but current approaches require dedicated instrumentation and have limited opportunities for multiplexing. Here, we present an isothermal platform for digital enumeration of DNA reaction products in multiplex via standard fluorescen...
journal_title:Nucleic acids research
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journal_title:Nucleic acids research
pub_type: 杂志文章
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更新日期:2005-03-01 00:00:00
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
pub_type: 杂志文章
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更新日期:2008-04-01 00:00:00
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journal_title:Nucleic acids research
pub_type: 杂志文章,评审
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更新日期:2017-10-13 00:00:00
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journal_title:Nucleic acids research
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更新日期:1979-12-20 00:00:00
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journal_title:Nucleic acids research
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更新日期:2011-07-01 00:00:00
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journal_title:Nucleic acids research
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pub_type: 杂志文章
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