Abstract：
BACKGROUND:COPD physiopathology involves multiple pathways and evidence indicates that brain-derived neurotrophic factor (BDNF) is an important biomarker associated with parameters of COPD severity. This study aimed to analyze the time course of the effects of a pulmonary rehabilitation program (PRP) on BDNF levels and on functional status in COPD patients. METHODS:Patients were enrolled in a 24-session PRP. Exercise capacity, dyspnea, health-related quality of life, and the BODE index were assessed at baseline and after the PRP. BDNF plasma levels were measured at baseline (immediately before the 1st session), after the 1st session, and before and after the 24th session. RESULTS:Sixteen patients were included. A reduction in BDNF levels was observed after the 1st session and an increase was observed between the end of the 1st session and the beginning of the 24th session. The PRP promoted an improvement in exercise capacity and health-related quality of life and a reduction in dyspnea and the BODE index. CONCLUSION:Exercise acutely reduced BDNF levels, an effect that was nullified by the overall intervention.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
de Araujo CLP,da Silva IRV,Reinaldo GP,Peccin PK,Pochmann D,Teixeira PJZ,Elsner VR,Dal Lago Pdoi
10.1016/j.resp.2018.07.011subject
Has Abstractpub_date
2019-01-01 00:00:00pages
63-69eissn
1569-9048issn
1878-1519pii
S1569-9048(18)30071-5journal_volume
259pub_type
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