Effects of Taohongsiwu decoction on the expression of α-SMA and TGF-β1 mRNA in the liver tissues of a rat model of hepatic cirrhosis.

abstract：:The present study aimed to analyze the expression and effects of NUAK2 in gastric cancer and adjacent normal gastric tissues. The protein expression levels of NUAK2 were detected by western blot analysis. The effects of NUAK2 expression on the proliferation of gastric cancer cells was detected using an MTT and BrdU in...

journal_title：Experimental and therapeutic medicine

authors： Tang L,Tong SJ,Zhan Z,Wang Q,Tian Y,Chen F

更新日期：2017-02-01 00:00:00

abstract：:Intrahepatic cholangiocarcinoma (ICC) is a cancer type with high malignancy and a current lack of biomarkers to predict recurrence. In the present study, to identify potential biomarkers, five ICC datasets from the Gene Expression Omnibus database were analyzed to construct initial datasets by using a robust rank aggr...

journal_title：Experimental and therapeutic medicine

authors： Chen FY,Zhou C,Zhang XY,Zhou KQ,Peng YF,Yu L,Fan J,Zhou J,Hu J,Wang Z

更新日期：2020-11-01 00:00:00

abstract：:The epileptic state, or status epilepticus (SE), is the most serious situation manifested by individuals with epilepsy, and SE events can lead to neuronal damage. An understanding of the molecular, biochemical and physiopathological mechanisms involved in this type of neurological disease will enable the identificatio...

journal_title：Experimental and therapeutic medicine

authors： Carmona-Aparicio L,Zavala-Tecuapetla C,González-Trujano ME,Sampieri AI,Montesinos-Correa H,Granados-Rojas L,Floriano-Sánchez E,Coballase-Urrutía E,Cárdenas-Rodríguez N

更新日期：2016-10-01 00:00:00

abstract：:The present study aimed to evaluate the prognostic value of venous-arterial CO2 to arterial-venous O2 (Cv-aCO2/Da-vO2) for patients with septic shock treated by fluid resuscitation. A total of 108 cases who received fluid resuscitation for septic shock at the Intensive Care Unit were retrospectively screened according...

journal_title：Experimental and therapeutic medicine

authors： Zang H,Shen X,Wang S,He Z,Cheng H

更新日期：2019-11-01 00:00:00

abstract：:Temozolomide (TMZ) resistance is a complication of treatment of glioma, and new strategies are urgently required to overcome chemoresistance in glioma cells. In the present study, it was demonstrated that tripartite motif-containing 31 (TRIM31) was abnormally upregulated in glioma tissues and cell lines compared with ...

journal_title：Experimental and therapeutic medicine

authors： Fan MD,Zhao XY,Qi JN,Jiang Y,Liu BY,Dun ZP,Zhang R,Wang CW,Pang Q

更新日期：2020-08-01 00:00:00

abstract：:Diagnostic value between IL-17 combined with IL-18 and CT angiography in carotid atherosclerosis was evaluated. A total of 158 patients with suspected carotid artery stenosis in People's Hospital of Dongying from March 2014 to April 2017 were selected as the subjects. One hundred and two patients with carotid atherosc...

journal_title：Experimental and therapeutic medicine

authors： Suo F,Jiang F,Fang X,Ma A,Ma L

更新日期：2019-02-01 00:00:00

abstract：:This study aimed to investigate the effects of hypoxia on the proliferation, mineralization and ultrastructure of human periodontal ligament fibroblasts (HPLFs) at various times in vitro in order to further study plateau-hypoxia-induced periodontal disease. HPLFs (fifth passage) cultured by the tissue culture method w...

journal_title：Experimental and therapeutic medicine

authors： Zhang HY,Liu R,Xing YJ,Xu P,Li Y,Li CJ

更新日期：2013-12-01 00:00:00

abstract：:The present study determined the expression of microRNA (miR)-663 in hypertrophic scar (HS) tissues and investigate the regulatory mechanisms of miR-663 in HS. A total of 51 patients diagnosed with HS between December 2013 and February 2016 were included in the present study. HS tissues (experimental group) and HS-adj...

journal_title：Experimental and therapeutic medicine

authors： Chen Q,Zhao T,Xie X,Yu D,Wu L,Yu W,Sun W

更新日期：2018-08-01 00:00:00

abstract：:This study aimed to assess the effect on solid tumors of mild temperature hyperthermia (MTH) combined with hexamethylenetetramine (HMTA) or tirapazamine (TPZ). Squamous cell carcinoma (SCC VII) tumor-bearing mice were continuously administered 5-bromo-2'-deoxyuridine (BrdU) to label intratumor proliferating (P) cells....

journal_title：Experimental and therapeutic medicine

authors： Masunaga SI,Tano K,Nakamura J,Watanabe M,Kashino G,Suzuki M,Kinashi Y,Ono K

更新日期：2010-01-01 00:00:00

abstract：:Choroidal neovascularization secondary to retinitis pigmentosa is rarely observed in clinical practice. The present study describes a case of atypical retinitis pigmentosa, crystalline retinal pigmentary degeneration, complicated by choroidal neovascularization (CNV) in a 26-year-old man presenting with blurred vision...

journal_title：Experimental and therapeutic medicine

authors： Hua R,Chen K,Hu Y,Wang X,Chen L

更新日期：2015-11-01 00:00:00

abstract：:Previous studies by our group demonstrated that radix Sophorae tonkinensis could induce hepatotoxicity. However, it remains unclear which components of this herb may be responsible for its hepatotoxicity. The present study aimed to investigate the hepatic toxicity of treatment with matrine (MT) and oxymatrine (OMT) al...

journal_title：Experimental and therapeutic medicine

authors： Gu Y,Lu J,Sun W,Jin R,Ohira T,Zhang Z,Tian X

更新日期：2019-04-01 00:00:00

abstract：:Secreted frizzled-related protein 1 (SFRP1), which is an extracellular inhibitor involved in Wnt signalling, is downregulated by promoter hypermethylation in the early stages of colorectal tumorigenesis. Polycomb (PCG) and methyl-CpG-binding domain (MBD) proteins that serve a role in epigenetic gene regulation. The ai...

journal_title：Experimental and therapeutic medicine

authors： Yu J,Xie Y,Liu Y,Wang F,Li M,Qi J

更新日期：2020-12-01 00:00:00

abstract：:The aim of the present study was to investigate the role of homocysteine (Hcy) in the pathogenesis of pulmonary embolism (PE) and the associated molecular mechanisms in human umbilical vein endothelial cells (HUVECs). Hcy contents were detected with high-performance liquid chromatography. Apoptosis was detected by flo...

journal_title：Experimental and therapeutic medicine

authors： Yang F,Qi X,Gao Z,Yang X,Zheng X,Duan C,Zheng J

更新日期：2016-10-01 00:00:00

abstract：:In patients undergoing off-pump coronary artery bypass surgery (OPCAB), it is important to attenuate myocardium injury during the surgery. The present study aimed to observe the cardioprotection induced by sevoflurane induction and maintenance compared with propofol intravenous anesthesia, and to detect its potential ...

journal_title：Experimental and therapeutic medicine

authors： Liu X,Liu X,Wang R,Luo H,Qin G,Wang LU,Ye Z,Guo Q,Wang E

更新日期：2016-06-01 00:00:00

abstract：:The pathogenesis underlying alcoholic liver disease (ALD), which is often a result of alcohol abuse, currently remains unclear. Previous studies have reported that enteric dysbiosis serves an important role in the pathogenesis of ALD. The present study aimed to investigate the effects of glutamine and probiotics on a ...

journal_title：Experimental and therapeutic medicine

authors： Huang H,Lin Z,Zeng Y,Lin X,Zhang Y

更新日期：2019-12-01 00:00:00

abstract：:Electroacupuncture (EA) may stimulate neurogenesis in animal models of ischemic stroke; however, the associated mechanisms are not clear. The present study aimed to evaluate the neurogenesis efficacy of EA on ischemic stroke and the underlying associated mechanisms. A model of middle cerebral artery occlusion (MCAO) w...

journal_title：Experimental and therapeutic medicine

authors： Tan F,Wang J,Liu JX,Wang C,Li M,Gu Y

更新日期：2018-12-01 00:00:00

abstract：:The status of the three retinoic acid receptors (RARs) α, β and γ in human colorectal cancer (CRC) has not as yet been examined. RARs are in part responsible for the actions of the retinoids (vitamin A and its derivatives), which are essential for human health and survival due to their extensive involvement in numerou...

journal_title：Experimental and therapeutic medicine

authors： Perraud A,Nouaille M,Akil H,Petit D,Labrousse F,Jauberteau MO,Mathonnet M

更新日期：2011-05-01 00:00:00

abstract：:Cnidium officinale Makino and Capsella bursa-pastoris are used as traditional herbs with diverse medicinal effects, including the inhibition of inflammation, reduction of blood pressure and as diuretics, however, the anti-cancer effects of C. officinale Makino and C. bursa-pastoris are poorly defined. The aims of this...

journal_title：Experimental and therapeutic medicine

authors： Lee KE,Shin JA,Hong IS,Cho NP,Cho SD

更新日期：2013-03-01 00:00:00

abstract：:Although thrombocytosis has been reported in a variety of cancer types, the standard of thrombocytosis in gastric cancer (GC) and the association between thrombocytosis and the clinicopathological features of patients with GC remain unclear. In the present study, 1,763 GC patients were retrospectively filtered by preo...

journal_title：Experimental and therapeutic medicine

authors： Hu C,Chen R,Chen W,Pang W,Xue X,Zhu G,Shen X

更新日期：2014-07-01 00:00:00

abstract：:Thymic carcinoma is a rare thymic epithelial tumor in which chemotherapy for advanced disease has not yet been established. Thymidylate synthase (TS) and orotate phosphoribosyltransferase (OPRT) protein expression levels in thymic carcinoma were evaluated as possible indicators of the anticancer activity of 5-fluorour...

journal_title：Experimental and therapeutic medicine

authors： Yokota K,Sasaki H,Okuda K,Shitara M,Hikosaka Y,Moriyama S,Yano M,Fujii Y

更新日期：2012-10-01 00:00:00

abstract：:The activation of monocytes and macrophages is associated with steroid-resistant (SR) asthma. Interleukin-35 (IL-35) is an important anti-inflammatory cytokine, but its regulatory effects on monocytes in patients with SR asthma is not fully understood. Based on clinical response to oral prednisolone, 34 patients with ...

journal_title：Experimental and therapeutic medicine

authors： Qian L,Xu D,Xue F,Li M,Wang X,Liu G

更新日期：2020-05-01 00:00:00

abstract：:MicroRNA (miR) are short non-coding RNA that bind to the 3'-untranslational region of their target genes, inhibiting translation and causing mRNA degradation. miR deregulation has been implicated in human cancer; however, the detailed regulatory mechanism of miR-137 in osteosarcoma (OS) remains largely unknown. In the...

journal_title：Experimental and therapeutic medicine

authors： Feng Q,Wu Q,Liu X,Xiong Y,Li H

更新日期：2017-06-01 00:00:00

abstract：:Here, we present a case of post-operative liver metastases from pancreatic head cancer in a patient with leukocytopenia, who was safely treated by hepatic arterial infusion (HAI) chemotherapy consisting of gemcitabine and 5-FU. The patient was a 61-year-old woman who underwent pancreaticoduodenectomy for pancreatic he...

journal_title：Experimental and therapeutic medicine

authors： Tajima H,Ohta T,Kitagawa H,Sakai S,Makino I,Hayashi H,Nakagawara H,Onishi I,Takamura H,Ninomiya I,Fushida S,Tani T,Fujimura T,Kayahara M,Koda W,Minami T,Ryu Y,Sanada J,Matsui O

更新日期：2010-11-01 00:00:00

abstract：:Alcohol use disorder (AUD) is a primary, chronic and relapsing disease of brain reward, motivation and memory, which is associated with several comorbidities, including major depression and post-traumatic stress disorder. It has been revealed that Ibudilast (IBUD), a dual inhibitor of phosphodiesterase-4 and -10 and o...

journal_title：Experimental and therapeutic medicine

authors： Petralia MC,Mazzon E,Mangano K,Fagone P,Di Marco R,Falzone L,Basile MS,Nicoletti F,Cavalli E

更新日期：2020-03-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/etm.2016.3317.]. ...

journal_title：Experimental and therapeutic medicine

authors：

更新日期：2016-09-01 00:00:00

abstract：:Cell-based adoptive immunotherapy for the treatment of various cancer types has attracted the attention of scientists. However, due to the absence of unitary standard protocols to produce large quantities of clinical-grade effector cells, it remains challenging to translate the experimental findings into clinical appl...

journal_title：Experimental and therapeutic medicine

authors： Yu H,Chen W,Li C,Lin D,Liu J,Yang Z,Yang J,Sun Y,Ma D

更新日期：2017-12-01 00:00:00

abstract：:Opioids and α2-agonists have been used as epidural adjuvants in local anesthetics for a long time, but the effect of the combination of opioids and α2-agonists as epidural adjuvants is not completely understood. In the present study, the combination of dexmedetomidine (Dex) and sufentanil as adjuvants to ropivacaine f...

journal_title：Experimental and therapeutic medicine

authors： Li G,Xiao Y,Qi X,Wang H,Wang X,Sun J,Li Y,Li Y

更新日期：2020-07-01 00:00:00

abstract：:In Traditional Chinese Medicine, Polygonum multiflorum (PM) is known for its anti-aging properties. A previous study by our group showed that extracts of PM were able to prevent and treat bone loss in vivo, and the active components emodin and 2,3,5,4,-tetrahydroxystilbene-2-O-β-glucoside (TSG) promoted the osteogenic...

journal_title：Experimental and therapeutic medicine

authors： Zhou M,Li J,Wu J,Yang Y,Zeng X,Lv X,Cui L,Yao W,Liu Y

更新日期：2017-09-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effects of sodium ferulate (SF) on HT22 hippocampal cells under a high glucose concentration. Cells were cultured in normal glucose (25 mM D-glucose) or high glucose (50 mM D-glucose) with various concentrations of SF (50, 100, 250 or 500 µM) for 0, 48 and...

journal_title：Experimental and therapeutic medicine

authors： Zhao J,Liu L,Zhang L,Lv J,Guo X,Li X,Zhao T

更新日期：2019-09-01 00:00:00

abstract：:The present study aimed to investigate the effect of goniothalamin on apoptosis induction in the A375 melanoma cell line. Melanoma is a type of skin cancer with increased prevalence and no potential standard treatment. Goniothalamin is a plant, bioactive styrly-lactone, which has various bioactivities including anti-m...

journal_title：Experimental and therapeutic medicine

authors： Tangchirakhaphan S,Innajak S,Nilwarangkoon S,Tanjapatkul N,Mahabusrakum W,Watanapokasin R

更新日期：2018-03-01 00:00:00