Abstract:
Importance:The prevalence of autism spectrum disorder (ASD) has been increasing rapidly, with current estimates of 1 in 68 children affected. Simultaneously, use of prenatal ultrasonography has increased substantially, with limited investigation into its safety and effects on brain development. Animal studies have demonstrated that prenatal ultrasonography can adversely affect neuronal migration. Objective:To quantify prenatal ultrasound exposure by the frequency, timing, duration, and strength of ultrasonographic scans in children with later ASD, developmental delay, and typical development. Design, Setting, and Participants:This case-control study included 107 patients with ASD, 104 control individuals with developmental delay, and 209 controls with typical development. Participants were identified from medical records based on prenatal care and delivery at Boston Medical Center, a diverse, academic, safety-net medical center, from July 1, 2006, through December 31, 2014, with a gestational age at birth of at least 37 weeks. Data were analyzed from May 1, 2015, through November 30, 2017. Exposures:Ultrasonographic exposure was quantified by the number and timing of scans, duration of exposure, mean strength (depth, frame rate, mechanical index, and thermal index), and time of Doppler and 3- and 4-dimensional imaging. Main Outcomes and Measures:Among participants with ASD and controls with developmental delay and typical development, ultrasound exposure was quantified and compared per trimester and for the entire pregnancy, with adjustment for infant sex, gestational age at birth, and maternal age. Results:A total of 420 participants were included in the study (328 boys [78.1%] and 92 girls [21.9%]; mean age as of January 1, 2016, 6.6 years; 95% CI, 6.5-6.8 years). The ASD group received a mean of 5.9 scans (95% CI, 5.2-6.6), which was not significantly different from the 6.1 scans (95% CI, 5.4-6.8) in the developmental delay group or the 6.3 scans (95% CI, 5.8-6.8) in the typical development group. Compared with the typical development group, the ASD group had shorter duration of ultrasound exposure during the first (290.4 seconds [95% CI, 212.8-368.0 seconds] vs 406.4 seconds [95% CI, 349.5-463.3 seconds]) and second (1687.6 seconds [95% CI, 1493.8-1881.4 seconds] vs 2011.0 seconds [95% CI, 1868.9-2153.1 seconds]) trimesters but no difference in the number of scans. The ASD group had greater mean depth of ultrasonographic penetration than the developmental delay group in the first trimester (12.5 cm [95% CI, 12.0-13.0 cm] vs 11.6 cm [95% CI, 11.1-12.1 cm]). The ASD group had greater mean depth than the typical development group during the first (12.5 cm [95% CI, 12.0-13.0 cm] vs 11.6 cm [95% CI, 11.3-12.0 cm]) and the second (12.9 cm [95% CI, 12.6-13.3 cm] vs 12.5 cm [95% CI, 12.2-12.7 cm]) trimesters. Conclusions and Relevance:This study found significantly greater mean depth of ultrasonographic penetration in the ASD group compared with the developmental delay group in the first trimester and compared with the typical development group in the first and second trimesters. Further research is needed to determine whether other variables of ultrasound exposure also have adverse effects on the developing fetus.
journal_name
JAMA Pediatrjournal_title
JAMA pediatricsauthors
Rosman NP,Vassar R,Doros G,DeRosa J,Froman A,DiMauro A,Santiago S,Abbott Jdoi
10.1001/jamapediatrics.2017.5634subject
Has Abstractpub_date
2018-04-01 00:00:00pages
336-344issue
4eissn
2168-6203issn
2168-6211pii
2672728journal_volume
172pub_type
杂志文章相关文献
JAMA Pediatrics文献大全abstract:Importance:Approximately 90% of adult smokers first tried a cigarette by 18 years of age, and even infrequent smoking in adolescence is associated with established adult smoking. Noncigarette tobacco use is increasing and could stimulate subsequent conventional cigarette smoking in youths. Objective:To estimate the lo...
journal_title:JAMA pediatrics
pub_type: 杂志文章
doi:10.1001/jamapediatrics.2017.4173
更新日期:2018-02-01 00:00:00
abstract:IMPORTANCE:Late-term gestation (defined as the 41st week of pregnancy) is associated with increased risk of perinatal health complications. It is not known to what extent late-term gestation is associated with long-term cognitive and physical outcomes. Information about long-term outcomes may influence physician and pa...
journal_title:JAMA pediatrics
pub_type: 杂志文章
doi:10.1001/jamapediatrics.2016.0238
更新日期:2016-08-01 00:00:00
abstract:Importance:Incorporating combination vaccines, such as the measles-mumps-rubella-varicella (MMRV) vaccine, into immunization schedules should be evaluated from a benefit-risk perspective. Use of MMRV vaccine poses challenges due to a recognized increased risk of febrile seizures (FSs) when used as the first dose in the...
journal_title:JAMA pediatrics
pub_type: 杂志文章
doi:10.1001/jamapediatrics.2017.1965
更新日期:2017-10-01 00:00:00
abstract:Importance:The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) uses the Sequential Organ Failure Assessment (SOFA) score to grade organ dysfunction in adult patients with suspected infection. However, the SOFA score is not adjusted for age and therefore not suitable for children. Objec...
journal_title:JAMA pediatrics
pub_type: 杂志文章
doi:10.1001/jamapediatrics.2017.2352
更新日期:2017-10-02 00:00:00
abstract:Clinical Question:Do dietary interventions, such as probiotics, improve pain in children with recurrent abdominal pain? Clinical Application:Compared with placebo, children who were treated with probiotic preparations were more likely to experience improvement in pain in the short term (odds ratio, 1.63; 95% CI, 1.07-...
journal_title:JAMA pediatrics
pub_type: 杂志文章
doi:10.1001/jamapediatrics.2018.4575
更新日期:2019-02-01 00:00:00
abstract:Importance:Supplemental oxygen is commonly administered to pregnant women at the time of delivery to prevent fetal hypoxia and acidemia. There is mixed evidence on the utility of this practice. Objective:To compare the association of peripartum maternal oxygen administration with room air on umbilical artery (UA) gas ...
journal_title:JAMA pediatrics
pub_type: 杂志文章
doi:10.1001/jamapediatrics.2020.5351
更新日期:2021-01-04 00:00:00
abstract:IMPORTANCE:Most patients with asthma take fewer than half of prescribed doses of controller medication. Interventions to improve adherence have typically been costly, impractical, and at best only minimally successful. OBJECTIVE:To test a speech recognition (SR) intervention to improve adherence to pediatric asthma co...
journal_title:JAMA pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1001/jamapediatrics.2014.3280
更新日期:2015-04-01 00:00:00
abstract:Importance:Millions of low-income children in the United States reside in substandard or unaffordable housing. Relieving these burdens may be associated with changes in asthma outcomes. Objectives:To examine whether participation in the US Department of Housing and Urban Development's (HUD) rental assistance programs ...
journal_title:JAMA pediatrics
pub_type: 杂志文章
doi:10.1001/jamapediatrics.2019.6242
更新日期:2020-06-01 00:00:00
abstract:IMPORTANCE:Outcomes associated with use of high-frequency oscillatory ventilation (HFOV) in children with acute respiratory failure have not been established. OBJECTIVE:To compare the outcomes of HFOV with those of conventional mechanical ventilation (CMV) in children with acute respiratory failure. DESIGN, SETTING, ...
journal_title:JAMA pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1001/jamapediatrics.2013.4463
更新日期:2014-03-01 00:00:00
abstract:Importance:Acute kidney injury (AKI) occurs commonly in preterm neonates and is associated with increased morbidity and mortality. Objectives:To examine the association between caffeine citrate administration and AKI in preterm neonates in the first 7 days after birth and to test the hypothesis that caffeine administr...
journal_title:JAMA pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1001/jamapediatrics.2018.0322
更新日期:2018-06-04 00:00:00
abstract:Importance:Enamel defects of developmental origin affect up to 38% of schoolchildren and is recognized as a global public health challenge. The impaired enamel formation results in pain owing to hypersensitivity, posteruptive breakdowns, rapid caries progression, and extractions in some cases. The etiology is unknown; ...
journal_title:JAMA pediatrics
pub_type: 杂志文章
doi:10.1001/jamapediatrics.2019.2545
更新日期:2019-08-05 00:00:00
abstract:Importance:Maternally derived antibodies are a key element of neonatal immunity. Understanding the dynamics of maternal antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy and subsequent transplacental antibody transfer can inform neonatal management as well as ...
journal_title:JAMA pediatrics
pub_type: 杂志文章
doi:10.1001/jamapediatrics.2021.0038
更新日期:2021-01-29 00:00:00
abstract:Importance:Retention in addiction treatment is associated with reduced mortality for individuals with opioid use disorder (OUD). Although clinical trials support use of OUD medications among youths (adolescents and young adults), data on timely receipt of buprenorphine hydrochloride, naltrexone hydrochloride, and metha...
journal_title:JAMA pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1001/jamapediatrics.2018.2143
更新日期:2018-11-01 00:00:00
abstract:IMPORTANCE:Little is known about the long-term effect of a chef-enhanced menu on healthier food selection and consumption in school lunchrooms. In addition, it remains unclear if extended exposure to other strategies to promote healthier foods (eg, choice architecture) also improves food selection or consumption. OBJE...
journal_title:JAMA pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1001/jamapediatrics.2014.3805
更新日期:2015-05-01 00:00:00
abstract:Importance:Studies of cranial ultrasonography and early childhood outcomes among cohorts of extremely preterm neonates have linked periventricular-intraventricular hemorrhage and cystic periventricular leukomalacia with adverse neurodevelopmental outcomes. However, the association between nonhemorrhagic ventriculomegal...
journal_title:JAMA pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1001/jamapediatrics.2017.3545
更新日期:2018-01-01 00:00:00
abstract:Importance:After initial resuscitation, critically ill children may accumulate fluid and develop fluid overload. Accruing evidence suggests that fluid overload contributes to greater complexity of care and worse outcomes. Objective:To describe the methods to measure fluid balance, define fluid overload, and evaluate t...
journal_title:JAMA pediatrics
pub_type: 杂志文章,meta分析
doi:10.1001/jamapediatrics.2017.4540
更新日期:2018-03-01 00:00:00
abstract:IMPORTANCE:Community-based efforts to prevent adolescent problem behaviors are essential to promote public health and achieve collective impact community wide. OBJECTIVE To test whether the Communities That Care (CTC) prevention system reduced levels of risk and adolescent problem behaviors community wide 8 years after...
journal_title:JAMA pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1001/jamapediatrics.2013.4009
更新日期:2014-02-01 00:00:00
abstract:Importance:Firearm injuries are the second leading cause of death among US children and adolescents. Because of the lack of resources allocated to firearm injury prevention during the past 25 years, research has lagged behind other areas of injury prevention. Identifying timely and important research questions regardin...
journal_title:JAMA pediatrics
pub_type: 杂志文章
doi:10.1001/jamapediatrics.2019.1494
更新日期:2019-06-10 00:00:00
abstract:Importance:Preterm and postterm births are associated with adverse neuropsychiatric outcomes. However, it remains unclear whether variation of gestational age within the 37- to 42-week range of term deliveries is associated with neurodevelopment. Objective:To investigate the association of gestational age at birth (GA...
journal_title:JAMA pediatrics
pub_type: 杂志文章
doi:10.1001/jamapediatrics.2020.2991
更新日期:2020-09-21 00:00:00
abstract::Although screening for elevated blood pressure (BP) in adults is beneficial, evidence of its beneficial effects in children is not clear. Elevated BP in children is associated with atherosclerosis early in life and tracks across the life course. However, because of the high variability in BP, tracking is weak, and hav...
journal_title:JAMA pediatrics
pub_type: 杂志文章,评审
doi:10.1001/jamapediatrics.2013.438
更新日期:2013-03-01 00:00:00
abstract::IMPORTANCE Excessive infant crying is common, distressing, but without proven effective prevention or management options. Probiotics may be a promising solution. OBJECTIVE To examine whether probiotics are effective in the prevention/management of crying ("colic") in infants 3 months or younger. DATA SOURCES A systema...
journal_title:JAMA pediatrics
pub_type: 杂志文章,meta分析,评审
doi:10.1001/jamapediatrics.2013.2572
更新日期:2013-12-01 00:00:00
abstract:IMPORTANCE:It is unclear whether the benefits of tobacco control policies extend to pregnant women and infants, especially among racial/ethnic minority and low socioeconomic populations that are at highest risk for adverse birth outcomes. OBJECTIVE:To examine the associations of state cigarette taxes and the enactment...
journal_title:JAMA pediatrics
pub_type: 杂志文章
doi:10.1001/jamapediatrics.2014.2365
更新日期:2014-11-01 00:00:00
abstract:Importance:Adverse childhood experiences (ACEs) are associated with long-term poor mental health. Less is known about factors that improve long-term mental health among those with ACEs. Objective:To evaluate, among those exposed to ACEs, whether team sports participation during adolescence is associated with better me...
journal_title:JAMA pediatrics
pub_type: 杂志文章
doi:10.1001/jamapediatrics.2019.1212
更新日期:2019-07-01 00:00:00
abstract:IMPORTANCE:One in 88 children in the United States is diagnosed as having autism spectrum disorder. Significant interest centers on understanding the environmental factors that may contribute to autism risk. OBJECTIVE:To examine whether induced (stimulating uterine contractions prior to the onset of spontaneous labor)...
journal_title:JAMA pediatrics
pub_type: 杂志文章
doi:10.1001/jamapediatrics.2013.2904
更新日期:2013-10-01 00:00:00
abstract:Importance:Sudden infant death syndrome remains the leading cause of death in infants aged 1 month to 1 year in the United States. Observations:While its exact cause is unknown, sudden infant death syndrome is believed to be multifactorial, ie, occurs in infants with underlying biological vulnerability who experience ...
journal_title:JAMA pediatrics
pub_type: 杂志文章,评审
doi:10.1001/jamapediatrics.2016.3345
更新日期:2017-02-01 00:00:00
abstract:IMPORTANCE:Peer victimization is related to an increased chance of suicidal ideation and suicide attempts among children and adolescents. OBJECTIVE To examine the relationship between peer victimization and suicidal ideation or suicide attempts using meta-analysis. DATA SOURCES Ovid MEDLINE, PsycINFO, and Web of Scienc...
journal_title:JAMA pediatrics
pub_type: 杂志文章,meta分析
doi:10.1001/jamapediatrics.2013.4143
更新日期:2014-05-01 00:00:00
abstract:IMPORTANCE:In recent years, across the United States, many school districts have cut on-site delivery of health services by eliminating or reducing services provided by qualified school nurses. Providing cost-benefit information will help policy makers and decision makers better understand the value of school nursing s...
journal_title:JAMA pediatrics
pub_type: 杂志文章
doi:10.1001/jamapediatrics.2013.5441
更新日期:2014-07-01 00:00:00
abstract:IMPORTANCE:Smaller cerebral volumes at hospital discharge in very preterm (VPT) infants are associated with poor neurobehavioral outcomes. Brain growth from the newborn period to middle childhood has not been explored because longitudinal data have been lacking. OBJECTIVES:To examine the pattern of growth of cerebral ...
journal_title:JAMA pediatrics
pub_type: 杂志文章
doi:10.1001/jamapediatrics.2016.0781
更新日期:2016-08-01 00:00:00
abstract:IMPORTANCE:Early adversity is an important risk factor that relates to internalizing symptoms and altered brain structure. OBJECTIVE:To assess the direct effects of early adversity and child internalizing symptoms (ie, depression, anxiety) on cortical gray matter (GM) volume, as well as the extent to which early adver...
journal_title:JAMA pediatrics
pub_type: 杂志文章
doi:10.1001/jamapediatrics.2015.1486
更新日期:2015-10-01 00:00:00
abstract:Importance:Breast milk substitutes (BMS) are important nutritional products evaluated in clinical trials. Concerns have been raised about the risk of bias in BMS trials, the reliability of claims that arise from such trials, and the potential for BMS trials to undermine breastfeeding in trial participants. Existing cli...
journal_title:JAMA pediatrics
pub_type: 杂志文章
doi:10.1001/jamapediatrics.2020.0578
更新日期:2020-09-01 00:00:00