Abstract:
:A local tissue-specific renin-angiotensin system (local RAS) has been identified in many organs. However, no report has described the role of a local RAS in the hypertrophic differentiation of chondrocytes. To examine the role of a local RAS in the hypertrophic differentiation, we activated angiotensin II type 1 receptor (AT1R) and angiotensin II type 2 receptor (AT2R) separately in the cell line ATDC5, which involves differentiation from mesenchymal stem cells to hypertrophic chondrocytes. Activation of AT1R suppressed and activation of AT2R enhanced the expression of markers of hypertrophic differentiation, including type X collagen, matrix metalloproteinase 13 and runt-related transcription factor 2.
journal_name
FEBS Open Biojournal_title
FEBS open bioauthors
Tsukamoto I,Inoue S,Teramura T,Takehara T,Ohtani K,Akagi Mdoi
10.1016/j.fob.2013.07.001subject
Has Abstractpub_date
2013-07-04 00:00:00pages
279-84issn
2211-5463pii
FOB102journal_volume
3pub_type
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