Chromatin Loop Formation Induced by a Subtelomeric Protosilencer Represses EPA Genes in Candida glabrata.

abstract：:The parasitoid wasp Nasonia represents a genus of four species that is emerging as a powerful genetic model system that has made and will continue to make important contributions to our understanding of evolutionary biology, development, ecology, and behavior. Particularly powerful are the haplodiploid genetics of the...

journal_title：Genetics

authors： Lynch JA

更新日期：2015-04-01 00:00:00

abstract：:Chromatin insulators separate active from repressed chromatin domains. In yeast the RNA pol III transcription machinery bound to tRNA genes function with histone acetylases and chromatin remodelers to restrict the spread of heterochromatin. Our results collectively demonstrate that binding of TFIIIC is necessary for i...

journal_title：Genetics

authors： Valenzuela L,Dhillon N,Kamakaka RT

更新日期：2009-09-01 00:00:00

abstract：:As one of the world's most important food crops, the potato (Solanum tuberosum L.) has spurred innovation in autotetraploid genetics, including in the use of SNP arrays to determine allele dosage at thousands of markers. By combining genotype and pedigree information with phenotype data for economically important trai...

journal_title：Genetics

authors： Endelman JB,Carley CAS,Bethke PC,Coombs JJ,Clough ME,da Silva WL,De Jong WS,Douches DS,Frederick CM,Haynes KG,Holm DG,Miller JC,Muñoz PR,Navarro FM,Novy RG,Palta JP,Porter GA,Rak KT,Sathuvalli VR,Thompson AL,Yench

更新日期：2018-05-01 00:00:00

abstract：:Recombination in mammalian cells is thought to involve both reciprocal and nonreciprocal modes of exchange, although rigorous proof is lacking due to the inability to recover all products of an exchange. To investigate further the relationship between these modes of exchange, we have analyzed intrachromosomal recombin...

journal_title：Genetics

authors： Bollag RJ,Liskay RM

更新日期：1988-05-01 00:00:00

abstract：:The concept of haplotype blocks has been shown to be useful in genetics. Fields of application range from the detection of regions under positive selection to statistical methods that make use of dimension reduction. We propose a novel approach ("HaploBlocker") for defining and inferring haplotype blocks that focuses ...

journal_title：Genetics

authors： Pook T,Schlather M,de Los Campos G,Mayer M,Schoen CC,Simianer H

更新日期：2019-08-01 00:00:00

abstract：:Protein aggregates are a common pathological feature of most neurodegenerative diseases (NDs). Understanding their formation and regulation will help clarify their controversial roles in disease pathogenesis. To date, there have been few systematic studies of aggregates formation in Drosophila, a model organism that h...

journal_title：Genetics

authors： Zhang S,Binari R,Zhou R,Perrimon N

更新日期：2010-04-01 00:00:00

abstract：:A mutant strain of Chlamydomonas reinhardi which is UV sensitive as a result of a single-gene chromosomal mutation has also been found to exhibit reduced recombination. In crosses homozygous for the mutant allele, a reduction in recombination frequency was demonstrated in two different linkage groups and in three diff...

journal_title：Genetics

authors： Rosen H,Ebersold WT

更新日期：1972-06-01 00:00:00

abstract：:We propose a simple algorithm for estimating the number of nucleotide differences between a pair of RNA or DNA sequences through comparison of their RNAse A mismatch cleavage patterns. In the RNAse A mismatch cleavage technique two or more sample sequences are hybridized to the same RNA probe, the hybrids are partiall...

journal_title：Genetics

authors： Rzhetsky A,Dopazo J,Snyder E,Dangler CA,Ayala FJ

更新日期：1996-12-01 00:00:00

abstract：:Forty-eight new mutations at the am locus of Neurospora crassa have been characterized. Nineteen mutations were induced by UV; of these, eight were missense, two were frameshifts, two were nonsense, three were deletions and four were unidentified. Twenty-nine mutations were induced with nitrous acid; of these, twenty-...

journal_title：Genetics

authors： Kinsey JA,Hung BS

更新日期：1981-11-01 00:00:00

abstract：:The fixation probability is determined when population size and selection change over time and differs from Kimura's result, with long-term implications for a population. It is found that changes in population size are not equivalent to the corresponding changes in selection and can result in less drift than anticipat...

journal_title：Genetics

authors： Waxman D

更新日期：2011-08-01 00:00:00

abstract：:Precocious entry into S phase due to overproduction of G1 regulators can cause genomic instability. The mechanisms of this phenomenon are largely unknown. We explored the consequences of precocious S phase in yeast by overproducing a deregulated form of Swi4 (Swi4-t). Swi4 is a late G1-specific transcriptional activat...

journal_title：Genetics

authors： Sidorova JM,Breeden LL

更新日期：2002-01-01 00:00:00

abstract：:We have examined the effects of prolonged histidine deprivation on the reversion of Salmonella typhimurium histidine auxotrophs containing either hisG46, a missense mutation (CTC----CCC), or hisG428, an ochre mutation (CAA----TAA). Both of these mutants can revert to His+ via intragenic and extragenic mechanisms. Wher...

journal_title：Genetics

authors： Prival MJ,Cebula TA

更新日期：1992-10-01 00:00:00

abstract：:A model is presented showing that natural selection operating at the individual level can adequately explain the evolution of multiple mating behavior by honey bee queens. Group selection need not be invoked. The fitness of a given female genotype is a function of the number of sex alleles in the population, the numbe...

journal_title：Genetics

authors： Page RE Jr

更新日期：1980-09-01 00:00:00

abstract：:In somatic cells of Drosophila, the ratio of X chromosomes to autosomes (X:A ratio) determines sex and dosage compensation. The present paper addresses the question of whether germ cells also use the X:A ratio for sex determination and dosage compensation. Triploid female embryos were generated which, through the loss...

journal_title：Genetics

authors： Schüpbach T

更新日期：1985-03-01 00:00:00

abstract：:Crossovers (COs) between homologous chromosomes are critical for meiotic chromosome segregation and form in the context of the synaptonemal complex (SC), a meiosis-specific structure that assembles between aligned homologs. During Caenorhabditis elegans meiosis, central region components of the SC (SYP proteins) are e...

journal_title：Genetics

authors： Cahoon CK,Helm JM,Libuda DE

更新日期：2019-10-01 00:00:00

abstract：:During meiotic prophase I, sister chromatid cohesion is established in a way that supports the assembly of the synaptonemal complex (SC). The SC connects homologous chromosomes, directing meiotic recombination to create crossovers. In this paper, we identify two proteins that cooperate to import and load meiotic cohes...

journal_title：Genetics

authors： Bowman R,Balukof N,Ford T,Smolikove S

更新日期：2019-02-01 00:00:00

abstract：:Mutations in arg-13 result in slow growth in minimal medium and can suppress mutations in carbamyl phosphate synthase-aspartate carbamyl transferase within the pyrimidine pathway; the exact biochemical function of the gene product is unknown. To understand the role of arg-13 in arginine metabolism, cosmids rescuing gr...

journal_title：Genetics

authors： Liu Q,Dunlap JC

更新日期：1996-07-01 00:00:00

abstract：:Twelve laboratory populations of recently collected Drosophila willistoni were begun with different frequencies of alleles at three enzyme loci, six populations at 25 degrees and six at 19 degrees . Periodic sampling of the populations allowed monitoring of the frequency changes in allozymes over time.-At Lap-5 (a loc...

journal_title：Genetics

authors： Powell JR

更新日期：1973-11-01 00:00:00

abstract：:Immature spermatids from Caenorhabditis elegans are stimulated by an external activation signal to reorganize their membranes and cytoskeleton to form crawling spermatozoa. This rapid maturation, termed spermiogenesis, occurs without any new gene expression. To better understand this signal transduction pathway, we is...

journal_title：Genetics

authors： Muhlrad PJ,Ward S

更新日期：2002-05-01 00:00:00

abstract：:The T-box genes comprise an ancient family of putative transcription factors conserved across species as divergent as Mus musculus and Caenorhabditis elegans. All T-box gene products are characterized by a novel 174-186-amino acid DNA binding domain called the T-box that was first discovered in the polypeptide product...

journal_title：Genetics

authors： Agulnik SI,Garvey N,Hancock S,Ruvinsky I,Chapman DL,Agulnik I,Bollag R,Papaioannou V,Silver LM

更新日期：1996-09-01 00:00:00

abstract：:The interval mapping method is widely used for the mapping of quantitative trait loci (QTLs) in segregating generations derived from crosses between inbred lines. The efficiency of detecting and the accuracy of mapping multiple QTLs by using genetic markers are much increased by employing multiple QTL models instead o...

journal_title：Genetics

authors： Jansen RC

更新日期：1993-09-01 00:00:00

abstract：:The K1 killer plasmid, [KIL-k1], of Saccharomyces cerevisiae is a 1.25 x 10(6) dalton linear double-stranded RNA plasmid coding for a protein toxin and immunity to that toxin. The [KIL-sd1] plasmid is a replication-defective mutant of [KIL-k1] that depends on one of the recessive chromosomal superkiller (ski-) mutatio...

journal_title：Genetics

authors： Wickner RB,Toh-e A

更新日期：1982-02-01 00:00:00

abstract：:We have employed a system that utilizes homologous pairs of human DNA-derived yeast artificial chromosomes (YACs) as marker chromosomes to assess the specific role(s) of conserved centromere DNA elements (CDEI, CDEII and CDEIII) in meiotic chromosome disjunction fidelity. Thirteen different centromere (CEN) mutations ...

journal_title：Genetics

authors： Sears DD,Hegemann JH,Shero JH,Hieter P

更新日期：1995-03-01 00:00:00

abstract：:For more than 60 years, evolutionary cytogeneticists have been using naturally occurring chromosomal inversions to infer phylogenetic histories, especially in insects with polytene chromosomes. The validity of this method is predicated on the assumption that inversions arise only once in the history of a lineage, so t...

journal_title：Genetics

authors： Caccone A,Min GS,Powell JR

更新日期：1998-10-01 00:00:00

abstract：:A reversion study of EMS- or ICR170-induced ascospore color mutants in Ascobolus immersus is reported. Twenty-three new intragenic suppressors were isolated within the b2 locus. These are localized within three distinct groups on a genetic fine-structure map containing 21 identifiable sites. The pattern of reversion i...

journal_title：Genetics

authors： Leblon G,Paquette N

更新日期：1978-11-01 00:00:00

abstract：:Neural ganglia of wild type third-instar larvae of Drosophila melanogaster were incubated for 13 hours at various concentrations of BUdR (1, 3, 9, 27 micrograms/ml). Metaphases were collected with colchicine, stained with Hoechst 33258, and scored under a fluorescence microscope. Metaphases in which the sister chromat...

journal_title：Genetics

authors： Gatti M,Santini G,Pimpinelli S,Olivieri G

更新日期：1979-02-01 00:00:00

abstract：:In its hypermutable state, an unstable singed allele, sn(w), mutates in the germline to two other alleleic forms at a total frequency usually between 40 and 60%. In its stable state, the mutation rate of sn(w) is essentially zero. Its state depends on an extrachromosomal condition indistinguishable from a property cal...

journal_title：Genetics

authors： Engels WR

更新日期：1981-07-01 00:00:00

abstract：:Amoebae of the Colonia (CL) strain, which normally produce plasmodia in clones, are shown to cross with mt3 and mt4 amoebae under appropriate conditions. Strains carrying mt3 and mt4 in a CL genetic background were constructed and used in the genetic analysis of mutants isolated in CL. ...

journal_title：Genetics

authors： Adler PN,Holt CE

更新日期：1974-12-01 00:00:00

abstract：:The Saccharomyces cerevisiae SEN1 gene codes for a nuclear-localized superfamily I helicase. SEN1 is an ortholog of human SETX (senataxin), which has been implicated in the neurological disorders ataxia-ocular apraxia type 2 and juvenile amyotrophic lateral sclerosis. Pleiotropic phenotypes conferred by sen1 mutations...

journal_title：Genetics

authors： Finkel JS,Chinchilla K,Ursic D,Culbertson MR

更新日期：2010-01-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. While many AMD susceptibility variants have been identified, their influence on AMD progression has not been elucidated. Using data from two large clinical trials, Age-Related Eye Disease Study (AREDS) and AREDS2, we evaluat...

journal_title：Genetics

authors： Ding Y,Liu Y,Yan Q,Fritsche LG,Cook RJ,Clemons T,Ratnapriya R,Klein ML,Abecasis GR,Swaroop A,Chew EY,Weeks DE,Chen W,AREDS2 Research Group.

更新日期：2017-05-01 00:00:00