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Leishmania donovani: surface membrane acid phosphatase blocks neutrophil oxidative metabolite production.

Abstract：

:We show that a purified preparation of the prominent tartrate-resistant acid phosphatase (E.C.3.1.3.2), isolated from the external surface of the intracellular parasite Leishmania donovani (promastigote form), inhibits toxic oxidative metabolite production of neutrophils. Preincubation of a neutrophil suspension (2.5 X 10(6) cells/ml) for 15 min at 37 C with 250 units (1 unit equals 1 nmole of 4-methylumbelliferyl phosphate cleaved per hr at pH 5.5) of the acid phosphatase in Krebs-Ringer phosphate buffer (pH 7.4) decreased O2 consumption, O2- production, and H2O2 production of N-formyl-methionyl-leucyl-phenylalanine (fMet-Leu-Phe)-stimulated neutrophils to 15-25% of control values. The acid phosphatase also affected concanavalin A-stimulated O2-production by neutrophils, but had no effect on the rate of phorbol myristic acetate-stimulated O2- production, chemotactic peptide binding, degranulation, or membrane depolarization. Addition of an acid phosphatase inhibitor (Complex E; (NH4)6[P2Mo18O62] X 9H2O) to suspensions of opsonized promastigotes and neutrophils resulted in a threefold or greater enhancement of O2- production. These results suggest a possible pathophysiologic role for the acid phosphatase of L. donovani promastigotes.

journal_name

Exp Parasitol

journal_title

Experimental parasitology

authors

Remaley AT,Glew RH,Kuhns DB,Basford RE,Waggoner AS,Ernst LA,Pope M

doi

10.1016/0014-4894(85)90039-6

subject

Has Abstract

pub_date

1985-12-01 00:00:00

pages

331-41

issue

3

eissn

0014-4894

issn

1090-2449

journal_volume

60

pub_type

杂志文章

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