Abstract:
:miR-193a-3p is a tumor-related miRNA playing an essential role in tumorigenesis and progression of non-small cell lung cancer (NSCLC). The objective of the present study was to investigate the relationship between miR-193a-3p expression and clinical value and to further explore the potential signaling of miR-193a-3p in the carcinogenesis of NSCLC. RNA-sequencing and microarray data were collected from the databases GEO, ArrayExpress and The Cancer Genome Atlas (TCGA). Furthermore, in silico assessments were performed to analyze the prospective pathways and networks of the target genes of miR-193a-3p. In total, 453 cases of NSCLC patients and 476 normal controls were included in blood samples, while 920 cases of NSCLC patients and 406 normal controls were included in tissue samples. The pooled positive likelihood ratio, the pooled negative likelihood ratio and the pooled diagnostic odds ratio were calculated to reflect the diagnostic value of miR-193a-3p in blood and tissue samples. Moreover, the areas under the curve of the summary receiver operating characteristic curve of blood and tissue were 0.64 and 0.79, respectively. In addition, we found a lower level of miR-193a in NSCLC tissues than in non-cancerous controls based on TCGA. A gene ontology (GO) enrichment analysis demonstrated that miR-193a-3p could be related to key signaling pathways in NSCLC. Also, several vital pathways were illustrated by KEGG. Lower expression of miR-193a-3p in tissue samples of NSCLC may be associated with tumorigenesis and be a predictor of deterioration of NSCLC patients, and pathway analysis revealed crucial signaling pathways correlated with the incidence and progress of NSCLC.
journal_name
FEBS Open Biojournal_title
FEBS open bioauthors
Gao X,Tang RX,Xie QN,Lin JY,Shi HL,Chen G,Li ZYdoi
10.1002/2211-5463.12354subject
Has Abstractpub_date
2018-01-04 00:00:00pages
94-109issue
1issn
2211-5463pii
FEB412354journal_volume
8pub_type
杂志文章相关文献
FEBS Open Bio文献大全abstract::Post-transcriptional regulation of cytokine production is crucial to ensure appropriate immune responses. We previously demonstrated that poly-rC-binding protein-1 (PCBP1) can act as a trans-acting factor to stabilize transcripts encoding sortilin, which mediates cytokine trafficking. Here, we report that PCBP2, which...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12794
更新日期:2020-03-01 00:00:00
abstract::Insulin signaling plays a central role in the regulation of facilitative glucose transporters (GLUTs) in humans. To establish Caenorhabditis elegans (C. elegans) as a model to study the mechanism underlying insulin regulation of GLUT, we identified that FGT-1 is most likely the only functional GLUT homolog in C. elega...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12068
更新日期:2016-04-21 00:00:00
abstract::The antipsychotic drug olanzapine is widely prescribed to treat schizophrenia and other psychotic disorders. However, it often causes unwanted side effects, including diabetes, due to disruption of insulin-dependant glucose metabolism through a mechanism yet to be elucidated. To determine if olanzapine can affect the ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2015.04.006
更新日期:2015-04-15 00:00:00
abstract::Extensive simple sequence repeat (SSR) surveys have been performed for eukaryotic prokaryotic and viral genomes, but information regarding SSRs in viroids is limited. We undertook a survey to examine the presence of SSRs in viroid genomes. Our results show that the distribution of SSRs in viroids may influence seconda...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2014.02.001
更新日期:2014-02-07 00:00:00
abstract::The expression of death receptor 6 (DR6) is abnormal in some cancer types, but the function and underlying molecular mechanisms of DR6 in tumor progression are not yet clear. In the present study, our analysis of ovarian cancer RNA sequencing data from The Cancer Genome Atlas revealed that DR6 is upregulated in human ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12492
更新日期:2018-08-07 00:00:00
abstract::The nuclear envelopes surrounding the oocyte germinal vesicles of lower vertebrates (fish and frog) are supported by the lamina, which consists of the protein lamin B3 encoded by a gene found also in birds but lost in the lineage leading to mammals. Like other members of the lamin family, goldfish lamin B3 (gfLB3) con...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2013.03.003
更新日期:2013-03-29 00:00:00
abstract::Tropomyosins, a family of actin-associated proteins, bestow actin filaments with distinct biochemical and physical properties which are important for determining cell shape and regulating many cellular processes in eukaryotic cells. Here, we used RNA-seq to investigate the effect of four tropomyosin isoforms on gene e...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12386
更新日期:2018-02-19 00:00:00
abstract::Osteoarthritis (OA) is a chronic degenerative disease that commonly affects the elderly. Current drug therapies for treating OA may cause adverse side effects, and so there remains a need to develop alternative treatments. Bergapten (BG) is a coumarin phytohormone that is widely found in fruits and has antioxidative a...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12648
更新日期:2019-06-01 00:00:00
abstract::Dedifferentiation of adipocytes contributes to the generation of a proliferative cell population that could be useful in cellular therapy or tissue engineering. Adipocytes can dedifferentiate into precursor cells to acquire a fibroblast-like phenotype using ceiling culture, in which the buoyancy of fat cells is exploi...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12250
更新日期:2017-07-10 00:00:00
abstract::In this study, it was shown for the first time that l-amino acid oxidase of Pseudomonas sp. AIU813, renamed as l-amino acid oxidase/monooxygenase (l-AAO/MOG), exhibits l-lysine 2-monooxygenase as well as oxidase activity. l-Lysine oxidase activity of l-AAO/MOG was increased in a p-chloromercuribenzoate (p-CMB) concent...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2014.02.002
更新日期:2014-02-07 00:00:00
abstract::Receptor activator of nuclear factor-κB ligand (RANKL) is required for initiation of osteoclastogenesis, with the signaling pathway including the NF-kB, c-Fos, and nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) transcription factors. Because NFATc1 expression is autoamplified, we investigated the molecula...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12513
更新日期:2018-09-10 00:00:00
abstract::RAC3 is a coactivator of glucocorticoid receptor and nuclear factor-κB (NF-κB) that is usually over-expressed in tumors and which also has important functions in the immune system. We investigated the role of the inflammatory response in the control of RAC3 expression levels in vivo and in vitro. We found that inflamm...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2014.04.009
更新日期:2014-05-02 00:00:00
abstract::Acute lung injury (ALI) is accompanied by overactivation of multiple pro-inflammatory factors. Cytochrome P450 1A1 (CYP1A1) has been shown to aggravate lung injury in response to hyperoxia. However, the relationship between CYP1A1 and lipopolysaccharide (LPS)-induced ALI is unknown. In this study, CYP1A1 was shown to ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12977
更新日期:2020-09-15 00:00:00
abstract::Neural stem cells (NSC) from the adult hippocampus easily lose their activity in vitro. Efficient in vitro expansion of adult hippocampus-derived NSC is important for generation of tools for research and cell therapy. Here, we show that a single copy disruption or pharmacological inhibition of p38α enables successful ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2015.05.001
更新日期:2015-05-08 00:00:00
abstract::Sunitinib (Sun), a tyrosine kinase inhibitor of vascular endothelial growth factor receptor, is the standard first-line treatment against advanced clear cell renal cell carcinoma (RCC), but resistance to therapy is inevitable. Reactive oxygen species production is associated with sensitivity to chemotherapy, but the u...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.13090
更新日期:2021-01-16 00:00:00
abstract::Fibroblast growth factor 11 (FGF11) is a member of the intracellular fibroblast growth factor superfamily. Here, we identified FGF11 as a novel mediator of adipogenesis. During 3T3-L1 adipocyte differentiation, the expression of FGF11 decreased at the mitotic clonal expansion stage and increased at the terminal differ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12619
更新日期:2019-03-12 00:00:00
abstract::Postoperative cognitive dysfunction is a common complication in elderly patients after surgeries involving anesthesia, but the underlying mechanisms are poorly understood. Lithium is a conventional treatment for bipolar disorder, which exerts a neuroprotective role in various diseases by inhibiting glycogen synthase k...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12779
更新日期:2019-12-22 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic inflammatory disease with increased risk of cardiovascular events and mortality that can be attributed to accelerated atherosclerosis. This pilot study aimed to investigate if changes in blood parameters were compatible with atherosclerotic events in RA patients. To this aim, 45 ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12531
更新日期:2018-11-06 00:00:00
abstract::Inovirus XacF1 (7325 nucleotides) is integrated into the genome of Xanthomonas citri pv. citri (Xcc) strains at the host dif site (attB) by the host XerC/D recombination system. The XacF1 attP sequence is located within the coding region of ORF12, a possible phage regulator. After integration, this open reading frame ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12312
更新日期:2017-09-19 00:00:00
abstract::Angiotensin converting enzyme (ACE) is a zinc-dependent dipeptidyl carboxypeptidase with an essential role in blood pressure homeostasis in mammals. ACE has long been targeted in the treatment of hypertension through ACE inhibitors, however current inhibitors are known to cause severe side effects. Therefore, there is...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2015.08.004
更新日期:2015-08-11 00:00:00
abstract::Soft cheese with white rind lacks essential fatty acids (EFAs), and as a result its long-term consumption may lead to various kinds of cardiovascular and cerebrovascular diseases, such as hyperlipidemia, hypertension, and atherosclerosis. Geotrichum candidum is a dimorphic yeast that plays an important role in the rip...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12553
更新日期:2018-12-06 00:00:00
abstract::IL-1 family cytokines act as apical initiators of inflammation in many settings and can promote the production of a battery of inflammatory cytokines, chemokines and other inflammatory mediators in diverse cell types. IL-36α, IL-36β and IL-36γ, which belong to the extended IL-1 family, have been implicated as key init...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12406
更新日期:2018-03-25 00:00:00
abstract::In this study, we showed that cyanocobalamin dodecylamine, a ribose 5'-carbamate derivative of cyanocobalamin, was absorbed and accumulated to significant levels by Caenorhabditis elegans and was not further metabolized. The levels of methylmalonic acid and homocysteine, which serve as indicators of cobalamin deficien...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2014.07.008
更新日期:2014-08-01 00:00:00
abstract::Oxidative stress in plants causes ferredoxin down-regulation and NADP(+) shortage, over-reduction of the photosynthetic electron transport chain, electron leakage to oxygen and generation of reactive oxygen species (ROS). Expression of cyanobacterial flavodoxin in tobacco chloroplasts compensates for ferredoxin declin...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2011.10.004
更新日期:2011-11-11 00:00:00
abstract::Hirschmanniella mucronata is a plant-parasitic nematode that is widespread in rice production areas and causes 10-25% yield losses a year on average. Here, we investigated the mechanism of resistance to this nematode by comparing the transcriptomes of roots from resistant (Jiabali) and susceptible (Bawangbian) varieti...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12737
更新日期:2019-11-01 00:00:00
abstract::Increased glucose consumption is a known hallmark of cancer cells. Increased glycolysis provides ATP, reducing agents and substrates for macromolecular synthesis in intensely dividing cells. Therefore, inhibition of glycolysis is one strategy in anticancer therapy as well as in improved efficacy of conventional antica...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12628
更新日期:2019-05-01 00:00:00
abstract::Centrins are members of the EF-hand family of calcium-binding proteins, which are highly conserved among eukaryotes. Centrins bind to several cellular targets, through a hydrophobic triad. However, the W(1)xxL(4)xxxL(8) triad in XPC (Xeroderma Pigmentosum Group C protein) is found in the reverse orientation, as in the...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2013.11.005
更新日期:2013-12-05 00:00:00
abstract::Goji berries have been used as food and medicine for millennia. Due to their high morphological similarity, fruits of two distinct species belonging to the family Solanaceae, Lycium barbarum (LB) and Lycium chinense (Chinese boxthorn), are usually marketed together as goji berries, but nearly 90% of all commercially a...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12910
更新日期:2020-08-01 00:00:00
abstract::Tight regulation of the eukaryotic cell cycle is paramount to ensure genomic integrity throughout life. Cell cycle checkpoints are present in each phase of the cell cycle and prevent cell cycle progression when genomic integrity is compromised. The G2 checkpoint is an intricate signaling network that regulates the pro...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12206
更新日期:2017-03-04 00:00:00
abstract::Human cytomegalovirus (HCMV) infection can be accelerated by intracellular and extracellular hydrogen peroxide (H2O2) stimulation, mediated by the activation of the p38 mitogen-activated protein kinase (MAPK) pathway. However, it remains unknown whether host gene expression is involved in H2O2-upregulated HCMV replica...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12105
更新日期:2016-08-15 00:00:00