Discovery of novel interacting partners of PSMD9, a proteasomal chaperone: Role of an Atypical and versatile PDZ-domain motif interaction and identification of putative functional modules.

abstract：:Baicalin (5,6-dihydroxy-7-o-glucuronide flavone) is an extract from the roots of Chinese herb Huang Qin (Scutellaria baicalensis Georgi) and is reported to have antioxidative, antiproliferative, anti-inflammatory, and anticancer activities. This study aimed to investigate the inhibitory effect of baicalin on human hep...

journal_title：FEBS open bio

authors： Yu Z,Luo X,Wang C,Ye J,Liu S,Xie L,Wang F,Bao J

更新日期：2016-10-24 00:00:00

abstract：:Adult T-cell leukemia/lymphoma (ATL), an aggressive T-cell malignancy that develops after long-term infection with human T-cell leukemia virus (HTLV-1), requires new treatments. Drug repositioning, reuse of a drug previously approved for the treatment of another condition to treat ATL, offers the possibility of reduce...

journal_title：FEBS open bio

authors： Kozako T,Soeda S,Yoshimitsu M,Arima N,Kuroki A,Hirata S,Tanaka H,Imakyure O,Tone N,Honda S,Soeda S

更新日期：2016-04-13 00:00:00

abstract：:Osteosarcoma is a malignant bone tumor, and clinically detectable metastases can be detected in ~ 15-20% of patients when they seek medical advice; patients with metastatic disease have extremely poor prognosis. Here, we examined the involvement of the microRNA miR-505 in osteosarcoma. Eighty-four patients seeking tre...

journal_title：FEBS open bio

authors： Li G,Liu F,Miao J,Hu Y

更新日期：2020-07-01 00:00:00

abstract：:In this study, it was shown for the first time that l-amino acid oxidase of Pseudomonas sp. AIU813, renamed as l-amino acid oxidase/monooxygenase (l-AAO/MOG), exhibits l-lysine 2-monooxygenase as well as oxidase activity. l-Lysine oxidase activity of l-AAO/MOG was increased in a p-chloromercuribenzoate (p-CMB) concent...

journal_title：FEBS open bio

authors： Matsui D,Im DH,Sugawara A,Fukuta Y,Fushinobu S,Isobe K,Asano Y

更新日期：2014-02-07 00:00:00

abstract：:Redox-coupled folding pathways of bovine pancreatic ribonuclease A (RNase A) with four intramolecular disulfide (SS) bonds comprise three phases: (I) SS formation to generate partially oxidized intermediate ensembles with no rigid folded structure; (II) SS rearrangement from the three SS intermediate ensemble (3S) to ...

journal_title：FEBS open bio

authors： Arai K,Kumakura F,Iwaoka M

更新日期：2012-04-16 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most malignant form of brain tumor and is associated with resistance to conventional therapy and poor patient survival. Prostate apoptosis response (Par)-4, a tumor suppressor, is expressed as both an intracellular and secretory/extracellular protein. Though secretory Par-4 induces...

journal_title：FEBS open bio

authors： Jagtap JC,Parveen D,Shah RD,Desai A,Bhosale D,Chugh A,Ranade D,Karnik S,Khedkar B,Mathur A,Natesh K,Chandrika G,Shastry P

更新日期：2014-11-21 00:00:00

abstract：:The extreme halophile Halococcus morrhuae (ATCC® 17082) contains a 108-nucleotide insertion in its 5S rRNA. Large rRNA expansions in Archaea are rare. This one almost doubles the length of the 5S rRNA. In order to understand how such an insertion is accommodated in the ribosome, we obtained a cryo-electron microscopy ...

journal_title：FEBS open bio

authors： Tirumalai MR,Kaelber JT,Park DR,Tran Q,Fox GE

更新日期：2020-10-01 00:00:00

abstract：:Metastasis is the primary contributor to colorectal cancer mortality. High-intensity focused ultrasound (HIFU) is an emerging technology for tumor therapy that exerts its effects through tumor ablation, mechanical disruption, and enhancement of immune responses. However, it remains unclear whether HIFU can influence t...

journal_title：FEBS open bio

authors： Li M,Wan G,Yu H,Xiong W

更新日期：2019-06-01 00:00:00

abstract：:Oxidized cholesterol (oxysterols) plays an important and multifaceted role in lipid metabolism. Here we examined whether dietary oxysterols accelerate hepatic lipid accumulation and inflammation in nonhuman primates. We also examined the effect of the Niemann-Pick C1-like1 inhibitor, ezetimibe (Ez). Macaca fasciculari...

journal_title：FEBS open bio

authors： Deushi M,Osaka M,Nakano K,Osada K,Egashira K,Yoshida M

更新日期：2016-09-20 00:00:00

abstract：:Decorin (DCN) is a major member of the small leucine-rich proteoglycan (SLRP) family that is critically involved in tumorigenesis and the development of metastasis of cancers, including glioma. Overexpression of DCN was indicated to suppress glioma cell growth. However, the role of DCN in the migration of glioma cells...

journal_title：FEBS open bio

authors： Yao T,Zhang CG,Gong MT,Zhang M,Wang L,Ding W

更新日期：2016-05-31 00:00:00

abstract：:Obesity during pregnancy has been shown to increase the risk of metabolic diseases in the offspring. However, the factors within the maternal milieu which affect offspring phenotypes and the underlying mechanisms remain unknown. The adipocyte hormone leptin plays a key role in regulating energy homeostasis and is know...

journal_title：FEBS open bio

authors： Denisova EI,Kozhevnikova VV,Bazhan NM,Makarova EN

更新日期：2020-01-01 00:00:00

abstract：:In brain cells, glutamine transporters are vital to monitor and control the levels of glutamate and GABA. There are 11 members of the SLC38 family of amino acid transporters of which eight have been functionally characterized. Here, we report the first histological and functional characterization of the previously orp...

journal_title：FEBS open bio

authors： Hellsten SV,Hägglund MG,Eriksson MM,Fredriksson R

更新日期：2017-04-26 00:00:00

abstract：:Nitrobindins (Nbs), constituting a heme-protein family spanning from bacteria to Homo sapiens, display an all-β-barrel structural organization. Human Nb has been described as a domain of the nuclear protein named THAP4, whose physiological function is still unknown. We report the first evidence of the heme-Fe(III)-bas...

journal_title：FEBS open bio

authors： De Simone G,di Masi A,Polticelli F,Ascenzi P

更新日期：2018-11-09 00:00:00

abstract：:The base excision repair pathway plays an important role in correcting damage induced by either physiological or external effects. This repair pathway removes incorrect bases from the DNA. The uracil base is among the most frequently occurring erroneous bases in DNA, and is cut out from the phosphodiester backbone via...

journal_title：FEBS open bio

authors： Papp-Kádár V,Balázs Z,Vékey K,Ozohanics O,Vértessy BG

更新日期：2019-02-09 00:00:00

abstract：:The nuclear envelopes surrounding the oocyte germinal vesicles of lower vertebrates (fish and frog) are supported by the lamina, which consists of the protein lamin B3 encoded by a gene found also in birds but lost in the lineage leading to mammals. Like other members of the lamin family, goldfish lamin B3 (gfLB3) con...

journal_title：FEBS open bio

authors： Yamaguchi A,Iwatani M,Ogawa M,Kitano H,Matsuyama M

更新日期：2013-03-29 00:00:00

abstract：:Dedifferentiation of adipocytes contributes to the generation of a proliferative cell population that could be useful in cellular therapy or tissue engineering. Adipocytes can dedifferentiate into precursor cells to acquire a fibroblast-like phenotype using ceiling culture, in which the buoyancy of fat cells is exploi...

journal_title：FEBS open bio

authors： Côté JA,Lessard J,Pelletier M,Marceau S,Lescelleur O,Fradette J,Tchernof A

更新日期：2017-07-10 00:00:00

abstract：:Human type 2 diabetes is associated with β-cell apoptosis, and human islets from diabetic donors are ∼80% deficient in PAK1 protein. Toward addressing linkage of PAK1 to β-cell survival, PAK1-siRNA targeted MIN6 pancreatic β-cells were found to exhibit increased caspase-3 cleavage, cytosolic cytochrome-C and the pro-a...

journal_title：FEBS open bio

authors： Wang Z,Thurmond DC

更新日期：2012-09-08 00:00:00

abstract：:Small heat shock proteins (sHsps) endow cells with stress tolerance. Of the various sHsps in mammals, HspB1, also known as Hsp27, is the most ubiquitous. To examine the structure and function of HspB1, we expressed, purified, and characterized HspB1 from Chinese hamster (Cricetulus griseus) ovary cells (CgHspB1). CgHs...

journal_title：FEBS open bio

authors： Sha E,Nakamura M,Ankai K,Yamamoto YY,Oka T,Yohda M

更新日期：2019-10-01 00:00:00

abstract：:DNA damage-inducible 1 (Ddi1) is a multidomain protein with one of the domains being retropepsin-like. HIV-1 protease inhibitors were found to reduce opportunistic infections caused by pathogens like Leishmania and Plasmodium, and some of them were shown to inhibit the growth of these parasites. In Leishmania, Ddi1 wa...

journal_title：FEBS open bio

authors： Kumar S,Suguna K

更新日期：2018-08-03 00:00:00

abstract：:The pathogenic bacteria Streptococcus pyogenes can cause an array of diseases in humans, including moderate infections such as pharyngitis (strep throat) as well as life threatening conditions such as necrotizing fasciitis and puerperal fever. The antigen I/II family proteins are cell wall anchored adhesin proteins fo...

journal_title：FEBS open bio

authors： Hall M,Nylander S,Jenkinson HF,Persson K

更新日期：2014-03-12 00:00:00

abstract：:RAC3 is a coactivator of glucocorticoid receptor and nuclear factor-κB (NF-κB) that is usually over-expressed in tumors and which also has important functions in the immune system. We investigated the role of the inflammatory response in the control of RAC3 expression levels in vivo and in vitro. We found that inflamm...

journal_title：FEBS open bio

authors： Alvarado CV,Rubio MF,Fernández Larrosa PN,Panelo LC,Azurmendi PJ,Ruiz Grecco M,Martínez-Nöel GA,Costas MA

更新日期：2014-05-02 00:00:00

abstract：:Flavonoids represent one of the most important molecules of plant secondary metabolism, playing many different biochemical and physiological roles. Although their essential role in plant life and human health has been elucidated by many studies, their subcellular transport and accumulation in plant tissues remains unc...

journal_title：FEBS open bio

authors： Filippi A,Petrussa E,Peresson C,Bertolini A,Vianello A,Braidot E

更新日期：2015-08-29 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) has been identified as a crucial inflammatory cytokine in immune homeostasis. Previous studies have reported conflicting effects of TSLP on sepsis in mice, and the effect of TSLP on sepsis in humans has not been investigated. In this study, we used the ELISA to measure serum levels ...

journal_title：FEBS open bio

authors： Yu Q,Li Y,Wang H,Xiong H

更新日期：2019-12-01 00:00:00

abstract：:Eukaryotic protein O-mannosyltransferases (Pmts) are divided into three subfamilies (Pmt1, Pmt2, and Pmt4) and activity of Pmts in yeasts and animals requires assembly into complexes. In Saccharomyces cerevisiae, Pmt1 and Pmt2 form a heteromeric complex and Pmt 4 forms a homomeric complex. The filamentous fungus Asper...

journal_title：FEBS open bio

authors： Kriangkripipat T,Momany M

更新日期：2014-03-19 00:00:00

abstract：:Increased glucose consumption is a known hallmark of cancer cells. Increased glycolysis provides ATP, reducing agents and substrates for macromolecular synthesis in intensely dividing cells. Therefore, inhibition of glycolysis is one strategy in anticancer therapy as well as in improved efficacy of conventional antica...

journal_title：FEBS open bio

authors： Korga A,Ostrowska M,Iwan M,Herbet M,Dudka J

更新日期：2019-05-01 00:00:00

abstract：:Fluorine is a bone-seeking element ubiquitously present in the environment and widely used in many oral hygiene products. In humans, excessive intake of fluoride may cause dental and skeletal fluorosis. However, endemic fluorosis does not appear to develop in a proportion of individuals exposed to the same levels of f...

journal_title：FEBS open bio

authors： Ran S,Sun N,Liu Y,Zhang W,Li Y,Wei L,Wang J,Liu B

更新日期：2017-06-05 00:00:00

abstract：:Zinc deficiency impairs the immune system leading to frequent infections. Although zinc is known to play critical roles in maintaining healthy immune function, the underlying molecular targets are largely unknown. In this study, we demonstrate that zinc is important for the CD154-CD40-mediated activation of downstream...

journal_title：FEBS open bio

authors： Tepaamorndech S,Oort P,Kirschke CP,Cai Y,Huang L

更新日期：2017-03-27 00:00:00

abstract：:Organisms living in temperate regions are sensitive to seasonal variations in the environment; they are known to accumulate energy as fat in their livers during the winter when days are shorter, temperatures are lower, and food is scarce. However, the effect of variations in photoperiod alone on hepatic lipid metaboli...

journal_title：FEBS open bio

authors： Fujisawa K,Takami T,Shintani H,Sasai N,Matsumoto T,Yamamoto N,Sakaida I

更新日期：2021-01-21 00:00:00

abstract：:Due to its exceptionally small genome size and protogynous hermaphroditism, Monopterus albus has been proposed as a model for vertebrate sexual development. The Kiss/GPR54 system is a central regulator of sexual development in most vertebrates, but its role in sex reversal remains hypothetical. In contrast to mammals,...

journal_title：FEBS open bio

authors： Yi TL,Pei MT,Yang DQ

更新日期：2019-10-01 00:00:00

abstract：:Heterocyst-forming cyanobacteria grow as filaments that can be hundreds of cells long. Proteinaceous septal junctions provide cell-cell binding and communication functions in the filament. In Anabaena sp. strain PCC 7120, the SepJ protein is important for the formation of septal junctions. SepJ consists of integral me...

journal_title：FEBS open bio

authors： Ramos-León F,Mariscal V,Battchikova N,Aro EM,Flores E

更新日期：2017-08-30 00:00:00