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Angiopoietin-1 and endostatin levels in cord plasma predict the development of bronchopulmonary dysplasia in preterm infants.

Abstract：

OBJECTIVE:To determine whether angiopoietin-1 and endostatin levels in the cord blood could predict the subsequent development of bronchopulmonary dysplasia (BPD) in preterm infants. PATIENTS AND METHODS:A total of 102 preterm (gestational age ≤ 32 weeks) infants (28 infants developed BPD and 74 had no BPD) were enrolled in the study. Cord plasma levels of angiopoietin-1 and endostatin were measured by enzyme-linked immunosorbent assay. RESULTS:Preterm infants who subsequently developed BPD had significantly lower cord plasma levels of angiopoietin-1 than those who did not (p < 0.001). Our results showed that cord plasma levels of endostatin were significantly higher in infants with BPD than in those without (p < 0.001). In infants with BPD, angiopoietin-1 levels in cord plasma correlated negatively with endostatin (r = -0.48; p = 0.008). CONCLUSION:In preterm infants, low-angiopoietin-1 and high-endostatin levels in cord plasma at birth predict the subsequent development of BPD.

journal_name

J Trop Pediatr

journal_title

Journal of tropical pediatrics

authors

Mohamed WA,Niyazy WH,Mahfouz AA

doi

10.1093/tropej/fmq112

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

385-8

issue

5

eissn

0142-6338

issn

1465-3664

pii

fmq112

journal_volume

57

pub_type

临床试验,杂志文章

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