Abstract:
:Several of the 28 mammalian transient receptor potential (TRP) channel subunits are expressed throughout the alimentary canal where they play important roles in taste, chemo- and mechanosensation, thermoregulation, pain and hyperalgesia, mucosal function and homeostasis, control of motility by neurons, interstitial cells of Cajal and muscle cells, and vascular function. While the implications of some TRP channels, notably TRPA1, TRPC4, TRPM5, TRPM6, TRPM7, TRPV1, TRPV4, and TRPV6, have been investigated in much detail, the understanding of other TRP channels in their relevance to digestive function lags behind. The polymodal chemo- and mechanosensory function of TRPA1, TRPM5, TRPV1 and TRPV4 is particularly relevant to the alimentary canal whose digestive and absorptive function depends on the surveillance and integration of many chemical and physical stimuli. TRPV5 and TRPV6 as well as TRPM6 and TRPM7 appear to be essential for the absorption of Ca(2+) and Mg(2+), respectively, while TRPM7 appears to contribute to the pacemaker activity of the interstitial cells of Cajal, and TRPC4 transduces smooth muscle contraction evoked by muscarinic acetylcholine receptor activation. The implication of some TRP channels in pathological processes has raised enormous interest in exploiting them as a therapeutic target. This is particularly true for TRPV1, TRPV4 and TRPA1, which may be targeted for the treatment of several conditions of chronic abdominal pain. Consequently, blockers of these TRP channels have been developed, and their clinical usefulness has yet to be established.
journal_name
Curr Pharm Biotechnoljournal_title
Current pharmaceutical biotechnologyauthors
Holzer Pdoi
10.2174/138920111793937862subject
Has Abstractpub_date
2011-01-01 00:00:00pages
24-34issue
1eissn
1389-2010issn
1873-4316pii
BSP/CPB/E-Pub/0004-12-1journal_volume
12pub_type
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journal_title:Current pharmaceutical biotechnology
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journal_title:Current pharmaceutical biotechnology
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更新日期:2014-01-01 00:00:00
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journal_title:Current pharmaceutical biotechnology
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更新日期:2011-12-01 00:00:00
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journal_title:Current pharmaceutical biotechnology
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更新日期:2020-10-09 00:00:00
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更新日期:2013-01-01 00:00:00
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