Current climate for digital game-based learning of science in further and higher education.


:Digital game-based learning (DGBL) is being used increasingly as an alternative learning tool to teach science in further and higher education. A variety of digital game formats currently exist for science learning, alongside diverse methods for their implementation and evaluation. This paper aims to provide a broad summary of the field by discussing the current platforms for DGBL and examples of games played on them. These include gamified simulations and traditional digital games delivered through personal computer and online software; mobile games delivered through downloaded applications for devices such as tablets and mobile phones; and educational modifications of commercial games, known amongst gamers as 'mods'. To conclude the summary, the paper discusses the current challenges and barriers associated with DGBL in further and higher science education, and potential strategies researchers may consider to overcome them.


FEMS Microbiol Lett


Brown CL,Comunale MA,Wigdahl B,Urdaneta-Hartmann S




Has Abstract


2018-11-01 00:00:00












  • Nested PCR for the detection of Candidatus arthromitus in fish.

    abstract::Rainbow trout gastroenteritis has been related to the accumulation of segmented filamentous bacteria in the digestive tract of fish, which presents lethargy, reduced appetite and accumulation of mucoid faeces. Some authors associate the comparison of illness with the presence of viable filaments, which produce and rel...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Manzano M,Giusto C,Iacumin L,Patthey C,Cecchini F,Fontanillas R,Comi G

    更新日期:2010-07-01 00:00:00

  • Virulence determinants in enteroaggregative Escherichia coli from North India and their interaction in in vitro organ culture system.

    abstract::Enteroaggregative Escherichia coli (EAEC) is an important diarrhoeal pathogen causing diseases in multiple epidemiological and clinical settings. In developing countries like India, diarrhoeal diseases are one of the major killers among paediatric population and oddly, few studies are available from Indian paediatric ...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Gupta D,Sharma M,Sarkar S,Thapa BR,Chakraborti A

    更新日期:2016-09-01 00:00:00

  • Antibacterial effects of protruding and recessed shark skin micropatterned surfaces of polyacrylate plate with a shallow groove.

    abstract::Antibacterial effects in terms of biofilm formation and swarming motility were studied using polyacrylate plates having protruding or recessed shark skin micropatterned surfaces with a shallow groove (2 μm pattern width and spacing, 0.4 μm pattern height). It was found that biofilm formation and swarming motility of P...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Sakamoto A,Terui Y,Horie C,Fukui T,Masuzawa T,Sugawara S,Shigeta K,Shigeta T,Igarashi K,Kashiwagi K

    更新日期:2014-12-01 00:00:00

  • The discriminatory power of MALDI-TOF mass spectrometry to differentiate between isogenic teicoplanin-susceptible and teicoplanin-resistant strains of methicillin-resistant Staphylococcus aureus.

    abstract::To explore the discriminatory power of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) for detecting subtle differences in isogenic isolates, we tested isogenic strains of Staphylococcus aureus differing in their expression of resistance to methicillin or teicoplanin. More i...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Majcherczyk PA,McKenna T,Moreillon P,Vaudaux P

    更新日期:2006-02-01 00:00:00

  • Transposon mutagenesis in Staphylococcus epidermidis using the Enterococcus faecalis transposon Tn917.

    abstract::We transformed a clinical Staphylococcus epidermidis isolate with the Enterococcus faecalis transposon Tn917-carrying plasmid pTV1. Loss of plasmid replication was observed at 47 degrees C. Tn917 transposes efficiently and apparently randomly. The transposition frequency could be stimulated by erythromycin. Transposon...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Grueter L,Koenig O,Laufs R

    更新日期:1991-08-01 00:00:00

  • Stage-specific proteinases of Leishmania mexicana mexicana promastigotes.

    abstract::Four distinct bands of cysteine proteinase activity were detected when stationary-phase populations of Leishmania mexicana mexicana were subjected to gelatin-SDS-PAGE. The highest mobility band contained at least three isoforms separable by mono Q anion exchange chromatography. These high mobility activities were dist...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Robertson CD,Coombs GH

    更新日期:1992-07-01 00:00:00

  • Growth of Salmonella enteritidis and S. pullorum on Hektoen agar and the expression of lipopolysaccharide or flagella.

    abstract::Growth of strains of Salmonella enteritidis and Salmonella pullorum on Hektoen agar has been reported to influence the expression of long-chain lipopolysaccharide and motility respectively. In this study we used a panel of strains of S. enteritidis and S. pullorum to investigate these phenomena. Culture on Hektoen aga...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Chart H,Rowe B

    更新日期:1998-06-15 00:00:00

  • Clonal relationships among Escherichia coli serogroup 06 isolates from human and animal infections.

    abstract::The clonal relationship of thirty E. coli strains of 0 antigen serotype 06 isolated from human, dog, pig or cow infections were investigated. Two main clones with serotypes 06 : H1 or 06 : H31, H- were identified. Isolates from humans, dogs, pigs and cows were found in both clones, indicating that animals are a possib...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Cherifi A,Contrepois M,Picard B,Goullet P,Orskov I,Orskov F,De Rycke J

    更新日期:1991-05-15 00:00:00

  • Cloning and sequencing of a species-specific nucleotide fragment of Borrelia burgdorferi sensu stricto, which is repeated in several plasmids of the species.

    abstract::Among the etiological agents of Lyme disease, Borrelia burgdorferi sensu stricto strains carry a 16 kb plasmid, which did not hybridize to plasmids of B. garinii and B. afzelii strains. A 1271 bp DNA fragment of the 16 kb plasmid was cloned. It hybridized to several plasmids of this species (16, 27 and 55 kb). Sequenc...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Misonne MC,Schuttler M,Dernelle JM,De Kesel M,Hoet PP

    更新日期:1997-05-01 00:00:00

  • bkaR is a TetR-type repressor that controls an operon associated with branched-chain keto-acid metabolism in Mycobacteria.

    abstract::This study describes how bkaR, a highly conserved mycobacterial TetR-like transcriptional repressor, regulates a number of nearby genes that have associations with branched-chain keto-acid metabolism. bkaR (MSMEG_4718) was deleted from the nonpathogenic species Mycobacterium smegmatis, and changes in global gene expre...

    journal_title:FEMS microbiology letters

    pub_type: 信件


    authors: Balhana RJ,Swanston SN,Coade S,Withers M,Sikder MH,Stoker NG,Kendall SL

    更新日期:2013-08-01 00:00:00

  • Industrial production of acetone and butanol by fermentation-100 years later.

    abstract::Microbial production of acetone and butanol was one of the first large-scale industrial fermentation processes of global importance. During the first part of the 20th century, it was indeed the second largest fermentation process, superseded in importance only by the ethanol fermentation. After a rapid decline after t...

    journal_title:FEMS microbiology letters

    pub_type: 历史文章,杂志文章


    authors: Sauer M

    更新日期:2016-07-01 00:00:00

  • Ku70 or Ku80 deficiencies in the fungus Botrytis cinerea facilitate targeting of genes that are hard to knock out in a wild-type context.

    abstract::The filamentous ascomycete Botrytis cinerea is one of the most studied models for understanding the necrotrophic behaviour of phytopathogenic fungi. The genomes of two strains of B. cinerea have been sequenced (B05.10 and T4), which may contribute to elucidating the virulence polymorphism in this fungus. In this study...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Choquer M,Robin G,Le Pêcheur P,Giraud C,Levis C,Viaud M

    更新日期:2008-12-01 00:00:00

  • Characterization of SCAR markers of Eimeria spp. of domestic fowl and construction of a public relational database (The Eimeria SCARdb).

    abstract::This study reports the development and characterization of 151 sequence characterized amplified region (SCAR) markers for the seven Eimeria species that infect the domestic fowl. From this set, 84 markers are species-specific and 67 present partial specificity. The complete nucleotide sequence was derived for all mark...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Fernandez S,Katsuyama AM,Kashiwabara AY,Madeira AM,Durham AM,Gruber A

    更新日期:2004-09-01 00:00:00

  • Tetratricopeptide repeats are essential for PcrH chaperone function in Pseudomonas aeruginosa type III secretion.

    abstract::The type III secretion system (T3SS) is a specialized apparatus evolved by Gram-negative bacteria to deliver effector proteins into host cells, thus facilitating the establishment of an infection. Effector translocation across the target cell plasma membrane is believed to occur via pores formed by at least two secret...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Bröms JE,Edqvist PJ,Forsberg A,Francis MS

    更新日期:2006-03-01 00:00:00

  • High catalytic activity of alanine racemase from psychrophilic Bacillus psychrosaccharolyticus at high temperatures in the presence of pyridoxal 5'-phosphate.

    abstract::We examined the effect of the pyridoxal 5'-phosphate (PLP) cofactor on the activity and stability of the psychrophilic alanine racemase, having a high catalytic activity at low temperature, from Bacillus psychrosaccharolyticus at high temperatures. The decrease in the enzyme activity at incubation temperatures over 40...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Okubo Y,Yokoigawa K,Esaki N,Soda K,Misono H

    更新日期:2000-11-15 00:00:00

  • Mycobacterium avium rough-to-smooth colony conversion resulting from growth in Tween 80 without presence of type-specific glycopeptidolipid antigens.

    abstract::Growth of a Mycobacterium avium complex serotype 20 rough-colony variant in 1.0% Tween 80 resulted in a smooth-colony morphological conversion that was reversible upon removal of Tween and was not associated with the presence of serotype-specific glycopeptidolipid antigens. Electron microscopic examination suggested t...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Wright EL,Pourshafie M,Barrow WW

    更新日期:1992-11-01 00:00:00

  • Candida albicans hyphal invasion: thigmotropism or chemotropism?

    abstract::Hyphae of the human pathogenic fungus Candida albicans exhibit thigmotropic behaviour in vitro, in common with phytopathogenic and saprotrophic fungi. An examination of the literature on C. albicans hyphal penetration of epithelial and endothelial membranes does not support the premise that hyphal thigmotropism plays ...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章,评审


    authors: Davies JM,Stacey AJ,Gilligan CA

    更新日期:1999-02-15 00:00:00

  • Separation of Pneumocystis carinii from the lung of the steroid-suppressed rat.

    abstract::Pneumocystis carinii pneumonia was induced in rats by chronic corticosteroid immunosuppression. The parasite was separated from virtually all contaminating host cells using the technique of unit gravity sedimentation. Cellular contamination was routinely below 0.02%. The same technique allowed partial separation of th...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Taylor MB,Easmon CS

    更新日期:1990-06-15 00:00:00

  • Sequencing and characterization of a novel serine metalloprotease from Burkholderia pseudomallei.

    abstract::Burkholderia pseudomallei, a Gram-negative bacterium is found in the soil and water, mainly in Southeast Asia and Northern Australia. It is responsible for melioidosis in human and animals. The bacteria produce several potential virulent factors such as extracellular protease, hemolysin, lipase and lecithinase. The is...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Lee MA,Liu Y

    更新日期:2000-11-01 00:00:00

  • Novel putative rhizobial species with different symbiovars nodulate Lotus creticus and their differential preference to distinctive soil properties.

    abstract::Phylogenetically diverse rhizobial strains endemic to Tunisia were isolated from symbiotic nodules of Lotus creticus, growing in different arid extremophile geographical regions of Tunisia, and speciated using multiloci-phylogenetic analysis as Neorhizobium huautlense (LCK33, LCK35, LCO42 and LCO49), Ensifer numidicus...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Rejili M,BenAbderrahim MA,Mars M,Sherrier JD

    更新日期:2020-06-01 00:00:00

  • Role of Helicobacter pylori rfaJ genes (HP0159 and HP1416) in lipopolysaccharide synthesis.

    abstract::The genome of Helicobacter pylori 26695 has been sequenced and the lipopolysaccharide (LPS) O sidechain of this strain has been shown to express both Lewis x and Lewis y units. To determine the role of HP0159 and HP1416, genes recognized as rfaJ homologs and implicated in LPS synthesis, isogenic mutants of H. pylori 2...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Moran AP,Shiberu B,Ferris JA,Knirel YA,Senchenkova SN,Perepelov AV,Jansson PE,Goldberg JB

    更新日期:2004-12-01 00:00:00

  • CpaA a novel protease from Acinetobacter baumannii clinical isolates deregulates blood coagulation.

    abstract::Acinetobacter baumannii is an important nosocomial pathogen that displays high antibiotic resistance. It causes a variety of infections including pneumonias and sepsis which may result in disseminated intravascular coagulation. In this work, we identify and characterize a novel secreted, zinc-dependent, metallo-endope...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Tilley D,Law R,Warren S,Samis JA,Kumar A

    更新日期:2014-07-01 00:00:00

  • Mechanisms of protein kinase Sch9 regulating Bcy1 in Saccharomyces cerevisiae.

    abstract::In this study, we investigated the mechanisms of Sch9 regulating the localization and phosphorylation of Bcy1. Our research indicated that Sch9 regulated localization of Bcy1 via Zds1 for the following reasons: (1) deletions of SCH9 or ZDS1 both caused nuclear localization of Bcy1; (2) Sch9 and Zds1 interacted physica...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Zhang A,Gao W

    更新日期:2012-06-01 00:00:00

  • Identification of genes transcribed by Pasteurella multocida in rabbit livers through the selective capture of transcribed sequences.

    abstract::Pasteurella multocida, a Gram-negative nonmotile coccobacillus, is the causative agent of fowl cholera in poultry, hemorrhagic septicemia in cattle, atropic rhinitis in swine, and snuffles in rabbits. The differentially expressed gene profile of P. multocida in infected rabbit livers was identified and compared with t...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Guo D,Lu Y,Zhang A,Liu J,Yuan D,Jiang Q,Lin H,Si C,Qu L

    更新日期:2012-06-01 00:00:00

  • Phylogenetic relationships between Tuber pseudoexcavatum, a Chinese truffle, and other Tuber species based on parsimony and distance analysis of four different gene sequences.

    abstract::Phylogenetic relationships between Tuber pseudoexcavatum and other Tuber species were investigated by studying the sequences of four genes: 5.8S-ITS2, beta-tubulin, protein kinase C and elongation factor 1alpha. The four phylogenetic trees allowed to differentiate the black truffle clade, composed of two subclades, on...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Wang Y,Tan ZM,Zhang DC,Murat C,Jeandroz S,Le Tacon F

    更新日期:2006-06-01 00:00:00

  • ABC transporters in antibiotic-producing actinomycetes.

    abstract::Many antibiotic-producing actinomycetes possess at least one ABC (ATP-binding cassette) transporter which forms part of the antibiotic biosynthetic pathway and in most cases confers resistance to the drug in an heterologous host. Three types of antibiotic ABC transporters have been so far described in producer organis...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章,评审


    authors: Méndez C,Salas JA

    更新日期:1998-01-01 00:00:00

  • Nitrogen regulation in Corynebacterium glutamicum: isolation of genes involved and biochemical characterization of corresponding proteins.

    abstract::The regulation of nitrogen assimilation was investigated in the Gram-positive actinomycete Corynebacterium glutamicum. Biochemical studies and site-directed mutagenesis revealed that glutamine synthetase activity is regulated via adenylylation in this organism. The genes encoding the central signal transduction protei...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Jakoby M,Krämer R,Burkovski A

    更新日期:1999-04-15 00:00:00

  • Correlation between glycosylation of flagellin proteins and sensitivity of flagellar filaments to Triton X-100 in methanogens.

    abstract::The flagellins of Methanospirillum hungatei strains JF1 and GP1, Methanococcus deltae, and Methanothermus fervidus are glycosylated. Isolated flagellar filaments from these organisms are dissociated by low concentrations (0.5% (v/v)) of Triton X-100. Flagellar filaments from other methanogens (Methanococcus voltae, Me...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Faguy DM,Koval SF,Jarrell KF

    更新日期:1992-01-01 00:00:00

  • The triazine hydrolase gene trzN from Nocardioides sp. strain C190: cloning and construction of gene-specific primers.

    abstract::Using oligonucleotides derived from the N-terminal sequence of a triazine hydrolase from Nocardioides sp. strain C190, two DNA fragments containing trzN were cloned into Escherichia coli and their nucleotide sequences were determined. The 456-amino acid polypeptide predicted from the 1356-bp trzN ORF displayed signifi...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Mulbry WW,Zhu H,Nour SM,Topp E

    更新日期:2002-01-02 00:00:00

  • Assessment of the serodiagnostic potential of nine novel proteins from Mycobacterium tuberculosis.

    abstract::To identify antigens that would improve the accuracy of serological diagnosis of active tuberculosis, we cloned the genes encoding nine potentially immunogenic secreted or surface-associated proteins of Mycobacterium tuberculosis. Recombinant proteins were reacted with sera from HIV-negative individuals with extrapulm...

    journal_title:FEMS microbiology letters

    pub_type: 杂志文章


    authors: Moran AJ,Treit JD,Whitney JL,Abomoelak B,Houghton R,Skeiky YA,Sampaio DP,Badaró R,Nano FE

    更新日期:2001-04-20 00:00:00