Abstract:
:Codon usage data has been compiled for 110 yeast genes. Cluster analysis on relative synonymous codon usage revealed two distinct groups of genes. One group corresponds to highly expressed genes, and has much more extreme synonymous codon preference. The pattern of codon usage observed is consistent with that expected if a need to match abundant tRNAs, and intermediacy of tRNA-mRNA interaction energies are important selective constraints. Thus codon usage in the highly expressed group shows a higher correlation with tRNA abundance, a greater degree of third base pyrimidine bias, and a lesser tendency to the A+T richness which is characteristic of the yeast genome. The cluster analysis can be used to predict the likely level of gene expression of any gene, and identifies the pattern of codon usage likely to yield optimal gene expression in yeast.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Sharp PM,Tuohy TM,Mosurski KRdoi
10.1093/nar/14.13.5125subject
Has Abstractpub_date
1986-07-11 00:00:00pages
5125-43issue
13eissn
0305-1048issn
1362-4962journal_volume
14pub_type
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journal_title:Nucleic acids research
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更新日期:2012-10-01 00:00:00
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更新日期:1996-06-15 00:00:00
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更新日期:2007-01-01 00:00:00
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