Ilex latifolia Thunb protects mice from HFD-induced body weight gain.

abstract：:Recent reports have demonstrated the role of phyto-constituents in modulating inflammatory responses. Mangiferin isolated from Mangifera indica is known to induce potent anti-oxidative, anti-diabetic and anti-inflammatory activity. However, the molecular mechanism of its anti-inflammatory activity is not properly unde...

journal_title：Scientific reports

authors： Bulugonda RK,Kumar KA,Gangappa D,Beeda H,Philip GH,Muralidhara Rao D,Faisal SM

更新日期：2017-02-20 00:00:00

abstract：:Quality assessment of protein models using no other information than the structure of the model itself has been shown to be useful for structure prediction. Here, we introduce two novel methods, ProQRosFA and ProQRosCen, inspired by the state-of-art method ProQ2, but using a completely different description of a prote...

journal_title：Scientific reports

authors： Uziela K,Shu N,Wallner B,Elofsson A

更新日期：2016-10-04 00:00:00

abstract：:Graphene oxide is being used in energy, optical, electronic and sensor devices due to its unique properties. However, unlike its counterpart - graphene - the thermal transport properties of graphene oxide remain unknown. In this work, we use large-scale molecular dynamics simulations with reactive potentials to system...

journal_title：Scientific reports

authors： Mu X,Wu X,Zhang T,Go DB,Luo T

更新日期：2014-01-28 00:00:00

abstract：:α-glucosidase is an essential enzyme located at the brush border of intestines. It is an important therapeutic target for type II diabetes. Herein we have designed a library of novel α-arylketones as inhibitors of α-glucosidase (yeast origin) via scaffold hopping and bioisosteric modification of known inhibitors of α-...

journal_title：Scientific reports

authors： Luthra T,Agarwal R,Estari M,Adepally U,Sen S

更新日期：2017-10-16 00:00:00

abstract：:Most studies examining the relationships between vitamin D and disease or health focus on the main 25-hydroxyvitamin D3 (25(OH)D3) metabolite, thus potentially overlooking contributions and dynamic effects of other vitamin D metabolites, the crucial roles of several of which have been previously demonstrated. The idea...

journal_title：Scientific reports

authors： Müller MJ,Stokes CS,Lammert F,Volmer DA

更新日期：2016-02-11 00:00:00

abstract：:After nearly a century of vaccination and six decades of drug therapy, tuberculosis (TB) kills more people annually than any other infectious disease. Substantial challenges to disease eradication remain among vulnerable and underserved populations. The Guarani-Kaiowá people are an indigenous population in Paraguay an...

journal_title：Scientific reports

authors： Hadi SA,Kolte IV,Brenner EP,Cunha EAT,Simonsen V,Ferrazoli L,Villela DAM,Santos RS,Ravi J,Sreevatsan S,Basta PC

更新日期：2021-01-13 00:00:00

abstract：:Centenarians exhibit extreme longevity and a remarkable compression of morbidity. They have a unique capacity to maintain homeostatic mechanisms. Since small non-coding RNAs (including microRNAs) are implicated in the regulation of gene expression, we hypothesised that longevity of centenarians may reflect alterations...

journal_title：Scientific reports

authors： Serna E,Gambini J,Borras C,Abdelaziz KM,Belenguer A,Sanchis P,Avellana JA,Rodriguez-Mañas L,Viña J

更新日期：2012-01-01 00:00:00

abstract：:Phosphorus (P) is a non-renewable resource which may be depleted within next few decades; hence high P use efficiency is need of time. Plants have evolved an array of adaptive mechanisms to enhance external P acquisition and reprioritize internal utilization under P deficiency. Tissue specific biomass and P allocation...

journal_title：Scientific reports

authors： Irfan M,Aziz T,Maqsood MA,Bilal HM,Siddique KHM,Xu M

更新日期：2020-03-09 00:00:00

abstract：ABTRACT:Establishing a cure for HIV is hindered by the persistence of latently infected cells which constitute the viral reservoir. Real-time qPCR, used for quantification of this reservoir by measuring HIV DNA, requires external calibration; a common choice of calibrator is the 8E5 cell line, which is assumed to be st...

journal_title：Scientific reports

authors： Busby E,Whale AS,Ferns RB,Grant PR,Morley G,Campbell J,Foy CA,Nastouli E,Huggett JF,Garson JA

更新日期：2017-04-26 00:00:00

abstract：:Neonatal hypoxic-ischaemic (HI) encephalopathy is among the most serious complications in neonatology. In the present study, we studied the immediate (0 hour), subacute (36 hours) and late (144 hours) responses of the neonatal brain to experimental HI insult in laboratory rats. At the striatal level, the mass spectrom...

journal_title：Scientific reports

authors： Luptakova D,Baciak L,Pluhacek T,Skriba A,Sediva B,Havlicek V,Juranek I

更新日期：2018-05-03 00:00:00

abstract：:In a single glass of champagne about a million bubbles nucleate on the wall and rise towards the surface. When these bubbles reach the surface and rupture, they project a multitude of tiny droplets in the form of a particular aerosol holding a concentrate of wine aromas. Based on the model experiment of a single bubbl...

journal_title：Scientific reports

authors： Ghabache E,Liger-Belair G,Antkowiak A,Séon T

更新日期：2016-04-29 00:00:00

abstract：:An image fiber-based miniature suspended solid sensor has been demonstrated. The diameter of the sensor is only a few millimeters. A superhydrophobic material is coated on the end of the image fiber to avoid the adsorption of suspended solids and bubbles. Multiple parameters, including mass concentration, morphology a...

journal_title：Scientific reports

authors： Qi P,Lin L,Huang R,Zhao S,Tian H,Li S,Zhang Q,Liu W

更新日期：2017-12-01 00:00:00

abstract：:The ability to induce reversible phase transitions between homogeneous solutions and biphasic liquid-liquid systems, at pre-defined and suitable operating temperatures, is of crucial relevance in the design of separation processes. Ionic-liquid-based aqueous biphasic systems (IL-based ABS) have demonstrated superior p...

journal_title：Scientific reports

authors： Passos H,Luís A,Coutinho JA,Freire MG

更新日期：2016-02-04 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Uranga RM,Millán C,Barahona MJ,Recabal A,Salgado M,Martinez F,Ordenes P,Elizondo-Vega R,Sepúlveda F,Uribe E,García-Robles MLÁ

更新日期：2019-08-28 00:00:00

abstract：:Asymmetric cell divisions are required for cellular diversity and defects can lead to altered daughter cell fates and numbers. In a genetic screen for C. elegans mutants with defects in dopaminergic head neuron specification or differentiation, we isolated a new allele of the transcription factor HAM-1 [HSN (Hermaphro...

journal_title：Scientific reports

authors： Offenburger SL,Bensaddek D,Murillo AB,Lamond AI,Gartner A

更新日期：2017-06-28 00:00:00

abstract：:HIV-1 Tat protein is released from HIV-1-infected cells and can enter non-permissive cells including neurons. Tat disrupts neuronal homeostasis and may contribute to the neuropathogenesis in people living with HIV (PLWH). The use of cocaine by PLWH exacerbates neuronal dysfunction. Here, we examined the mechanisms by ...

journal_title：Scientific reports

authors： Mohseni Ahooyi T,Shekarabi M,Torkzaban B,Langford TD,Burdo TH,Gordon J,Datta PK,Amini S,Khalili K

更新日期：2018-11-02 00:00:00

abstract：:The blood brain barrier (BBB) is often an insurmountable obstacle for a large number of candidate drugs, including peptides, antibiotics, and chemotherapeutic agents. Devising an adroit delivery method to cross the BBB is essential to unlocking widespread application of peptide therapeutics. Presented here is an engin...

journal_title：Scientific reports

authors： Anand P,O'Neil A,Lin E,Douglas T,Holford M

更新日期：2015-08-03 00:00:00

abstract：:We address the impact of the spin-orbit (SO) coupling on the localization-delocalization-transition (LDT) in a spin-orbit coupled Bose-Einstein condensate in a bichromatic potential. We find that SO coupling significantly alters the threshold depth of the one of sublattices above which the lowest eigenstates transform...

journal_title：Scientific reports

authors： Li C,Ye F,Kartashov YV,Konotop VV,Chen X

更新日期：2016-08-17 00:00:00

abstract：:Although semantic processing has traditionally been associated with brain responses maximal at 350-400 ms, recent studies reported that words of different semantic types elicit topographically distinct brain responses substantially earlier, at 100-200 ms. These earlier responses have, however, been achieved using insu...

journal_title：Scientific reports

authors： Moseley RL,Pulvermüller F,Shtyrov Y

更新日期：2013-01-01 00:00:00

abstract：:Duchenne muscular dystrophy, one of the most common lethal genetic disorders, is caused by mutations in the DMD gene and a lack of dystrophin protein. In most DMD patients and animal models, sporadic dystrophin-positive muscle fibres, called revertant fibres (RFs), are observed in otherwise dystrophin-negative backgro...

journal_title：Scientific reports

authors： Rodrigues M,Echigoya Y,Maruyama R,Lim KR,Fukada SI,Yokota T

更新日期：2016-12-07 00:00:00

abstract：:This study aimed to evaluate the effect of brain atrophy on the functional outcome of patients with moderate-volume basal ganglia hemorrhage. Of 1003 patients with spontaneous intracerebral hemorrhage, 124 with moderate-volume basal ganglia hemorrhage (hematoma volume of 20-50 mL) were enrolled. The intercaudate dista...

journal_title：Scientific reports

authors： Kwon SM,Choi KS,Yi HJ,Ko Y,Kim YS,Bak KH,Chun HJ,Lee YJ,Lee JY

更新日期：2018-03-19 00:00:00

abstract：:The Edinburgh Postnatal Depression Scale (EPDS) is frequently used to screen for postpartum depression. However, its factor structure exhibits noticeable inconsistencies between studies. We examined the EPDS at two postpartum time points using a large dataset from outside Western countries. Participants were 91,063 mo...

journal_title：Scientific reports

authors： Matsumura K,Hamazaki K,Tsuchida A,Kasamatsu H,Inadera H,Japan Environment and Children’s Study (JECS) Group.

更新日期：2020-07-15 00:00:00

abstract：:Vaginal delivery with obstetrical trauma is a risk factor for pelvic organ prolapse later in life. Loss of fibulin-5 (FBLN5), an elastogenesis-promoting cellular matrix protein, results in prolapse in mice. Here, we evaluated effects of pregnancy, parturition, and obstetrical injury on FBLN5 content, elastic fibers, b...

journal_title：Scientific reports

authors： Hamner J,Florian-Rodriguez M,Acevedo J,Shi H,Word RA

更新日期：2020-04-14 00:00:00

abstract：:Glassy carbon electrode (GCE) was modified with metal oxides (MO = Fe3O4, ZnO) nanoparticles doped phthalocyanine (Pc) and functionalized MWCNTs, and the electrocatalytic properties were studied. Successful synthesis of the metal oxide nanoparticles and the MO/Pc/MWCNT composite were confirmed using FTIR, Raman and SE...

journal_title：Scientific reports

authors： Mphuthi NG,Adekunle AS,Ebenso EE

更新日期：2016-06-01 00:00:00

abstract：:Late embryogenesis abundant (LEA) proteins are a large and highly diverse gene family present in a wide range of plant species. LEAs are proposed to play a role in various stress tolerance responses. Our study represents the first-ever survey of LEA proteins and their encoding genes in a widely distributed pine (Pinus...

journal_title：Scientific reports

authors： Gao J,Lan T

更新日期：2016-01-19 00:00:00

abstract：:Large (>10 kb) palindromic sequences are enriched on mammalian sex chromosomes. In mice, these palindromes harbor gene families (≥2 gene copies) expressed exclusively in post-meiotic testicular germ cells, a time when most single-copy sex-linked genes are transcriptionally repressed. This observation led to the hypoth...

journal_title：Scientific reports

authors： Kruger AN,Ellison Q,Brogley MA,Gerlinger ER,Mueller JL

更新日期：2018-06-12 00:00:00

abstract：:Cardiac magnetic resonance (CMR) has emerged as a powerful tool for in vivo assessments of cardiac parameters in experimental animal models of cardiovascular diseases, but its reproducibility in this setting remains poorly explored. To address this issue, we investigated the test-retest reproducibility of preclinical ...

journal_title：Scientific reports

authors： Joubert M,Tager P,Legallois D,Defourneaux E,Le Guellec B,Gerber B,Morello R,Manrique A

更新日期：2017-07-27 00:00:00

abstract：:We estimated the prevalence of anemia among school children and investigated factors associated with this problem in Kuwait. A cross-sectional study was conducted on 1415 adolescents randomly selected from middle schools in Kuwait. Hemoglobin, iron, ferritin, folate and vitamin B12, in addition to many other laborator...

journal_title：Scientific reports

authors： Shaban L,Al-Taiar A,Rahman A,Al-Sabah R,Mojiminiyi O

更新日期：2020-04-03 00:00:00

abstract：:Tuberculosis, a severe infectious disease caused by the Mycobacterium tuberculosis, arouses huge concerns globally. In this study, a total of 331,594 TB cases in Zhejiang Province were notified during the period of 2009-2018 with the gender ratio of male to female 2.16:1. The notified TB incidences demonstrated a cont...

journal_title：Scientific reports

authors： Liu K,Li T,Vongpradith A,Wang F,Peng Y,Wang W,Chai C,Chen S,Zhang Y,Zhou L,Chen X,Bian Q,Chen B,Wang X,Jiang J

更新日期：2020-05-04 00:00:00

abstract：:Prenylated indole diketopiperazine (DKP) alkaloids are important bioactive molecules or their precursors. In the context of synthetic biology, efficient means for their biological production would increase their chemical diversification and the discovery of novel bioactive compounds. Here, we prove the suitability of ...

journal_title：Scientific reports

authors： Dubois P,Correia I,Le Chevalier F,Dubois S,Jacques I,Canu N,Moutiez M,Thai R,Gondry M,Lequin O,Belin P

更新日期：2019-06-25 00:00:00