Abstract：
AIMS:The present study aimed to monitor the levels of selected salivary biomarkers during the development and treatment of periodontitis and to evaluate their ability to identify periodontitis in dogs. MATERIALS AND METHODS:A total of 15 beagle dogs were divided into a control group (no ligature), group 1 (ligature on six teeth), and group 2 (ligature on 12 teeth). The experimental periods consisted of 8 weeks of periodontitis induction and 4 weeks of treatment. Clinical measurements and the sampling of saliva were performed every 4 weeks. The levels of S100A8, S100A9, S100A8/A9, and matrix metalloproteinase (MMP)-9 were measured by enzyme-linked immunosorbent assay. RESULTS:All experimental animals and two control animals developed periodontitis, which was successfully treated. All salivary biomarkers were significantly increased in periodontitis with high diagnostic power (c-index ≥ 0.944) and were able to identify animals with periodontitis on a single tooth. Whereas the levels of salivary S100A8/A9 recovered to levels in health, those of S100A8, S100A9, and MMP-9 in periodontitis stability remained significantly higher than in health. CONCLUSION:Salivary S100A8, S100A9, S100A8/A9, and MMP-9 may be used for the screening of periodontitis in dogs, but with caution of other conditions that can affect their levels in saliva.
journal_name
J Clin Periodontoljournal_title
Journal of clinical periodontologyauthors
Liu M,Won Lee J,Jung S,Ji S,Choi Ydoi
10.1111/jcpe.13215subject
Has Abstractpub_date
2020-02-01 00:00:00pages
182-192issue
2eissn
0303-6979issn
1600-051Xjournal_volume
47pub_type
杂志文章abstract：OBJECTIVES:The aim of the present study was to compare the combination therapy of deep intrabony periodontal defects using an Er:YAG laser (ERL) and enamel matrix protein derivative (EMD) to scaling and root planing+ ethylenediaminetetraacetic acid (EDTA)+EMD. MATERIAL AND METHODS:Twenty-two patients with chronic peri...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1034/j.1600-051x.2003.00412.x
更新日期：2003-11-01 00:00:00
abstract：:Platelet-derived growth factor (PDGF) and the glucocorticoid dexamethasone combined with a collagen carrier matrix (CM) induced regeneration of the periodontium in monkeys. Regeneration was stringently defined as: (1) new cementum, (2) new supra-crestal bone extending coronally from the residual alveolar interdental s...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1993.tb00403.x
更新日期：1993-08-01 00:00:00
abstract：:The aim of the present study was to compare periodontal healing after successive removal of periodontal tissue components, from the alveolar bone to the dentin surface. The prevailing tissue reaction when adhering PDM was left on the exposed roots was that most of the bone tissue that had been removed from the buccal ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1993.tb01753.x
更新日期：1993-01-01 00:00:00
abstract：OBJECTIVES:Our aim in this cross-sectional study was to investigate whether self-reported gingivitis and tooth loss were associated with elevated levels of C-reactive protein (CRP) using the same study population where these dental conditions have earlier been associated with prevalent angina pectoris. MATERIAL AND ME...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2007.01175.x
更新日期：2008-02-01 00:00:00
abstract：:The aim of this study was to monitor the presence of sulfate-reducing bacteria (SRB) at different sites in the mouths of both healthy individuals and periodontitis patients. In 20 healthy subjects and 21 periodontitis patients, samples were taken from the palate, vestibulum, dorsum of the tongue, supragingival plaque,...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1034/j.1600-051x.1999.260906.x
更新日期：1999-09-01 00:00:00
abstract：:The healing of the dento-epithelial junction following the use of dental floss was studied on 28 first premolars in seven children who were under orthodontic treatment. On the mesial surfaces the floss was brought to the depth of the pocket and moved back and forth three to five times, while being pressed against the ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1981.tb02354.x
更新日期：1981-04-01 00:00:00
abstract：BACKGROUND:The aim of this study was to report on the prevalence of Actinobacillus actinomycetemcomitans (Aa) and the periodontal clinical conditions in children and adolescents from a rural area of central Italy compared with the ones from an urban area of the same region. METHOD:The study population consisted of 780...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1034/j.1600-051x.2000.027008549.x
更新日期：2000-08-01 00:00:00
abstract：:The aim of this study was to evaluate the effect of supragingival plaque control on the composition of the subgingival microflora. 8 subjects with moderate to severe periodontitis were chosen for the study. Sites with periodontal destruction (GI greater than 2; probing depth greater than 6.5 mm; vertical alveolar bone...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1987.tb00960.x
更新日期：1987-03-01 00:00:00
abstract：OBJECTIVE:To systematically review the incidence of biological and technical complications in implant therapy reported in prospective longitudinal studies of at least 5 years. METHODS:A MEDLINE search was conducted for prospective longitudinal studies with follow-up periods of at least 5 years. Screening and data abst...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,meta分析,评审
doi：10.1034/j.1600-051x.29.s3.12.x
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:The aim of this randomized clinical trial was to evaluate the efficacy of Apically Positioned Flap with Fibre Retention Osseous Resective Surgery (FibReORS) or Osseous Resective Surgery (ORS) to treat periodontal pockets associated with infrabony defect ≤3 mm at posterior natural teeth. MATERIAL AND METHODS...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1111/jcpe.12042
更新日期：2013-02-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to describe self-reported oral health, oral hygiene habits, and frequency of visits to a dentist among pregnant women in Kuwait. MATERIAL AND METHODS:A cross-sectional study with an anonymous structured questionnaire was distributed among 650 pregnant women during May-June 2003, wh...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2005.00770.x
更新日期：2005-07-01 00:00:00
abstract：:The osteoclast may play an important rŏle in the variable rate of osseous destruction seen in periodontitis. Current understanding of various aspects of the osteoclast may help explain this fact. This review paper will first look at two theories of cell origin of the osteoclast: the multipotential osteoprogenitor cell...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,评审
doi：10.1111/j.1600-051x.1986.tb02220.x
更新日期：1986-04-01 00:00:00
abstract：:This report will focus attention on the diagnostic and therapeutic difficulties involved in a patient who presented with a gingival papillary-verrucous lesion, which subsequently developed into a squamous cell carcinoma. ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1987.tb01515.x
更新日期：1987-01-01 00:00:00
abstract：:The importance of microbial surveillance is illustrated in 3 clinical cases. Each case demonstrated a continued lack of response to conventional periodontal treatment. Repeated bouts of periodontal abscess formation and bone loss occurred over a 3- to 4-year period, despite numerous surgeries supplemented with antibio...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1994.tb00286.x
更新日期：1994-02-01 00:00:00
abstract：AIM:Antimicrobial peptides (AMPs) are one of the most active components of innate immunity and have characteristics that could place them at the heart of the pathogenesis of periodontal disease. This study investigated differences in the expression of AMP coding genes obtained using a simple harvesting technique, gingi...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.12879
更新日期：2018-05-01 00:00:00
abstract：AIMS:The aims of this study were to evaluate the effect of mechanical periodontal treatment with local application of minocycline (APT) on serum adiponectin as a marker of insulin resistance improvement in type 2 diabetes mellitus (T2DM) patients and to investigate if effect of APT on serum adiponectin level was sustai...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1600-051X.2008.01359.x
更新日期：2009-02-01 00:00:00
abstract：AIM:The aim of the present study was to evaluate whether periodontitis is independently associated with oral health-related quality of life (OHRQoL) in individuals with end-stage renal disease (ESRD). MATERIALS AND METHODS:Calibrated examiners assessed 180 adults with ESRD. A full-mouth periodontal examination was per...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.13233
更新日期：2020-03-01 00:00:00
abstract：AIM:To investigate the in vivo role of gingipains in Porphyromonas gingivalis' virulence, and suggest a possible host mechanisms through which the bacteria cause alveolar bone loss. MATERIALS AND METHODS:Mice were orally infected with P. gingivalis wild type, or the gingipains mutants (RgpA⁻, Kgp⁻, RgpA⁻/Kgp⁻). Mice w...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.12139
更新日期：2013-10-01 00:00:00
abstract：:A trial was conducted to compare the effectiveness of povidone iodine and chlorhexidine gluconate with buffered peroxyborate in the treatment of acute ulcerative gingivitis. After 20 patients had entered the trial and 11 had required additional therapy with metronidazole to control their symptoms, the study was termin...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1600-051x.1978.tb01919.x
更新日期：1978-11-01 00:00:00
abstract：AIM:Reports regarding prevalence of peri-implant diseases show widely varying prevalence rates, which can be explained partially by variable diagnostic criteria adopted. Furthermore, several different factors have been associated with peri-implant diseases. Hence, the aim of this cross-sectional study is to (a) determi...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.13111
更新日期：2019-05-01 00:00:00
abstract：:The purpose of this investigation was to examine the regeneration of alveolar bone following surgical and non-surgical periodontal treatment. A total of 16 patients who had advanced periodontitis and demonstrated angular bony defects on radiographs participated in the study. After the initial examination, they receive...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1985.tb00940.x
更新日期：1985-09-01 00:00:00
abstract：OBJECTIVES:To evaluate the ability of different statistical approaches in finding a statistically significant difference in plaque removal efficiency between brushes in clinical trials. MATERIALS AND METHODS:The approaches, which are evaluated, concern the scores after brushing only, the difference in scores before an...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1600-051X.2005.00735.x
更新日期：2005-06-01 00:00:00
abstract：:The subgingival microflora was assessed by means of dark field microscopy in 106 pockets of 47 subjects with long-term insulin-dependent diabetes mellitus (IDD). The microbiota of 55 healthy sulci (probing depth < 4 mm) and 51 periodontally diseased (probing depth > or = 4 and 6 mm) pockets were analyzed. The mean dur...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1996.tb00536.x
更新日期：1996-02-01 00:00:00
abstract：OBJECTIVES:We aimed to assess how the 2018 and 1999 classifications of periodontal diseases reflect (a) patients' characteristics, (b) disease severity/extent/progression and (c) tooth loss (TL) during observation period. METHODS:A total of 251 patients were followed over 21.8 ± 6.2 years. For the 1999 classification,...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/jcpe.13157
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVES:The purpose of this investigation is to describe histologically the undisturbed healing of fresh extraction sockets when compared to immediate implant placement. METHODS:In eight beagle dogs, after extraction of the 3P3 and 4P4, implants were inserted into the distal sockets of the premolars, while the mesi...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2011.01803.x
更新日期：2012-01-01 00:00:00
abstract：:The aim of the study was to evaluate the adjunctive effect of systemic tetracycline (250 mg qds for 14 days) in sequential root planing and surgical phases of treatment in a randomised, double-blind controlled trial. 38 patients who were under 26 years of age, in good general health and with localised (15 test/15 cont...
journal_title：Journal of clinical periodontology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1600-051x.1996.tb00592.x
更新日期：1996-07-01 00:00:00
abstract：:13 patients with untreated adult periodontitis (AP) were compared to 8 subjects free of periodontal disease (H) with respect to plaque index (PlI), gingival index (GI), probing depth (PD) and differential counts of subgingival bacterial morphotypes from a pooled sample of 6 surfaces with the greatest probing depth. Se...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1986.tb00878.x
更新日期：1986-09-01 00:00:00
abstract：:The aim of the present study was to determine by standard cultivation procedures the detection frequencies of Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Actinobacillus actinomycetemcomitans, Bacteroides forsythus, and Capnocytophaga species as well as various enteric rods in subgingival ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1996.tb00546.x
更新日期：1996-02-01 00:00:00
abstract：:The aims of this study were to investigate the prevalence and severity of periodontal diseases in HIV seropositive and assumed HIV seronegative individuals in the Edinburgh area. 29 HIV seropositive subjects were examined at baseline and at 3-monthly intervals. Attachment loss and dichotomous indicators of periodontal...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1995.tb00805.x
更新日期：1995-07-01 00:00:00
abstract：:The prevalence of juvenile periodontitis was studied in Finland, in an ethnic group representing a uniform Caucasoid population. The study population consisted of the 16-year-old subjects in the county of Uusimaa, population approximately 1,000,000. The screening study was based on the well-organized national dental c...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1980.tb01961.x
更新日期：1980-06-01 00:00:00
