The fine structure of the CNS in multiple sclerosis. I. Interpretation of cytoplasmic papovavirus-like and paramyxovirus-like inclusions.

abstract：:Two HIV-positive male patients presented with a variety of symptoms including hemiparesis, unsteadiness, progressive loss of vision and poor memory. There were multiple non-enhancing lesions shown by CT scan in the white matter of the cerebral hemispheres. Specimens obtained by burr-hole biopsy showed the features of ...

journal_title：Neuropathology and applied neurobiology

authors： Scaravilli F,Ellis DS,Tovey G,Harcourt-Webster JN,Guiloff RJ,Sinclair E

更新日期：1989-09-01 00:00:00

abstract：:Changes of 5'-nucleotidase (5'-N) activity during subcultivation of C6 clonal rat glioma cells were studied histochemically, cytochemically and biochemically. Two different cell populations were seeded with high or low cell density respectively. 5'-N activity in cultured cells increased continuously in both population...

journal_title：Neuropathology and applied neurobiology

authors： Amano S,Sasahara M,Yamada E,Kataoka H,Hazama F

更新日期：1985-05-01 00:00:00

abstract：:The cellular distribution of the lysosomal proteinase cathepsin D was studied in a series of 76 neoplasms and 18 non-neoplastic tissues from the human central nervous system, using a well-characterized polyclonal antibody in a peroxidase-antiperoxidase technique. In the normal and developing brain, cathepsin D is conf...

journal_title：Neuropathology and applied neurobiology

authors： Robson DK,Ironside JW,Reid WA,Bogue PR

更新日期：1990-02-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) was taken from strain 13 guinea pigs in various stages of chronic relapsing experimental allergic encephalomyelitis, the spinal cords removed for histological examination and meningeal stretch preparations made. CSF cells were counted and characterized by morphological studies, anti-IgG and a...

journal_title：Neuropathology and applied neurobiology

authors： Suckling AJ,Wilson NR,Kirby JA,Rumsby MG

更新日期：1983-05-01 00:00:00

abstract：:A detailed investigation of the neuropathology of a horse affected with stringhalt was performed. Qualitative and quantitative light and electron microscopy, and single teased fibre preparations of peripheral nerve demonstrated predominantly axonal degeneration, the stage of which was appropriate for the duration of c...

journal_title：Neuropathology and applied neurobiology

authors： Cahill JI,Goulden BE,Jolly RD

更新日期：1986-09-01 00:00:00

abstract：AIMS:Clusterin is a topologically dynamic chaperone protein with the ability to participate in both intra- and extacellular proteostasis. Clusterin has been shown to be upregulated in the spinal cord of patients with amyotrophic lateral sclerosis (ALS) and has been shown to protect against TDP-43 protein misfolding in ...

journal_title：Neuropathology and applied neurobiology

authors： Gregory JM,Elliott E,McDade K,Bak T,Pal S,Chandran S,Abrahams S,Smith C

更新日期：2020-04-01 00:00:00

abstract：AIM:Peroxisomes play a key role in lipid metabolism, and peroxisome defects have been associated with neurodegenerative diseases such as X-adrenoleukodystrophy and Alzheimer's disease. This study aims to elucidate the contribution of peroxisomes in lipid alterations of area 8 of the frontal cortex in the spectrum of TD...

journal_title：Neuropathology and applied neurobiology

authors： Andrés-Benito P,Gelpi E,Jové M,Mota-Martorell N,Obis È,Portero-Otin M,Povedano M,Pujol A,Pamplona R,Ferrer I

更新日期：2020-12-17 00:00:00

abstract：:Ubiquitin targets proteins for attack by certain proteolytic enzymes, but the ubiquitinated cytoplasmic inclusions seen in some chronic neurodegenerative diseases may indicate the occurrence of reparative rather than destructive metabolic events. We have examined the production of ubiquitin in motor neurons of the rat...

journal_title：Neuropathology and applied neurobiology

authors： Savedia S,Kiernan JA

更新日期：1994-12-01 00:00:00

abstract：:Fibre type differentiation was carried out on 20 biopsies from Duchenne Muscular Dystrophy (DMD) sufferers using the acid-preincubated reaction for myofibrillar ATPase. Fibres, classified as either type 1, type 2 or 2C, were counted and their minimum diameters (least fibre axis) measured. Particular attention was paid...

journal_title：Neuropathology and applied neurobiology

authors： Watkins SC,Cullen MJ

更新日期：1985-11-01 00:00:00

abstract：AIMS:Paediatric low-grade gliomas (pLGGs) are a heterogeneous group of brain tumours associated with a high overall survival: however, they are prone to recur and supratentorial lesions are difficult to resect, being associated with high percentage of disease recurrence. Our aim was to shed light on the biology of pLGG...

journal_title：Neuropathology and applied neurobiology

authors： Catanzaro G,Besharat ZM,Miele E,Chiacchiarini M,Po A,Carai A,Marras CE,Antonelli M,Badiali M,Raso A,Mascelli S,Schrimpf D,Stichel D,Tartaglia M,Capper D,von Deimling A,Giangaspero F,Mastronuzzi A,Locatelli F,Ferrett

更新日期：2018-12-01 00:00:00

abstract：:The effects of exposure to a cytotoxic agent, methylazoxymethanol acetate (MAM Ac), on the distribution, density and quantitative morphology of microglia in the rat forebrain have been examined with the aid of a peroxidase-conjugated lectin derived from Griffonia simplicifolia. Following exposure to MAM Ac (25 mg/kg m...

journal_title：Neuropathology and applied neurobiology

authors： Ashwell KW

更新日期：1992-12-01 00:00:00

abstract：AIMS:Neurogenesis in adult humans occurs in at least two areas of the brain, the subventricular zone of the telencephalon and the subgranular layer of the dentate gyrus in the hippocampal formation. We studied dentate gyrus subgranular layer neurogenesis in patients subjected to tailored antero-mesial temporal resectio...

journal_title：Neuropathology and applied neurobiology

authors： Paradisi M,Fernández M,Del Vecchio G,Lizzo G,Marucci G,Giulioni M,Pozzati E,Antonelli T,Lanzoni G,Bagnara GP,Giardino L,Calzà L

更新日期：2010-10-01 00:00:00

abstract：:To characterize the distribution of apoptotic neurons and their relationships with the stage of disease, a history of HIV-dementia, and the degree of productive HIV infection, microglial activation and axonal damage, we examined the brains of 40 patients. Samples of frontal and temporal cortex, basal ganglia and brain...

journal_title：Neuropathology and applied neurobiology

authors： Adle-Biassette H,Chrétien F,Wingertsmann L,Héry C,Ereau T,Scaravilli F,Tardieu M,Gray F

更新日期：1999-04-01 00:00:00

abstract：:In this study we describe the effects of trapidil, a putative platelet-derived growth factor-antagonist, on spontaneously occurring remyelination in rat spinal cord. Demyelination was created in the dorsal funiculus of 6- and 11-week-old female rats by the direct injection of 1.0 microliter of 1% lysolecithin. The ani...

journal_title：Neuropathology and applied neurobiology

authors： McKay JS,Blakemore WF,Franklin RJ

更新日期：1997-02-01 00:00:00

abstract：AIMS:Alzheimer's disease (AD) is characterized by degeneration of cholinergic basal forebrain (CBF) neurons in the nucleus basalis of Meynert (nbM), which provides the major cholinergic input to the cortical mantle and is related to cognitive decline in patients with AD. Cortical histone deacetylase (HDAC) dysregulatio...

journal_title：Neuropathology and applied neurobiology

authors： Mahady L,Nadeem M,Malek-Ahmadi M,Chen K,Perez SE,Mufson EJ

更新日期：2019-06-01 00:00:00

abstract：:Rats were given 2,5-hexanediol in their water for more than 5 weeks. The changes in the optic pathways were studied both qualitatively and quantitatively. Increase in 10-nm filaments within axons was noticeable from 10 days onwards in the superior colliculus and in the brachium of the superior colliculus. From then on...

journal_title：Neuropathology and applied neurobiology

authors： Jones HB,Cavanagh JB

更新日期：1982-07-01 00:00:00

abstract：AIMS:Although telomere length (TL) and telomere maintenance proteins (shelterins) are markers of cellular senescence and peripheral blood biomarkers of Alzheimer's disease (AD), little information is available on telomeric alterations during the prodromal stage (MCI) of AD. We investigated TL in the default mode networ...

journal_title：Neuropathology and applied neurobiology

authors： Mahady LJ,He B,Malek-Ahmadi M,Mufson EJ

更新日期：2020-10-26 00:00:00

abstract：:Brains from human fetuses of 13 to 27 weeks gestation have been examined immunohistologically for the presence of macrophages using the marker alpha-1-anti-chymotrypsin. A preliminary study demonstrated this to be a satisfactory marker of brain macrophages, although macrophages were also weakly positive for the more s...

journal_title：Neuropathology and applied neurobiology

authors： Gould SJ,Howard S

更新日期：1991-10-01 00:00:00

abstract：:Productive infection of the central nervous system by HIV predominantly involves the white matter and basal ganglia. Involvement of the cerebral cortex with neuronal loss is also described in AIDS patients but not in asymptomatic HIV-positive patients. The mechanism of neuronal damage is unknown. To enquire whether ne...

journal_title：Neuropathology and applied neurobiology

authors： Adle-Biassette H,Levy Y,Colombel M,Poron F,Natchev S,Keohane C,Gray F

更新日期：1995-06-01 00:00:00

abstract：:The expression of two heat shock proteins, HSP72 and p57, in addition to ubiquitin, has been studied immunocytochemically in nine amyotrophic lateral sclerosis (ALS) cases and 10 age-matched controls. HSP72 and p57 antibodies did not identify the characteristic ubiquitin-immunoreactive inclusions present in anterior h...

journal_title：Neuropathology and applied neurobiology

authors： Garofalo O,Kennedy PG,Swash M,Martin JE,Luthert P,Anderton BH,Leigh PN

更新日期：1991-02-01 00:00:00

abstract：:Obstructive hydrocephalus was induced in 12-day-old rats by the infusion of kaolin into the cisterna magna. After 7 days, cortical and ependymal lesions were made with thin wire in non-hydrocephalic brains and in hydrocephalic brains. The wounds were allowed to heal for times ranging from 1 day to 10 days post-lesion,...

journal_title：Neuropathology and applied neurobiology

authors： Collins P,Goulding DA

更新日期：1992-08-01 00:00:00

abstract：:Mitochondrial dysfunction leads to oxygen free radical (ROS) generation with consequent oxidative stress and cellular damage. Recently, activation of the cellular antioxidant system and apoptosis were demonstrated in skeletal muscle fibres from patients with mitochondrial diseases, but the underlying mechanisms remain...

journal_title：Neuropathology and applied neurobiology

authors： Filosto M,Tonin P,Vattemi G,Savio C,Rizzuto N,Tomelleri G

更新日期：2003-02-01 00:00:00

abstract：AIMS:14,15-Epoxyeicosatrienoic acid (14,15-EET) is abundantly expressed in brain and exerts protective effects against ischaemia. 14,15-EET is hydrolysed by soluble epoxide hydrolase (sEH). sEH-/- mice show a higher level of 14,15-EET in the brain. Astrocytes play a pivotal role in neuronal survival under ischaemic con...

journal_title：Neuropathology and applied neurobiology

authors： Yuan L,Liu J,Dong R,Zhu J,Tao C,Zheng R,Zhu S

更新日期：2016-12-01 00:00:00

abstract：:In many experimental models of skeletal muscle damage and in human muscle disease, empty basement membrane tubes remain following the destruction of muscle fibres. In the present study we test the hypothesis that the empty basement membrane tubes play an essential role in the orientation of regenerating muscle fibres....

journal_title：Neuropathology and applied neurobiology

authors： Caldwell CJ,Mattey DL,Weller RO

更新日期：1990-06-01 00:00:00

abstract：:Dysfunction of the ubiquitin-dependent proteolytic pathway contributes to progressive accumulation of ubiquitinated protein inclusions in neurodegenerative disorders, such as Parkinson's disease (PD). Ubiquitin C-terminal hydrolase-L1 (UCH-L1), alternatively designated protein gene product 9.5 (PGP9.5), is a neural de...

journal_title：Neuropathology and applied neurobiology

authors： Satoh JI,Kuroda Y

更新日期：2001-04-01 00:00:00

abstract：:The human chromosome 22 displays an unusual concentration of medically relevant genes, especially gene(s) involved in malignancies of the central nervous system. A full genomic and transcriptional characterization of this autosome will no doubt make a strong impact on the understanding of some of the processes which l...

journal_title：Neuropathology and applied neurobiology

authors： Dumanski JP

更新日期：1996-10-01 00:00:00

abstract：:An unusual inherited progressive distal myopathy of early childhood onset is described in two sisters from a consanguineous Asian family. Motor milestones were normal but gait deteriorated slowly thereafter with development of generalized hypotonia and muscle weakness particularly in the wrist extensors and hand muscl...

journal_title：Neuropathology and applied neurobiology

authors： Mahon M,Kristmundsdottir F,Cumming WJ,Noronha MJ

更新日期：1989-01-01 00:00:00

abstract：:We present the clinical and neuropathological findings of a patient with early onset Alzheimer's dementia (AD), heterozygous carrier of the rare Apolipoprotein E Christchurch (APOEch) variant. The patient did not harbor any pathogenic mutation in known Mendelian genes related to AD or other neurodegenerative disorders...

journal_title：Neuropathology and applied neurobiology

authors： Hernandez I,Gelpi E,Molina-Porcel L,Bernal S,Rodríguez-Santiago B,Dols-Icardo O,Ruiz A,Alcolea D,Boada M,Lleó A,Clarimón J

更新日期：2020-10-23 00:00:00

abstract：AIMS:Much evidence demonstrates that Toll-like receptor-4 (TLR4)-mediated microglial activation is an important contributor to the inflammatory injury in intracerebral haemorrhage (ICH). However, the exact mechanism of TLR4-mediated microglial activation induced by ICH is not clear. In addition, microglial autophagy is...

journal_title：Neuropathology and applied neurobiology

authors： Yang Z,Liu B,Zhong L,Shen H,Lin C,Lin L,Zhang N,Yuan B

更新日期：2015-06-01 00:00:00

abstract：AIMS:EphB2 is a member of receptor tyrosine kinases (RTKs) family that is essential for the cell adhesion, neural crest migration, axon guidance and synaptogenesis in the nervous system. Recent studies show that preservation of EphB2 in a transgenic mouse model of Alzheimer's disease (AD) rescues the cognitive deficit,...

journal_title：Neuropathology and applied neurobiology

authors： Qu M,Jiang J,Liu XP,Tian Q,Chen LM,Yin G,Liu D,Wang JZ,Zhu LQ

更新日期：2013-10-01 00:00:00