Report and literature review on two cases with different kinds of Creutzfeldt-Jakob disease.

abstract：:Gastric ulcer is one of the most common chronic gastrointestinal diseases characterized by a significant defect in the mucosal barrier. Helicobacter pylori (H. pylori) infection and the frequent long-term use of non-steroidal anti-inflammatory drugs are major factors involved in gastric ulcer development. Acid inhibit...

journal_title：Experimental and therapeutic medicine

authors： Khoder G,Al-Menhali AA,Al-Yassir F,Karam SM

更新日期：2016-07-01 00:00:00

abstract：:Efficient apoptosis requires Bcl-2 family-mediated mitochondrial outer membrane permeabilization (MOMP), which releases pro-apoptotic proteins to the cytosol, activating apoptosis and inhibiting X-linked inhibitor of apoptosis protein (XIAP). XIAP is a member of the inhibitors of apoptosis protein family whose express...

journal_title：Experimental and therapeutic medicine

authors： Chen C,Liu TS,Zhao SC,Yang WZ,Chen ZP,Yan Y

更新日期：2018-05-01 00:00:00

abstract：:The main function of adipocyte fatty acid-binding protein (A-FABP) is to regulate fatty acid metabolism as its molecular chaperone. The clinical significance of A-FABP in hypoxic-ischemic brain damage (HIBD) neonates is not yet clear. Free fatty acid (FFA) in cerebral cortex increases along with hypoxia ischemia degre...

journal_title：Experimental and therapeutic medicine

authors： Li M,Jiang L,Zhang H,Wang D,Zhang M,Zhang L

更新日期：2016-08-01 00:00:00

abstract：:Lung adenocarcinoma (LACA) is the leading cause of cancer-associated death worldwide. The present study intended to identify DNA methylation patterns that may serve as diagnostic and prognostic biomarkers for LACA. Data on DNA methylation and the survival data of the patients of LACA were obtained from The Cancer Geno...

journal_title：Experimental and therapeutic medicine

authors： Zheng R,Xu H,Mao W,Du Z,Wang M,Hu M,Gu X

更新日期：2020-01-01 00:00:00

abstract：:Ischemia-reperfusion (I/R) often leads to acute kidney injury, chronic renal failure and kidney transplantation failure. Glycyrrhizin is extracted from Glycyrrhiza glabra roots and is the predominant active component, which exhibits anti-inflammatory effects. However, to the best of our knowledge, the effect of glycyr...

journal_title：Experimental and therapeutic medicine

authors： Ye S,Zhu Y,Ming Y,She X,Liu H,Ye Q

更新日期：2014-05-01 00:00:00

abstract：:Expression and characteristics of matrix metalloproteinase-9 (MMP-9) and TIMP metallopeptidase inhibitor-1 (TIMP-1) in the placenta of pregnancy induced hypertension (PIH) were detected in Uygur to analyze its correlation with PIH, and to provide a theoretical basis for clinical work. Ninety cases of placental tissue ...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Li P,Guo Y,Liu X,Zhang Y

更新日期：2019-07-01 00:00:00

abstract：:Asthma is a major inflammatory airway disease with high incidence and mortality rates. The Global Initiative for Asthma released a report called 'The Global Burden of Asthma' in 2004. However, the specific pathogenesis of asthma remains unclear. An increasing number of studies have demonstrated that neuromedin U (NMU)...

journal_title：Experimental and therapeutic medicine

authors： Ren X,Dong F,Zhuang Y,Wang Y,Ma W

更新日期：2020-02-01 00:00:00

abstract：:The present study aimed to explore the treatment effects of Taohongsiwu decoction on the liver fibrosis in a rat model, as few prior studies have investigated the anti-fibrotic effects of Taohongsiwu decoction. High-performance liquid chromatography was used to measure the concentration of ferulic acid and hydrosafflo...

journal_title：Experimental and therapeutic medicine

authors： Wang T,Wu D,Li P,Zhang K,Tao S,Li Z,Li J

更新日期：2017-08-01 00:00:00

abstract：:Hyponatremia is a risk factor associated with poor prognosis in patients with heart failure (HF) with reduced ejection fraction. However, whether hyponatremia has a similar role in patients with HF with preserved ejection fraction (HFpEF) has remained controversial. Therefore, the present study aimed to investigate th...

journal_title：Experimental and therapeutic medicine

authors： Su Y,Ma M,Zhang H,Pan X,Zhang X,Zhang F,Lv Y,Yan C

更新日期：2020-11-01 00:00:00

abstract：:It is well established that altered expression of microRNAs (miRs) is critical in numerous human cancer types. Nevertheless, the molecular mechanisms of many miRs are yet to be elucidated. In the present study, reverse transcription-quantitative polymerase chain reaction and western blot analyses, and cell migration a...

journal_title：Experimental and therapeutic medicine

authors： Bai X,Yang M,Xu Y

更新日期：2018-12-01 00:00:00

abstract：:Alcohol use disorder (AUD) is a primary, chronic and relapsing disease of brain reward, motivation and memory, which is associated with several comorbidities, including major depression and post-traumatic stress disorder. It has been revealed that Ibudilast (IBUD), a dual inhibitor of phosphodiesterase-4 and -10 and o...

journal_title：Experimental and therapeutic medicine

authors： Petralia MC,Mazzon E,Mangano K,Fagone P,Di Marco R,Falzone L,Basile MS,Nicoletti F,Cavalli E

更新日期：2020-03-01 00:00:00

abstract：:The aim of the present study was to evaluate the concentrations of fetuin-A, osteoprotegerin (OPG) and α-Klotho protein in patients with alcoholic cirrhosis at different stages of the disease, and to demonstrate that fetuin-A, osteoprotegin and α-Klotho may be used as markers of the severity of cirrhosis. A total of 5...

journal_title：Experimental and therapeutic medicine

authors： Prystupa A,Dąbrowska A,Sak JJ,Tarach J,Toruń-Jurkowska A,Lachowska-Kotowska P,Dzida G

更新日期：2016-11-01 00:00:00

abstract：:Professor Alan Michael Weindling, Emeritus Professor of Perinatal Medicine at the University of Liverpool in the UK, is one of the pioneers of modern neonatal care worldwide with an enormous contribution to the care of premature babies in the city of Liverpool. During the last 3 decades, his contributions focused on t...

journal_title：Experimental and therapeutic medicine

authors： Mammas IN,Spandidos DA

更新日期：2018-09-01 00:00:00

abstract：:The aim of the present study was to assess miR-625 and Fas expression in normal and degenerative cervical cartilage endplate (CEP) tissues. Following biof-informatics analysis, the Fas gene was predicted to be one of the targets of miR-625. Quantitative PCR (qPCR) and western blotting were used to detect miR-625 and F...

journal_title：Experimental and therapeutic medicine

authors： Zhan B,Zhan Y,Wang W,Zhan Y,Liu B

更新日期：2018-01-01 00:00:00

abstract：:The present study aimed to explore the effects of dexmedetomidine combined with etomidate on the expression levels of interleukin (IL)-17A and S-100β in rats with postoperative cognitive dysfunction (POCD). A total of 50 SD rats were randomly allocated into the control group, model group, etomidate group (Eto group), ...

journal_title：Experimental and therapeutic medicine

authors： Yu X,Xie Y

更新日期：2020-12-01 00:00:00

abstract：:The Chinese population are at an increased risk of autoimmune hepatitis (AIH). The aims of this study were to determine the demographic and clinical features of AIH in China. A total of 83 patients with AIH diagnosed by the revised scoring system were re-analyzed, and the clinical presentations among the different age...

journal_title：Experimental and therapeutic medicine

authors： Peng M,Li Y,Zhang M,Jiang Y,Xu Y,Tian Y,Peng F,Gong G

更新日期：2014-01-01 00:00:00

abstract：:The aim of the present study was to investigate the functional status of dendritic cells (DCs) in nasal polyps (NP) and their interactions with T lymphocytes. The interactions between DC and T lymphocytes in the pathogenesis of NP was also studied. The expression of cluster of differentiation (CD)1a and CD83 in NP was...

journal_title：Experimental and therapeutic medicine

authors： Lin X,Zhuang X,Li C,Wang X

更新日期：2018-06-01 00:00:00

abstract：:The aim of the present study was to evaluate the diagnostic value of ultrasound (US) elastography in differentiating between benign and malignant peripheral lung lesions (PLLs). This retrospective study included 91 consecutive patients with 91 PLLs. Conventional US, strain elastography (SE), acoustic radiation force i...

journal_title：Experimental and therapeutic medicine

authors： Wei H,Lu Y,Ji Q,Zhou H,Zhou X

更新日期：2018-08-01 00:00:00

abstract：:Recurrent patellar dislocations were treated via knee arthroscopy combined with C-arm fluoroscopy, and reconstruction of the medial patellofemoral ligaments. Between October 2013 and March 2017, 52 cases of recurrent patellar dislocation [27 males and 25 females; age, 16-47 years (mean, 21.90 years)] were treated. Art...

journal_title：Experimental and therapeutic medicine

authors： Li L,Wang H,He Y,Si Y,Zhou H,Wang X

更新日期：2018-06-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is a component of metabolic syndrome that significantly increases the cardiovascular risk of patients with glucose metabolism alterations. This study identified the prevalence of NAFLD, predictors of NAFLD and explored the link between insulin sensitivity, insulin resistance a...

journal_title：Experimental and therapeutic medicine

authors： Vesa CM,Behl T,Nemeth S,Bratu OG,Diaconu CC,Moleriu RD,Negrut N,Zaha DC,Bustea C,Radu FI,Bungau S

更新日期：2020-12-01 00:00:00

abstract：:Electrospinning using biocompatible polymer scaffolds, seeded with or without stem cells, is considered a promising technique for producing fibrous scaffolds with therapeutic possibilities for ischemic heart disease. However, no optimal scaffolds for treating ischemic heart disease have been identified thus far. In th...

journal_title：Experimental and therapeutic medicine

authors： Du M,Gu J,Wang J,Xue Y,Ma Y,Mo X,Xue S

更新日期：2019-05-01 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD) is common in elderly patients. Senegenin, an active component of extracts from Polygala tenuifolia root, a traditional Chinese medicine, has neuroprotective and neuroregenerative effects. However, the mechanism underlying the effects of senegenin against postoperative cogniti...

journal_title：Experimental and therapeutic medicine

authors： Yu L,Sun L,Chen S

更新日期：2014-04-01 00:00:00

abstract：:This study aimed to analyze the correlation between single nucleotide polymorphisms (SNPs) of the actin, aortic smooth muscle (ACTA2) gene and coronary artery stenosis in patients with type 2 diabetes mellitus (T2DM). Eight SNPs from the promoter region of the ACTA2 gene were screened. Patients with T2DM (n=251) were ...

journal_title：Experimental and therapeutic medicine

authors： Fang H,Luo X,Wang Y,Liu N,Fu C,Wang H,Fang Y,Shi W,Zhang Y,Zeng C,Wang X

更新日期：2014-04-01 00:00:00

abstract：:This study was designed to investigate the clinical efficacy of intravenous anesthesia on breast segmental surgery and the effects on hemodynamics of patients. A total of 267 patients were collected as research subjects. These patients underwent breast segmental surgery in Chun'an First People's Hospital from March 20...

journal_title：Experimental and therapeutic medicine

authors： Yu X,Zhou Y,Zheng X,Shao S,He H

更新日期：2021-01-01 00:00:00

abstract：:Sodium 4-phenylbutyrate (PBA) exerts therapeutic effects in a wide range of pathologies. A previous study by the present authors revealed that intraperitoneal administration of PBA suppresses the onset of dextran sulfate sodium (DSS)-induced colitis in mice. In the present study, the effects of orally administered PBA...

journal_title：Experimental and therapeutic medicine

authors： Ono K,Nimura S,Hideshima Y,Nabeshima K,Nakashima M

更新日期：2017-12-01 00:00:00

abstract：:Glucocorticoids are a class of steroid hormones commonly used for the treatment of hematological malignancies due to their ability to induce apoptosis in lymphoid cells. An understanding of the critical steps in glucocorticoid-induced apoptosis is required to identify sources of drug resistance. Previously, we found t...

journal_title：Experimental and therapeutic medicine

authors： Tome ME,Lee K,Jaramillo MC,Briehl MM

更新日期：2012-02-01 00:00:00

abstract：:Temozolomide (TMZ) resistance is a complication of treatment of glioma, and new strategies are urgently required to overcome chemoresistance in glioma cells. In the present study, it was demonstrated that tripartite motif-containing 31 (TRIM31) was abnormally upregulated in glioma tissues and cell lines compared with ...

journal_title：Experimental and therapeutic medicine

authors： Fan MD,Zhao XY,Qi JN,Jiang Y,Liu BY,Dun ZP,Zhang R,Wang CW,Pang Q

更新日期：2020-08-01 00:00:00

abstract：:Intravitreal bevacizumab injection (IVB) is emerging as a safe and effective therapy for retinopathy of prematurity (ROP); however, follow-up investigations after IVB have indicated that endophthalmitis, a rare and devastating complication, may develop. The present study reports a case of an infant with ROP who develo...

journal_title：Experimental and therapeutic medicine

authors： Wang J,Xiang D

更新日期：2017-06-01 00:00:00

abstract：:Cervical cancer is one of the most common gynecological cancers worldwide. Aberrant expression of E3 ubiquitin ligase isolated by differential display (EDD) has been detected in various types of tumor and has been demonstrated to have an important role in carcinogenesis, tumor growth and drug resistance. However, the ...

journal_title：Experimental and therapeutic medicine

authors： Li J,Wang X,Zhang Y,Zhang Y

更新日期：2016-08-01 00:00:00

abstract：:The aim of the present study was to investigate the mucus secretion status of mature goblet cells following the application of mitomycin-C (MMC) in ileal neobladder rat models. Bladder substitution models were established in Sprague Dawley rats, which had been divided into five groups, namely the control (sham), norma...

journal_title：Experimental and therapeutic medicine

authors： Fan W,Yu Y,Shu J,Ming H,Li W,Fan Z

更新日期：2015-08-01 00:00:00