Abstract:
:Human keratinocytes were recently shown to respond to anti-EGFR (epidermal growth factor receptor) drugs with activation of an interferon-κ-driven autocrine loop, leading to enhanced expression of innate antiviral effectors and of the pro-inflammatory chemokines CXCL10 (C-X-C motif chemokine 10) and CCL2 (C-C motif ligand 2). Here we showed active type I interferon signaling in the skin lesions of cancer patients undergoing treatment with the anti-EGFR drug cetuximab. Strong nuclear positivity for Interferon Regulatory Factor 1 and phosphorylated Signal Transducer and Activator of Transcription 1, enhanced interferon-κ expression and CXCL10 was associated to the epidermal compartment. Notably, 50 micromolar resveratrol and quercetin fully suppressed the low constitutive levels of type I interferon signaling and prevented its activation by the anti-EGFR cetuximab or gefitinib in cultured keratinocytes. In sensitized mice undergoing DNFB (2,4-dinitro-1-fluorobenzene)-induced contact hypersensitivity, local administration of gefitinib prior to elicitation further amplified hapten-induced type I interferon activation, tissue edema, and infiltration by T cells, whereas resveratrol or quercetin suppressed this inflammatory cascade. Overall, these data suggest that topical application of resveratrol or quercetin could be potentially effective in preventing pathological conditions due to overactivation of type I IFN (interferon)-driven circuits in the skin, including the inflammatory manifestations of anti-EGFR drug-induced skin-targeted toxicity.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Carbone ML,Lulli D,Passarelli F,Pastore Sdoi
10.3390/ijms19092652subject
Has Abstractpub_date
2018-09-06 00:00:00issue
9issn
1422-0067pii
ijms19092652journal_volume
19pub_type
杂志文章abstract::The diagnosis and treatment of prostate cancer (PCa) is a major health-care concern worldwide. This cancer can manifest itself in many distinct forms and the transition from clinically indolent PCa to the more invasive aggressive form remains poorly understood. It is now universally accepted that glycan expression pat...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21239233
更新日期:2020-12-03 00:00:00
abstract::As the worldwide application of nanomaterials in commercial products increases every year, various nanoparticles from industry might present possible risks to aquatic systems and human health. Presently, there are many unknowns about the toxic effects of nanomaterials, especially because the unique physicochemical pro...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21082864
更新日期:2020-04-20 00:00:00
abstract:BACKGROUND:A growing body of data indicates that the physiology of the liver is sex-hormone dependent, with some types of liver failure occurring more frequently in males, and some in females. In males, in physiological conditions, testosterone acts via androgen receptors (AR) to increase insulin receptor (IR) expressi...
journal_title:International journal of molecular sciences
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doi:10.3390/ijms22031242
更新日期:2021-01-27 00:00:00
abstract::The critical initial steps in insulin action include phosphorylation of adapter proteins and activation of phosphatidylinositol 3-kinase (PI3K). One of important components in this process is a protein called Akt/protein kinase B (PKB). The work of numerous different researchers indicates a role of PKB in regulating i...
journal_title:International journal of molecular sciences
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doi:10.3390/ijms9112217
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:Growth failure and delayed puberty are well known features of children and adolescents with inflammatory bowel disease (IBD), in addition to the chronic course of the disease. Urinary metabonomics was applied in order to better understand metabolic changes between healthy and IBD children. METHODS:21 Pediat...
journal_title:International journal of molecular sciences
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doi:10.3390/ijms17081310
更新日期:2016-08-11 00:00:00
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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更新日期:2019-10-24 00:00:00
abstract::Characterizations of fatty acids composition in % of total methylester of fatty acids (FAMEs) of fourteen vegetable oils--safflower, grape, silybum marianum, hemp, sunflower, wheat germ, pumpkin seed, sesame, rice bran, almond, rapeseed, peanut, olive, and coconut oil--were obtained by using gas chromatography (GC). S...
journal_title:International journal of molecular sciences
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doi:10.3390/ijms160612871
更新日期:2015-06-05 00:00:00
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doi:10.3390/ijms18091921
更新日期:2017-09-07 00:00:00
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doi:10.3390/ijms12074465
更新日期:2011-01-01 00:00:00
abstract::Cancers are heterogeneous at the cell level, and the mechanisms leading to cancer heterogeneity could be clonal evolution or cancer stem cells. Cancer stem cells are resistant to most anti-cancer treatments and could be preferential targets to reverse this resistance, either targeting stemness pathways or cancer stem ...
journal_title:International journal of molecular sciences
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更新日期:2018-12-13 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18061113
更新日期:2017-05-24 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms21062084
更新日期:2020-03-18 00:00:00
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doi:10.3390/ijms11020492
更新日期:2010-02-02 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms21197077
更新日期:2020-09-25 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms18112277
更新日期:2017-10-30 00:00:00
abstract::Protein microarrays are powerful tools that are widely used in systems biology research. For infectious diseases, proteome microarrays assembled from proteins of pathogens will play an increasingly important role in discovery of diagnostic markers, vaccines, and therapeutics. Distinct formats of protein microarrays ha...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms11125165
更新日期:2010-01-01 00:00:00
abstract::Experiments were carried out to investigate the effects of various factors on the activity and conformation of recombinant leucine aminopeptidase of Bacillus kaustophilus CCRC 11223 (BkLAP) and potential utilization of BkLAP in the hydrolysis of anchovy protein. Optimal temperature and pH of BkLAP were 70 °C and 8.0 i...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms12117609
更新日期:2011-01-01 00:00:00
abstract::Non-communicable diseases (NCDs) have become the largest contributor to worldwide morbidity and mortality. Among them, cancer and cardiovascular diseases (CVDs) are responsible for a 47% of worldwide mortality. In general, preventive approaches modifying lifestyle are more cost-effective than treatments after disease ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19082305
更新日期:2018-08-06 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms21072317
更新日期:2020-03-27 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20071604
更新日期:2019-03-31 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms17060809
更新日期:2016-05-26 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms21197354
更新日期:2020-10-05 00:00:00
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journal_title:International journal of molecular sciences
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更新日期:2019-05-17 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms17030323
更新日期:2016-03-01 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19030865
更新日期:2018-03-15 00:00:00
abstract::Cannabis sativa L. is a plant long used for its textile fibers, seed oil, and oleoresin with medicinal and psychoactive properties. It is the main source of phytocannabinoids, with over 100 compounds detected so far. In recent years, a lot of attention has been given to the main phytochemicals present in Cannabis sati...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20235905
更新日期:2019-11-25 00:00:00
abstract::Preterm birth (PTB) can be defined as the endpoint of a complex process that could be influenced by maternal and environmental factors. Epigenetics recently emerged as an interesting field of investigation since it represents an important mechanism of regulation. This study evaluates epigenetic impact of preterm birth...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21145044
更新日期:2020-07-17 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms20061322
更新日期:2019-03-15 00:00:00