Abstract:
:The present study extends our previous observation (Kasambalides and Lanks, J. Cell. Physiol., 114:93-98, 1983), that dexamethasone inhibits the alterations in heat shock protein (HSP) and glucose-regulated protein (GRP) synthesis caused by glucose deprivation. We now show that insulin, even in the presence of high extracellular glucose concentrations, will induce 95K and 82K GRP synthesis while suppressing 85K and 69K HSP synthesis. Heat shock of insulin-treated cultures causes induction of the 82K GRP rather than the 85K and 69K HSP's. All of the insulin effects are antagonized by dexamethasone. These data suggest that the changes in GRP and HSP synthesis induced by glucose deprivation and heat shock, respectively, may reflect the operation of a normal physiological mechanism that regulates glucose metabolism.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Kasambalides EJ,Lanks KWdoi
10.1002/jcp.1041230220subject
Has Abstractpub_date
1985-05-01 00:00:00pages
283-7issue
2eissn
0021-9541issn
1097-4652journal_volume
123pub_type
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