Frailty in lung transplantation: a systematic review.

abstract：:Mometasone furoate and formoterol fumarate dihydrate (MF/F) administered via metered-dose inhaler with a dose counter is a new fixed-dose combination of an inhaled corticosteroid and a long-acting β2-agonist indicated for daily maintenance therapy in patients aged ≥12 years with persistent asthma. Randomized, controll...

journal_title：Expert review of respiratory medicine

authors： Berger WE

更新日期：2011-12-01 00:00:00

abstract：:Asthma is a disease that affects approximately 7% of adults residing in the USA; the prevalence is even greater in children and approaches 10%. The CDC has reported that the overall prevalence of lifetime asthma is 10.5%. New-onset asthma is most often seen in children and is associated with atopy; however, the majori...

journal_title：Expert review of respiratory medicine

authors： Braman SS

更新日期：2010-04-01 00:00:00

abstract：:Background: Few studies have provided real-world evidence of mepolizumab efficacy and safety. We aimed to evaluate mepolizumab for severe eosinophilic asthma in daily clinical practice.Research design and methods: Patients included in the RINOVA (Interdisciplinary Network for the management of severe asthma in Veneto ...

journal_title：Expert review of respiratory medicine

authors： Caminati M,Cegolon L,Vianello A,Chieco Bianchi F,Festi G,Marchi MR,Micheletto C,Mazza F,Tognella S,Senna G

更新日期：2019-12-01 00:00:00

abstract：INTRODUCTION:Non-small cell lung cancer patients harboring uncommon epidermal growth factor receptor (EGFR) mutations together account for approximately 10% of all EGFR mutations. The most common of which being G719X, S768I, L861Q, and exon 20 insertions. The clinical significance, particularly their response to EGFR t...

journal_title：Expert review of respiratory medicine

authors： Wu TH,Hsiue EH,Lee JH,Lin CC,Yang JC

更新日期：2017-01-01 00:00:00

abstract：:Sarcoidosis is a multisystem disease for which diagnosis relies on the integration of clinical, radiologic, laboratory, and pathologic information. Assessment of clinical features is an important part of the disease evaluation. Computer Tomography provides information not available on routine chest roentgenogram which...

journal_title：Expert review of respiratory medicine

authors： Zhou Y,Lower EE,Li H,Baughman RP

更新日期：2016-01-01 00:00:00

abstract：:Introduction: Obstructive sleep apnea (OSA) is highly prevalent and constitutes a major health hazard. Current pharmacotherapy is ineffective in correcting sleep-disordered breathing and is used adjunctively to address residual sleepiness. A new drug, solriamfetol, a selective norepinephrine-dopamine reuptake inhibito...

journal_title：Expert review of respiratory medicine

authors： Abad VC,Guilleminault C

更新日期：2018-12-01 00:00:00

abstract：:In many countries numbers of adults with cystic fibrosis (CF) exceed that of children, with median survival predicted to surpass 50 years. Increasing longevity is, in part, due to intensive therapies including eradication of early infection and suppressive therapies and pulmonary exacerbations. Initial infections with...

journal_title：Expert review of respiratory medicine

authors： Ramsay KA,Stockwell RE,Bell SC,Kidd TJ

更新日期：2016-01-01 00:00:00

abstract：:Introduction: Idiopathic pulmonary fibrosis (IPF), the most common of the idiopathic interstitial pneumonias, is a disease with a poor prognosis, and a highly heterogeneous and unpredictable clinical course. While most patients experience a relatively slow clinical, functional and radiological deterioration, a signifi...

journal_title：Expert review of respiratory medicine

authors： Biondini D,Balestro E,Sverzellati N,Cocconcelli E,Bernardinello N,Ryerson CJ,Spagnolo P

更新日期：2020-04-01 00:00:00

abstract：:Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have significantly improved the survival of patients with advanced non-small cell lung cancer (NSCLC) harboring EGFR activating mutations. However, nearly all EGFR-mutant NSCLC tumors eventually acquire resistance to the currently used EGFR-TKIs a...

journal_title：Expert review of respiratory medicine

authors： Noda S,Kanda S

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Cystic fibrosis (CF) outcomes and survival have improved over the last century primarily due to advancements in antibiotics, nutritional, and pulmonary therapies. Reviewed here are the significant unmet needs that exist for individuals with CF. Areas covered: With the recent development of medications that...

journal_title：Expert review of respiratory medicine

authors： West NE,Flume PA

更新日期：2018-07-01 00:00:00

abstract：INTRODUCTION:Cystic Fibrosis is among the first diseases to have general population genetic screening tests and one of the most common indications of prenatal and preimplantation genetic diagnosis for single gene disorders. During the past twenty years, thanks to the evolution of diagnostic techniques, our knowledge of...

journal_title：Expert review of respiratory medicine

authors： Bergougnoux A,Taulan-Cadars M,Claustres M,Raynal C

更新日期：2018-05-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a very common disease all around the world and has become an increasing public health concern to the Chinese medical community. In the past decades, telehealthcare technology has become a good way to manage COPD but current evidence makes it hard to determine the effecti...

journal_title：Expert review of respiratory medicine

authors： Lao X,Zhang J,Bai C

更新日期：2013-10-01 00:00:00

abstract：:Some basic scientific data suggest that (S)-enantiomers of beta(2)-agonists have different and sometimes opposing effects to (R)-enantiomers. These data may explain the paradoxical response of the airways to the repeated, chronic administration of racemic beta(2)-agonists. Therefore, it is possible that the use of (R)...

journal_title：Expert review of respiratory medicine

authors： Cazzola M,Hanania NA,Matera MG

更新日期：2010-04-01 00:00:00

abstract：:Introduction: Detection and characterization of pulmonary nodules is an important issue, because the process is the first step in the management of lung cancers.Areas covered: Literature review was performed on May 15 2019 by using the PubMed, US National Library of Medicine National Institutes of Health, and the Nati...

journal_title：Expert review of respiratory medicine

authors： Kim TJ,Kim CH,Lee HY,Chung MJ,Shin SH,Lee KJ,Lee KS

更新日期：2020-02-01 00:00:00

abstract：:Non-small-cell lung cancer is the most common cause of cancer-related death worldwide. Surgery remains the cornerstone of treatment for localized, resectable lung cancer, although advanced stages are associated with a high risk of developing distant metastases. Large randomized trials have demonstrated an improvement ...

journal_title：Expert review of respiratory medicine

authors： Kueng MM,Betticher DC

更新日期：2008-10-01 00:00:00

abstract：:During the last decade, there have been major advances in knowledge of the effects of oxygen therapy in patients with acute exacerbations of chronic obstructive pulmonary disease. This includes a randomised controlled trial of oxygen therapy in the pre-hospital setting, which showed that high concentration oxygen ther...

journal_title：Expert review of respiratory medicine

authors： Pilcher J,Weatherall M,Perrin K,Beasley R

更新日期：2015-06-01 00:00:00

abstract：:Objectives: Pleurodesis is an important management option to palliate breathlessness in patients with malignant pleural effusion (MPE). This systematic review aimed to examine available literature for studies investigating factors that predict pleurodesis outcome.Methods: The healthcare databases advanced search (HDAS...

journal_title：Expert review of respiratory medicine

authors： Hassan M,Gadallah M,Mercer RM,Harriss E,Rahman NM

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:Positive airway pressure (PAP) devices are generally considered to be the first-line treatment of choice for most adults with obstructive sleep apnea (OSA). However, there are several alternatives. It is important for patients and their sleep providers to be aware of the most up-to-date information regardi...

journal_title：Expert review of respiratory medicine

authors： Camacho M,Chang ET,Neighbors CLP,Noller MW,Mack D,Capasso R,Kushida CA

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:The Global Initiative for Asthma (GINA) annual report summarizes the latest evidence for asthma management. GINA recommends stepwise pharmacological treatment, advocating inhaled corticosteroids (ICS) plus rapid, long-acting β2-agonists (LABA) delivered in a single inhaler for maintenance and relief at Ste...

journal_title：Expert review of respiratory medicine

authors： Lin J,Zhou X,Wang C,Liu C,Cai S,Huang M

更新日期：2018-03-01 00:00:00

abstract：INTRODUCTION:Exercise intolerance is a common and often significant limitation in pulmonary arterial hypertension (PAH). This intolerance greatly affects the quality of life and function of the individual with PAH, irrespective of its etiology. In PAH associated with connective tissue disorders (PAH-CTD), exercise into...

journal_title：Expert review of respiratory medicine

authors： Babu AS,Morris NR,Arena R,Myers J

更新日期：2018-07-01 00:00:00

abstract：INTRODUCTION:Cystic fibrosis-related diabetes (CFRD) is the end-point of a spectrum of glucose abnormalities in cystic fibrosis that begins with early insulin deficiency and ultimately results in accelerated nutritional decline and loss of lung function. Current diagnostic and management regimens are unable to entirely...

journal_title：Expert review of respiratory medicine

authors： Prentice B,Hameed S,Verge CF,Ooi CY,Jaffe A,Widger J

更新日期：2016-07-01 00:00:00

abstract：:The airway epithelium is constantly faced with inflammatory and potentially injurious stimuli. Following damage, rapid repair mechanisms involving proliferation and differentiation of resident progenitor and stem cell pools are necessary in order to maintain a protective barrier. In asthma, evidence pointing to a comp...

journal_title：Expert review of respiratory medicine

authors： Knight DA,Rossi FM,Hackett TL

更新日期：2010-12-01 00:00:00

abstract：:Middle East respiratory syndrome coronavirus (MERS-CoV) was first recognized in 2012 and since then has resulted in cases in 23 countries in four continents. The majority of these cases were reported from the Kingdom of Saudi Arabia. The disease caused a spectrum of illness, from asymptomatic to severe and possibly fa...

journal_title：Expert review of respiratory medicine

authors： Al-Tawfiq JA,Memish ZA

更新日期：2015-06-01 00:00:00

abstract：INTRODUCTION:Chronic obstructive pulmonary disease (COPD) patients experience the morning as the worst period of the day. Nevertheless, morning symptoms are not mentioned in COPD guidelines. Areas covered: Different topics on morning symptoms are covered in this review to underline their importance: occurrence, tools f...

journal_title：Expert review of respiratory medicine

authors： van Buul AR,Kasteleyn MJ,Chavannes NH,Taube C

更新日期：2017-04-01 00:00:00

abstract：:Introduction: Bronchopulmonary dysplasia (BPD) is a common long-term adverse complication of very premature delivery. Affected infants can suffer chronic respiratory morbidities including lung function abnormalities and reduced exercise capacity even as young adults. Many studies have investigated possible preventativ...

journal_title：Expert review of respiratory medicine

authors： Williams E,Greenough A

更新日期：2019-08-01 00:00:00

abstract：:Conducting clinical trials on pulmonary hypertension in the US and Western Europe has become increasingly difficult and costly because of many challenges. These include a limited patient population that makes recruitment difficult. Recruiting internationally has helped, but can add variability. The choice of end point...

journal_title：Expert review of respiratory medicine

authors： Hill NS,Roberts K,Preston I

更新日期：2015-10-01 00:00:00

abstract：:Introduction: Acute respiratory distress syndrome (ARDS) is a severe form of acute lung injury common in critically ill patients and characterized by significant morbidity and mortality. It frequently manifests long-lasting effects beyond hospitalization, from cognitive impairment to physical weakness.Areas covered: S...

journal_title：Expert review of respiratory medicine

authors： Mart MF,Ware LB

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:Idiopathic pulmonary fibrosis (IPF) is a chronic, debilitating, fibrotic lung disease leading to respiratory failure, and ultimately to death. It is characterized by marked heterogeneity regarding its clinical course. Despite significant progress in the understanding of its pathogenesis, the course of the ...

journal_title：Expert review of respiratory medicine

authors： Inchingolo R,Varone F,Sgalla G,Richeldi L

更新日期：2019-01-01 00:00:00

abstract：:Introduction: There is an unmet clinical need for improved diagnostic tests for active tuberculosis (TB) to provide high sensitivity for all cases, accelerate time to diagnosis and ensure timely and appropriate treatment. Whilst the measurement of M.tb-specific immune responses is widely used for detecting infection i...

journal_title：Expert review of respiratory medicine

authors： Halliday A,Masonou T,Tolosa-Wright M,Mandagere V,Lalvani A

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:Asthmatic patients show a large heterogeneity in response to asthma medication. Rapidly evolving genotyping technologies have led to the identification of various genetic variants associated with treatment outcomes. Areas covered: This review focuses on the current knowledge of genetic variants influencing...

journal_title：Expert review of respiratory medicine

authors： Vijverberg SJH,Farzan N,Slob EMA,Neerincx AH,Maitland-van der Zee AH

更新日期：2018-01-01 00:00:00