Emerging biomarkers of lymphangioleiomyomatosis.

abstract：:The need for novel and more effective approaches to tobacco control is unquestionable. The electronic cigarette is a battery-powered electronic nicotine delivery system that looks very similar to a conventional cigarette and is capable of emulating smoking, but without the combustion products accountable for smoking's...

journal_title：Expert review of respiratory medicine

authors： Caponnetto P,Campagna D,Papale G,Russo C,Polosa R

更新日期：2012-02-01 00:00:00

abstract：INTRODUCTION:Cystic Fibrosis is among the first diseases to have general population genetic screening tests and one of the most common indications of prenatal and preimplantation genetic diagnosis for single gene disorders. During the past twenty years, thanks to the evolution of diagnostic techniques, our knowledge of...

journal_title：Expert review of respiratory medicine

authors： Bergougnoux A,Taulan-Cadars M,Claustres M,Raynal C

更新日期：2018-05-01 00:00:00

abstract：:For the last 100 years, the tuberculin skin test (TST) has been the only diagnostic tool available for latent TB infection (LTBI) and no biomarker per se is available to diagnose the presence of LTBI. With the introduction of M. tuberculosis-specific IFN-gamma release assays (IGRAs), a new area of in vitro immunodiagn...

journal_title：Expert review of respiratory medicine

authors： Ruhwald M,Ravn P

更新日期：2009-08-01 00:00:00

abstract：INTRODUCTION:There is an ongoing need for additional interventions in idiopathic pulmonary fibrosis (IPF) as antifibrotic drugs currently available only inhibit and do not stall disease progression. Vitamin K is a co-factor for the activation of coagulation factors. However, it is also required to activate proteins wit...

journal_title：Expert review of respiratory medicine

authors： De Brouwer B,Piscaer I,Von Der Thusen JH,Grutters JC,Schutgens RE,Wouters EF,Janssen R

更新日期：2018-03-01 00:00:00

abstract：INTRODUCTION:Cystic fibrosis (CF) outcomes and survival have improved over the last century primarily due to advancements in antibiotics, nutritional, and pulmonary therapies. Reviewed here are the significant unmet needs that exist for individuals with CF. Areas covered: With the recent development of medications that...

journal_title：Expert review of respiratory medicine

authors： West NE,Flume PA

更新日期：2018-07-01 00:00:00

abstract：:Cigarette smoking in asthma is frequently present and is associated with worsening of symptoms, accelerated lung-function decline, a higher frequency of hospital admissions, a higher degree of asthma severity, poorer asthma control and reduced responsiveness to corticosteroids. Furthermore, it is associated with reduc...

journal_title：Expert review of respiratory medicine

authors： Fattahi F,Hylkema MN,Melgert BN,Timens W,Postma DS,ten Hacken NH

更新日期：2011-02-01 00:00:00

abstract：:Introduction: Lung transplantation is an effective treatment for certain types of end-stage lung disease. Frailty is a complex clinical syndrome associated with decreased physiological reserve and an increased risk for suboptimal health outcomes.Area covered: This article reviews the current literature on frailty in l...

journal_title：Expert review of respiratory medicine

authors： Montgomery E,Macdonald PS,Newton PJ,Jha SR,Malouf M

更新日期：2020-02-01 00:00:00

abstract：:Since chronic obstructive pulmonary disease (COPD) has a progressive and major impact on health management, many aspects of this disorder, including development of effective and reliable biomarkers to monitor disease progression, are under intensive investigation. A huge amount of data, accumulated over the years, hav...

journal_title：Expert review of respiratory medicine

authors： Iadarola P,Luisetti M

更新日期：2013-04-01 00:00:00

abstract：:Allergic airway disease is a major global health burden, and novel treatment options are urgently needed. Numerous epidemiological and experimental studies suggest that certain helminths and bacteria protect against respiratory allergies. These microorganisms are strong regulators of the immune system, and various pot...

journal_title：Expert review of respiratory medicine

authors： Obieglo K,van Wijck Y,de Kleijn S,Smits HH,Taube C

更新日期：2014-12-01 00:00:00

abstract：:Although wheezing illness is at its most prevalent in infancy and early childhood, its self-limiting nature in the majority poses considerable challenges in offering a long-term prognosis and in initiating long-term prophylaxis. Many of the established treatments in adults have not been adequately assessed in children...

journal_title：Expert review of respiratory medicine

authors： Helms PJ

更新日期：2009-04-01 00:00:00

abstract：INTRODUCTION:The independent and central role of the patient with a complex chronic respiratory disease in targeted, personalized disease management strategies is becoming increasingly important. Patients are the ones living with the disease and are finally responsible for their lives underlining their role as essentia...

journal_title：Expert review of respiratory medicine

authors： Houben-Wilke S,Augustin IM,Wouters BB,Stevens RA,Janssen DJ,Spruit MA,Vanfleteren LE,Franssen FM,Wouters EF

更新日期：2017-12-01 00:00:00

abstract：:Studies on cough have come a long way but many shortfalls still exist. These shortfalls can be attributed to: the lack of randomized controlled studies with a focus on cough; studies not using robust cough outcome measures, poor definition of target groups in studies and guidelines, the lack of safe and efficacious tr...

journal_title：Expert review of respiratory medicine

authors： Chang AB

更新日期：2011-08-01 00:00:00

abstract：:Erdosteine is a multimechanism, mucolytic agent that decreases the sputum viscoelastic properties and bacterial adhesion to the cell membrane, endowed with bronchial anti-inflammatory activity and a scavenging effect on free oxidant radicals. Erdosteine is a prodrug and metabolite I is the active metabolite of erdoste...

journal_title：Expert review of respiratory medicine

authors： Moretti M

更新日期：2007-12-01 00:00:00

abstract：INTRODUCTION:Exercise intolerance is a common and often significant limitation in pulmonary arterial hypertension (PAH). This intolerance greatly affects the quality of life and function of the individual with PAH, irrespective of its etiology. In PAH associated with connective tissue disorders (PAH-CTD), exercise into...

journal_title：Expert review of respiratory medicine

authors： Babu AS,Morris NR,Arena R,Myers J

更新日期：2018-07-01 00:00:00

abstract：:Conducting clinical trials on pulmonary hypertension in the US and Western Europe has become increasingly difficult and costly because of many challenges. These include a limited patient population that makes recruitment difficult. Recruiting internationally has helped, but can add variability. The choice of end point...

journal_title：Expert review of respiratory medicine

authors： Hill NS,Roberts K,Preston I

更新日期：2015-10-01 00:00:00

abstract：INTRODUCTION:Interstitial lung diseases (ILD) include a broad range of diffuse parenchymal lung disorders of known and unknown etiologies. Patients with ILD can experience acute exacerbations (AE) which are associated with extremely high morbidity and mortality. Little is known about the etiology of AEs, and whether in...

journal_title：Expert review of respiratory medicine

authors： Azadeh N,Moua T,Baqir M,Ryu JH

更新日期：2018-04-01 00:00:00

abstract：:Introduction: The forced expiratory flow between 25% and 75% of forced vital capacity (FEF25-75) is a spirometry parameter that may be useful in many clinical settings. Values <65% of predicted have been defined as abnormal.Areas covered: The current report discusses the clinical value of FEF25-75 in different setting...

journal_title：Expert review of respiratory medicine

authors： Ciprandi G,Cirillo I

更新日期：2019-12-01 00:00:00

abstract：:Introduction: Acute respiratory distress syndrome (ARDS) is a severe form of acute lung injury common in critically ill patients and characterized by significant morbidity and mortality. It frequently manifests long-lasting effects beyond hospitalization, from cognitive impairment to physical weakness.Areas covered: S...

journal_title：Expert review of respiratory medicine

authors： Mart MF,Ware LB

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:Acute exacerbations of chronic lung disease account for substantial morbidity and health costs. Repeated inflammatory episodes and attendant bronchoconstriction cause structural remodeling of the airway. Remodeling is a multicellular response to mucosal injury that results in epithelial cell-state changes,...

journal_title：Expert review of respiratory medicine

authors： Brasier AR

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:Survival after lung transplantation lags behind outcomes of other solid organ transplants, and complications from lung transplant are the second most common cause of death in cystic fibrosis. Evolving surgical techniques, therapeutics, and perioperative management have improved short-term survival after lu...

journal_title：Expert review of respiratory medicine

authors： Li SS,Tumin D,Krone KA,Boyer D,Kirkby SE,Mansour HM,Hayes D Jr

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:Pulmonary mold infections are caused by ubiquitous organisms found in soil, water, and decaying vegetation, including Aspergillus spp., the Mucormycetes, hyaline molds, and dematiaceous (black) molds. Areas covered: These infections are often a challenge to diagnose and even more difficult to treat. Recent...

journal_title：Expert review of respiratory medicine

authors： McCarthy MW,Petraitis V,Walsh TJ

更新日期：2017-06-01 00:00:00

abstract：:Smoke inhalation injury continues to increase morbidity and mortality in burn patients in both the third world and industrialized countries. The lack of uniform criteria for the diagnosis and definition of smoke inhalation injury contributes to the fact that, despite extensive research, mortality rates have changed li...

journal_title：Expert review of respiratory medicine

authors： Rehberg S,Maybauer MO,Enkhbaatar P,Maybauer DM,Yamamoto Y,Traber DL

更新日期：2009-06-01 00:00:00

abstract：INTRODUCTION:Chronic obstructive pulmonary disease (COPD) patients experience the morning as the worst period of the day. Nevertheless, morning symptoms are not mentioned in COPD guidelines. Areas covered: Different topics on morning symptoms are covered in this review to underline their importance: occurrence, tools f...

journal_title：Expert review of respiratory medicine

authors： van Buul AR,Kasteleyn MJ,Chavannes NH,Taube C

更新日期：2017-04-01 00:00:00

abstract：:Introduction: Muscle impairments are prevalent in COPD and have adverse clinical implications in terms of physical performance capacity, disease burden, quality of life and even mortality. During acute exacerbations of COPD (AECOPDs) the respiratory symptoms worsen and this might also apply to the muscle impairments. ...

journal_title：Expert review of respiratory medicine

authors： Gosker HR,Langen RC,Simons SO

更新日期：2021-01-01 00:00:00

abstract：INTRODUCTION:The Global Initiative for Asthma (GINA) annual report summarizes the latest evidence for asthma management. GINA recommends stepwise pharmacological treatment, advocating inhaled corticosteroids (ICS) plus rapid, long-acting β2-agonists (LABA) delivered in a single inhaler for maintenance and relief at Ste...

journal_title：Expert review of respiratory medicine

authors： Lin J,Zhou X,Wang C,Liu C,Cai S,Huang M

更新日期：2018-03-01 00:00:00

abstract：INTRODUCTION:Asthmatic patients show a large heterogeneity in response to asthma medication. Rapidly evolving genotyping technologies have led to the identification of various genetic variants associated with treatment outcomes. Areas covered: This review focuses on the current knowledge of genetic variants influencing...

journal_title：Expert review of respiratory medicine

authors： Vijverberg SJH,Farzan N,Slob EMA,Neerincx AH,Maitland-van der Zee AH

更新日期：2018-01-01 00:00:00

abstract：:Although mechanical ventilation (MV) is a life-saving intervention for patients with acute respiratory distress syndrome (ARDS), it can aggravate or cause lung injury, known as ventilator-induced lung injury (VILI). The biophysical characteristics of heterogeneously injured ARDS lungs increase the parenchymal stress a...

journal_title：Expert review of respiratory medicine

authors： Plataki M,Hubmayr RD

更新日期：2010-06-01 00:00:00

abstract：INTRODUCTION:Pleural disease encompasses a large range of conditions, is a common presentation to the acute medical take and often requires comprehensive investigation and treatment. Ultrasound is well recognised as a useful investigative tool in pleural disease especially in the field of pleural effusion, pleural thic...

journal_title：Expert review of respiratory medicine

authors： Mercer RM,Psallidas I,Rahman NM

更新日期：2017-04-01 00:00:00

abstract：:Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have significantly improved the survival of patients with advanced non-small cell lung cancer (NSCLC) harboring EGFR activating mutations. However, nearly all EGFR-mutant NSCLC tumors eventually acquire resistance to the currently used EGFR-TKIs a...

journal_title：Expert review of respiratory medicine

authors： Noda S,Kanda S

更新日期：2016-01-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a very common disease all around the world and has become an increasing public health concern to the Chinese medical community. In the past decades, telehealthcare technology has become a good way to manage COPD but current evidence makes it hard to determine the effecti...

journal_title：Expert review of respiratory medicine

authors： Lao X,Zhang J,Bai C

更新日期：2013-10-01 00:00:00