Abstract:
:In this paper, we describe the first steps in the design of a synthetic biological system based on the use of genetically modified bacteria to detect elevated pressures in soils and respond by cementing soil particles. Such a system might, for example, enable a self- constructed foundation to form in response to load using engineered bacteria which could be seeded and grown in the soils. This process would reduce the need for large-scale excavations and may be the basis for a new generation of self-assembling and responsive bio-based materials. A prototype computational model is presented which integrates experimental data from a pressure sensitive gene within Escherichia coli bacteria with geotechnical models of soil loading and pore water pressure. The results from the integrated model are visualised by mapping expected gene expression values onto the soil volume. We also use our experimental data to design a two component system where one type of bacteria acts as a sensor and signals to another material synthesis bacteria. The simulation demonstrates the potential of computational models which integrate multiple scales from macro stresses in soils to the expression of individual genes to inform new types of design process. The work also illustrates the combination of in silico (silicon based computing) computation with in vivo (in the living) computation.
journal_name
Bioinspir Biomimjournal_title
Bioinspiration & biomimeticsauthors
Dade-Robertson M,Mitrani H,Corral JR,Zhang M,Hernan L,Guyet A,Wipat Adoi
10.1088/1748-3190/aabe15subject
Has Abstractpub_date
2018-05-25 00:00:00pages
046004issue
4eissn
1748-3182issn
1748-3190journal_volume
13pub_type
杂志文章abstract::Birds demonstrate that flapping-wing flight (FWF) is a versatile flight mode, compatible with hovering, forward flight and gliding to save energy. This extended flight domain would be especially useful on mini-UAVs. However, design is challenging because aerodynamic efficiency is conditioned by complex movements of th...
journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3182/2/4/002
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章,评审
doi:10.1088/1748-3190/aa806e
更新日期:2017-11-08 00:00:00
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3190/ab8f6c
更新日期:2020-08-12 00:00:00
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章,评审
doi:10.1088/1748-3182/2/1/P01
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3190/ab2298
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3182/6/1/016003
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3190/abb521
更新日期:2020-11-07 00:00:00
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3190/aac788
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3190/aa64a5
更新日期:2017-04-04 00:00:00
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3182/2/3/002
更新日期:2007-09-01 00:00:00
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3190/ab1621
更新日期:2019-04-24 00:00:00
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3182/9/3/036004
更新日期:2014-09-01 00:00:00
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3182/7/1/015003
更新日期:2012-03-01 00:00:00
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3182/1/3/003
更新日期:2006-09-01 00:00:00
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3182/9/1/016001
更新日期:2014-03-01 00:00:00
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3190/ab2fa8
更新日期:2019-07-29 00:00:00
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3190/aab19c
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3190/aae23f
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3190/aa8f33
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pub_type: 杂志文章
doi:10.1088/1748-3190/11/3/036002
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3182/3/4/046002
更新日期:2008-12-01 00:00:00
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3182/3/3/034002
更新日期:2008-09-01 00:00:00
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3190/10/5/056008
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3182/3/2/026003
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3190/aaea56
更新日期:2018-11-09 00:00:00
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journal_title:Bioinspiration & biomimetics
pub_type: 杂志文章
doi:10.1088/1748-3190/10/2/025005
更新日期:2015-03-26 00:00:00