Muscarinic acetylcholine receptor subtypes in the rat seminal vesicle.

abstract：:Reg family proteins are expressed in the pancreas and involved in pancreatitis and islet β-cell growth. In order to explore transcriptional control, we transfected luciferase reporter genes driven by Reg promoters into acinar AR42J and islet MIN6 cells. Dexamethasone (DEX) significantly increased the promoter expressi...

journal_title：Molecular and cellular endocrinology

authors： Luo C,Li B,Liu L,Yin HP,Wang M,Liu JL

更新日期：2013-01-30 00:00:00

abstract：:The requirement for caspases (ICE-like proteases) were investigated in mediating apoptosis of WEHI7.2 mouse lymphoma cells in response to two death inducers with different mechanisms of action, the glucocorticoid hormone dexamethasone (DX) and the calcium-ATPase inhibitor thapsigargin (TG). Apoptosis induction by thes...

journal_title：Molecular and cellular endocrinology

authors： McColl KS,He H,Zhong H,Whitacre CM,Berger NA,Distelhorst CW

更新日期：1998-04-30 00:00:00

abstract：:In this study we examined the mode of triiodothyronine (T3) and tetraiodothyronine (T4) transport in synaptosomal preparations from cerebral hemispheres of adult rat brain. Our results show that these hormones are transported by different mechanisms: T3 uptake is a saturable process and Hofstee analysis of the data re...

journal_title：Molecular and cellular endocrinology

authors： Kastellakis A,Valcana T

更新日期：1989-12-01 00:00:00

abstract：:Aldosterone treatment of M1-CCD cells stimulated an increase in epithelial Na(+) channel (ENaC) alpha-subunit expression that was mainly localized to the apical membrane. PKD1-suppressed cells constitutively expressed ENaCalpha at low abundance, with no increase after aldosterone treatment. In the PKD1-suppressed cell...

journal_title：Molecular and cellular endocrinology

authors： McEneaney V,Dooley R,Yusef YR,Keating N,Quinn U,Harvey BJ,Thomas W

更新日期：2010-08-30 00:00:00

abstract：:Human type II iodothyronine deiodinase (hDII) belongs to a family of selenoproteins. It catalyzes 5'-deiodination of thyroxine to generate an active thyroid hormone, 3,3',5-triiodothyronine. Two novel splice variants of hDII gene transcript; namely hDII-b and hDII-c, were identified. Three distinct DNA fragments (hDII...

journal_title：Molecular and cellular endocrinology

authors： Ohba K,Yoshioka T,Muraki T

更新日期：2001-02-14 00:00:00

abstract：:In the presence of retinoic acid (RA), F9 murine teratocarcinoma cells differentiate into cells resembling the extra-embryonic endoderm of the early mouse embryo. Using differential hybridization, we have cloned and characterized six cDNAs corresponding to mRNAs that exhibit reduced expression in F9 cells following RA...

journal_title：Molecular and cellular endocrinology

authors： Faria TN,LaRosa GJ,Wilen E,Liao J,Gudas LJ

更新日期：1998-08-25 00:00:00

abstract：:Placental leptin secretion has important implications for maternal adaptation to pregnancy, fetal growth and development, and local autocrine/paracrine actions within trophoblast. In this study we used a cell culture insert model to examine directional secretion of leptin from the basal and apical surfaces of human ch...

journal_title：Molecular and cellular endocrinology

authors： Wyrwoll CS,Mark PJ,Waddell BJ

更新日期：2005-09-28 00:00:00

abstract：:Cytochrome b(5) (cyt-b(5)) is essential for the regulation of steroidogenesis and as such has been implicated in a number of clinical conditions. It is well documented that this small hemoprotein augments the 17,20-lyase activity of cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17A1). Studies have revealed that this...

journal_title：Molecular and cellular endocrinology

authors： Storbeck KH,Swart AC,Goosen P,Swart P

更新日期：2013-05-22 00:00:00

abstract：:To elucidate the cellular origin of interleukin-1 (IL-1) in the mammalian testis, we assayed IL-1 activity in culture media of Sertoli cells collected from rats at 20, 35 and 45 days of age as well as in culture media of interstitial, peritubular and germ cells from adult rats. IL-1 was detected in Sertoli cell cultur...

journal_title：Molecular and cellular endocrinology

authors： Gérard N,Syed V,Bardin W,Genetet N,Jégou B

更新日期：1991-11-01 00:00:00

abstract：:In the characterization of newly identified proteins, subcellular localization studies can provide important hints to the proteins' metabolic functions. Depending on the biochemical task of an enzyme, certain subcellular environmental conditions as pH or availability of cofactors and substrates have to be fulfilled. C...

journal_title：Molecular and cellular endocrinology

authors： Keller B,Meier M,Adamski J

更新日期：2009-03-25 00:00:00

abstract：:The role of estrogens produced by the testis may involve negative feedback regulation of androgen biosynthesis. Estrogens are also associated with contractile processes of seminiferous tubules, and might have mitogenic effects on Sertoli and Leydig cells. To investigate the location of aromatase (estrogen synthetase) ...

journal_title：Molecular and cellular endocrinology

authors： Brodie A,Inkster S,Yue W

更新日期：2001-06-10 00:00:00

abstract：:Sperm cryopreservation still represents a valuable clinical aid in the management of infertility. Its current principal indications include (1) donor sperm insemination; (2) freezing before cancer therapy to maintain reproductive capacity; (3) patient's convenience; and (4) because of the outstanding success with ICSI...

journal_title：Molecular and cellular endocrinology

authors： Oehninger S,Duru NK,Srisombut C,Morshedi M

更新日期：2000-11-27 00:00:00

abstract：:The growth of ZR-75-1 cells, a line of human breast cancer cells in culture, is stimulated by oestradiol and inhibited by anti-oestrogens. Changes in growth rate caused by these agents are accompanied by changes in activity of ornithine decarboxylase, a rate-limiting enzyme for polyamine synthesis. Furthermore, the gr...

journal_title：Molecular and cellular endocrinology

authors： Hoggard N,Green CD

更新日期：1986-06-01 00:00:00

abstract：:Perfluorooctanoic acid (PFOA) is a persistent pollutant worldwide and even found in human cord blood and breast milk. Some animal studies have reported that PFOA causes developmental toxicity such as fetal weight loss, but the mechanism is still unclear. This study focused on developmental toxicity of PFOA, particular...

journal_title：Molecular and cellular endocrinology

authors： Suh CH,Cho NK,Lee CK,Lee CH,Kim DH,Kim JH,Son BC,Lee JT

更新日期：2011-04-30 00:00:00

abstract：:Insulin receptor substrate-1 (IRS-1) is a protein expressed in 3T3-L1 adipocytes that is involved in most, if not all of the biological responses to insulin. Chronic exposure of these cells to insulin down-regulates IRS-1 by stimulating its degradation (Rice, K.M., Turnbow, M.A. and Garner, C.W. (1993) Biochem. Biophy...

journal_title：Molecular and cellular endocrinology

authors： Smith LK,Rice KM,Garner CW

更新日期：1996-08-30 00:00:00

abstract：:Menin is a protein product of a tumor supressor gene MEN1, mutations of which are responsible for multiple endocrine neoplasia type 1, an autosomal dominant familial cancer syndrome. We determined the nucleotide sequence of the Drosophila menin cDNA using RT-PCR and RACE, and confirmed it by direct sequencing of genom...

journal_title：Molecular and cellular endocrinology

authors： Maruyama K,Tsukada T,Honda M,Nara-Ashizawa N,Noguchi K,Cheng J,Ohkura N,Sasaki K,Yamaguchi K

更新日期：2000-10-25 00:00:00

abstract：:The fish reproductive axis is regulated by many neuroendocrine factors. However, factors involved in the suppression of this axis are largely uncharacterized. In this study, we describe a novel neuropeptide derived from the spexin precursor acting as a negative factor to suppress the reproductive axis in teleost. The ...

journal_title：Molecular and cellular endocrinology

authors： Liu Y,Li S,Qi X,Zhou W,Liu X,Lin H,Zhang Y,Cheng CH

更新日期：2013-07-15 00:00:00

abstract：:The defining characteristic of obesity is increased adipose tissue (AT) mass following chronic positive energy supply. AT mass is determined by adipocyte number and size, which reflect proliferation and differentiation of preadipocytes and hypertrophy of pre-existing adipocytes. The molecular pathways governing AT exp...

journal_title：Molecular and cellular endocrinology

authors： Hutley LJ,Newell FS,Kim YH,Luo X,Widberg CH,Shurety W,Prins JB,Whitehead JP

更新日期：2011-06-06 00:00:00

abstract：:A critical regulatory component of the hypothalamus/pituitary/adrenal axis (HPA) in mammals, reptiles and birds, and in the hypothalamus/pituitary/interrenal (HPI) axis of amphibians and teleosts (modern bony fishes) is the strict ligand selectivity of the melanocortin-2 receptor (MC2R). Tetrapod and teleost MC2R orth...

journal_title：Molecular and cellular endocrinology

authors： Dores RM,Garcia Y

更新日期：2015-06-15 00:00:00

abstract：:Imprinted gene expression in preimplantation development has been extensively studied in the mouse. Different imprinted genes vary in their time of onset of expression and also in the timing and tissue-specificity of mono-allelic expression. We have surveyed a range of imprinted genes for expression, and mono-allelic ...

journal_title：Molecular and cellular endocrinology

authors： Monk M,Salpekar A

更新日期：2001-10-22 00:00:00

abstract：:The so-called calcium antagonist D-600 and agents that enhance the influx of calcium ions into nerve terminals during action potentials (4-aminopyridine, tetraethylammonium, guanidine) interact with alpha-adrenoceptors. The interaction was revealed by binding experiments in vitro with the alpha 2- and alpha 1-specific...

journal_title：Molecular and cellular endocrinology

authors： Glossmann H,Hornung R

更新日期：1980-09-01 00:00:00

abstract：:The mechanisms of cytokine-induced beta-cell death are poorly characterised. In rat insulin-producing RINm5F cells, the combination of interleukin-1beta, interferon-gamma and tumour necrosis factor-alpha presently induced disruption of the mitochondrial membrane potential (Deltapsi(m)) as demonstrated by reduced JC-1 ...

journal_title：Molecular and cellular endocrinology

authors： Barbu A,Welsh N,Saldeen J

更新日期：2002-04-25 00:00:00

abstract：:Luteinized intrasplenic ovarian tumors develop in response to high circulating gonadotropins. The relationship between tumor development, gonadotropins and inhibins was studied. Tumor-bearing animals were sacrificed weekly along the first 6 weeks of development. Inhibins were measured by enzyme-linked immunosorbent as...

journal_title：Molecular and cellular endocrinology

authors： Hockl P,Sorianello E,Chamson-Reig A,Ballerini G,Campo S,Groome N,Lux-Lantos V,Libertun C

更新日期：2003-05-30 00:00:00

abstract：:Interleukin-1 has been shown to contribute to infection-induced inflammatory processes during pregnancy. Prior work from this laboratory has demonstrated that serotonin-induced IL-1alpha also is required for the in-vitro production of collagenase in uterine smooth muscle cells, a normal, non-inflammatory process that ...

journal_title：Molecular and cellular endocrinology

authors： Huang TT,Vinci JM,Lan L,Jeffrey JJ,Wilcox BD

更新日期：1999-06-25 00:00:00

abstract：:Polymerase chain reaction (PCR) amplification of nt 4502 to nt 5184 of the thyroglobulin (Tg) mRNA from several patients, with or without elevated serum thyrotropin (TSH), showed a predominant fragment of the expected size (683 bp) and a minor fragment of 512 bp. The sequence of this minor fragment revealed that 171 b...

journal_title：Molecular and cellular endocrinology

authors： Targovnik HM,Cochaux P,Corach D,Vassart G

更新日期：1992-03-01 00:00:00

abstract：CONTEXT:Apart from 21 Hydroxylase deficiency, other subtypes of congenital adrenal hyperplasia (CAH) are rare. We studied the clinical features and molecular genetics of a relatively large series of patients with CYP17A1, HSD3β2 and StAR deficiencies. PATIENTS AND METHODS:We studied 21 patients including 7 patients wi...

journal_title：Molecular and cellular endocrinology

authors： Alswailem MM,Alzahrani OS,Alhomaidah DS,Alasmari R,Qasem E,Murugan AK,Alsagheir A,Brema I,Abbas BB,Almehthel M,Almeqbali A,Alzahrani AS

更新日期：2018-02-05 00:00:00

abstract：:Four abundant cDNA clones have been isolated from a rat epididymal cDNA library. Northern blot analysis has shown that these clones partially encode 4.5 kb, 2.8 kb, 1.2 kb and 0.85 kb mRNAs and that their expression is not detectable in total RNA preparations from heart, kidney, liver or testis. Fourteen days after ca...

journal_title：Molecular and cellular endocrinology

authors： Walker JE,Jones R,Moore A,Hamilton DW,Hall L

更新日期：1990-11-12 00:00:00

abstract：:Brown fat has been highlight as a new therapeutic target for treatment of obesity and diabetes. However, molecular mechanism underlying brown adipogenesis are not fully understood. Here, we identified that MAP kinase phosphatase 3 (MKP3) has a novel role as regulator of brown adipocyte differentiation. The expression ...

journal_title：Molecular and cellular endocrinology

authors： Kim WK,Oh KJ,Choi HR,Park A,Han BS,Chi SW,Kim SJ,Bae KH,Lee SC

更新日期：2015-11-15 00:00:00

abstract：:TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC); they arise from the fusion of the 3' terminal sequences of the NTRK1/NGF receptor gene with 5' terminal sequences of various activating genes, such as TPM3, TPR and TFG. TRK oncoproteins display constitutive tyrosine-kinase activ...

journal_title：Molecular and cellular endocrinology

authors： Greco A,Miranda C,Pierotti MA

更新日期：2010-05-28 00:00:00

abstract：:The androgen receptor (AR), which mediates androgen action in the cell, belongs to the superfamily of nuclear receptors, a large group of transcription factors. Recent studies have described how the AR acts on specific target genes. The receptor's specificity of action depends on its regulation at different levels: ex...

journal_title：Molecular and cellular endocrinology

authors： Gobinet J,Poujol N,Sultan Ch

更新日期：2002-12-30 00:00:00