当前位置： SCI文献检索 > MOLECULAR AND CELLULAR ENDOCRINOLOGY期刊下所有文献 > Reduction of protein phosphatase 2A Cα promotes in vivo bone formation and adipocyte differentiation.

Reduction of protein phosphatase 2A Cα promotes in vivo bone formation and adipocyte differentiation.

Abstract：

:Serine/threonine protein phosphatase 2A (PP2A) regulates diverse physiological processes such as cell cycle, growth, apoptosis, and signal transduction. Previously, we demonstrated that silencing of the α-isoform of PP2A catalytic subunit (PP2A Cα) in osteoblasts accelerated osteoblast differentiation, whereas its overexpression suppressed differentiation. In this study, we examined the role of PP2A Cα in in vivo bone formation by generating transgenic mice (PP2A-Tg), in which the dominant negative form of PP2A Cα was specifically expressed in osteoblasts. PP2A-Tg mice exhibited an increase in body weight, cortical bone mineral density, and cortical bone thickness. Interestingly, they also displayed higher amounts of adipose tissue in the bone marrow of tibiae. The co-culture study showed that PP2A Cα-knockdown osteoblasts stimulated adipocyte differentiation from undifferentiated mesenchymal cells via upregulation of the adipocyte marker genes, such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα). These results indicated that the reduction of PP2A Cα levels in osteoblasts promoted bone formation in vivo. Additionally, PP2A Cα in osteoblasts was also potentially involved in controlling adipocyte differentiation through a paracrine mechanism.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Yoshida K,Teramachi J,Uchibe K,Ikegame M,Qiu L,Yang D,Okamura H

doi

10.1016/j.mce.2017.11.005

subject

Has Abstract

pub_date

2018-07-15 00:00:00

pages

251-258

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(17)30570-1

journal_volume

470

pub_type

杂志文章

相关文献

MOLECULAR AND CELLULAR ENDOCRINOLOGY文献大全
  • Hyaluronan in the bovine oviduct--modulation of synthases and receptors during the estrous cycle.

    abstract：:The extracellular matrix (ECM) component hyaluronan (HA) is considered to contribute to the optimal development of the gametes and the embryo. In this study, the regulation and localization of HA, its synthases (HAS 1-3) and the receptors CD44, RHAMM, and putative HARE were investigated in bovine oviducts during the e...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2003.12.002

    authors： Ulbrich SE,Schoenfelder M,Thoene S,Einspanier R

    更新日期：2004-02-12 00:00:00

  • Rearrangements of NTRK1 gene in papillary thyroid carcinoma.

    abstract：:TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC); they arise from the fusion of the 3' terminal sequences of the NTRK1/NGF receptor gene with 5' terminal sequences of various activating genes, such as TPM3, TPR and TFG. TRK oncoproteins display constitutive tyrosine-kinase activ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2009.10.009

    authors： Greco A,Miranda C,Pierotti MA

    更新日期：2010-05-28 00:00:00

  • Conserved amino acids in the ligand-binding and tau(i) domains of the peroxisome proliferator-activated receptor alpha are necessary for heterodimerization with RXR.

    abstract：:The peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily. These ligand-activated transcription factors are implicated in the regulation of lipid metabolism and adipocyte differentiation and in the regulation of anti-inflammatory processes. In order to bind to DNA ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(98)00217-2

    authors： Gorla-Bajszczak A,Juge-Aubry C,Pernin A,Burger AG,Meier CA

    更新日期：1999-01-25 00:00:00

  • The zinc finger/homeodomain protein deltaEF1 mediates estrogen-specific induction of the ovalbumin gene.

    abstract：:Regulation of the ovalbumin (Ov) gene is strictly controlled by precise developmental, tissue-specific, and hormonal cues. The Ov gene is transcriptionally activated by four classes of steroid hormones: estrogens, androgens, glucocorticoids, and progestins. Although it has served as a model to study multi-hormone gene...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(02)00088-6

    authors： Dillner NB,Sanders MM

    更新日期：2002-06-28 00:00:00

  • Deletion of lysine 13 alters the structure and function of parathyroid hormone.

    abstract：:A peptide of unknown structure was found as a side product in a commercial preparation of the 1-34 fragment of bovine parathyroid hormone (PTH). CNBr cleavage and amino acid analysis showed that this peptide is the des-lys-13 form of 1-34 bovine PTH. The peptide thus represents a deletion mutant of PTH and structure-f...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(87)90037-2

    authors： Zull JE,Smith LM,Chuang J,Jentoft J

    更新日期：1987-06-01 00:00:00

  • Islet distribution of Peptide YY and its regulatory role in primary mouse islets and immortalised rodent and human beta-cell function and survival.

    abstract：:Recent evidence suggests that the classic gut peptide, Peptide YY (PYY), could play a fundamental role in endocrine pancreatic function. In the present study expression of PYY and its NPY receptors on mouse islets and immortalised rodent and human beta-cells was examined together with the effects of both major circula...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2016.07.020

    authors： Khan D,Vasu S,Moffett RC,Irwin N,Flatt PR

    更新日期：2016-11-15 00:00:00

  • Differential impact of oleate, palmitate, and adipokines on expression of NF-κB target genes in human vascular smooth muscle cells.

    abstract：:It is widely accepted that obesity is a major risk factor for the development of atherosclerosis. In this context, adipose tissue produces a variety of adipokines and releases free fatty acids, contributing to a chronic-low grade inflammation state implicated in vascular complications. In this study, we investigated t...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2012.06.010

    authors： Lamers D,Schlich R,Horrighs A,Cramer A,Sell H,Eckel J

    更新日期：2012-10-15 00:00:00

  • Spironolactone increases integrin beta3 gene expression in kidney and heart muscle cells.

    abstract：:In clinical trials of heart failure, spironolactone, an antagonist of the mineralocorticoid receptor (MR), reduced mortality rates by unknown mechanisms. We hypothesized that spironolactone functions by upregulating expression of certain cardiovascular genes. An RNA differential display technique was used to identify ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(02)00112-0

    authors： Chun TY,Bloem L,Pratt JH

    更新日期：2002-08-30 00:00:00

  • Muscarinic acetylcholine receptor subtypes in the rat seminal vesicle.

    abstract：:The aim of the present study was to identify the muscarinic acetylcholine receptor (mAChR) mRNA subtypes in the rat seminal vesicle. Furthermore, the mAChR subtypes involved in the contraction of the seminal vesicle were also explored. Reverse transcriptase-polymerase chain reaction (PCR) was performed and five PCR pr...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2006.01.004

    authors： Hamamura M,Maróstica E,de Avellar MC,Porto CS

    更新日期：2006-03-09 00:00:00

  • Molecular regulation of gonadotropin receptor expression: relationship to sterol metabolism.

    abstract：:We have identified a specific LHR mRNA binding protein that selectively binds to the polypyrimidine-rich bipartite sequence in the coding region of the LHR mRNA and accelerates its degradation. This process has been shown to be one of the mechanisms that is responsible for the loss of the steady-state levels of LHR mR...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2010.05.014

    authors： Menon KM,Menon B,Wang L,Gulappa T,Harada M

    更新日期：2010-11-25 00:00:00

  • The role of the renin-angiotensin system in the development of insulin resistance in skeletal muscle.

    abstract：:The canonical renin-angiotensin system (RAS) involves the initial action of renin to cleave angiotensinogen to angiotensin I (ANG I), which is then converted to ANG II by the angiotensin converting enzyme (ACE). ANG II plays a critical role in numerous physiological functions, and RAS overactivity underlies many condi...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2012.04.011

    authors： Henriksen EJ,Prasannarong M

    更新日期：2013-09-25 00:00:00

  • Comparative study of the developmental patterns of vasopressin, glucagon, angiotensin II, and alpha 1-adrenergic receptors in the liver of developing and adult hypothyroid rats.

    abstract：:The effects of propylthiouracil (PTU) treatment on vasopressin, angiotensin II, glucagon and alpha 1-adrenergic receptors in both developing and adult rats were studied in liver membrane preparations by measuring the binding of the following ligands: [3H][8-lysine]vasopressin, [3H]Sar-angiotensin II, [125I]glucagon an...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(87)90125-0

    authors： Ali M,Cantau B,Chicot D,Clos J

    更新日期：1987-05-01 00:00:00

  • Human growth hormone but not ovine or bovine growth hormones exhibits galactopoietic prolactin-like activity in organ culture from bovine lactating mammary gland.

    abstract：:Explants from the mammary gland of 6 lactating cows were cultured in M-199 medium containing insulin (1.0 micrograms/ml) and hydrocortisone (0.5 micrograms/ml) and supplemented with bPRL (0.2-1.0 micrograms/ml) or oGH (0.1, 0.5 and 2.5 micrograms/ml) or bGH or hGH (0.2 and 1.0 micrograms/ml). It was found that neither...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(83)90165-x

    authors： Gertler A,Cohen N,Maoz A

    更新日期：1983-12-01 00:00:00

  • The expression of prostatic acid phosphatase is transcriptionally regulated in human prostate carcinoma cells.

    abstract：:The expression of prostatic acid phosphatase (PAcP) in three human prostate carcinoma cell lines including LNCaP, DU 145 and PC-3, was studied to explore its potential role as a marker in the progression of prostate cancer. Although Southern blot analysis suggested the presence of PAcP gene in all three prostate carci...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(95)03544-h

    authors： Garcia-Arenas R,Lin FF,Lin D,Jin LP,Shih CC,Chang C,Lin MF

    更新日期：1995-04-28 00:00:00

  • Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling.

    abstract：:The adapter protein Grb10 binds to phosphotyrosine residues in insulin receptors via its C-terminal region and regulates insulin signaling. This study investigated Grb10 regulation of glucose uptake and the importance of the Grb10 N-terminal region using 3T3-L1 adipocytes overexpressing full-length (FL-Grb10) or N-ter...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2004.11.004

    authors： Mori K,Giovannone B,Smith RJ

    更新日期：2005-01-31 00:00:00

  • Auto-regulation of estrogen receptor subtypes and gene expression profiling of 17beta-estradiol action in the neuroendocrine axis of male goldfish.

    abstract：:Auto-regulation of the three goldfish estrogen receptor (ER) subtypes was examined simultaneously in multiple tissues, in relation to mRNA levels of liver vitellogenin (VTG) and brain transcripts. Male goldfish were implanted with a silastic implant containing either no steroid or 17beta-estradiol (E2) (100 microg/g b...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2007.10.013

    authors： Marlatt VL,Martyniuk CJ,Zhang D,Xiong H,Watt J,Xia X,Moon T,Trudeau VL

    更新日期：2008-02-13 00:00:00

  • Eppin: an effective target for male contraception.

    abstract：:Eppin (epididymal protease inhibitor) is a member of the whey acidic protein (WAP)-type four-disulfide core (WFDC) gene family. This study provides updated information on Eppin and the Eppin-like genes within the Eppin cluster on human chromosome 20. A virtual structural model of the Eppin protein demonstrates that th...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2005.12.039

    authors： O'Rand MG,Widgren EE,Wang Z,Richardson RT

    更新日期：2006-05-16 00:00:00

  • Imaging of the pituitary gland in dogs with pituitary-dependent hyperadrenocorticism.

    abstract：:Detailed imaging of the pituitary gland is a prerequisite for a successful outcome of transsphenoidal hypophysectomy in dogs because it allows for accurate preoperative localization and assessment of the size of the pituitary gland. Cisternography allows assessment of even small increases in the height of the pituitar...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(02)00282-4

    authors： van der Vlugt-Meijer RH,Voorhout G,Meij BP

    更新日期：2002-11-29 00:00:00

  • Ontogeny of the neurosteroid enzyme Cyp7b in the mouse.

    abstract：:The function of the major adrenal steroid dehydroepiandrosterone (DHEA) is not known. It has been reported to improve learning and memory in mice and can exert neuroprotective and trophic effects, particularly in the hippocampus. We recently described a cytochrome P450 (Cyp7b), that catalyses the 7alpha-hydroxylation ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(00)00443-3

    authors： Bean R,Seckl JR,Lathe R,Martin C

    更新日期：2001-03-28 00:00:00

  • Serotonin-inducible transcription of interleukin-1alpha in uterine smooth muscle cells requires an AP-1 site: cloning and partial characterization of the rat IL-1alpha promoter.

    abstract：:Interleukin-1 has been shown to contribute to infection-induced inflammatory processes during pregnancy. Prior work from this laboratory has demonstrated that serotonin-induced IL-1alpha also is required for the in-vitro production of collagenase in uterine smooth muscle cells, a normal, non-inflammatory process that ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(99)00067-2

    authors： Huang TT,Vinci JM,Lan L,Jeffrey JJ,Wilcox BD

    更新日期：1999-06-25 00:00:00

  • Cloning, sequence analysis, tissue distribution, and sex-specific expression of the neural form of P450 aromatase in juvenile sea bass (Dicentrarchus labrax).

    abstract：:The teleost brain is characterized by exceptionally high levels of aromatase, the enzyme that converts androgens into estrogens, and by its continuous growth throughout life. Gonadal estrogens have been implicated in sex differentiation and the control of reproduction in adult fish, but the role of neural estrogens du...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2004.01.006

    authors： Blázquez M,Piferrer F

    更新日期：2004-04-30 00:00:00

  • CYP2C7 expression in rat liver and hepatocytes: regulation by retinoids.

    abstract：:Rats deficient in vitamin A express low levels of P4502C7 mRNA in the liver. Administration of all-trans retinoic acid (at-RA) or growth hormone (GH) to deficient animals only partially restored the expression whereas the combined treatment returned the P4502C7 mRNA levels to that observed in normal rats. That a retin...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(97)04055-0

    authors： Westin S,Sonneveld E,van der Leede BM,van der Saag PT,Gustafsson JA,Mode A

    更新日期：1997-05-16 00:00:00

  • The Klotho gene family as a regulator of endocrine fibroblast growth factors.

    abstract：:The Klotho gene encodes a single-pass transmembrane protein and functions as an aging-suppressor gene, which extends lifespan when overexpressed and accelerates the development of aging-like phenotypes when disrupted in mice. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphate and vi...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2008.10.052

    authors： Kurosu H,Kuro-O M

    更新日期：2009-02-05 00:00:00

  • Point mutations abolish 11 beta-hydroxysteroid dehydrogenase type II activity in three families with the congenital syndrome of apparent mineralocorticoid excess.

    abstract：:The 11 beta-hydroxysteroid dehydrogenase type II enzyme (11 beta HSD2) converts cortisol into mineralocorticoid receptor inactive cortisone, thus preventing occupation of the non-selective mineralocorticoid receptor by glucocorticoids in the kidney. Mutations generating inactive enzymes have been described in the HSD1...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(96)03787-2

    authors： Ferrari P,Obeyesekere VR,Li K,Wilson RC,New MI,Funder JW,Krozowski ZS

    更新日期：1996-05-17 00:00:00

  • Luteinizing hormone and human chorionic gonadotropin: origins of difference.

    abstract：:Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are widely recognized for their roles in ovulation and the support of early pregnancy. Aside from the timing of expression, however, the differences between LH and hCG have largely been overlooked in the clinical realm because of their similar molecular s...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2013.12.009

    authors： Choi J,Smitz J

    更新日期：2014-03-05 00:00:00

  • Regulation of steroidogenesis in crayfish molting glands: involvement of protein synthesis.

    abstract：:The involvement of continuous protein synthesis in the mechanisms of crustacean steroidogenesis was investigated using crayfish molting glands (Y-organs). During intermolt, Y-organ steroidogenic activity is low. Eyestalk ablation initiates premolt which is characterized by a rapid increase in the production of ecdyste...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(95)03489-t

    authors： Dauphin-Villemant C,Böcking D,Sedlmeier D

    更新日期：1995-03-01 00:00:00

  • Vitamin A modulates the effects of thyroid hormone on UDP-glucuronosyltransferase expression and activity in rat liver.

    abstract：:We studied the influence of thyroid hormones and vitamin A status on the regulation of UDP-glucuronosyltransferase (UGT) expression and the glucuronidation of thyroid hormones by UGTs. For this, we used an original model of rats fed with different vitamin A diets and implanted subcutaneously by osmotic minipumps deliv...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(01)00681-5

    authors： Haberkorn V,Heydel JM,Mounie J,Artur Y,Goudonnet H

    更新日期：2002-04-25 00:00:00

  • Metabolism of hCG and hLH to multiple urinary forms.

    abstract：:Human chorionic gonadotropin (hCG) is synthesized primarily in the placenta while human luteinizing hormone (hLH) is produced in the pituitary. Both hormones are highly homologous in structure and both appear to be altered to analogous molecular forms as the hormones are proteolytically processed, or metabolized, from...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/s0303-7207(96)03942-1

    authors： Birken S,Kovalevskaya G,O'Connor J

    更新日期：1996-12-20 00:00:00

  • Characterization of gonadotropin-sensitive adenylate cyclase activity in human testis: uncoupling of the receptor-cyclase complex by specific hormonal antagonist.

    abstract：:Basal and gonadotropin stimulated adenylate cyclase activity was assessed in testicular tissues obtained from men (20-80 years). A disparity was observed in the gonadotropin responsiveness of the human testicular adenylate cyclase system to hFSH and hCG stimulation. Of the tissues analyzed, 61% were FSH responsive and...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(85)90006-1

    authors： Berman MI,Anand-Srivastava MB,Sairam MR

    更新日期：1985-08-01 00:00:00

  • A periodicity in the response of SJL/J thymocytes to isoproterenol. Simulation by cell lines.

    abstract：:Thymocytes from SJL/J mice exhibit a periodicity in their response to hormonal stimulation with isoproterenol. This periodicity (5-9 days) is expressed in large changes in the intensity of the response (peak levels of intracellular cAMP which vary approximately 6-fold), and in the response pattern, i.e., in the occurr...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(90)90134-t

    authors： Riven-Kreitman R,Tauber-Finkelstein M,Zipori D,Shaltiel S

    更新日期：1990-10-22 00:00:00