Abstract：
BACKGROUND:The role of neutrophil-to-lymphocyte ratio (NLR) and preoperative prediction model in gastric cancer is controversial, while postoperative prognostic models are available. This study investigated NLR as a preoperative prognostic indicator in gastric cancer. METHODS:We reviewed patients with primary gastric cancer who underwent surgery during 2007-2010. Preoperative clinicopathologic factors were analyzed with their interaction and used to develop a prognosis prediction nomogram. That preoperative prediction nomogram was compared to a nomogram using pTNM or a historical postoperative prediction nomogram. The contribution of NLR to a preoperative nomogram was evaluated with integrated discrimination improvement (IDI). RESULTS:Using 2539 records, multivariable analysis revealed that NLR was one of the independent prognostic factors and had a significant interaction with only age among other preoperative factors (especially significant in patients < 50 years old). NLR was constantly significant between 1.1 and 3.1 without any distinctive cutoff value. Preoperative prediction nomogram using NLR showed a Harrell's C-index of 0.79 and an R2 of 25.2%, which was comparable to the C-index of 0.78 and 0.82 and R2 of 26.6 and 25.8% from nomogram using pTNM and a historical postoperative prediction nomogram, respectively. IDI of NLR to nomogram in the overall population was 0.65%, and that of patients < 50 years old was 2.72%. CONCLUSIONS:NLR is an independent prognostic factor for gastric cancer, especially in patients < 50 years old. A preoperative prediction nomogram using NLR can predict prognosis of gastric cancer as effectively as pTNM and a historical postoperative prediction nomogram.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Choi JH,Suh YS,Choi Y,Han J,Kim TH,Park SH,Kong SH,Lee HJ,Yang HKdoi
10.1007/s00268-018-4510-4subject
Has Abstractpub_date
2018-08-01 00:00:00pages
2530-2541issue
8eissn
0364-2313issn
1432-2323pii
10.1007/s00268-018-4510-4journal_volume
42pub_type
杂志文章abstract：BACKGROUND:Video-assisted thoracoscopic surgery (VATS) is a new area of exploration and evolution in thoracic minimal invasive surgery. The uniportal VATS approach has become popular during lung resection for small nodules and ground glass lesions. Our objective is to investigate the efficacy, availability and safety o...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05781-y
更新日期：2021-01-01 00:00:00
abstract：:In 1989-90, all 37 lung cancer patients scheduled for surgery underwent transesophageal endoscopic ultrasonography (EUS) for pre-operative detection of hilar and mediastinal lymph node metastases. An electronic ultrasonic fiberscope with a linear array (EPB-503-FS, Machida-Toshiba) was used. Of 380 nodes surgically re...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF02067013
更新日期：1992-09-01 00:00:00
abstract：:Radiologically demonstrable pancreatic endocrine tumors are a frequent requirement for exploration in patients with multiple endocrine neoplasia type I (MEN-I). Such delayed intervention is accompanied by a 30% to 50% incidence of pancreatic endocrine metastases. This study explores biochemical tumor markers and opera...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900451
更新日期：1998-07-01 00:00:00
abstract：:The combination of conventional traumatic injuries and radiation exposure has synergistic consequences, the full extent of which may take days to weeks to become apparent. Our understanding of such is derived from a variety of laboratory and clinical scenarios involving both therapeutic and accidental exposures. When ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF02066992
更新日期：1992-09-01 00:00:00
abstract：BACKGROUND:Utilization of breast reconstruction (BR) is low in many jurisdictions. We studied the geographical and surgical workforce factors that contribute to access and use of BR using a small area analysis approach with a geographical unit of analysis. METHODS:We linked administrative data from Ontario Canada to c...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3060-2
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Some patients complain of long-lasting voice symptoms after thyroid surgery without objective vocal fold pathology. We assessed the factors that may influence voice symptoms more than 12 months after thyroidectomy. METHODS:We performed a retrospective analysis of 68 patients from July 2010 to May 2012. The ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4438-0
更新日期：2018-07-01 00:00:00
abstract：:Persistent pain after hernia repair is common, although it is usually mild. In 3% of patients it is severe, however, and has significant effects on work and social activities. The purpose of this review was to examine factors that affect pain after hernia repair. Although the type of anaesthetic used, local or general...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-005-7903-0
更新日期：2005-08-01 00:00:00
abstract：:A mathematic model is created to determine the economic cost per year of anticipated prolongation of life that would result from a program of abdominal ultrasonographic (US) screening for abdominal aortic aneurysm. The protocol involves US screening at age 60, 67, and 74 years with additional annual follow-up US and e...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01659032
更新日期：1989-05-01 00:00:00
abstract：BACKGROUND:Many patients who undergo emergency laparotomy are working, which is a key determinant for an individual's socio-economic status and financial security. The objectives of this study were to compare labour market participation and sick leave in a nationwide patient population undergoing non-malignant emergenc...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4830-4
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:The number of lymph nodes retrieved and examined from a resected colon cancer specimen may be crucial for correct staging. We examined if efforts to increase the lymph node harvest to more than 12 lymph nodes per specimen would upstage some patients from TNM stage II to III. METHODS:Three hospitals compared...
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s00268-011-1248-7
更新日期：2011-12-01 00:00:00
abstract：:There has been a long, unresolved debate regarding the operation of choice for well differentiated carcinoma of the thyroid. We therefore analyzed the feasibility, scope, sample size, and length of follow-up required to determine the optimal operation for papillary thyroid carcinoma. A statistical approach was used to...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s002689900016
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:Sometimes, it seems to be difficult to preserve the aberrant hepatic artery (HA) during pancreaticoduodenectomy (PD), with respect to en bloc lymph node dissection, especially in the case of aberrant right hepatic artery (RHA). Therefore, we evaluated the influence of incomplete en bloc lymph node (LN) disse...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0063-x
更新日期：2009-08-01 00:00:00
abstract：:Innovation is responsible for most advances in the field of surgery. Innovative approaches to solving clinical problems have significantly decreased morbidity and mortality for many surgical procedures, and have led to improved patient outcomes. While innovation is motivated by the surgeon's expectation that the new a...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2568-1
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:Parathyroid glands can mimic thyroid follicular lesions on fine-needle aspiration (FNA) cytology and can lead to unnecessary or incorrect surgery. Newer molecular panel tests using next-generation sequencing (NGS) include analysis of cell type-specific gene expression profiles such as parathyroid. The study ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4548-3
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:The selection of the type of fundoplication or the necessity for an added fundoplication after esophagomyotomy (Heller's operation) for the treatment of achalasia remains controversial. The present retrospective study was designed to compare the long-term results of total and partial fundoplication on the my...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9385-8
更新日期：2008-03-01 00:00:00
abstract：:The angiogenic factor called vascular endothelial growth factor (VEGF)-D is a ligand for VEGF receptor-2 (VEGFR-2/KDR) and receptor-3 (VEGFR-3/Flt-4). It is implicated in the development of lymphatic vessels and promotion of lymphatic metastasis. The purpose of this study was to investigate the prognostic significance...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0076-z
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:Neurosurgical capacity is extremely deficient in East African countries where 27 neurosurgeons serve more than 250 million people. To build capacity, the Duke University Medical Center and New Mulago Hospital in Uganda applied a two-pronged twinning approach that placed usable surplus equipment in a developi...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1080-0
更新日期：2011-06-01 00:00:00
abstract：:This article attempts to put into a risk-related perspective modern red blood cell (RBC) transfusion therapy. When making the decision to transfuse, RBCs or blood products, it is important to weigh the risks and benefits of the proposed therapy. It is equally important to evaluate the risk of not transfusing and the m...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900181
更新日期：1996-11-01 00:00:00
abstract：BACKGROUND:This study reviews the 15 year program of our Department of Pediatric Surgery for the treatment and follow-up of children born with a cleft in Benin and Togo. METHODS:We analyzed files of children born in Africa with a cleft. They were referred to us through a nongovernmental organization (NGO) between 1993...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1607-z
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:There are scant studies that have analyzed the prognostic factors for malignant nonfunctioning endocrine tumors of the pancreas. We identified the predictive factors associated with long-term survival after surgical resection for malignant nonfunctioning endocrine tumors. METHODS:Among the 25 patients seen ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-006-0585-4
更新日期：2007-03-01 00:00:00
abstract：BACKGROUND:Although various complications after hepatectomy have been reported, there have been no large studies on postoperative portal vein thrombosis (PVT) as a complication. This study evaluated the incidence, risk factors, and clinical outcomes of PVT after hepatectomy. METHODS:The preoperative and postoperative ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2440-8
更新日期：2014-06-01 00:00:00
abstract：PURPOSE:The aim of the study was to evaluate risk factors for small bowel obstruction (SBO) in early postoperative period after anterior resection for rectal cancer. METHODS:Patients who underwent anterior resection (AR) [high AR (HAR) or low AR (LAR)] for rectal cancer between January 2009 and April 2016 were enrolle...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4152-y
更新日期：2018-01-01 00:00:00
abstract：:Knowledge of lymphatic involvement in patients with colorectal cancer is important in surgery and in the postoperative decision-making process. Fifty-eight patients with recurrent colorectal cancer underwent operation with the RIGS/(Radioimmunoguided Surgery) technology. Preoperatively, patients were injected with 1 m...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-001-0158-5
更新日期：2001-12-01 00:00:00
abstract：:We conducted a prospective case series study to investigate the causes of and factors influencing morbidity and mortality in 102 consecutive patients after elective infrarenal abdominal aneurysm (AAA) surgery between 1992 and 1995. Preoperative factors (demographics, risk factor indexes, electrocardiographic findings,...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900382
更新日期：1998-03-01 00:00:00
abstract：:Multiple organ failure (MOF) is considered to be the leading cause of death after severe trauma. Although there is extensive literature on MOF, little is known about the pattern, sequence, and onset of this clinical syndrome. The first goal of this clinical study was to define MOF; the second was to assess the typical...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900067
更新日期：1996-05-01 00:00:00
abstract：:Precise localization of cervical node metastasis of papillary thyroid carcinoma is rarely described. The aim of this retrospective study was to map their cervical involvement. Between 1974 and 1996 a series of 119 patients had total thyroidectomy with bilateral cervical lymph node dissection. Patients who had secondar...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900609
更新日期：1999-09-01 00:00:00
abstract：:Individuals in clinical training programs concerned with critical medical care must learn to manage clinical cases effectively as a member of a team. However, practice on live patients is often unpredictable and frequently repetitive. The widely substituted alternative for real patients-high-fidelity, manikin-based si...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9354-2
更新日期：2008-02-01 00:00:00
abstract：:Despite a slow decline in the incidence of gastric cancer over the last 90 years, we can still expect to see over 100,000 patients die of this disease each decade in England and Wales. The 5-year survival rate has not improved during this century, which is largely due to the stage at diagnosis being unchanged. There a...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF00294709
更新日期：1995-07-01 00:00:00
abstract：:Evaluation of prognostic factors of adenocarcinoma of Vater's ampulla is still a matter of debate. The aim of this study was to evaluate retrospectively factors that influence early and long-term outcomes in a 20-year single-institution experience on ampullary carcinoma. A total of 94 consecutive patients with ampulla...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7498-x
更新日期：2005-04-01 00:00:00
abstract：:Personalized genomic medicine and surgery (PGMS) represents a new approach to health care that customizes patients' medical treatment according to their own genetic information. This new approach is the result of increased knowledge of the human genome and ways this information can be applied by physicians in the medi...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-011-1056-0
更新日期：2011-08-01 00:00:00
