Histopathology of Bordetella pertussis in the Baboon Model.

abstract：:Clostridium perfringens enterotoxin caused a 26 to 41% reduction in the rate of oxygen consumption by rat liver mitochondria when various tricarboxylic acid cycle intermediates were used as substrate. However, P/O ratios were unaltered. ...

journal_title：Infection and immunity

authors： McDonel JL,Duncan CL

更新日期：1977-03-01 00:00:00

abstract：:The addition of a sonic extract of Capnocytophaga sputigena to the culture fluid to human fibroblasts resulted in an inhibition of cell proliferation. The inhibition was dose-related (200 micrograms/ml caused a 90% inhibition, and 1,000 micrograms/ml caused a complete cessation of growth). The growth inhibition was no...

journal_title：Infection and immunity

authors： Stevens RH,Sela MN,Shapira J,Hammond BF

更新日期：1980-01-01 00:00:00

abstract：:Ehrlichia chaffeensis, a tick-transmitted rickettsial, is the causative agent of human monocytic ehrlichiosis. To examine protein expression patterns, we analyzed total, membrane, and immunogenic proteomes of E. chaffeensis originating from macrophage and tick cell cultures. Total proteins resolved by one-dimensional ...

journal_title：Infection and immunity

authors： Seo GM,Cheng C,Tomich J,Ganta RR

更新日期：2008-11-01 00:00:00

abstract：:N-Acetyl-muramyl-L-alanyl-D-isoglutamine (MDP), a structurally defined fragment of bacterial peptidoglycan, stimulated significant release of previously incorporated 45Ca from fetal rat bones in tissue culture over the concentration range of 0.1 to 10.0 micrograms/ml. MDP-Stimulated bone resorption was not inhibited b...

journal_title：Infection and immunity

authors： Dewhirst FE

更新日期：1982-01-01 00:00:00

abstract：:While gamma/delta T cells are involved in host defense and immunopathology in a variety of infectious diseases, their precise role is not yet clearly defined. In the absence of gamma/delta T cells, mice die after infection with a dose of Listeria monocytogenes that is not lethal in immunologically intact animals. Morb...

journal_title：Infection and immunity

authors： Skeen MJ,Rix EP,Freeman MM,Ziegler HK

更新日期：2001-12-01 00:00:00

abstract：:Culture filtrate proteins from Mycobacterium tuberculosis induce protective immunity in various animal models of tuberculosis. Two molecular mass regions (6 to 10 kDa and 24 to 36 kDa) of short-term culture filtrate are preferentially recognized by Th1 cells in animal models as well as by patients with minimal disease...

journal_title：Infection and immunity

authors： Rosenkrands I,Rasmussen PB,Carnio M,Jacobsen S,Theisen M,Andersen P

更新日期：1998-06-01 00:00:00

abstract：:Conjunctival infection of guinea pigs by the chlamydial agent of guinea pig inclusion conjunctivitis confers immunity. However, the mechanism of resistance to this intracellular pathogen is not yet defined. In the study reported here, serum immunoglobulin was passively transferred with resultant titers in excess of th...

journal_title：Infection and immunity

authors： Watson RR,Mull JD,MacDonald AB,Thompson SE 3rd,Bear SE

更新日期：1973-04-01 00:00:00

abstract：:Two enteropathogenic strains of Escherichia coli (EEC) differed from a nonenteropathogenic strain of E. coli (NEEC) in their association with porcine small intestinal epithelium. The EEC characteristically were found along villi from tip to base and contiguous to the brush border. They were not in crypts. In contrast,...

journal_title：Infection and immunity

authors： Bertschinger HU,Moon HW,Whipp SC

更新日期：1972-04-01 00:00:00

abstract：:Porphyromonas gingivalis forms communities with antecedent oral biofilm constituent streptococci. P. gingivalis major fimbriae bind to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) present on the streptococcal surface, and this interaction plays an important role in P. gingivalis colonization. This study identified...

journal_title：Infection and immunity

authors： Nagata H,Iwasaki M,Maeda K,Kuboniwa M,Hashino E,Toe M,Minamino N,Kuwahara H,Shizukuishi S

更新日期：2009-11-01 00:00:00

abstract：:The effect of growth temperature on the virulence of a strain of broth-grown serogroup 1 Legionella pneumophila (Wadsworth F889) was examined by growing the bacterium at different temperatures and then infecting guinea pigs (by intratracheal injection) and guinea pig alveolar macrophages. The 50% lethal dose for guine...

journal_title：Infection and immunity

authors： Edelstein PH,Beer KB,DeBoynton ED

更新日期：1987-11-01 00:00:00

abstract：:Studies of mice suggest that pneumococcal proteins, including PspA, pneumolysin, PsaA, and CbpA, are promising vaccine candidates. To determine whether these proteins are good mucosal immunogens in humans, adenoidal lymphocytes from 20 children who had adenoidectomies were isolated and tested by ELISpot for antigen-sp...

journal_title：Infection and immunity

authors： Zhang Q,Choo S,Finn A

更新日期：2002-10-01 00:00:00

abstract：:Host resistance to African trypanosomiasis is partially dependent on an early and strong T-independent B-cell response against the variant surface glycoprotein (VSG) coat expressed by trypanosomes. The repetitive array of surface epitopes displayed by a monotypic surface coat, in which identical VSG molecules are clos...

journal_title：Infection and immunity

authors： Dubois ME,Demick KP,Mansfield JM

更新日期：2005-05-01 00:00:00

abstract：:Helicobacter pylori colonizes the gastric mucosa and secretes a pore-forming toxin (VacA). Two main types of VacA, m1 and m2, can be distinguished by phylogenetic analysis. Type m1 forms of VacA have been extensively studied, but there has been relatively little study of m2 forms. In this study, we generated H. pylori...

journal_title：Infection and immunity

authors： Caston RR,Sierra JC,Foegeding NJ,Truelock MD,Campbell AM,Frick-Cheng AE,Bimczok D,Wilson KT,McClain MS,Cover TL

更新日期：2020-05-20 00:00:00

abstract：:Repeated immunizations of CF1 mice with irradiated noninfectious Trypanosoma cruzi trypomastigotes resulted in partial protection against infection with live parasites. It also induced a limited number of antibody species that were reactive in Western blots with trypomastigote but not with epimastigote or amastigote p...

journal_title：Infection and immunity

authors： Zweerink HJ,Weston HD,Andersen OF,Garber SS,Hayes EC

更新日期：1984-12-01 00:00:00

abstract：:Nucleotide-binding oligomerization domain (NOD) protein 1 (NOD1) and NOD2 are pathogen recognition receptors that sense breakdown products of peptidoglycan (PGN) (muropeptides). It is shown that a number of these muropeptides can induce tumor necrosis factor alpha (TNF-alpha) gene expression without significant TNF-al...

journal_title：Infection and immunity

authors： Wolfert MA,Roychowdhury A,Boons GJ

更新日期：2007-02-01 00:00:00

abstract：:The antigenic relationship of glucosyltransferases (GTF) produced by different serotypes of Streptococcus mutans was studied by using a functional inhibition assay. Rat, rabbit, or hamster immune fluids, directed to cell-associated or supernatant-derived GTF, were tested against ammonium sulfate-precipitated culture s...

journal_title：Infection and immunity

authors： Smith DJ,Taubman MA

更新日期：1977-01-01 00:00:00

abstract：:Nonopsonic invasion of mononuclear phagocytes by Mycobacterium tuberculosis is likely important in the establishment of a primary infection in the lung. M. tuberculosis binds to a variety of phagocyte receptors, of which the mannose receptor and complement receptor type 3 (CR3) may support nonopsonic binding. CR3, a b...

journal_title：Infection and immunity

authors： Cywes C,Godenir NL,Hoppe HC,Scholle RR,Steyn LM,Kirsch RE,Ehlers MR

更新日期：1996-12-01 00:00:00

abstract：:Mice with disrupted beta 2-microglobulin (beta 2m-/-), I-A (class II-/-), or CD4 (CD4-/-) genes were examined for their capacity to resolve Chlamydia trachomatis genital tract infection. C57BL/6 and beta 2m-/- mice resolved infection similarly and were culture negative by 4 to 5 weeks following infection. Conversely, ...

journal_title：Infection and immunity

authors： Morrison RP,Feilzer K,Tumas DB

更新日期：1995-12-01 00:00:00

abstract：:EspC is an autotransporter protein secreted by enteropathogenic Escherichia coli (EPEC). The pathogenic role of EspC in EPEC infection is unknown. We have shown that the purified EspC produces enterotoxicity and cytotoxicity; for the latter effect, EspC must be internalized. However, the internalization mechanism is u...

journal_title：Infection and immunity

authors： Vidal JE,Navarro-García F

更新日期：2006-04-01 00:00:00

abstract：:Chlamydia trachomatis is a strict human pathogen producing infections that cause medically important chronic inflammatory diseases, such as blinding trachoma and tubal factor infertility. Isolates exist as serotypes that fall into distinct biologic and pathological groups corresponding to differences in infection tiss...

journal_title：Infection and immunity

authors： Carlson JH,Hughes S,Hogan D,Cieplak G,Sturdevant DE,McClarty G,Caldwell HD,Belland RJ

更新日期：2004-12-01 00:00:00

abstract：:F1651 and the pyelonephritis-associated pili (Pap) are two members of the type P family of adhesive factors. They play a key role in establishing disease caused by extraintestinal pathogenic Escherichia coli (ExPEC) strains in animals and humans. Both F1651 and Pap are under the control of an epigenetic and reversible...

journal_title：Infection and immunity

authors： Graveline R,Lavoie R,Garneau P,Daigle F,Sénéchal S,Martin C,Harel J

更新日期：2015-05-01 00:00:00

abstract：:In experimental Leishmania donovani infection in BALB/c mice, initial susceptibility gives way to T-cell-dependent acquired resistance and eventual control over visceral infection. Since various cytokines appear to underlie the host response to Leishmania infection, we examined infected liver tissue for gene expressio...

journal_title：Infection and immunity

authors： Miralles GD,Stoeckle MY,McDermott DF,Finkelman FD,Murray HW

更新日期：1994-03-01 00:00:00

abstract：:Previous studies have suggested that interleukin-4 (IL-4) has a protective effect in host defense to Borrelia burgdorferi infection, both in limiting the severity of arthritis and in controlling spirochete numbers in tissues, and a mapping study revealed suggestive linkage to a cluster of genes on mouse chromosome 11,...

journal_title：Infection and immunity

authors： Potter MR,Noben-Trauth N,Weis JH,Teuscher C,Weis JJ

更新日期：2000-10-01 00:00:00

abstract：:Comparative studies on the virulence of two strains of Pseudomonas aeruginosa isolated from otic pus and mink pneumonic lesion, respectively, were made by means of intranasal inoculation in mink. The minimal lethal dose of the former (strain NC-5, highly virulent for mice) was 10(10), and that of the latter (strain No...

journal_title：Infection and immunity

authors： Shimizu T,Homma JY,Aoyama T,Onodera T,Noda H

更新日期：1974-07-01 00:00:00

abstract：:We have compared the intraleukocytic survival of isogenic strains of Salmonella typhimurium, whose outer membrane lipopolysaccharide differed in O antigen and lipid A composition and whose susceptibility to nonoxidative antimicrobial granule proteins of human polymorphonuclear neutrophilis (PMN) could be established. ...

journal_title：Infection and immunity

authors： Stinavage P,Martin LE,Spitznagel JK

更新日期：1989-12-01 00:00:00

abstract：:Helicobacter pylori vacuolating cytotoxin (VacA) is a secreted protein that induces vacuolation of epithelial cells. To study VacA structure and function, we immunized mice with purified type s1-m1 VacA from H. pylori strain 60190 and generated a panel of 10 immunoglobulin G1kappa anti-VacA monoclonal antibodies. All ...

journal_title：Infection and immunity

authors： Vinion-Dubiel AD,McClain MS,Cao P,Mernaugh RL,Cover TL

更新日期：2001-07-01 00:00:00

abstract：:The serum opacity factor (SOF) of Streptococcus pyogenes is a serotyping tool and pathogenesis factor. Using SOF-coated latex beads in cell adherence assays and antiserum directed against SOF in S. pyogenes-HEp-2 cell adherence inhibition experiments, we demonstrate SOF involvement in the fibronectin-mediated adherenc...

journal_title：Infection and immunity

authors： Oehmcke S,Podbielski A,Kreikemeyer B

更新日期：2004-07-01 00:00:00

abstract：:The host immune response plays an important role in the onset and progression of cerebral malaria (CM). The complement system is an essential component of the innate immune response to malaria, and its activation generates the anaphylatoxin C5a. To test the hypothesis that C5a signaling contributes to the pathogenesis...

journal_title：Infection and immunity

authors： Kim H,Erdman LK,Lu Z,Serghides L,Zhong K,Dhabangi A,Musoke C,Gerard C,Cserti-Gazdewich C,Liles WC,Kain KC

更新日期：2014-01-01 00:00:00

abstract：:Klebsiella pneumoniae is a leading cause of both community-acquired and nosocomial gram-negative-bacterial pneumonia. A further clinical complication of pulmonary K. pneumoniae infection is dissemination of bacteria from the lung into the peripheral blood, resulting in bacteremia concurrent with the localized pulmonar...

journal_title：Infection and immunity

authors： Moore TA,Perry ML,Getsoian AG,Newstead MW,Standiford TJ

更新日期：2002-11-01 00:00:00

abstract：:To test the importance of lipopolysaccharide (LPS) and adhesin as major antigens in vaccination against rabbit enteropathogenic Escherichia coli (EPEC)-like E. coli O103 infection, we used two nonpathogenic wild-type strains to immunize rabbits at weaning. One of these strains (C127) harbors the O103 LPS but does not ...

journal_title：Infection and immunity

authors： Milon A,Esslinger J,Camguilhem R

更新日期：1992-07-01 00:00:00