Abstract:
:Cigarette smoking in asthma is frequently present and is associated with worsening of symptoms, accelerated lung-function decline, a higher frequency of hospital admissions, a higher degree of asthma severity, poorer asthma control and reduced responsiveness to corticosteroids. Furthermore, it is associated with reduced numbers of eosinophils and higher numbers of mast cells in the submucosa of the airway wall. Airway remodeling is increased as evidenced by increased epithelial thickness and goblet cell hyperplasia in smoking asthmatics. The pathogenesis responsible for smoking-induced changes in airway inflammation and remodeling in asthma is complex and largely unknown. The underlying mechanism of reduced corticosteroid responsiveness is also unknown. This article discusses differences between smoking and nonsmoking asthmatics regarding the clinical expression of asthma, lung function, response to corticosteroids, airway inflammation and remodeling processes. Possible pathogenetic mechanisms that may explain the links between cigarette smoking and changes in the clinical expression of asthma will be discussed, as well as the beneficial effects of smoking cessation.
journal_name
Expert Rev Respir Medjournal_title
Expert review of respiratory medicineauthors
Fattahi F,Hylkema MN,Melgert BN,Timens W,Postma DS,ten Hacken NHdoi
10.1586/ers.10.85subject
Has Abstractpub_date
2011-02-01 00:00:00pages
93-105issue
1eissn
1747-6348issn
1747-6356journal_volume
5pub_type
杂志文章,评审abstract::Introduction: Neuromotor control of diaphragm muscle and the recovery of diaphragm activity following spinal cord injury have been narrowly focused on ventilation. By contrast, the understanding of neuromotor control for non-ventilatory expulsive/straining maneuvers (including coughing, defecation, and parturition) is...
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journal_title:Expert review of respiratory medicine
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journal_title:Expert review of respiratory medicine
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journal_title:Expert review of respiratory medicine
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journal_title:Expert review of respiratory medicine
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journal_title:Expert review of respiratory medicine
pub_type: 杂志文章,评审
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journal_title:Expert review of respiratory medicine
pub_type: 杂志文章,评审
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journal_title:Expert review of respiratory medicine
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journal_title:Expert review of respiratory medicine
pub_type: 杂志文章,评审
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journal_title:Expert review of respiratory medicine
pub_type: 杂志文章
doi:10.1080/17476348.2017.1392242
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journal_title:Expert review of respiratory medicine
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Expert review of respiratory medicine
pub_type: 社论
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更新日期:2014-08-01 00:00:00
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journal_title:Expert review of respiratory medicine
pub_type: 杂志文章,评审
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更新日期:2011-06-01 00:00:00
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journal_title:Expert review of respiratory medicine
pub_type: 杂志文章,评审
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更新日期:2018-02-01 00:00:00
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journal_title:Expert review of respiratory medicine
pub_type: 杂志文章,评审
doi:10.1586/17476348.2014.905915
更新日期:2014-06-01 00:00:00
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journal_title:Expert review of respiratory medicine
pub_type: 杂志文章
doi:10.1586/17476348.2.1.37
更新日期:2008-02-01 00:00:00
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journal_title:Expert review of respiratory medicine
pub_type: 杂志文章,评审
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更新日期:2018-08-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Expert review of respiratory medicine
pub_type: 杂志文章
doi:10.1586/17476348.1.3.307
更新日期:2007-12-01 00:00:00
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journal_title:Expert review of respiratory medicine
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Expert review of respiratory medicine
pub_type: 杂志文章,评审
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更新日期:2018-12-01 00:00:00
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journal_title:Expert review of respiratory medicine
pub_type: 杂志文章
doi:10.1586/17476348.2.4.473
更新日期:2008-08-01 00:00:00
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pub_type: 杂志文章
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journal_title:Expert review of respiratory medicine
pub_type: 杂志文章,评审
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更新日期:2011-10-01 00:00:00
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journal_title:Expert review of respiratory medicine
pub_type: 杂志文章,评审
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更新日期:2018-10-01 00:00:00