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Cellular aspects of and effects on the gingiva in children with Down's syndrome during experimental gingivitis.

Abstract：

:In a previous experimental gingivitis study, it was shown that in children with Down's syndrome (DS), gingival inflammation started earlier, was more extensive and developed faster, than in normal healthy control children. In both groups, the start of the process was accompanied by an acute inflammatory response and an increase of the infiltrated connective tissue area (ICT). The purpose of the present study was to investigate how these facts were reflected at a cytological level. The study was carried out in 8 DS and 8 matched control children. Their ages ranged from 5-10 years. A "normal" healthy gingiva was attained after strict oral hygiene procedures. During a period of 21 days in which oral hygiene was abolished, gingival biopsies were taken on days 0, 7, 14, and 21. In both groups, junctional epithelium (JE) and ICT contained low numbers of polymorphonuclear leucocytes (PMNs). The start of the inflammation (day 7 for the DS and day 14 for the control children) was marked by a significant positive correlation between the numbers of PMNs in the JE and the ICT, and a significant increase of the numbers of PMNs in ICT. In ICT, a concomitant decrease in collagen fibre density was observed. In the control group, the decrease correlated with the numbers of PMNs in ICT, which suggests that this collagen breakdown is caused by PMN products. After the initial decrease, the collagen fibre density remained fairly constant in this group throughout the study. In the DS group, there was a tendency to a further decrease in the ICT3 area, correlated with the numbers of PMNs in ICT.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

J Clin Periodontol

journal_title

Journal of clinical periodontology

authors

Reuland-Bosma W,Liem RS,Jansen HW,van Dijk LJ,van der Weele LT

doi

10.1111/j.1600-051x.1988.tb01588.x

subject

Has Abstract

pub_date

1988-05-01 00:00:00

pages

303-11

issue

5

eissn

0303-6979

issn

1600-051X

journal_volume

15

pub_type

杂志文章

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