Abstract：
:Knowledge of lymphatic involvement in patients with colorectal cancer is important in surgery and in the postoperative decision-making process. Fifty-eight patients with recurrent colorectal cancer underwent operation with the RIGS/(Radioimmunoguided Surgery) technology. Preoperatively, patients were injected with 1 mg monoclonal antibody (MoAb) CC49 (anti-TAG-72-tumor-associated glycoprotein) labeled with 2 mCi of iodine 125. Traditional surgical exploration was followed by survey with a gamma-detecting probe. Localization of MoAb on tumor was noted in 54/58 patients (93%). Traditional exploration identified 117 suspected tumor sites. With RIGS, 177 suspected tumor sites were detected. In 17 of the 58 patients (27.5%), at least one occult tumor site identified by RIGS was confirmed by pathology with hematoxylin & eosin (H & E) staining. This finding resulted in 16 major changes in surgical plan. RIGS performance varied between lymphatic and non-lymphatic tissue, with a positive predictive value (PPV) of 95.6% and negative predictive value (NPV) of 90% in non-lymphoid tissue compared to PPV of 40% and NPV of 100% in lymphoid tissue. In patients with tumors that localize, no RIGS activity in lymph nodes signifies no tumor, while decisions based on RIGS activity in lymph nodes requires H & E confirmation. Using this guideline, additional information acquired by RIGS can help the surgeon in making an informed decision during surgery and in planning postoperative therapy.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Schneebaum S,Troitsa A,Haddad R,Avital S,Kashtan H,Baratz M,Brazovsky E,Papo J,Skornick Ydoi
10.1007/s00268-001-0158-5keywords:
subject
Has Abstractpub_date
2001-12-01 00:00:00pages
1495-8; discussion 1499issue
12eissn
0364-2313issn
1432-2323journal_volume
25pub_type
杂志文章abstract：:Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced breast cancer. It can be diagnosed based on a clinical or pathologic basis. We evaluated the usefulness of (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET) scans for diagnosing and staging IBC. We retrospectively reviewed t...
journal_title：World journal of surgery
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更新日期：2003-10-01 00:00:00
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journal_title：World journal of surgery
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pub_type： 杂志文章,多中心研究
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journal_title：World journal of surgery
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更新日期：1997-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2013-03-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：World journal of surgery
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更新日期：1992-09-01 00:00:00
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pub_type： 杂志文章,已发布勘误
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