Potential Use of Pentoxifylline in Cancer Therapy.

abstract：BACKGROUND:Nanotechnology involves the synthesis of materials that are in nanometre sizes (1 to 100 nm). Nanotechnology has appeared as a new area of fundamental science and is getting worldwide consideration due to its extensive applications. They have exceptional physicochemical properties due to their unique size, s...

journal_title：Current pharmaceutical biotechnology

authors： Roy A

更新日期：2020-10-27 00:00:00

abstract：AIMS:Candida species is the common cause of opportunistic fungal infections all over the world with increased mortality and morbidity especially in immunosuppressed patients. Fluconazole is the first line therapy for candidiasis. The antifungal resistance pattern in high-risk patients is a major concern. The present st...

journal_title：Current pharmaceutical biotechnology

authors： Paul S,Mohanram K,Kannan I

更新日期：2018-01-01 00:00:00

abstract：:This mini-review describes how single-molecule sensitive fluorescence resonance energy transfer (FRET) and photoinduced electron transfer (PET) reactions can be successfully applied to monitor conformational dynamics in biopolymers. Single-pair FRET experiments are ideally suited to study conformational dynamics occur...

journal_title：Current pharmaceutical biotechnology

authors： Neuweiler H,Sauer M

更新日期：2004-06-01 00:00:00

abstract：:The biliary secretion of bile acids is critical for multiple liver functions including digesting fatty nutrients and driving bile flow. When this process is impaired, the accumulating bile acids cause inflammatory liver injury. Multiple ABC transporters in the liver are key players to safeguard the hepatocyte and avoi...

journal_title：Current pharmaceutical biotechnology

authors： Wang R,Sheps JA,Ling V

更新日期：2011-04-01 00:00:00

abstract：:This paper reviews the current state-of-the-art development of single-molecule detection (SMD)-based methods for ultrasensitive and specific analysis of genomic sequences. We first discuss several newly devised single fluorescent probe strategies that allow separation-free detection of low-abundance DNA sequences, suc...

journal_title：Current pharmaceutical biotechnology

authors： Yeh HC,Chao SY,Ho YP,Wang TH

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:Frequent administrations for DPPIV-resistant GLP-1 analogs are necessary to maintain the blood concentrations due to the short half-life of less than 5 minutes. However, most delivery systems that possess the ability of sustainable release of GLP-1 have drawbacks such as low yield, high cost and undesirable s...

journal_title：Current pharmaceutical biotechnology

authors： Fan L,Fan Y,Fan H,Huang K

更新日期：2020-01-01 00:00:00

abstract：:The prospect of mobilizing the power of the immune system in the fight against cancer has fascinated generations of immunologists. After decades of sporadic successes scattered amongst frequent failures, the field of tumor immunology is now poised to take advantage of a greatly improved understanding of the molecular ...

journal_title：Current pharmaceutical biotechnology

authors： Rabinovich BA,Radu CG

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Connexin (Cx) proteins are the building blocks of gap junctions. Among these, Cx37 and Cx40 are expressed on vascular system and reported to have cardioprotective role. Linking polymorphisms in genes coding for Cx and coronary artery disease (CAD) risk showed conflicting results in different populations. Non...

journal_title：Current pharmaceutical biotechnology

authors： El Tahry FA,Hashad IM,Abdel Rahman MF,Gad MZ

更新日期：2017-11-10 00:00:00

abstract：:Tuberculosis (TB) is a disease of global concern. About one third of the world population is infected with Mycobacterium tuberculosis. Every year, approximately 8 million people get the disease and 2 million die of TB. The currently available vaccine against TB is the attenuated strain of Mycobacterium bovis, Bacillus...

journal_title：Current pharmaceutical biotechnology

authors： Mustafa AS

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Active principles from natural sources, in the form of extracts and natural compounds, provide an infinite number of bioactive compounds with consummate disposal of chemical diversity. These compounds and active principles are of utmost importance in the discovery of drugs of biological origin particularly, ...

journal_title：Current pharmaceutical biotechnology

authors： Das G,Patra JK,Kang SS,Shin HS

更新日期：2021-01-22 00:00:00

abstract：BACKGROUND:Bacteriophages are viruses, which are obligate parasites of specific bacteria for the completion of their lifecycle. Bacteriophages could be the possible alternative to antibioticresistant bacterial diseases. With this objective, extensive research in different fields is published which are discussed in this...

journal_title：Current pharmaceutical biotechnology

authors： Adhikari N,Acharya KP

更新日期：2020-01-01 00:00:00

abstract：:Staphylococcus aureus is a leading causative agent in sepsis, endocarditis, and pneumonia. An emerging concept is that prognosis worsens when the infecting S. aureus strain has the capacity to not only colonize tissue as an extracellular pathogen, but to invade host cells and establish intracellular bacterial populati...

journal_title：Current pharmaceutical biotechnology

authors： Cordero D,Fullenkamp CR,Pelly RR,Reed KM,Caffo LM,Zahrt AN,Newman M,Komanapalli S,Niemeier EM,Bishop DL,Bruns HA,Haynes MK,Sklar LA,Sammelson RE,McDowell SA

更新日期：2014-01-01 00:00:00

abstract：:Many theoretical models of molecular interactions, biochemical and chemical reactions are described on the single-molecule level, although our knowledge about the biochemical/chemical structure and dynamics primarily originates from the investigation of many-molecule systems. At present, there are four experimental pl...

journal_title：Current pharmaceutical biotechnology

authors： Földes-Papp Z,Baumann G,Demel U,Tilz GP

更新日期：2004-04-01 00:00:00

abstract：:Spirulina, a filamentous cyanobacterium, possesses diverse biological activities and nutritional significance due to high concentration of natural nutrients, having bio-modulatory and immuno-modulatory functions. Different Spirulina preparations influence immune system viz. increase phagocytic activity of macrophages,...

journal_title：Current pharmaceutical biotechnology

authors： Khan Z,Bhadouria P,Bisen PS

更新日期：2005-10-01 00:00:00

abstract：:Several of the 28 mammalian transient receptor potential (TRP) channel subunits are expressed throughout the alimentary canal where they play important roles in taste, chemo- and mechanosensation, thermoregulation, pain and hyperalgesia, mucosal function and homeostasis, control of motility by neurons, interstitial ce...

journal_title：Current pharmaceutical biotechnology

authors： Holzer P

更新日期：2011-01-01 00:00:00

abstract：:The idea of cancer stem cell (CSC) has recently moved to the forefront of cancer research. There is still a lack of a widespread consensus on their description and definition. ,The increasing literature on CSCs has compelled researchers worldwide to rewrite the natural history of cancer including those cells as princi...

journal_title：Current pharmaceutical biotechnology

authors： Albini A,Cesana E,Noonan DM

更新日期：2011-02-01 00:00:00

abstract：:Until recently, most research efforts aimed at developing anti-cancer tools were focusing on small molecules. Alternative compounds are now being increasingly assessed for their potential anti-cancer properties, including peptides and their derivatives. One earlier limitation to the use of peptides was their limited c...

journal_title：Current pharmaceutical biotechnology

authors： Barras D,Widmann C

更新日期：2011-08-01 00:00:00

abstract：:The most challenging and fruitful biomedical research endeavor of this decade will be the mapping of cell signaling systems and establishing their linkages to normal and disease-related processes. Amongst other things, the Human Genome Sequencing Project has greatly facilitated MALDI-TOF mass spectrometry identificati...

journal_title：Current pharmaceutical biotechnology

authors： Pelech S

更新日期：2004-02-01 00:00:00

abstract：PURPOSE:The work was performed to investigate the feasibility of preparing ocular inserts loaded with Poly-ε-Caprolactone (PCL) nanoparticles as a sustained ocular delivery system. METHODS:First, Atorvastatin Calcium-Poly-ε-Caprolactone (ATC-PCL) nanoparticles were prepared and characterized. Then, the optimized nanop...

journal_title：Current pharmaceutical biotechnology

authors： Girgis GNS

更新日期：2020-01-01 00:00:00

abstract：:Assessment of immunogenicity is a major aspect in evaluating the safety of biological therapeutic proteins. It is important to evaluate the immunogenic potential of the biologics in an appropriate fashion using clearly defined strategy and clinical trials. The studies must include the appropriate risk assessment proce...

journal_title：Current pharmaceutical biotechnology

authors： Kaliyaperumal A,Jing S

更新日期：2009-06-01 00:00:00

abstract：:The interaction between reactive oxygen species (ROS) and inflammation plays an important role in the pathogenesis of endothelial dysfunction and cardiovascular disease, cancer and other diseases. Thus, antioxidant strategies may be important in immune regulation and in limiting inflammation. Surprisingly, large clini...

journal_title：Current pharmaceutical biotechnology

authors： Spychalowicz A,Wilk G,Śliwa T,Ludew D,Guzik TJ

更新日期：2012-10-01 00:00:00

abstract：:Tinospora cordifolia (Giloy) is a medicinal plant used in folk and Ayurvedic medicines throughout India since ancient times. All the parts of the plant are immensely useful due to the presence of different compounds of pharmaceutical importance belonging to various groups as alkaloids, diterpenoid lactones, glycosides...

journal_title：Current pharmaceutical biotechnology

authors： Kumar P,Kamle M,Mahato DK,Bora H,Sharma B,Rasane P,Bajpai VK

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Alfalfa and red clover are the most widespread and most important perennial legumes, primarily used as a high-quality feed for livestock. Both alfalfa and red clover, as well as some other plant species from Fabaceae family, are a rich natural source of phytoestrogens, nonsteroidal compounds with an estrogen...

journal_title：Current pharmaceutical biotechnology

authors： Tucak M,Horvat D,Cupic T,Krizmanic G,Tomas V,Ravlic M,Popovic S

更新日期：2018-01-01 00:00:00

abstract：:Interstitial lung disease (ILD) is one of the most common complications of polymyositis (PM) and dermatomyositis (DM). It is always progressive and does not respond to conventional immunosuppressive agent treatment. Biologics are commonly used in treatment of rheumatic diseases. They are also used in polymyositis and ...

journal_title：Current pharmaceutical biotechnology

authors： Sun Y,He Y,Liu Y,Shi G

更新日期：2014-01-01 00:00:00

abstract：:Pulmonary fibrosis is an unremitting degenerative lung disease that has an associated high mortality. The major pathological features include the growth of fibroblasts, emergence of myofibroblasts and their production of extracellular matrix that distorts the peripheral lung tissue and impairs respiratory function. Ef...

journal_title：Current pharmaceutical biotechnology

authors： Glasser SW,Senft AP

更新日期：2011-09-01 00:00:00

abstract：:The number of diseases found to be associated with defects of the mitochondrial genome has grown significantly over the last decade. Despite major advances in understanding mtDNA defects at the genetic and biochemical level, there is no satisfactory treatment for the vast majority of patients available. This is largel...

journal_title：Current pharmaceutical biotechnology

authors： Weissig V,Torchilin VP

更新日期：2000-12-01 00:00:00

abstract：:Unlike any other cell type, T cells have a unique potential to eliminate cancer cells and to eventually cure cancer patients. As a result, researchers have made extensive efforts over the past three decades to develop therapeutics with the potential to mount T cell responses against cancer cells. One way in which such...

journal_title：Current pharmaceutical biotechnology

authors： Baeuerle PA,Itin C

更新日期：2012-06-01 00:00:00

abstract：:Schizophrenia is a severe mental disorder, characterized by a complex symptomatology and a chronic relapsing course, leading to a more or less intensive residual syndrome. The disorder has strong consequences on social functioning and on the patients' quality of life and is associated with a huge economical burden for...

journal_title：Current pharmaceutical biotechnology

authors： Moller HJ

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:To date, an increasing number of pet owners, especially in the USA, are using cannabis-derived products containing generally delta 9-tetrahydrocannabinol (THC) and cannabidiol (CBD) to help their animals' health. Unfortunately, studies on the clinical use of cannabinoids in veterinary medicine are still limi...

journal_title：Current pharmaceutical biotechnology

authors： Rotolo MC,Graziano S,Pellegrini M,Corlazzoli D,Antinori L,Porcarelli L,Pichini S

更新日期：2017-01-01 00:00:00

abstract：:After a tooth extraction both hard and soft tissues undergo dimensional changes. The use of a ridge preservation technique at the moment of the tooth extraction could help could help to prevent the volume loss, thus simplifying the subsequent prosthetic and/or implant therapy. Some studies were conducted in order to e...

journal_title：Current pharmaceutical biotechnology

authors： Alfonsi F,Borgia V,Iezzi G,Piattelli A,Covani U,Tonelli P,Barone A

更新日期：2017-01-01 00:00:00