Abstract:
:Vascular endothelial growth factor (VEGF) is an angiogenic factor essential for the formation of new blood vessels during embryogenesis and in many pathological conditions. A new role for VEGF as a neurotrophic factor has recently emerged. In the developing nervous system, VEGF plays a pivotal role not only in vascularization, but also in neuronal proliferation, and the growth of coordinated vascular and neuronal networks. After injury to the nervous system, activation of VEGF and its receptors may restore blood supply and promote neuronal survival and repair. There is a growing body of evidence that VEGF is essential for motor neurone survival, and that aberrant regulation of VEGF may play a role in the degeneration of neurones in diseases such as amyotrophic lateral sclerosis.
journal_name
Neuropathol Appl Neurobioljournal_title
Neuropathology and applied neurobiologyauthors
Brockington A,Lewis C,Wharton S,Shaw PJdoi
10.1111/j.1365-2990.2004.00600.xkeywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
427-46issue
5eissn
0305-1846issn
1365-2990pii
NAN600journal_volume
30pub_type
杂志文章,评审abstract::There is a great deal of evidence suggesting an important role for systemic inflammation in the pathogenesis of Alzheimer's disease. The role of systemic inflammation, and indeed inflammation in general, is still largely considered to be as a contributor to the disease process rather than of aetiological importance al...
journal_title:Neuropathology and applied neurobiology
pub_type: 杂志文章,评审
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abstract::This paper continues the historical review on the concept of a sensorimotor cortex into the twentieth century. Paul Flechsig was probably the first to accept this concept after the turn of the century. Like Munk, he believed in an almost reflex-like unity between cortical sensory and motor function. With the help of h...
journal_title:Neuropathology and applied neurobiology
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abstract::We have previously demonstrated that amyloid beta (Abeta) peptide is acutely toxic to retinal neurones in vivo and that this toxicity is mediated by an indirect mechanism. We have now extended these studies to look at the chronic effect of intravitreal injection of Abeta peptides on retinal ganglion cells (RGC), the p...
journal_title:Neuropathology and applied neurobiology
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journal_title:Neuropathology and applied neurobiology
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abstract::Immunohistochemical staining of Thy-1 antigen was studied in rat peripheral nerves shortly after a complete crush lesion and after an epineural depot injection of lysophosphatidylcholine-palmitate (lysoPC). The Thy-1 antigen was expressed in endoneurial capillaries after 20-30 h and was visible previous to alterations...
journal_title:Neuropathology and applied neurobiology
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journal_title:Neuropathology and applied neurobiology
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doi:10.1111/nan.12501
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journal_title:Neuropathology and applied neurobiology
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journal_title:Neuropathology and applied neurobiology
pub_type: 杂志文章
doi:10.1111/nan.12252
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journal_title:Neuropathology and applied neurobiology
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更新日期:2003-12-01 00:00:00
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journal_title:Neuropathology and applied neurobiology
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journal_title:Neuropathology and applied neurobiology
pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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journal_title:Neuropathology and applied neurobiology
pub_type: 杂志文章
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更新日期:1994-02-01 00:00:00
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journal_title:Neuropathology and applied neurobiology
pub_type: 杂志文章
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更新日期:1993-10-01 00:00:00
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journal_title:Neuropathology and applied neurobiology
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doi:10.1111/nan.12376
更新日期:2017-06-01 00:00:00
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journal_title:Neuropathology and applied neurobiology
pub_type: 杂志文章
doi:10.1111/nan.12177
更新日期:2015-06-01 00:00:00
abstract::An unusual inherited progressive distal myopathy of early childhood onset is described in two sisters from a consanguineous Asian family. Motor milestones were normal but gait deteriorated slowly thereafter with development of generalized hypotonia and muscle weakness particularly in the wrist extensors and hand muscl...
journal_title:Neuropathology and applied neurobiology
pub_type: 杂志文章
doi:10.1111/j.1365-2990.1989.tb01145.x
更新日期:1989-01-01 00:00:00
abstract::Telomerase is a ribonucleoprotein enzyme complex that synthesizes telomere DNA. It is detected in 85-90% of malignant tumours in humans, but not in most somatic cells. Because telomerase plays a critical role in cell immortality, it represents an important target for anticancer therapies. We have previously shown that...
journal_title:Neuropathology and applied neurobiology
pub_type: 杂志文章
doi:10.1111/j.1365-2990.2006.00776.x
更新日期:2006-12-01 00:00:00
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journal_title:Neuropathology and applied neurobiology
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doi:10.1111/nan.12182
更新日期:2015-06-01 00:00:00
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journal_title:Neuropathology and applied neurobiology
pub_type: 杂志文章
doi:10.1111/j.1365-2990.2007.00854.x
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journal_title:Neuropathology and applied neurobiology
pub_type: 杂志文章,评审
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abstract::Two HIV-positive male patients presented with a variety of symptoms including hemiparesis, unsteadiness, progressive loss of vision and poor memory. There were multiple non-enhancing lesions shown by CT scan in the white matter of the cerebral hemispheres. Specimens obtained by burr-hole biopsy showed the features of ...
journal_title:Neuropathology and applied neurobiology
pub_type: 杂志文章
doi:10.1111/j.1365-2990.1989.tb01242.x
更新日期:1989-09-01 00:00:00
abstract:AIMS:Granulovacuolar degeneration involves the accumulation of large, double membrane-bound bodies within certain neurones during the course of Alzheimer's disease (AD) and other adult-onset dementias. Because of the two-layer membrane morphology, it has been proposed that the bodies are related to autophagic organelle...
journal_title:Neuropathology and applied neurobiology
pub_type: 杂志文章
doi:10.1111/j.1365-2990.2010.01135.x
更新日期:2011-04-01 00:00:00
abstract::During an electron microscopic study of the white matter in multiple sclerosis (MS), spheroidal reticular particles were found both in MS and in control brains. These particles have previously been described in the brain in MS and in brain-derived cell cultures in subacute sclerosing panencephalitis. In both cases the...
journal_title:Neuropathology and applied neurobiology
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doi:10.1111/j.1365-2990.1978.tb01347.x
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abstract::The relationships between the degree of cortical prion protein (PrP) deposition, tissue vacuolation and astrocytosis were studied in the frontal cortex of 27 cases of human spongiform encephalopathy, encompassing 13 cases of sporadic Creutzfeldt-Jakob disease (sCJD), four cases of familial CJD (fCJD) (one owing to E20...
journal_title:Neuropathology and applied neurobiology
pub_type: 杂志文章
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更新日期:2003-10-01 00:00:00
abstract::The curiously consistent localization of cerebellar cortical damage in chronic alcoholism is re-evaluated in the light of selective damage, with a similar topography in the cerebellar vermal region, in superficial siderosis in man and in experimental animals exposed to certain toxic substances. Attention is drawn to t...
journal_title:Neuropathology and applied neurobiology
pub_type: 杂志文章,评审
doi:
更新日期:1997-10-01 00:00:00
abstract::Mutation of the LRRK2 gene has been associated with autosomal dominant parkinsonism. An R1441C pathogenic substitution was identified in Family D, a large Western Nebraskan kindred, with four members demonstrating pleomorphic pathology at autopsy. One member of this family displayed tau pathology suggestive of progres...
journal_title:Neuropathology and applied neurobiology
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doi:10.1111/j.1365-2990.2006.00693.x
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abstract::The tight junction protein occludin 'glues' normal, adjacent brain microvessel endothelial cells together. Malignant brain tumours cause cerebral oedema because they have leaky endothelial tight junctions, which allow plasma fluid to enter the brain from the microvessel lumen. In order to identify molecular abnormalit...
journal_title:Neuropathology and applied neurobiology
pub_type: 杂志文章
doi:10.1046/j.0305-1846.2001.00341.x
更新日期:2001-10-01 00:00:00
abstract::Cell death in gliomas may occur either by apoptosis, or, in the case of high grade tumours, by necrosis, but questions remain as to the pathogenesis and relationship between these processes. The development of cell death was investigated in multicellular glioma spheroid cultures. Spheroids model the development of cel...
journal_title:Neuropathology and applied neurobiology
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doi:10.1046/j.0305-1846.2001.00319.x
更新日期:2001-08-01 00:00:00
abstract:AIMS:Plectin, a universally expressed multi-functional cytolinker protein, is crucial for intermediate filament networking, including crosstalk with actomyosin and microtubules. In addition to its involvement in a number of diseases affecting skin, skeletal muscle, heart, and other stress-exposed tissues, indications f...
journal_title:Neuropathology and applied neurobiology
pub_type: 杂志文章
doi:10.1111/nan.12635
更新日期:2021-02-01 00:00:00
abstract::Human tumour xenografts maintained in nude mice are a valuable research tool. The passaging and maintenance of human tumour xenografts in immune-deficient animals are expensive and labour-intensive. This study presents a protocol that permits long-term cryopreservation of viable glioblastoma xenograft tissue pieces in...
journal_title:Neuropathology and applied neurobiology
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doi:10.1046/j.1365-2990.2000.026002172.x
更新日期:2000-04-01 00:00:00