The neuronal and astrocytic protein SLC38A10 transports glutamine, glutamate, and aspartate, suggesting a role in neurotransmission.

abstract：:Receptor activator of nuclear factor-κB ligand (RANKL) is required for initiation of osteoclastogenesis, with the signaling pathway including the NF-kB, c-Fos, and nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) transcription factors. Because NFATc1 expression is autoamplified, we investigated the molecula...

journal_title：FEBS open bio

authors： Park KL,Oh DG,Kim YO,Song KS,Ahn DW

更新日期：2018-09-10 00:00:00

abstract：:Hypoxia-inducible factor (HIF) is a crucial regulator of cellular and systemic responses to low oxygen levels. Here we firstly cloned three HIF-α isoforms from the basal branches of Osteichthyes and used computational tools to characterise the molecular change underlying the functional divergence of HIF-α isoforms in ...

journal_title：FEBS open bio

authors： Chi W,Gan X,Xiao W,Wang W,He S

更新日期：2013-09-19 00:00:00

abstract：:Eukaryotic protein O-mannosyltransferases (Pmts) are divided into three subfamilies (Pmt1, Pmt2, and Pmt4) and activity of Pmts in yeasts and animals requires assembly into complexes. In Saccharomyces cerevisiae, Pmt1 and Pmt2 form a heteromeric complex and Pmt 4 forms a homomeric complex. The filamentous fungus Asper...

journal_title：FEBS open bio

authors： Kriangkripipat T,Momany M

更新日期：2014-03-19 00:00:00

abstract：:The antipsychotic drug olanzapine is widely prescribed to treat schizophrenia and other psychotic disorders. However, it often causes unwanted side effects, including diabetes, due to disruption of insulin-dependant glucose metabolism through a mechanism yet to be elucidated. To determine if olanzapine can affect the ...

journal_title：FEBS open bio

authors： Babkin P,George Thompson AM,Iancu CV,Walters DE,Choe JY

更新日期：2015-04-15 00:00:00

abstract：:Despite significant advances in understanding of the causes of and treatment of myocardial infarction (MI) in recent years, morbidity and mortality is still high. The aim of this study was to identify miRNA and genes potentially associated with MI. mRNA and miRNA expression datasets were downloaded from the Gene Expre...

journal_title：FEBS open bio

authors： Wu K,Zhao Q,Li Z,Li N,Xiao Q,Li X,Zhao Q

更新日期：2018-04-19 00:00:00

abstract：:The expression of death receptor 6 (DR6) is abnormal in some cancer types, but the function and underlying molecular mechanisms of DR6 in tumor progression are not yet clear. In the present study, our analysis of ovarian cancer RNA sequencing data from The Cancer Genome Atlas revealed that DR6 is upregulated in human ...

journal_title：FEBS open bio

authors： Shi B,Bao J,Liu Y,Shi J

更新日期：2018-08-07 00:00:00

abstract：:The nuclear envelopes surrounding the oocyte germinal vesicles of lower vertebrates (fish and frog) are supported by the lamina, which consists of the protein lamin B3 encoded by a gene found also in birds but lost in the lineage leading to mammals. Like other members of the lamin family, goldfish lamin B3 (gfLB3) con...

journal_title：FEBS open bio

authors： Yamaguchi A,Iwatani M,Ogawa M,Kitano H,Matsuyama M

更新日期：2013-03-29 00:00:00

abstract：:One practical application of genome-scale metabolic reconstructions is to interrogate multispecies relationships. Here, we report a consensus metabolic model in four yeast species (Saccharomyces cerevisiae, S. paradoxus, S. mikatae, and S. bayanus) by integrating metabolic network simulations with RNA sequencing (RNA-...

journal_title：FEBS open bio

authors： Zhao Y,Wang Y,Zou L,Huang J

更新日期：2016-02-27 00:00:00

abstract：:Low-density lipoprotein receptor (LDLR) mediates hepatic clearance of plasma cholesterol; proprotein convertase subtilisin/kexin 9 (PCSK9) opposes this clearance by promoting LDLR degradation. The plant flavonoid quercetin-3-β-d-glucoside (Q3G) has been shown to reduce hypercholesterolemia in experimental animals. Her...

journal_title：FEBS open bio

authors： Mbikay M,Sirois F,Simoes S,Mayne J,Chrétien M

更新日期：2014-09-02 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma coactivator-1β (PGC-1β) is a transcriptional regulator whose increased expression activates energy expenditure-related genes in skeletal muscles. However, how PGC-1β is regulated remains largely unclear. Here, we show that PGC-1β gene expression is negatively correlated...

journal_title：FEBS open bio

authors： Nakai S,Oyabu M,Hatazawa Y,Akashi S,Kitamura T,Miura S,Kamei Y

更新日期：2020-07-01 00:00:00

abstract：:Tight regulation of the eukaryotic cell cycle is paramount to ensure genomic integrity throughout life. Cell cycle checkpoints are present in each phase of the cell cycle and prevent cell cycle progression when genomic integrity is compromised. The G2 checkpoint is an intricate signaling network that regulates the pro...

journal_title：FEBS open bio

authors： de Gooijer MC,van den Top A,Bockaj I,Beijnen JH,Würdinger T,van Tellingen O

更新日期：2017-03-04 00:00:00

abstract：:Prostate cancer (PCa) is the most frequently diagnosed male cancer. An earlier study of a cohort of 333 primary prostate carcinomas showed that 74% of these tumors fell into one of seven subtypes of a molecular taxonomy defined by specific gene fusions (ERG, ETV1/4 and FLI1) or mutations (SPOP, FOXA1 and IDH1). Molecu...

journal_title：FEBS open bio

authors： Tang L,Zhang L,Liu L,Dong L,Dong Y,Zhu W,Wang H

更新日期：2020-12-01 00:00:00

abstract：:The identification of biomarkers for early diagnosis of Parkinson's disease (PD) prior to the onset of symptoms may improve the effectiveness of therapy. To identify potential biomarkers, we downloaded microarray datasets of PD from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) between PD...

journal_title：FEBS open bio

authors： Jiang F,Wu Q,Sun S,Bi G,Guo L

更新日期：2019-08-01 00:00:00

abstract：:Human STIL (SCL/TAL1 interrupting locus) protein maintains centriole stability and spindle pole localisation. It helps in recruitment of CENPJ (Centromere protein J)/CPAP (centrosomal P4.1-associated protein) and other centrosomal proteins. Mutations in STIL protein are reported in several disorders, especially in der...

journal_title：FEBS open bio

authors： Kumar A,Rajendran V,Sethumadhavan R,Purohit R

更新日期：2012-09-25 00:00:00

abstract：:NrrF is a small regulatory RNA of the human pathogen Neisseria meningitidis. NrrF was previously shown to repress succinate dehydrogenase (sdhCDAB) under control of the ferric uptake regulator (Fur). Here, we provide evidence that cytochrome bc 1 , encoded by the polycistro...

journal_title：FEBS open bio

authors： Pannekoek Y,Huis In 't Veld R,Schipper K,Bovenkerk S,Kramer G,Speijer D,van der Ende A

更新日期：2017-08-05 00:00:00

abstract：:Decorin (DCN) is a major member of the small leucine-rich proteoglycan (SLRP) family that is critically involved in tumorigenesis and the development of metastasis of cancers, including glioma. Overexpression of DCN was indicated to suppress glioma cell growth. However, the role of DCN in the migration of glioma cells...

journal_title：FEBS open bio

authors： Yao T,Zhang CG,Gong MT,Zhang M,Wang L,Ding W

更新日期：2016-05-31 00:00:00

abstract：:Human type 2 diabetes is associated with β-cell apoptosis, and human islets from diabetic donors are ∼80% deficient in PAK1 protein. Toward addressing linkage of PAK1 to β-cell survival, PAK1-siRNA targeted MIN6 pancreatic β-cells were found to exhibit increased caspase-3 cleavage, cytosolic cytochrome-C and the pro-a...

journal_title：FEBS open bio

authors： Wang Z,Thurmond DC

更新日期：2012-09-08 00:00:00

abstract：:Baicalin (5,6-dihydroxy-7-o-glucuronide flavone) is an extract from the roots of Chinese herb Huang Qin (Scutellaria baicalensis Georgi) and is reported to have antioxidative, antiproliferative, anti-inflammatory, and anticancer activities. This study aimed to investigate the inhibitory effect of baicalin on human hep...

journal_title：FEBS open bio

authors： Yu Z,Luo X,Wang C,Ye J,Liu S,Xie L,Wang F,Bao J

更新日期：2016-10-24 00:00:00

abstract：:miR-193a-3p is a tumor-related miRNA playing an essential role in tumorigenesis and progression of non-small cell lung cancer (NSCLC). The objective of the present study was to investigate the relationship between miR-193a-3p expression and clinical value and to further explore the potential signaling of miR-193a-3p i...

journal_title：FEBS open bio

authors： Gao X,Tang RX,Xie QN,Lin JY,Shi HL,Chen G,Li ZY

更新日期：2018-01-04 00:00:00

abstract：:Glutathione transferases (GSTs) are involved in many processes in plant biochemistry, with their best characterised role being the detoxification of xenobiotics through their conjugation with glutathione. GSTs have also been implicated in noncatalytic roles, including the binding and transport of small heterocyclic li...

journal_title：FEBS open bio

authors： Ahmad L,Rylott EL,Bruce NC,Edwards R,Grogan G

更新日期：2016-12-22 00:00:00

abstract：:Organisms living in temperate regions are sensitive to seasonal variations in the environment; they are known to accumulate energy as fat in their livers during the winter when days are shorter, temperatures are lower, and food is scarce. However, the effect of variations in photoperiod alone on hepatic lipid metaboli...

journal_title：FEBS open bio

authors： Fujisawa K,Takami T,Shintani H,Sasai N,Matsumoto T,Yamamoto N,Sakaida I

更新日期：2021-01-21 00:00:00

abstract：:Micro-exons are a set of ultrashort exons with lengths ≤ 51 nucleotides. Our previous study revealed that micro-exons were enriched in AP2 domains and K-box domains, which are crucial components of AP2/ERF (APETALA2/ethylene-responsive element-binding protein) and MADS-box (an acronym of MCM1, AGAMOUS, DEFICIENS and S...

journal_title：FEBS open bio

authors： Song Q,Bari A,Li H,Chen LL

更新日期：2020-12-01 00:00:00

abstract：:In this study, it was shown for the first time that l-amino acid oxidase of Pseudomonas sp. AIU813, renamed as l-amino acid oxidase/monooxygenase (l-AAO/MOG), exhibits l-lysine 2-monooxygenase as well as oxidase activity. l-Lysine oxidase activity of l-AAO/MOG was increased in a p-chloromercuribenzoate (p-CMB) concent...

journal_title：FEBS open bio

authors： Matsui D,Im DH,Sugawara A,Fukuta Y,Fushinobu S,Isobe K,Asano Y

更新日期：2014-02-07 00:00:00

abstract：:Increased glucose consumption is a known hallmark of cancer cells. Increased glycolysis provides ATP, reducing agents and substrates for macromolecular synthesis in intensely dividing cells. Therefore, inhibition of glycolysis is one strategy in anticancer therapy as well as in improved efficacy of conventional antica...

journal_title：FEBS open bio

authors： Korga A,Ostrowska M,Iwan M,Herbet M,Dudka J

更新日期：2019-05-01 00:00:00

abstract：:Small heat shock proteins (sHsps) endow cells with stress tolerance. Of the various sHsps in mammals, HspB1, also known as Hsp27, is the most ubiquitous. To examine the structure and function of HspB1, we expressed, purified, and characterized HspB1 from Chinese hamster (Cricetulus griseus) ovary cells (CgHspB1). CgHs...

journal_title：FEBS open bio

authors： Sha E,Nakamura M,Ankai K,Yamamoto YY,Oka T,Yohda M

更新日期：2019-10-01 00:00:00

abstract：:Microorganisms or LPS (lipopolysaccharide), an outer membrane component of Gram-negative bacteria, can induce a systemic inflammatory response that leads to sepsis, multiple organ dysfunction, and mortality. Here, we investigated the role of cyclophilin D (CypD)-dependent mitochondrial permeability transition (mPT) in...

journal_title：FEBS open bio

authors： Veres B,Eros K,Antus C,Kalman N,Fonai F,Jakus PB,Boros E,Hegedus Z,Nagy I,Tretter L,Gallyas F Jr,Sumegi B

更新日期：2021-01-20 00:00:00

abstract：:An imbalance of branched-chain amino acids (BCAAs) in the brain may result in neuropathological conditions, such as autism spectrum disorders. The L-type amino acid transporter 1 (LAT1), encoded by the solute carrier transporter 7a5 (Slc7a5) gene, is critical for maintaining normal levels of BCAAs in the brain. Howeve...

journal_title：FEBS open bio

authors： Onishi Y,Hiraiwa M,Kamada H,Iezaki T,Yamada T,Kaneda K,Hinoi E

更新日期：2019-01-07 00:00:00

abstract：:Oxidative stress has been associated with prostate cancer development and progression due to an increase of reactive oxygen species (ROS). However, the mechanisms whereby ROS and the antioxidant system participate in cancer progression remain unclear. In order to clarify the influence of oxidative stress in prostate c...

journal_title：FEBS open bio

authors： Freitas M,Baldeiras I,Proença T,Alves V,Mota-Pinto A,Sarmento-Ribeiro A

更新日期：2012-05-30 00:00:00

abstract：:Memory includes the processes of acquisition, consolidation and retrieval. In the study of aversive olfactory memory in Drosophila melanogaster, flies are first exposed to an odor (conditioned stimulus, CS+) that is associated with an electric shock (unconditioned stimulus, US), then to another odor (CS-) without the ...

journal_title：FEBS open bio

authors： Ueoka Y,Hiroi M,Abe T,Tabata T

更新日期：2017-02-22 00:00:00

abstract：:Previous studies have proposed that the human papillomavirus (HPV) E6 oncoproteins modify the transcriptional activity of eIF4E through mechanisms dependent on p53 degradation. However, the effect of these oncoproteins on pathways regulating the activity of the eIF4E protein remains poorly understood. Hence, we invest...

journal_title：FEBS open bio

authors： Morales-Garcia V,Contreras-Paredes A,Martinez-Abundis E,Gomez-Crisostomo NP,Lizano M,Hernandez-Landero F,de la Cruz-Hernandez E

更新日期：2020-12-01 00:00:00