Abstract：
:Toll receptors play a critical role in the rapid activation of innate immune responses to a variety of pathogens. In mammals, Toll-like receptors (TLR) have been found in both immune related cells and other cells. At present little is known about the participation of TLR in host defense mechanisms during parasitic infections. The aim of this study was to determine the expression of TLR2 and TLR4 genes in rat intestines during experimental hymenolepidosis. There is difference in expression of TLR2 and TLR4 genes in the colon and jejunum in uninfected rats: in the colon, mRNA of the examined TLR is present in much higher amounts than the jejunum, while the protein of the TLR also had a segmented specific distribution. In the jejunum isolated rats infected with Hymeolepis diminuta 6 and 8 days post infection (dpi), mRNA for TLR4 and TLR2 were significantly more strongly expressed in comparison with the uninfected controls. In the colon, a statistically significantly increased expression of TLR4 gene was observed only at 6 dpi, and at 8 dpi for the TLR2 gene. Moreover, we observed that during inflammation, the immunopositive cell number and the intensity of immunohistochemical staining (indicating the presence of TLR within intestinal epithelial cells), increased together with the duration of the infection period.
journal_name
Exp Parasitoljournal_title
Experimental parasitologyauthors
Kosik-Bogacka DI,Wojtkowiak-Giera A,Kolasa A,Salamatin R,Jagodzinski PP,Wandurska-Nowak Edoi
10.1016/j.exppara.2011.12.002subject
Has Abstractpub_date
2012-03-01 00:00:00pages
261-6issue
3eissn
0014-4894issn
1090-2449pii
S0014-4894(11)00349-3journal_volume
130pub_type
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