Abstract:
Introduction:Infantile tremor syndrome (ITS) is characterized by anaemia, skin depigmentation, tremors and developmental delay. The lack of sufficient literature on ITS and its conflicting association with vitamin B12 deficiency made us present this article. Objective:The objective of this study is to describe demographic, clinical and laboratory profile and outcome of ITS. Methods:This is a retrospective chart review of all children presenting with typical features of ITS attending a tertiary paediatric centre in southern India between January 2014 and January 2017. All children with pallor, skin depigmentation and developmental delay, with/without tremors, were included. Anaemia, developmental delay and tremors secondary to non-nutritional causes like metabolic causes were excluded. Results:Of 70 children, 66 were exclusively breastfed and 46 mothers were vegetarians. Mean age of presentation was 13.2 months. Developmental delay was noted in 64, regression in 6 and tremors in 40. Vitamin B12 levels were low in 62 cases. Conclusion:ITS should be considered in children <3 years with anaemia, developmental delay/regression and skin depigmentation, with/without tremors. ITS can be seen in < 3 months of age and in high socio-economic status.
journal_name
J Trop Pediatrjournal_title
Journal of tropical pediatricsauthors
Gowda VK,Kolli V,Benakappa A,Srinivasan VM,Shivappa SK,Benakappa Ndoi
10.1093/tropej/fmx062subject
Has Abstractpub_date
2018-08-01 00:00:00pages
284-288issue
4eissn
0142-6338issn
1465-3664pii
4049588journal_volume
64pub_type
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