Expression of Thy-1 antigen in reactive endoneurial capillaries of the rat following peripheral nerve damage.

abstract：:Oligodendrocyte progenitors, originating in the ventral ventricular zone of the embryonic rodent spinal cord, migrate and differentiate into the oligodendrocytes myelinating the future white matter. Transcripts for the dm-20 isoform of the proteolipid protein (plp) gene are detectable initially in cells of the ventral...

journal_title：Neuropathology and applied neurobiology

authors： Dickinson PJ,Fanarraga ML,Griffiths IR,Barrie JM,Kyriakides E,Montague P

更新日期：1996-06-01 00:00:00

abstract：:Damage to the frontal cortex and to the hippocampus, both in terms of cell loss and neuronal dysfunction, is thought to underlie many of the neurological and behavioural consequences of traumatic brain injury (TBI). Several studies have indicated that the hippocampus is particularly susceptible to central nervous syst...

journal_title：Neuropathology and applied neurobiology

authors： Rall JM,Matzilevich DA,Dash PK

更新日期：2003-04-01 00:00:00

abstract：:Tubular vesicular and net-like dissolution of myelin sheaths associated with complete demyelination and preservation of axons, is described in the brain, obtained within 4 h of death, from a patient who died with acute multiple sclerosis (MS). It was rare, being found in only three out of twenty-three blocks examined,...

journal_title：Neuropathology and applied neurobiology

authors： Kirk J

更新日期：1979-08-01 00:00:00

abstract：:Ten minutes of total cerebral ischaemia was produced in normo- and hypoglycaemic rats. The most conspicuous findings were loss of hippocampal (CA-1) pyramidal cells and Purkinje cells, which were most pronounced in the normoglycaemic rats. While pre-ischaemic hypoglycaemia to some extent protected these cells, it led ...

journal_title：Neuropathology and applied neurobiology

authors： Diemer NH,Siemkowicz E

更新日期：1981-05-01 00:00:00

abstract：:Sclerosing meningioma is a rare morphologic subtype of meningioma and may be mistaken for atypical or malignant meningioma and astrocytoma or schwannoma because of marked collagen deposits and a sparse population of cells with little resemblance to meningothelial cells. Authors describe the histopathologic and immunop...

journal_title：Neuropathology and applied neurobiology

authors： Kim NR,Im SH,Chung CK,Suh YL,Choe G,Chi JG

更新日期：2004-04-01 00:00:00

abstract：AIMS:To explore alterations in the expression of genes encoding enzymes involved in purine metabolism in Parkinson's disease (PD) brains as purines are the core of the DNA, RNA, nucleosides and nucleotides which participate in a wide variety of crucial metabolic pathways. METHODS:Analysis of mRNA using real-time quant...

journal_title：Neuropathology and applied neurobiology

authors： Garcia-Esparcia P,Hernández-Ortega K,Ansoleaga B,Carmona M,Ferrer I

更新日期：2015-12-01 00:00:00

abstract：:The brain is vulnerable to a number of acute insults, with traumatic brain injury being among the commonest. Neuroinflammation is a common response to acute injury and microglial activation is a key component of the inflammatory response. In the acute and subacute phase it is likely that this response is protective an...

journal_title：Neuropathology and applied neurobiology

authors： Smith C

更新日期：2013-02-01 00:00:00

abstract：:Neuronal loss is often quoted as an element of the pathology of the transmissible spongiform encephalopathies, but few data are published. To determine whether neuronal loss is a salient feature of murine scrapie, and whether there is a relationship with the other hallmark lesions of scrapie we compared the numbers of...

journal_title：Neuropathology and applied neurobiology

authors： Jeffrey M,Fraser JR,Halliday WG,Fowler N,Goodsir CM,Brown DA

更新日期：1995-02-01 00:00:00

abstract：:CADASIL (Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is a type of small-artery stroke and vascular dementia-inducing pathology of the brain. In order to explain the molecular mechanisms behind the alterations to the blood vessels in CADASIL subjects, we scrutinized the e...

journal_title：Neuropathology and applied neurobiology

authors： Brulin-Fardoux P,Godfrain C,Maurage CA,De Reuck J,Hauw JJ,Kaltner H,Bovin NV,Gabius HJ,Ruchoux MM,Kiss R,Camby I

更新日期：2003-08-01 00:00:00

abstract：:A few nanograms of tetanus toxin injected into a rat hippocampus causes a chronic epileptic syndrome characterized by brief seizures that recur intermittently for about 6 weeks. Cognitive and other behavioural impairments persist after the seizures and other epileptic electrographic activity have remitted, and may be ...

journal_title：Neuropathology and applied neurobiology

authors： Jefferys JG,Evans BJ,Hughes SA,Williams SF

更新日期：1992-02-01 00:00:00

abstract：AIMS:Cytoplasmic accumulation of the nuclear protein transactive response DNA-binding protein 43 (TDP-43) is an early determinant of motor neuron degeneration in most amyotrophic lateral sclerosis (ALS) cases. We previously disclosed this accumulation in circulating lymphomonocytes (CLM) of ALS patients with mutant TAR...

journal_title：Neuropathology and applied neurobiology

authors： De Marco G,Lomartire A,Calvo A,Risso A,De Luca E,Mostert M,Mandrioli J,Caponnetto C,Borghero G,Manera U,Canosa A,Moglia C,Restagno G,Fini N,Tarella C,Giordana MT,Rinaudo MT,Chiò A

更新日期：2017-02-01 00:00:00

abstract：AIM:Levels of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) are robustly increased in spinal muscular atrophy (SMA) patient fibroblasts and mouse models. We therefore wanted to establish whether changes in UCHL1 contribute directly to disease pathogenesis, and to assess whether pharmacological inhibition of UCHL1 re...

journal_title：Neuropathology and applied neurobiology

authors： Powis RA,Mutsaers CA,Wishart TM,Hunter G,Wirth B,Gillingwater TH

更新日期：2014-12-01 00:00:00

abstract：:Rats were given 2,5-hexanediol in their water for more than 5 weeks. The changes in the optic pathways were studied both qualitatively and quantitatively. Increase in 10-nm filaments within axons was noticeable from 10 days onwards in the superior colliculus and in the brachium of the superior colliculus. From then on...

journal_title：Neuropathology and applied neurobiology

authors： Jones HB,Cavanagh JB

更新日期：1982-07-01 00:00:00

abstract：AIMS:Brain mural cells (BMC), smooth muscle cells and pericytes, interact closely with endothelial cells and modulate numerous cerebrovascular functions. A loss of BMC function is suspected to play a role in the pathophysiology of Alzheimer's Disease (AD). METHODS:BMC markers, namely smooth muscle alpha actin (α-SMA) ...

journal_title：Neuropathology and applied neurobiology

authors： Bourassa P,Tremblay C,Schneider JA,Bennett DA,Calon F

更新日期：2020-08-01 00:00:00

abstract：:The causes of most neurological disorders are not fully understood. Inflammation and blood-brain barrier dysfunction appear to play major roles in the pathology of these diseases. Inflammatory insults that occur during brain development may have widespread effects later in life for a spectrum of neurological disorders...

journal_title：Neuropathology and applied neurobiology

authors： Stolp HB,Dziegielewska KM

更新日期：2009-04-01 00:00:00

abstract：:Two cases of Aspergillus infection of the nervous system are reported. In the first case it occurred in a healthy individual and presented as a space occupying lesion mimicking a tuberculous granuloma. In the second case it was an opportunistic infection in a patient with predisposing conditions and manifested as chro...

journal_title：Neuropathology and applied neurobiology

authors： Diengdoh JV,Barnard RO,Thomas DG

更新日期：1983-11-01 00:00:00

abstract：AIMS:Much evidence demonstrates that Toll-like receptor-4 (TLR4)-mediated microglial activation is an important contributor to the inflammatory injury in intracerebral haemorrhage (ICH). However, the exact mechanism of TLR4-mediated microglial activation induced by ICH is not clear. In addition, microglial autophagy is...

journal_title：Neuropathology and applied neurobiology

authors： Yang Z,Liu B,Zhong L,Shen H,Lin C,Lin L,Zhang N,Yuan B

更新日期：2015-06-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is an angiogenic factor essential for the formation of new blood vessels during embryogenesis and in many pathological conditions. A new role for VEGF as a neurotrophic factor has recently emerged. In the developing nervous system, VEGF plays a pivotal role not only in vascula...

journal_title：Neuropathology and applied neurobiology

authors： Brockington A,Lewis C,Wharton S,Shaw PJ

更新日期：2004-10-01 00:00:00

abstract：:Serial sections of the brains of two cases with Alzheimer's disease were stained with the standard Bodian, modified Bielschowsky (reformed Gros-Schultze's modification) and thioflavin S methods. The numbers of demonstrated Alzheimer's neurofibrillary tangles (NFTs) were different between the two silver stains: from 15...

journal_title：Neuropathology and applied neurobiology

authors： Yamamoto T,Hirano A

更新日期：1986-01-01 00:00:00

abstract：AIMS:post-haemorrhagic ventricular dilatation (PHVD) is a significant problem in neonatal care, with sequelae extending beyond childhood. Its management is important in determining outcome. Although rodent hydrocephalus models have been developed, PHVD, as a specific entity with a distinct pathophysiology, has not been...

journal_title：Neuropathology and applied neurobiology

authors： Aquilina K,Chakkarapani E,Love S,Thoresen M

更新日期：2011-02-01 00:00:00

abstract：AIMS:Granulovacuolar degeneration involves the accumulation of large, double membrane-bound bodies within certain neurones during the course of Alzheimer's disease (AD) and other adult-onset dementias. Because of the two-layer membrane morphology, it has been proposed that the bodies are related to autophagic organelle...

journal_title：Neuropathology and applied neurobiology

authors： Funk KE,Mrak RE,Kuret J

更新日期：2011-04-01 00:00:00

abstract：:Over the last decade, there has been increasing evidence that hyperactivation of the mechanistic target of rapamycin (mTOR) pathway is a hallmark of malformations of cortical development such as focal cortical dysplasia (FCD) or hemimegalencephaly. The mTOR pathway governs protein and lipid synthesis, cell growth and ...

journal_title：Neuropathology and applied neurobiology

authors： Marsan E,Baulac S

更新日期：2018-02-01 00:00:00

abstract：:The development of granule cells and the formation of synapses with mossy fibres were investigated in cerebella from jaundiced (j/j) Gunn rats with hereditary hyperbilirubinemia. The external granular layer was thinner than that in cerebella from heterozygous (+/j) Gunn rats without hyperbilirubinemia on days 12 and 1...

journal_title：Neuropathology and applied neurobiology

authors： Takagishi Y,Yamamura H

更新日期：1993-08-01 00:00:00

abstract：AIMS:Little is known about the immune response of the brain to invasive meningiomas. The present study was based upon the hypothesis that the microglial/macrophagic response towards brain-invasive meningiomas is dependent on the intactness of the pial-glial basement membrane. METHODS:We immunostained sections from 40 ...

journal_title：Neuropathology and applied neurobiology

authors： Grund S,Schittenhelm J,Roser F,Tatagiba M,Mawrin C,Kim YJ,Bornemann A

更新日期：2009-02-01 00:00:00

abstract：AIMS:The purpose of this study was to determine the functional recovery and protein regulation by transplanted induced pluripotent stem cells in a rat model of Huntington's disease (HD). METHODS:In a quinolinic acid-induced rat model of striatal degeneration, induced pluripotent stem cells were transplanted into the i...

journal_title：Neuropathology and applied neurobiology

authors： Mu S,Han L,Zhou G,Mo C,Duan J,He Z,Wang Z,Ren L,Zhang J

更新日期：2016-10-01 00:00:00

abstract：:In a stereological study of the human substantia nigra (SN), the total number of melanin-positive and melanin-negative neurones from 28 male subjects aged 19-92 years was estimated using a uniform sampling design and optical disectors. There was a significant decrease in the total number of melanin-positive neurones a...

journal_title：Neuropathology and applied neurobiology

authors： Cabello CR,Thune JJ,Pakkenberg H,Pakkenberg B

更新日期：2002-08-01 00:00:00

abstract：AIMS:Insufficient oligodendroglial differentiation of oligodendroglial progenitor cells (OPCs) is suggested to be responsible for remyelination failure and astroglial scar formation in Theiler's murine encephalomyelitis (TME). The aim of the present study is to identify molecular key regulators of OPC differentiation i...

journal_title：Neuropathology and applied neurobiology

authors： Sun Y,Lehmbecker A,Kalkuhl A,Deschl U,Sun W,Rohn K,Tzvetanova ID,Nave KA,Baumgärtner W,Ulrich R

更新日期：2015-04-01 00:00:00

abstract：:Mutation of the LRRK2 gene has been associated with autosomal dominant parkinsonism. An R1441C pathogenic substitution was identified in Family D, a large Western Nebraskan kindred, with four members demonstrating pleomorphic pathology at autopsy. One member of this family displayed tau pathology suggestive of progres...

journal_title：Neuropathology and applied neurobiology

authors： Ross OA,Whittle AJ,Cobb SA,Hulihan MM,Lincoln SJ,Toft M,Farrer MJ,Dickson DW

更新日期：2006-02-01 00:00:00

abstract：:Protein aggregation, mitochondrial impairment and oxidative stress are common to multiple neurodegenerative diseases. Homeostasis is regulated by a balanced set of anabolic and catabolic responses, which govern removal and repair of damaged proteins and organelles. Macroautophagy is an evolutionarily conserved pathway...

journal_title：Neuropathology and applied neurobiology

authors： Cherra SJ 3rd,Dagda RK,Chu CT

更新日期：2010-04-01 00:00:00

abstract：:The pattern of cell loss and neuronal degeneration resulting from multiple microinjections of N-methyl-D-aspartate (NMDA), ibotenate (IBO), quisqualate (QUIS), and kainate (KA) into hippocampus was studied, together with the protection provided by the NMDA antagonist 3-(+/-)-2-carboxypiperazin-4-yl-propyl-1-phosphonat...

journal_title：Neuropathology and applied neurobiology

authors： Jarrard LE,Meldrum BS

更新日期：1993-10-01 00:00:00