Abstract:
BACKGROUND:More information is needed for selection of patients with peritoneal metastases from endometrial cancer (EC) to undergo cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS:This study analyzed clinical, pathologic, and treatment data for patients with peritoneal metastases from EC who underwent CRS plus HIPEC at two tertiary centers. The outcome measures were morbidity, overall survival (OS), and progression-free survival (PFS) during a median 5 year follow-up period. Uni- and multivariate analyses were performed to identify significant factors related to outcome. RESULTS:A total of 33 patients met the inclusion criteria and completed the follow-up period. At laparotomy, the median peritoneal cancer index (PCI) was 15 (range 3-35). The CRS procedure required a mean 8.3 surgical procedures per patient, and for 22 patients (66.6%), a complete cytoreduction was achieved. The mean hospital stay was 18 days, and major morbidity developed in 21% of the patients. The operative mortality was 3%. When surgery ended, HIPEC was administered with cisplatin 75 mg/m2 for 60 min at 43 °C. During a median follow-up period of 73 months, Kaplan-Meier analysis indicated a 5 year OS of 30% (median 33.1 months) and a PFS of 15.5% (median 18 months). Multivariate analysis identified the completeness of cytoreduction (CC) score as the only significant factor independently influencing OS. Logistic regression for the clinicopathologic variables associated with complete cytoreduction (CC0) for patients with metachronous peritoneal spread from EC who underwent secondary CRS plus HIPEC identified the PCI as the only outcome predictor. CONCLUSIONS:For selected patients with peritoneal metastases from EC, when CRS leaves no residual disease, CRS plus HIPEC achieves outcomes approaching those for other indications such as colon and ovarian carcinoma.
journal_name
Ann Surg Oncoljournal_title
Annals of surgical oncologyauthors
Cornali T,Sammartino P,Kopanakis N,Christopoulou A,Framarino Dei Malatesta M,Efstathiou E,Spagnoli A,Ciardi A,Biacchi D,Spiliotis Jdoi
10.1245/s10434-017-6307-3subject
Has Abstractpub_date
2018-03-01 00:00:00pages
679-687issue
3eissn
1068-9265issn
1534-4681pii
10.1245/s10434-017-6307-3journal_volume
25pub_type
杂志文章,多中心研究abstract:PURPOSE:Intraoperative margin assessment can reduce positive margins in patients undergoing breast-conserving surgery. However, reports on intraoperative margin assessment have described only the use of either imprint cytology or frozen section. This study was designed to elucidate the effect of intraoperative margin a...
journal_title:Annals of surgical oncology
pub_type: 杂志文章
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journal_title:Annals of surgical oncology
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journal_title:Annals of surgical oncology
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abstract:: ...
journal_title:Annals of surgical oncology
pub_type: 评论,杂志文章
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journal_title:Annals of surgical oncology
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journal_title:Annals of surgical oncology
pub_type: 杂志文章,随机对照试验
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更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Inflammation has been demonstrated to promote cancer metastasis. Due to the well-known systemic inflammatory responses (SIR) after major surgery, it is critical to investigate and attenuate SIR-induced tumor metastasis of cancer patients suffering surgical procedures. METHODS:C57BL/6 mice were intravenously...
journal_title:Annals of surgical oncology
pub_type: 杂志文章
doi:10.1245/s10434-019-08076-2
更新日期:2020-04-01 00:00:00
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journal_title:Annals of surgical oncology
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
doi:10.1245/s10434-008-9815-3
更新日期:2008-04-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
doi:10.1245/s10434-013-3231-z
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journal_title:Annals of surgical oncology
pub_type: 临床试验,杂志文章
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更新日期:2003-11-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
doi:10.1245/s10434-014-3941-x
更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1245/s10434-013-3120-5
更新日期:2013-10-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 临床试验,杂志文章
doi:10.1245/s10434-013-3357-z
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
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journal_title:Annals of surgical oncology
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journal_title:Annals of surgical oncology
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
doi:10.1007/BF02303632
更新日期:1995-03-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
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更新日期:2000-06-01 00:00:00
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journal_title:Annals of surgical oncology
pub_type: 杂志文章
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更新日期:2012-12-01 00:00:00
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journal_title:Annals of surgical oncology
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