Abstract：
:Survivors of Ebola virus infection may become subclinically infected, but whether animal models recapitulate this complication is unclear. Using histology in combination with immunohistochemistry and in situ hybridization in a retrospective review of a guinea pig confirmation-of-virulence study, we demonstrate for the first time Ebola virus infection in hepatic oval cells, the endocardium and stroma of the atrioventricular valves and chordae tendinae, satellite cells of peripheral ganglia, neurofibroblasts and Schwann cells of peripheral nerves and ganglia, smooth muscle cells of the uterine myometrium and vaginal wall, acini of the parotid salivary glands, thyroid follicular cells, adrenal medullary cells, pancreatic islet cells, endometrial glandular and surface epithelium, and the epithelium of the vagina, penis and, prepuce. These findings indicate that standard animal models for Ebola virus disease are not as well-described as previously thought and may serve as a stepping stone for future identification of potential sites of virus persistence.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Cooper TK,Huzella L,Johnson JC,Rojas O,Yellayi S,Sun MG,Bavari S,Bonilla A,Hart R,Jahrling PB,Kuhn JH,Zeng Xdoi
10.1038/s41598-018-19638-xsubject
Has Abstractpub_date
2018-01-19 00:00:00pages
1250issue
1issn
2045-2322pii
10.1038/s41598-018-19638-xjournal_volume
8pub_type
杂志文章abstract：:A tool to predict peritonitis-associated treatment failure among peritoneal dialysis (PD) patients has not yet been established. We conducted a multicentre, retrospective cohort study among 1,025 PD patients between 2006 and 2016 in Thailand to develop and internally validate such a tool. Treatment failure was defined...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究
doi：10.1038/s41598-018-33196-2
更新日期：2018-10-04 00:00:00
abstract：:Balancing the upper body is pivotal for upright and efficient gait. While models have identified potentially useful characteristics of biarticular thigh muscles for postural control of the upper body, experimental evidence for their specific role is lacking. Based on theoretical findings, we hypothesised that biarticu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50995-3
更新日期：2019-10-10 00:00:00
abstract：:RT-qPCR offers high sensitivity, for accurate interpretations of qPCR results however, normalisation using suitable reference genes is fundamental. Androgens can regulate transcriptional expression including reference gene expression in prostate cancer. In this study, we evaluated ten mRNA and six non-protein coding R...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19458-z
更新日期：2018-01-31 00:00:00
abstract：:The transport properties of films assembled from metal nanoclusters can be significantly different from the metals in their bulk or thin film forms due to quantum confinement effects and several competing energy and length scales. For a film composed of metal nanoclusters as its building blocks, the cluster size and t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07685
更新日期：2015-01-08 00:00:00
abstract：:Chromosomal polymorphism is widespread in the Drosophila genus, with extensive evidence supporting its adaptive character in diverse species. Moreover, inversions are the major contributors to the genus chromosomal evolution. The molecular characterization of a reduced number of polymorphic inversion breakpoints in Dr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36248
更新日期：2016-10-26 00:00:00
abstract：:Mask ventilation and coughing during oro-tracheal suctioning produce aerosols that enhance nosocomial transmission of respiratory infections. We examined the extent of exhaled air dispersion from a human-patient-simulator during mask ventilation by different groups of healthcare workers and coughing bouts. The simulat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18614-1
更新日期：2018-01-09 00:00:00
abstract：:3,4-Methylenedioxymethamphetamine (MDMA), a common recreational drug, is known to cause serotonergic neurotoxicity in the brain. Dextromethorphan (DM) is a widely used antitussive reported to exert anti-inflammatory effect in vivo. In this study, we examined the long-term effect of MDMA on the primate serotonergic sys...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38695
更新日期：2016-12-12 00:00:00
abstract：:This study assessed cortical tracking of temporal information in incoming natural speech in seven-month-old infants. Cortical tracking refers to the process by which neural activity follows the dynamic patterns of the speech input. In adults, it has been shown to involve attentional mechanisms and to facilitate effect...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32150-6
更新日期：2018-09-13 00:00:00
abstract：:Articular chondrocytes are slowly dividing cells that tend to lose their cell type-specific phenotype and ability to produce structurally and functionally correct cartilage tissue when cultured. Thus, culture conditions, which enhance the maintenance of chondrocyte phenotype would be very useful for cartilage research...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03958-5
更新日期：2017-06-16 00:00:00
abstract：:Transcription factors (TFs) binding to specific DNA sequences or motifs, are elementary to the regulation of transcription. The gene is regulated by a combination of TFs in close proximity. Analysis of co-TFs is an important problem in understanding the mechanism of transcriptional regulation. Recently, ChIP-seq in ma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43597
更新日期：2017-02-27 00:00:00
abstract：:Uric acid (UA) has been proposed as an important risk factor for cardiovascular and renal morbidity. We conducted an interventional trial to assess effects of altered salt intake on plasma and urine UA levels and the relationship between UA levels and salt sensitivity in humans. Ninety subjects (18-65 years old) were ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-018-20048-2
更新日期：2018-01-23 00:00:00
abstract：:Domoic acid (DA, 1), a potent neurotoxin that causes amnesic shellfish poisoning, has been found in diatoms and red algae. While biosynthetic pathway towards DA from geranyl diphosphate and L-glutamate has been previously proposed, its late stage is still unclear. Here, six novel DA related compounds, 7'-methyl-isodom...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18651-w
更新日期：2018-01-10 00:00:00
abstract：:The design and fabrication of intricate hollow architectures as cost-effective and dual-function electrocatalyst for water and urea electrolysis is of vital importance to the energy and environment issues. Herein, a facile solvothermal strategy for construction of Prussian-blue analogue (PBA) hollow cages with an open...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52412-1
更新日期：2019-11-04 00:00:00
abstract：:Cellular locomotion is a central hallmark of eukaryotic life. It is governed by cell-extrinsic molecular factors, which can either emerge in the soluble phase or as immobilized, often adhesive ligands. To encode for direction, every cue must be present as a spatial or temporal gradient. Here, we developed a microfluid...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36440
更新日期：2016-11-07 00:00:00
abstract：:Streptococcus agalactiae (GBS) is the leading cause worldwide of neonatal sepsis. We sought to assess to which extent HIV exposure of neonates is associated with GBS neonatal disease. Furthermore, we assessed to which extent HIV infection in women is associated with maternal rectovaginal GBS carriage, the single most ...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-017-13218-1
更新日期：2017-10-23 00:00:00
abstract：:This study aims to identify promising biomarkers for the early detection of lung cancer and evaluate the prognosis of lung cancer patients. Genome-wide mRNA expression data obtained from the Gene Expression Omnibus (GSE19188, GSE18842 and GSE40791), including 231 primary tumor samples and 210 normal samples, were used...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08615-5
更新日期：2017-08-14 00:00:00
abstract：:The midline thalamus is reciprocally connected with the medial temporal lobe, where neural circuitry essential for spatial navigation and memory formation resides. Yet, little information is available on the dynamic relationship between activity patterns in the midline thalamus and medial temporal lobe. Here, we repor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29807
更新日期：2016-07-14 00:00:00
abstract：:Global change is predicted to cause shifts in species distributions and biodiversity in arctic tundra. We applied factorial warming and nutrient manipulation to a nutrient and species poor alpine/arctic heath community for seven years. Vascular plant abundance in control plots increased by 31%. There were also notable...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10197
更新日期：2015-05-07 00:00:00
abstract：:Zeolites/molecular sieves with uniform, molecular-sized pores are important for many adsorption-based separation processes. Pore size gaps, however, exist in the current zeolite family. This leads to a great challenge of separating molecules with size differences at ~0.01 nm level. Here, we report a novel concept, por...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13981
更新日期：2015-09-11 00:00:00
abstract：:Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Nox) are an important family of catalytic enzymes that generate reactive oxygen species (ROS), which mediate the regulation of diverse cellular functions. Although phagocyte Nox2/gp91phox is closely associated with the activation of host innate immune respo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06610-4
更新日期：2017-07-25 00:00:00
abstract：:The gut microbiome is shaped and modified by the polymorphisms of microorganisms in the intestinal tract. Its composition shows strong individual specificity and may play a crucial role in the human digestive system and metabolism. Several factors can affect the composition of the gut microbiome, such as eating habits...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23075
更新日期：2016-03-15 00:00:00
abstract：:Bipolar disorder (BD) is a debilitating mental disorder that cannot be diagnosed by objective laboratory-based modalities. Our previous studies have independently used nuclear magnetic resonance (NMR)-based and gas chromatography-mass spectrometry (GC-MS)-based metabonomic methods to characterize the urinary metabolic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05855
更新日期：2014-07-28 00:00:00
abstract：:Sensitivity to sounds is one frequent symptom of a sport-related concussion, but its assessment rarely goes beyond a single question. Here we examined sensitivity to sounds using psychoacoustic and psychometric outcomes in athletes beyond the acute phase of injury. Fifty-eight college athletes with normal hearing who ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28312-1
更新日期：2018-07-02 00:00:00
abstract：:A new, efficient method based on a series of matrices is introduced to completely describe the detailed topology of individual domains and their topology evolution in three-dimensional cellular structures. With this approach, we found a lot of new topological grain forms which are never reported before, i.e., there ar...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25877
更新日期：2016-05-10 00:00:00
abstract：:The possibility of producing transgenic cloned buffalos by nuclear transfer of fetal fibroblasts expressing enhanced green fluorescent protein (EGFP) was explored in this study. When buffalo fetal fibroblasts (BFFs) isolated from a male buffalo fetus were transfected with pEGFP-N1 (EGFP is driven by CMV and Neo is dri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25120-5
更新日期：2018-05-03 00:00:00
abstract：:Metastasis suppressor genes (MS genes) are genes that play important roles in inhibiting the process of cancer metastasis without preventing growth of the primary tumor. Identification of these genes and understanding their functions are critical for investigation of cancer metastasis. Recent studies on cancer metasta...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15478
更新日期：2015-10-21 00:00:00
abstract：:The sinusoidal endothelial cells present in the liver (LSECs) are tipically characterized by the presence of pores (fenestrae). During some pathological conditions LSECs undergo "capillarization", a process characterized by loss of fenestrations and acquisition of a vascular phenotype. In chronic liver disease capilla...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-019-45114-1
更新日期：2019-06-19 00:00:00
abstract：:We investigated the clinical characteristics of cilioretinal arteries (CAs) and cilioretinal veins (CVs) in eyes with pathologic myopia. Ninety-five eyes with pathologic myopia and CAs were studied. The retrobulbar vessels from which the CAs originated were identified by indocyanine green angiography (ICGA). The resul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38616-5
更新日期：2019-02-21 00:00:00
abstract：:LytR-cpsA-Psr (LCP) domain containing proteins fulfil important functions in bacterial cell wall synthesis. In Mycobacterium tuberculosis complex (Mtbc) strains, the causative agents of tuberculosis (TB), the genes Rv3484 and Rv3267 encode for LCP proteins which are putatively involved in arabinogalactan transfer to p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22012-6
更新日期：2018-03-02 00:00:00
abstract：:Mixtures of B4C, α-AlB12 and B powders were reactively spark plasma sintered at 1800 °C. Crystalline and amorphous boron powders were used. Samples were tested for their impact behavior by the Split Hopkinson Pressure Bar method. When the ratio R = B4C/α-AlB12 ≥ 1.3 for a constant B-amount, the major phase in the samp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55888-z
更新日期：2019-12-20 00:00:00
