Abstract：
:Viruses are increasingly recognized as emerging infectious disease agents in both humans and animals.[...].
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Lau SKPdoi
10.3390/ijms19020398subject
Has Abstractpub_date
2018-01-30 00:00:00issue
2issn
1422-0067pii
ijms19020398journal_volume
19pub_type
社论abstract：:A variety of Magnetic Resonance (MR) and nuclear medicine (NM) techniques have been used in symptomatic and presymptomatic SCA2 gene carriers to explore,in vivo, the physiopathological biomarkers of the neurological dysfunctions characterizing the associated progressive disease that presents with a cerebellar syndrome...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21031020
更新日期：2020-02-04 00:00:00
abstract：:Dilated cardiomyopathy (DCM) is the leading indication for heart transplantation. TTN gene truncating mutations account for about 25% of familial DCM cases and for 18% of sporadic DCM cases. The clinical relevance of specific variants in TTN has been difficult to determine because of the sheer size of the protein for ...
journal_title：International journal of molecular sciences
pub_type：
doi：10.3390/ijms22020670
更新日期：2021-01-12 00:00:00
abstract：:It has been suggested that GAP-43 (growth-associated protein) binds to various proteins in growing neurons as part of its mechanism of action. To test this hypothesis in vivo, differentiated N1E-115 neuroblastoma cells were labeled with [(35)S]-amino acids and were treated with a cleavable crosslinking reagent. The ce...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms9091753
更新日期：2008-09-01 00:00:00
abstract：:Transforming growth factor (TGF)-βs are pluripotent cytokines with stimulatory and inhibitory properties for multiple types of immune cells. Analyses of genetic knockouts of each isoform of TGF-β have revealed differing expression patterns and distinct roles for the three mammalian isoforms of TGF-β. Considerable effo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19082261
更新日期：2018-08-01 00:00:00
abstract：:Crude glycerol from the biodiesel manufacturing process is being produced in increasing quantities due to the expanding number of biodiesel plants. It has been previously shown that, in batch mode, semi-anaerobic fermentation of crude glycerol by Enterobacter aerogenes can produce biohydrogen and bioethanol simultaneo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160510650
更新日期：2015-05-11 00:00:00
abstract：:The relationships among 55 wheat accessions (47 accessions collected from Iran and eight accessions provided by the Institute of Plant Biology of the University of Zurich, Switzerland) belonging to eight species carrying A genome (Triticum monococcum L., T. boeoticum Boiss., T. urartu Tumanian ex Gandilyan, T. durum D...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms11114309
更新日期：2010-11-02 00:00:00
abstract：:Glioblastoma (GBM) is the most common malignant brain tumor and its malignant phenotypic characteristics are classified as grade IV tumors. Molecular interactions, such as protein-protein, protein-ncRNA, and protein-peptide interactions are crucial to transfer the signaling communications in cellular signaling pathway...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020517
更新日期：2021-01-06 00:00:00
abstract：:Despite advances in diagnosis and new treatments such as targeted therapies, breast cancer (BC) is still the most prevalent tumor in women worldwide and the leading cause of death. The principal obstacle for successful BC treatment is the acquired or de novo resistance of the tumors to the systemic therapy (chemothera...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18061182
更新日期：2017-06-02 00:00:00
abstract：:Melatonin has long been recognized as a positive signaling molecule and potent antioxidant in plants, which alleviates damage caused by adverse conditions such as salt, cold, and heat stress. In this study, we found a paradoxical role for melatonin in abiotic stress responses. Suppression of the serotonin N-acetyltran...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20205173
更新日期：2019-10-18 00:00:00
abstract：:Aquaporins (AQPs) are among the best structural-characterized membrane proteins, fulfilling the role of allowing water flux across cellular membranes. Thus far, 34 single amino acid polymorphisms have been reported in HUMSAVAR for human aquaporins as disease-related. They affect AQP2, AQP5 and AQP8, where they are ass...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19061577
更新日期：2018-05-25 00:00:00
abstract：:Green fluorescent protein (GFP) has been widely used in several molecular and cellular biology applications, since it is remarkably stable in vitro and in vivo. Interestingly, native GFP is resistant to the most common chemical denaturants; however, a low fluorescence signal has been observed after acid-induced denatu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12074625
更新日期：2011-01-01 00:00:00
abstract：:Genome instability is an essential hallmark in tumor development, including colorectal cancer. We have recently identified the oxysterol binding protein-related protein 3 (ORP3), also known as oxysterol binding protein-like 3 (OSBPL3), as a novel ploidy-control gene, whose knock-out leads to aneuploidy induction and p...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21165894
更新日期：2020-08-16 00:00:00
abstract：:Glutamate is not only a neurotransmitter but also an important neurotoxin in central nervous system (CNS). Chronic elevation of glutamate induces both neuronal and glial cell apoptosis. However, its effect on astrocytes is complex and still remains unclear. In this study, we investigated whether morphine, a common opi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17101523
更新日期：2016-10-24 00:00:00
abstract：:The presence of calcium deposits in human lesions is largely used as imaging biomarkers of human diseases such as breast cancer. Indeed, the presence of micro- or macrocalcifications is frequently associated with the development of both benign and malignant lesions. Nevertheless, the molecular mechanisms involved in t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22010120
更新日期：2020-12-24 00:00:00
abstract：:Metallothioneins have been viewed as modulators in a number of biological regulations regarding cancerous development; however, the function of metallothionein 3 (MT3) in bladder cancer is unexplored. We determined the regulatory mechanisms and potential function of MT3 in bladder carcinoma cells. Real-Time Reverse Tr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20040980
更新日期：2019-02-23 00:00:00
abstract：:Three pools of exhaled breath condensate (EBC) from non-smokers plus healthy smokers (NS + HS, n = 45); chronic obstructive pulmonary disease (COPD) without emphysema (COPD, n = 15) and subjects with pulmonary emphysema associated with α(1)-antitrypsin deficiency (AATD, n = 23) were used for an exploratory proteomic ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms131113894
更新日期：2012-10-29 00:00:00
abstract：:Human cytomegalovirus (HCMV) is ubiquitously prevalent. HCMV infection is typically asymptomatic and controlled by the immune system in healthy individuals, yet HCMV can be severely pathogenic for the fetus during pregnancy and in immunocompromised persons, such as transplant recipients or HIV infected patients. HCMV ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20153626
更新日期：2019-07-24 00:00:00
abstract：:Inflammasomes are components of the innate immune response that have recently emerged as crucial controllers of tissue homeostasis. In particular, the nucleotide-binding domain, leucine-rich-containing (NLR) family pyrin domain containing 3 (NLRP3) inflammasome is a complex platform involved in the activation of caspa...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22031064
更新日期：2021-01-21 00:00:00
abstract：:This Special Issue of International Journal of Molecular Sciences (IJMS) contains 7 reviews and 12 original research papers written by a panel of experts who highlight recent advances in molecular structure and cellular function of purinergic P2 receptors[...]. ...
journal_title：International journal of molecular sciences
pub_type： 社论
doi：10.3390/ijms22010383
更新日期：2020-12-31 00:00:00
abstract：:We have previously shown that ritonavir (RTV), a highly active anti-retroviral therapy (HAART) drug, can cause endothelial dysfunction through oxidative stress. Several antioxidants including ginsenoside Rb1, a compound with antioxidant effect, can effectively block this side effect of RTV in endothelial cells. In the...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20020294
更新日期：2019-01-12 00:00:00
abstract：:To decrease the cost of bioethanol production, biomass recalcitrance needs to be overcome so that the conversion of biomass to bioethanol becomes more efficient. CO(2) laser irradiation can disrupt the lignocellulosic physical structure and reduce the average size of fiber. Analyses with Fourier transform infrared spe...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13044141
更新日期：2012-01-01 00:00:00
abstract：:Fibrotic diseases, such as liver, pulmonary and renal fibrosis, are common end-stage conditions and represent a major global health problem. Furthermore, effective therapeutic measures are presently unavailable. Extracellular matrix accumulation is the most prominent characteristic in the pathogenesis of fibrotic dise...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms14010226
更新日期：2012-12-21 00:00:00
abstract：:Alzheimer's disease (AD) is a leading cause of dementia worldwide, associated with cognitive deficits and brain glucose metabolic alteration. However, the associations of glucose metabolic changes with cognitive dysfunction are less detailed. Here, we examined the brains of APP/presenilin 1 (PS1) transgenic (Tg) mice ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17101707
更新日期：2016-10-18 00:00:00
abstract：:Natural autoantibodies to the IGF1 receptor (IGF1R-aAb) have been described in relation to Graves' ophthalmopathy. Other physiological roles of natural IGF1R-aAb are not known. We hypothesized that IGF1R-aAb may be related to muscle development. Serum samples (n = 408) from young overweight subjects (n = 143) were col...
journal_title：International journal of molecular sciences
pub_type： 临床试验,杂志文章
doi：10.3390/ijms21020463
更新日期：2020-01-11 00:00:00
abstract：:In patients with aortic stenosis (AS), a novel staging classification of extra-valvular left and right heart damage with prognostic relevance was introduced in 2017. The aim of the study was to evaluate the biomarkers of cardiovascular tissue remodelling in relation to this novel staging classification. Patients were ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21114174
更新日期：2020-06-11 00:00:00
abstract：:An increase in intracellular Ca2+ concentration ([Ca2+]i) plays a key role in controlling endothelial functions; however, it is still unclear whether endothelial Ca2+ handling is altered by type 2 diabetes mellitus, which results in severe endothelial dysfunction. Herein, we analyzed for the first time the Ca2+ respon...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21010250
更新日期：2019-12-30 00:00:00
abstract：:The objective of the present study was to determine the antimicrobial resistance profile of planktonic and biofilm cells of Staphylococcus aureus and coagulase-negative staphylococci (CoNS). Two hundred Staphylococcus spp. strains were studied, including 50 S. aureus and 150 CoNS strains (50 S. epidermidis, 20 S. haem...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17091423
更新日期：2016-09-01 00:00:00
abstract：:Inherited bone marrow failure syndromes (IBMFS) are a group of cancer-prone genetic diseases characterized by hypocellular bone marrow with impairment in one or more hematopoietic lineages. The pathogenesis of IBMFS involves mutations in several genes which encode for proteins involved in DNA repair, telomere biology ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21134672
更新日期：2020-06-30 00:00:00
abstract：:The development of new therapeutic options against Clostridioides difficile (C. difficile) infection is a critical public health concern, as the causative bacterium is highly resistant to multiple classes of antibiotics. Antimicrobial host-defense peptides (HDPs) are highly effective at simultaneously modulating the i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215289
更新日期：2019-10-24 00:00:00
abstract：:Rolling-circle replication (RCR) elements constitute a diverse group that includes viruses, plasmids, and transposons, present in hosts from all domains of life. Eukaryotic RCR transposons, also known as Helitrons, are found in species from all eukaryotic kingdoms, sometimes representing a large portion of their genom...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19103079
更新日期：2018-10-09 00:00:00
