Harnessing bistability for directional propulsion of soft, untethered robots.

abstract：:Blot hybridization analysis that used labeled tubulin cDNA probes revealed that N6,O2'-dibutyryladenosine 3',5'-cyclic monophosphate [dibutyryl cyclic AMP (Bt2cAMP)] initially increases and later decreases the level of tubulin mRNA in a neuroblastoma-glioma hybrid cell line as well as in the parent cells. A significan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ginzburg I,Rybak S,Kimhi Y,Littauer UZ

更新日期：1983-07-01 00:00:00

abstract：:The protease encoded by the human immunodeficiency virus (HIV) processes the viral gag and gag-pol protein precursor by posttranslational cleavage. In this study we have demonstrated by site-specific mutagenesis (Asp----Thr) and by pepstatin A inhibition that the recombinant HIV protease is an aspartic-type protease. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seelmeier S,Schmidt H,Turk V,von der Helm K

更新日期：1988-09-01 00:00:00

abstract：:Compartmentalization of proteins into subcellular organelles in eukaryotic cells is a fundamental mechanism of regulating complex cellular functions. Many proteins of Plasmodium falciparum merozoites involved in invasion are compartmentalized into apical organelles. We have identified a new merozoite organelle that co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singh S,Plassmeyer M,Gaur D,Miller LH

更新日期：2007-12-11 00:00:00

abstract：:In adult skeletal muscles, 2 junctophilin isoforms (JPH1 and JPH2) tether the sarcoplasmic reticulum (SR) to transverse tubule (T-tubule) membranes, generating stable membrane contact sites known as triads. JPHs are anchored to the membrane of the SR by a C-terminal transmembrane domain (TMD) and bind the T-tubule mem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rossi D,Scarcella AM,Liguori E,Lorenzini S,Pierantozzi E,Kutchukian C,Jacquemond V,Messa M,De Camilli P,Sorrentino V

更新日期：2019-07-30 00:00:00

abstract：:Neurofibrillary tangles are one of two lesions found in the brain of Alzheimer disease victims. With synthetic peptide fragments of human neurofilament NF-M17 (Glu-Glu-Lys-Gly-Lys-Ser-Pro- Val-Pro-Lys-Ser-Pro-Val-Glu-Glu-Lys-Gly, phosphorylated and unphosphorylated), CD studies were done to examine the effect of sodiu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fasman GD,Moore CD

更新日期：1994-11-08 00:00:00

abstract：:Protein misfolding and the formation of aggregates are increasingly recognized components of the pathology of human genetic disease and hallmarks of many neurodegenerative disorders. As exemplified by polyglutamine diseases, the propensity for protein misfolding is associated with the length of polyglutamine expansion...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nollen EA,Garcia SM,van Haaften G,Kim S,Chavez A,Morimoto RI,Plasterk RH

更新日期：2004-04-27 00:00:00

abstract：:Induction of transformation, cell lethality, and DNA lesions were quantitatively compared in Syrian hamster embryo cells (HEC) treated with three different methylating agents: N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), N-methyl-N-nitrosourea (MNU), or methyl methanesulfonate (MMS). Each induced transformation in a d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doniger J,Day RS,DiPaolo JA

更新日期：1985-01-01 00:00:00

abstract：:The energy landscape theory provides a general framework for describing protein folding reactions. Because a large number of studies, however, have focused on two-state proteins with single well-defined folding pathways and without detectable intermediates, the extent to which free energy landscapes are shaped up by t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calosci N,Chi CN,Richter B,Camilloni C,Engström A,Eklund L,Travaglini-Allocatelli C,Gianni S,Vendruscolo M,Jemth P

更新日期：2008-12-09 00:00:00

abstract：:Measures of complexity derived from ergodic theory of dynamical systems were developed and applied to an exemplary data set describing locomotor movements of rats in a bounded space. A symbolic dynamical system was obtained by partitioning the event space into equally probable partition elements, using a k-dimensional...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paulus MP,Geyer MA,Gold LH,Mandell AJ

更新日期：1990-01-01 00:00:00

abstract：:Loss of IκB kinase (IKK) β-dependent NF-κB signaling in hematopoietic cells is associated with increased granulopoiesis. Here we identify a regulatory cytokine loop that causes neutrophilia in Ikkβ-deficient mice. TNF-α-dependent apoptosis of myeloid progenitor cells leads to the release of IL-1β, which promotes Th17 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mankan AK,Canli O,Schwitalla S,Ziegler P,Tschopp J,Korn T,Greten FR

更新日期：2011-04-19 00:00:00

abstract：:Burkitt's lymphomas, linked by previous studies with the DNA-containing Epstein-Barr virus, contain an RNA related in sequence to that of Rauscher leukemia virus. The present study establishes that the viral-related RNA found in Burkitt's tumors is a 70S component encapsulated with RNA-instructed DNA polymerase in a p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kufe D,Magrath IT,Ziegler JL,Spiegelman S

更新日期：1973-03-01 00:00:00

abstract：:The mitogen-activated kinase activating death domain protein (MADD) that is differentially expressed in neoplastic vs. normal cells (DENN) was identified as a substrate for c-Jun N-terminal kinase 3, the first demonstration of such an activity for this stress-activated kinase that is predominantly expressed in the bra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Zhou L,Miller CA

更新日期：1998-03-03 00:00:00

abstract：:There is considerable interest in engineering plant cell wall components, particularly lignin, to improve forage quality and biomass properties for processing to fuels and bioproducts. However, modifying lignin content and/or composition in transgenic plants through down-regulation of lignin biosynthetic enzymes can i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gallego-Giraldo L,Liu C,Pose-Albacete S,Pattathil S,Peralta AG,Young J,Westpheling J,Hahn MG,Rao X,Knox JP,De Meester B,Boerjan W,Dixon RA

更新日期：2020-02-11 00:00:00

abstract：:The in vitro biological activities of several rabies virus-neutralizing monoclonal antibodies (mAbs) were compared with their ability to prevent a lethal rabies virus encephalomyelitis. The protective activity of a particular mAb in vivo did not correlate with its virus-neutralizing activity in vitro; rather it was re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dietzschold B,Kao M,Zheng YM,Chen ZY,Maul G,Fu ZF,Rupprecht CE,Koprowski H

更新日期：1992-08-01 00:00:00

abstract：:In vitro, polynucleotide phosphorylase of Escherichia coli can both synthesize RNA by using nucleotide diphosphates as precursors and exonucleolytically degrade RNA in the presence of inorganic phosphate. However, because of the high in vivo concentration of inorganic phosphate in exponentially growing cells, it has b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mohanty BK,Kushner SR

更新日期：2000-10-24 00:00:00

abstract：:We measured the superconducting transition temperature of (6)Li between 16 and 26 GPa, and report the lightest system to exhibit superconductivity to date. The superconducting phase diagram of (6)Li is compared with that of (7)Li through simultaneous measurement in a diamond anvil cell (DAC). Below 21 GPa, Li exhibits...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schaeffer AM,Temple SR,Bishop JK,Deemyad S

更新日期：2015-01-06 00:00:00

abstract：:We have examined the use of our bis(sulfonamide) diol ligand (1) in the asymmetric addition of phenyl groups to cyclic alpha,beta-unsaturated ketones. Good to excellent enantioselectivities have been obtained with cyclic enones bearing alkyl substituents in the 2 position (71-97% enantiomeric excess). Furthermore, exc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li H,García C,Walsh PJ

更新日期：2004-04-13 00:00:00

abstract：:Physical activity increases energy metabolism in exercising muscle. Whether acute exercise elicits metabolic changes in nonexercising muscles remains unclear. We show that one of the few genes that is more highly induced in nonexercising muscle than in exercising human muscle during acute exercise encodes angiopoietin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Catoire M,Alex S,Paraskevopulos N,Mattijssen F,Evers-van Gogh I,Schaart G,Jeppesen J,Kneppers A,Mensink M,Voshol PJ,Olivecrona G,Tan NS,Hesselink MK,Berbée JF,Rensen PC,Kalkhoven E,Schrauwen P,Kersten S

更新日期：2014-03-18 00:00:00

abstract：:Historical data provide a baseline against which to judge the significance of recent ecological shifts and guide conservation strategies, especially for species decimated by pre-20th century harvesting. Northern fur seals (NFS; Callorhinus ursinus) are a common pinniped species in archaeological sites from southern Ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newsome SD,Etnier MA,Gifford-Gonzalez D,Phillips DL,van Tuinen M,Hadly EA,Costa DP,Kennett DJ,Guilderson TP,Koch PL

更新日期：2007-06-05 00:00:00

abstract：:Indoor residual spraying (IRS) is used to control visceral leishmaniasis (VL) in India, but it is poorly quality assured. Quality assurance was performed in eight VL endemic districts in Bihar State, India, in 2014. Residual dichlorodiphenyltrichloroethane (DDT) was sampled from walls using Bostik tape discs, and DDT ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coleman M,Foster GM,Deb R,Pratap Singh R,Ismail HM,Shivam P,Ghosh AK,Dunkley S,Kumar V,Coleman M,Hemingway J,Paine MJ,Das P

更新日期：2015-07-14 00:00:00

abstract：:The need to assess subtle, potentially exploitable changes in serial structure is paramount in the analysis of financial data. Herein, we demonstrate the utility of approximate entropy (ApEn), a model-independent measure of sequential irregularity, toward this goal, by several distinct applications. We consider both e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pincus S,Kalman RE

更新日期：2004-09-21 00:00:00

abstract：:We report the synthesis of a probe that permits the visualization by electron microscopy of acidic organelles in intact cells. This probe, 3-(2,4-dinitroanilino)-3'-amino-N-methyldipropylamine (DAMP), is a basic congener of dinitrophenol that readily diffuses into intact cells. Its primary and tertiary amino groups (a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson RG,Falck JR,Goldstein JL,Brown MS

更新日期：1984-08-01 00:00:00

abstract：:E12 and E47 are two non-tissue-specific helix-loop-helix (HLH) transcription factors encoded by the E2A gene. Previous studies suggested that they are involved in regulation of differentiation in many tissue types including muscle, blood, and nerve through direct heterodimer interactions with tissue-specific HLH prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhuang Y,Kim CG,Bartelmez S,Cheng P,Groudine M,Weintraub H

更新日期：1992-12-15 00:00:00

abstract：:We have shown recently that the temporal order of antioxidant consumption in human blood plasma exposed to a constant flux of aqueous peroxyl radicals is ascorbate = protein thiols greater than bilirubin greater than urate greater than alpha-tocopherol and that detectable lipid peroxidation starts only after ascorbate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frei B,England L,Ames BN

更新日期：1989-08-01 00:00:00

abstract：:HsPKS1 from Huperzia serrata is a type III polyketide synthase (PKS) with remarkable substrate tolerance and catalytic potential. Here we present the synthesis of unnatural unique polyketide-alkaloid hybrid molecules by exploiting the enzyme reaction using precursor-directed and structure-based approaches. HsPKS1 prod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morita H,Yamashita M,Shi SP,Wakimoto T,Kondo S,Kato R,Sugio S,Kohno T,Abe I

更新日期：2011-08-16 00:00:00

abstract：:p53, the most commonly mutated gene in human tumors, is believed to play a crucial role in the prevention of cancer by protecting cells from mutation, a theory commonly known as the "Guardian of the Genome" hypothesis. There are two hypotheses as to how this can occur. In the first, p53 protects the genome by retardin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bielas JH,Heddle JA

更新日期：2003-10-28 00:00:00

abstract：:Ischemia of the myocardium and lower limbs is a common consequence of arterial disease and a major source of morbidity and mortality in modernized countries. Inducing neovascularization for the treatment of ischemia is an appealing therapeutic strategy for patients for whom traditional treatment modalities cannot be p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jang E,Albadawi H,Watkins MT,Edelman ER,Baker AB

更新日期：2012-01-31 00:00:00

abstract：:Relying on a quantitative analysis of the patenting and assignment behavior of inventors, we highlight the evolution of institutions that encouraged trade in technology and a growing division of labor between those who invented new technologies and those who exploited them commercially over the nineteenth and early-tw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamoreaux NR,Sokoloff KL

更新日期：1996-11-12 00:00:00

abstract：:The "chlamydial anomaly," first coined by James Moulder, describes the inability of researchers to detect or purify peptidoglycan (PG) from pathogenic Chlamydiae despite genetic and biochemical evidence and antibiotic susceptibility data that suggest its existence. We recently detected PG in Chlamydia trachomatis by a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Packiam M,Weinrick B,Jacobs WR Jr,Maurelli AT

更新日期：2015-09-15 00:00:00

abstract：:Understanding the mechanisms by which compounds discovered using cell-based phenotypic screening strategies might exert their effects would be highly augmented by new approaches exploring their potential interactions with the genome. For example, altered androgen receptor (AR) transcriptional programs, including castr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin C,Yang L,Xie M,Lin C,Merkurjev D,Yang JC,Tanasa B,Oh S,Zhang J,Ohgi KA,Zhou H,Li W,Evans CP,Ding S,Rosenfeld MG

更新日期：2014-06-24 00:00:00