The role of microglia in diabetic retinopathy.

Abstract:

:There is growing evidence that chronic inflammation plays a role in both the development and progression of diabetic retinopathy. There is also evidence that molecules produced as a result of hyperglycemia can activate microglia. However the exact contribution of microglia, the resident immune cells of the central nervous system, to retinal tissue damage during diabetes remains unclear. Current data suggest that dysregulated microglial responses are linked to their deleterious effects in several neurological diseases associated with chronic inflammation. As inflammatory cytokines and hyperglycemia disseminate through the diabetic retina, microglia can change to an activated state, increase in number, translocate through the retina, and themselves become the producers of inflammatory and apoptotic molecules or alternatively exert anti-inflammatory effects. In addition, microglial genetic variations may account for some of the individual differences commonly seen in patient's susceptibility to diabetic retinopathy.

journal_name

J Ophthalmol

journal_title

Journal of ophthalmology

authors

Grigsby JG,Cardona SM,Pouw CE,Muniz A,Mendiola AS,Tsin AT,Allen DM,Cardona AE

doi

10.1155/2014/705783

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

705783

eissn

2090-004X

issn

2090-0058

journal_volume

2014

pub_type

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