Abstract:
:Proteins of the serum amyloid A (SAA) family have been remarkably conserved in evolution. Their biologic function(s) are not fully defined but they are likely to be a part of primordial host defense. We have detected a ∼ 12-kDa protein reacting with antibodies against serum amyloid A (SAA) in human colostrum by western blotting. Mass spectrometry identified the reactive species as SAA1, previously identified as a prominent member of the acute-phase response in serum. Our finding SAA1 in human colostrum contrasts with bovine, caprine and ovine colostrum where a species corresponding to putative SAA3 is uniformly present. SAA1 protein in human colostrum presumably contributes to neonatal protection.
journal_name
FEBS Open Biojournal_title
FEBS open bioauthors
Sack GH Jr,Zachara N,Rosenblum N,Talbot CC Jr,Kreimer S,Cole R,McDonald TLdoi
10.1002/2211-5463.12383subject
Has Abstractpub_date
2018-01-31 00:00:00pages
435-441issue
3issn
2211-5463pii
FEB412383journal_volume
8pub_type
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