Tailored delivery of analgesic ziconotide across a blood brain barrier model using viral nanocontainers.

abstract：:Several MRI contrast agent clinical formulations are now known to leave deposits of the heavy metal gadolinium in the brain, bones, and other organs of patients. This persistent biological accumulation of gadolinium has been recently recognized as a deleterious outcome in patients administered Gd-based contrast agents...

journal_title：Scientific reports

authors： Rees JA,Deblonde GJ,An DD,Ansoborlo C,Gauny SS,Abergel RJ

更新日期：2018-03-13 00:00:00

abstract：:Carbonic anhydrase plays a key role in CO2 transport, acid-base and ion regulation and metabolic processes in vertebrates. While several carbonic anhydrase isoforms have been identified in numerous vertebrate species, basal lineages such as the cyclostomes have remained largely unexamined. Here we investigate the repe...

journal_title：Scientific reports

authors： Ferreira-Martins D,McCormick SD,Campos A,Lopes-Marques M,Osório H,Coimbra J,Castro LF,Wilson JM

更新日期：2016-10-05 00:00:00

abstract：:We analyze a transition from single peaked to bimodal velocity distribution in a relativistic fluid under increasing temperature, in contrast with a non-relativistic gas, where only a monotonic broadening of the bell-shaped distribution is observed. Such transition results from the interplay between the raise in therm...

journal_title：Scientific reports

authors： Mendoza M,Araújo NA,Succi S,Herrmann HJ

更新日期：2012-01-01 00:00:00

abstract：:In applications involving large tissue specimens that have been sectioned into smaller tissue fragments, manual reconstruction of a "pseudo whole-mount" histological section (PWMHS) can facilitate (a) pathological disease annotation, and (b) image registration and correlation with radiological images. We have previous...

journal_title：Scientific reports

authors： Penzias G,Janowczyk A,Singanamalli A,Rusu M,Shih N,Feldman M,Stricker PD,Delprado W,Tiwari S,Böhm M,Haynes AM,Ponsky L,Viswanath S,Madabhushi A

更新日期：2016-07-26 00:00:00

abstract：:Fatigue is a very common non-motor symptom in Parkinson disease (PD) patients. It included physical fatigue and mental fatigue. The potential mechanisms of mental fatigue involving serotonergic dysfunction and abnormal iron metabolism are still unknown. Therefore, we evaluated the fatigue symptoms, classified PD patie...

journal_title：Scientific reports

authors： Zuo LJ,Yu SY,Hu Y,Wang F,Piao YS,Lian TH,Yu QJ,Wang RD,Li LX,Guo P,Du Y,Zhu RY,Jin Z,Wang YJ,Wang XM,Chan P,Chen SD,Wang YJ,Zhang W

更新日期：2016-12-21 00:00:00

abstract：:Quantification of cellular antigens and their interactions via antibody-based detection methods are widely used in scientific research. Accurate high-throughput quantitation of these assays using general image analysis software can be time consuming and challenging, particularly when attempted by users with limited im...

journal_title：Scientific reports

authors： Law AMK,Yin JXM,Castillo L,Young AIJ,Piggin C,Rogers S,Caldon CE,Burgess A,Millar EKA,O'Toole SA,Gallego-Ortega D,Ormandy CJ,Oakes SR

更新日期：2017-11-16 00:00:00

abstract：:After Alzheimer, Parkinson's disease (PD) is the second most common neurodegenerative disorder. Alpha synuclein (SNCA) is deemed as a major component of Lewy bodies, a neuropathological feature of PD. Five point mutations in SNCA have been reported so far, responsible for autosomal dominant PD. This study aims to deci...

journal_title：Scientific reports

authors： Siddiqui IJ,Pervaiz N,Abbasi AA

更新日期：2016-04-15 00:00:00

abstract：:Sarcopenia is an aging condition involving low muscle mass and function. Fetuin-A (FetA) appears to be a factor for body composition remodeling. We hypothesized that age increases FetA levels and deteriorates the myocardial function by affecting diastolic function, especially in people with sarcopenia. We enrolled 541...

journal_title：Scientific reports

authors： Chang WT,Tsai WC,Wu CH,Lee YW,Tai YL,Li YH,Tsai LM,Chen JH,Liu PY

更新日期：2015-07-10 00:00:00

abstract：:A two step excitation scheme in hot atomic sodium vapor is experimentally investigated. The observed effects reflect a coupling between the 32S, 32P and the 32D states. We present the relative dependence on detuning of the two utilized lasers around λ = 589 nm and 819 nm. Unlike expected, we achieve a higher detuning ...

journal_title：Scientific reports

authors： Docters B,Wrachtrup J,Gerhardt I

更新日期：2017-09-18 00:00:00

abstract：:Rheumatoid arthritis (RA) patients have been observed to be at a lower risk of developing Alzheimer's Disease (AD). Clinical trials have showed no relationship between nonsteroidal anti-inflammatory drug (NSAID) use and AD. The aim of this study was to establish if there is a causal link between RA and AD. A systemati...

journal_title：Scientific reports

authors： Policicchio S,Ahmad AN,Powell JF,Proitsi P

更新日期：2017-10-09 00:00:00

abstract：:Acute kidney injury (AKI) in patients with septic shock is associated with high mortality, but the appropriate timing for initiating continuous renal replacement therapy (CRRT) is controversial. We retrospectively enrolled 158 septic shock patients with AKI in the medical intensive care unit (ICU) from July 2016 to Ap...

journal_title：Scientific reports

authors： Yoon BR,Leem AY,Park MS,Kim YS,Chung KS

更新日期：2019-08-19 00:00:00

abstract：:There is a lack of evidence that either conventional observational rating scale or biomechanical system is a better tremor assessment tool. This work focuses on comparing a biomechanical system and the Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale in terms of test-retest ...

journal_title：Scientific reports

authors： Chan PY,Mohd Ripin Z,Abdul Halim S,Kamarudin MI,Ng KS,Eow GB,Tan K,Cheah CF,Then L,Soong N,Hor JY,Yahya AS,Arifin WN,Tharakan J,Mustapha M

更新日期：2019-05-31 00:00:00

abstract：:The association between choline uptake and androgen receptor (AR) expression is suggested by the upregulation of choline kinase-alpha in prostate cancer. Recently, detection of AR aberration in cell-free DNA as well as early 18F-fluorocholine positron emission tomography/computed tomography (FCH-PET/CT) were associate...

journal_title：Scientific reports

authors： Conteduca V,Scarpi E,Caroli P,Salvi S,Lolli C,Burgio SL,Menna C,Schepisi G,Testoni S,Gurioli G,Paganelli G,Casadio V,Matteucci F,De Giorgi U

更新日期：2017-11-14 00:00:00

abstract：:Evaluating and tuning the properties of two-dimensional (2D) materials is a major focus of advancing 2D science and technology. While many claim that the photonic properties of a 2D layer provide evidence that the material is "high quality", this may not be true for electronic performance. In this work, we deconvolute...

journal_title：Scientific reports

authors： Zhang K,Borys NJ,Bersch BM,Bhimanapati GR,Xu K,Wang B,Wang K,Labella M,Williams TA,Haque MA,Barnard ES,Fullerton-Shirey S,Schuck PJ,Robinson JA

更新日期：2017-12-05 00:00:00

abstract：:Despite improvements in systemic therapy options for renal cancer, it remains one of the most drug-resistant malignancies. Interestingly, reports have shown that kahweol and cafestol, natural diterpenes extracted from coffee beans, exhibit anti-cancer activity. However, the multiple potential pharmacological actions o...

journal_title：Scientific reports

authors： Makino T,Izumi K,Hiratsuka K,Kano H,Shimada T,Nakano T,Kadomoto S,Naito R,Iwamoto H,Yaegashi H,Shigehara K,Kadono Y,Nakata H,Saito Y,Nakagawa-Goto K,Sakai N,Iwata Y,Wada T,Mizokami A

更新日期：2021-01-12 00:00:00

abstract：:The surfactant and colloidal nanoparticles has been considered for various applications because of interaction of both complex mixtures. The hydrophilic SiO2 nanoparticle could not be surface active behavior at the liquid/air interface. In this study, the SiO2 nanoparticles have been modified with 3-isocyanatopropyltr...

journal_title：Scientific reports

authors： Choi M,Choi WK,Jung CH,Kim SB

更新日期：2020-11-10 00:00:00

abstract：:Growth in salmon aquaculture over the past two decades has raised concerns regarding the potential impacts of the industry on neighboring ecosystems and wild fish productivity. Despite limited evidence, sea lice have been identified as a major cause for the decline in some wild Pacific salmon populations on the west c...

journal_title：Scientific reports

authors： Nekouei O,Vanderstichel R,Thakur K,Arriagada G,Patanasatienkul T,Whittaker P,Milligan B,Stewardson L,Revie CW

更新日期：2018-03-05 00:00:00

abstract：:Gaussia luciferase (GLuc) is a small luciferase (18.2 kDa; 168 residues) and is thus attracting much attention as a reporter protein, but the lack of structural information is hampering further application. Here, we report the first solution structure of a fully active, recombinant GLuc determined by heteronuclear mul...

journal_title：Scientific reports

authors： Wu N,Kobayashi N,Tsuda K,Unzai S,Saotome T,Kuroda Y,Yamazaki T

更新日期：2020-11-18 00:00:00

abstract：:In this paper, the effects of random errors on the oscillating behaviors have been studied theoretically and numerically in a prototypical coupled nonlinear oscillator. Two kinds of noises have been employed respectively to represent the measurement errors accompanied with the parameter specifying the distance from a ...

journal_title：Scientific reports

authors： Sun Z,Ma N,Xu W

更新日期：2017-02-15 00:00:00

abstract：:Previously, we cloned a new gene termed 'tongue cancer resistance-associated protein 1' (TCRP1), which modulates tumorigenesis, enhances cisplatin (cDDP) resistance in cancers, and may be a potential target for reversing drug resistance. However, the mechanisms for regulating TCRP1 expression remain unclear. Herein, w...

journal_title：Scientific reports

authors： Jia X,Zhang Z,Luo K,Zheng G,Lu M,Song Y,Liu H,Qiu H,He Z

更新日期：2017-06-16 00:00:00

abstract：:Extreme differences between the sexes are usually explained by intense sexual selection on male weapons or ornaments. Sexually antagonistic genes, with a positive effect on male traits but a negative effect on female fitness, create a negative inter-sexual correlation for fitness (sexual conflict). However, such antag...

journal_title：Scientific reports

authors： Buzatto BA,Clark HL

更新日期：2020-02-11 00:00:00

abstract：:Changes in immune and coagulation systems and possible viral spread through the blood-brain barrier have been described in SARS-CoV-2 infection. In this study, we evaluated the possible retinal involvement and ocular findings in severe COVID-19 pneumonia patients. A cross-sectional study was conducted on 46 patients a...

journal_title：Scientific reports

authors： Pirraglia MP,Ceccarelli G,Cerini A,Visioli G,d'Ettorre G,Mastroianni CM,Pugliese F,Lambiase A,Gharbiya M

更新日期：2020-10-15 00:00:00

abstract：:The absorption spectra in array of Ge, Al and Ge/Al-shell nanoparticles immersed in alumina (Al2O3) matrix is calculated in framework of ab initio macroscopic dielectric model. It is demonstrated that absorption is strongly enhanced when germanium nanospheres are encapsulated by Al-shell. Two absorption peaks, appeari...

journal_title：Scientific reports

authors： Despoja V,Basioli L,Parramon JS,Mičetić M

更新日期：2020-01-09 00:00:00

abstract：:Organometallic trihalide perovskites are promising materials for photovoltaic applications, which have demonstrated a rapid rise in photovoltaic performance in a short period of time. We report a facile one-step method to fabricate planar heterojunction perovskite solar cells by chemical vapor deposition (CVD), with a...

journal_title：Scientific reports

authors： Tavakoli MM,Gu L,Gao Y,Reckmeier C,He J,Rogach AL,Yao Y,Fan Z

更新日期：2015-09-22 00:00:00

abstract：:Spatially-resolved neutron powder diffraction with a gauge volume of 2 × 2 × 20 mm(3) has been applied as an in situ method to probe the lithium concentration in the graphite anode of different Li-ion cells of 18650-type in charged state. Structural studies performed in combination with electrochemical measurements an...

journal_title：Scientific reports

authors： Senyshyn A,Mühlbauer MJ,Dolotko O,Hofmann M,Ehrenberg H

更新日期：2015-12-18 00:00:00

abstract：:The present study aimed to determine the effect of thyroid hormone dysfunction on brown adipose tissue activity and white adipose tissue browning in mice. Twenty randomized female C57BL/6NTac mice per treatment group housed at room temperature were rendered hypothyroid or hyperthyroid. In-vivo small animal 18F-FDG PET...

journal_title：Scientific reports

authors： Weiner J,Kranz M,Klöting N,Kunath A,Steinhoff K,Rijntjes E,Köhrle J,Zeisig V,Hankir M,Gebhardt C,Deuther-Conrad W,Heiker JT,Kralisch S,Stumvoll M,Blüher M,Sabri O,Hesse S,Brust P,Tönjes A,Krause K

更新日期：2016-12-12 00:00:00

abstract：:Lysine-specific demethylase 1 (LSD1) is a histone demethylase that participates in transcriptional repression or activation. Recent studies reported that LSD1 is involved in learning and memory. Although LSD1 phosphorylation by PKCα was implicated in circadian rhythmicity, the importance of LSD1 phosphorylation in lea...

journal_title：Scientific reports

authors： Lim CS,Nam HJ,Lee J,Kim D,Choi JE,Kang SJ,Kim S,Kim H,Kwak C,Shim KW,Kim S,Ko HG,Lee RU,Jang EH,Yoo J,Shim J,Islam MA,Lee YS,Lee JH,Baek SH,Kaang BK

更新日期：2017-07-07 00:00:00

abstract：:The quantification of hepatitis C virus (HCV) is essential for the management of chronic hepatitis C therapy. We have developed a fully automated microfluidic RT-qPCR system for rapid quantitative detection of HCV RNA in human EDTA-plasma and serum, and the performance of the method was assessed. The platform for the ...

journal_title：Scientific reports

authors： Chan SDH,Toyoda H,Sanjeeviraman J,Souppe A,Iwamoto M,Wu W,Eto D,Tada T,Kumada T,Zhang JP

更新日期：2020-04-30 00:00:00

abstract：:A tool to predict peritonitis-associated treatment failure among peritoneal dialysis (PD) patients has not yet been established. We conducted a multicentre, retrospective cohort study among 1,025 PD patients between 2006 and 2016 in Thailand to develop and internally validate such a tool. Treatment failure was defined...

journal_title：Scientific reports

authors： Nochaiwong S,Ruengorn C,Koyratkoson K,Thavorn K,Awiphan R,Chaisai C,Phatthanasobhon S,Noppakun K,Suteeka Y,Panyathong S,Dandecha P,Chongruksut W,Nanta S,Thai Renal Outcomes Research (THOR) Investigators.

更新日期：2018-10-04 00:00:00

abstract：:Gallbladder cancer (GBC) is a highly malignant tumor with poorly understood etiology. An insight into phenotypic features of this malignancy may add to the knowledge of its carcinogenesis and pave the way to new therapeutic approaches. We assessed the expression of female sex hormone receptors (ERα, ERβ, PR), connecti...

journal_title：Scientific reports

authors： Hryciuk B,Pęksa R,Bieńkowski M,Szymanowski B,Radecka B,Winnik K,Żok J,Cichowska N,Iliszko M,Duchnowska R

更新日期：2020-02-05 00:00:00