Abstract:
Objective:This study aims to describe the clinical manifestations and outcomes in a cohort of older Chinese patients. Method:A retrospective study of patients aged ≥ 45 years who had a first episode of optic neuritis (ON) between May 2008 and November 2012. Clinical features at onset and last follow-up were analyzed within subgroups (age 45-65 years and age ≥ 65 years). Results:76 patients (99 eyes) were included, of which 58% were females. The mean age at presentation was 55.53 ± 8.29 years (range: 45-83 years). Vision loss was severe at presentation, with initial best corrected vision activity (BCVA) < 20/200 in 93% and final BCVA < 20/200 in 53% of patients at 5-year follow-up. Final BCVA significantly correlated with the initial BCVA and peripapillary retinal nerve fiber layer. At last follow-up, 14.5% were diagnosed with neuromyelitis optica spectrum disorder (NMOSD), 1.3% were diagnosed with multiple sclerosis (MS), 5.2% with chronic relapsing inflammatory optic neuropathy, 1.3% with infectious ON, and 19.7% with autoimmune ON. None of the elderly group (≥65 years) developed NMOSD or MS. Conclusion:Chinese patients in the age group ≥ 65 years with ON are less likely to develop NMOSD or MS. Notwithstanding, they had more severe visual loss at onset and poor recovery.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
Wang J,Zhou H,Qin L,Peng C,Zhao J,Teng D,Lin D,Ai N,Xu Q,Wei Sdoi
10.1155/2017/3458356subject
Has Abstractpub_date
2017-01-01 00:00:00pages
3458356eissn
2090-004Xissn
2090-0058journal_volume
2017pub_type
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