Lrrk2 R1441 substitution and progressive supranuclear palsy.

abstract：BACKGROUND:In definite Creutzfeldt-Jakob disease (CJD), morphological and immunohistochemical patterns are useful to identify molecular subtypes. Severe cerebellar pathology and hippocampal involvement helps to identify VV subtypes. The rare VV1 variant (<1%), more frequent in young individuals, is additionally charact...

journal_title：Neuropathology and applied neurobiology

authors： Martinez-Saez E,Gelpi E,Rey MJ,Ferrer I,Ribalta T,Botta-Orfila T,Nos C,Yagüe J,Sanchez-Valle R

更新日期：2012-04-01 00:00:00

abstract：:Monolayer cultures of rat glial cells derived from 12 to 14 day fetal spinal cords and rat C6 glioma cells were examined for immunofluorescent reactivity with human or rabbit autoantibodies to intermediate filaments and with rabbit antibody to GFAP. The embryonic glial cells and C6 glima cells reacted identically with...

journal_title：Neuropathology and applied neurobiology

authors： Sotelo J,Toh BH,Lolait SJ,Yildiz A,Osung O,Holborow EJ

更新日期：1980-07-01 00:00:00

abstract：:Serial sections of the brains of two cases with Alzheimer's disease were stained with the standard Bodian, modified Bielschowsky (reformed Gros-Schultze's modification) and thioflavin S methods. The numbers of demonstrated Alzheimer's neurofibrillary tangles (NFTs) were different between the two silver stains: from 15...

journal_title：Neuropathology and applied neurobiology

authors： Yamamoto T,Hirano A

更新日期：1986-01-01 00:00:00

abstract：:We have developed a neuronal culture system to evaluate the neurotoxic effects of aluminium maltol on fetal rabbit midbrain sections containing the oculomotor nucleus. Cultures were treated with 5, 7, 9, 11, 13 and 15 mumol/l aluminium maltol or 39 and 45 mumol/l maltol (molal equivalents to 13 and 15 mumol/l aluminiu...

journal_title：Neuropathology and applied neurobiology

authors： Hewitt CD,Herman MM,Lopes MB,Savory J,Wills MR

更新日期：1991-02-01 00:00:00

abstract：INTRODUCTION:Cerebral ischaemia is the defining pathophysiological abnormality in most forms of vascular dementia (VAD), but the pathogenesis of the dementia remains poorly understood. In Alzheimer's disease (AD), there is early loss of synaptic proteins, but these have been little studied in VAD. MATERIALS AND METHOD...

journal_title：Neuropathology and applied neurobiology

authors： Sinclair LI,Tayler HM,Love S

更新日期：2015-06-01 00:00:00

abstract：AIMS:Oxidative damage and an associated DNA damage response (DDR) are evident in mild cognitive impairment and early Alzheimer's disease, suggesting that neuronal dysfunction resulting from oxidative DNA damage may account for some of the cognitive impairment not fully explained by Alzheimer-type pathology. METHODS:Fr...

journal_title：Neuropathology and applied neurobiology

authors： Simpson JE,Ince PG,Minett T,Matthews FE,Heath PR,Shaw PJ,Goodall E,Garwood CJ,Ratcliffe LE,Brayne C,Rattray M,Wharton SB,MRC Cognitive Function and Ageing Neuropathology Study Group.

更新日期：2016-02-01 00:00:00

abstract：:In a previous study, we described the inhibitory effects of the growth factor-antagonist, trapidil, on spontaneously occurring oligodendrocyte remyelination in the rat spinal cord following lysolecithin-induced demyelination [30]. The objective of the present study was to further investigate the mechanisms of trapidil...

journal_title：Neuropathology and applied neurobiology

authors： McKay JS,Blakemore WF,Franklin RJ

更新日期：1998-12-01 00:00:00

abstract：:The brain is frequently affected by the spread of lung cancer, and haematogenous metastasis is a common route to brain metastasis. We therefore developed an isogenic brain metastasis model of lung cancer to use the Lewis lung carcinoma cell line and analysed dynamics of neoplastic cells after extravasation. Histologic...

journal_title：Neuropathology and applied neurobiology

authors： Saito N,Hatori T,Murata N,Zhang ZA,Ishikawa F,Nonaka H,Iwabuchi S,Samejima H

更新日期：2007-06-01 00:00:00

abstract：AIMS:Frontotemporal lobar degeneration (FTLD) is clinically and pathologically heterogeneous. Although associated with variations in MAPT, GRN and C9ORF72, the pathogenesis of these, and of other nongenetic, forms of FTLD, remains unknown. Epigenetic factors such as histone regulation by histone deacetylases (HDAC) may...

journal_title：Neuropathology and applied neurobiology

authors： Whitehouse A,Doherty K,Yeh HH,Robinson AC,Rollinson S,Pickering-Brown S,Snowden J,Thompson JC,Davidson YS,Mann DM

更新日期：2015-02-01 00:00:00

abstract：AIMS:The serotonin 2A receptor (HTR2A) is widely expressed in the brain and involved in the modulation of fear, mood, anxiety and other symptoms. HTR2A and HTR2A gene variations are implicated in depression, schizophrenia, anxiety and obsessive-compulsive disorder. To understand HTR2A signalling changes in psychiatric ...

journal_title：Neuropathology and applied neurobiology

authors： Marinova Z,Monoranu CM,Fetz S,Walitza S,Grünblatt E

更新日期：2015-06-01 00:00:00

abstract：AIMS:The secondary dystroglycanopathies represent a heterogeneous group of congenital muscular dystrophies characterized by the defective glycosylation of alpha dystroglycan. These disorders are associated with mutations in at least 17 genes, including Fukutin-related protein (FKRP). At the severe end of the clinical s...

journal_title：Neuropathology and applied neurobiology

authors： Booler HS,Pagalday-Vergara V,Williams JL,Hopkinson M,Brown SC

更新日期：2017-06-01 00:00:00

abstract：:Ubiquitin targets proteins for attack by certain proteolytic enzymes, but the ubiquitinated cytoplasmic inclusions seen in some chronic neurodegenerative diseases may indicate the occurrence of reparative rather than destructive metabolic events. We have examined the production of ubiquitin in motor neurons of the rat...

journal_title：Neuropathology and applied neurobiology

authors： Savedia S,Kiernan JA

更新日期：1994-12-01 00:00:00

abstract：AIMS:Multiple sclerosis (MS) and neuromyelitis optica (NMO) are inflammatory autoimmune diseases that affect the central nervous system. Several genome-wide and candidate gene studies have identified genetic polymorphisms associated with the risk of MS or NMO. In particular, two recently published studies of meta-analy...

journal_title：Neuropathology and applied neurobiology

authors： Park TJ,Kim HJ,Kim JH,Bae JS,Cheong HS,Park BL,Shin HD

更新日期：2013-08-01 00:00:00

abstract：:The pattern of cell loss and neuronal degeneration resulting from multiple microinjections of N-methyl-D-aspartate (NMDA), ibotenate (IBO), quisqualate (QUIS), and kainate (KA) into hippocampus was studied, together with the protection provided by the NMDA antagonist 3-(+/-)-2-carboxypiperazin-4-yl-propyl-1-phosphonat...

journal_title：Neuropathology and applied neurobiology

authors： Jarrard LE,Meldrum BS

更新日期：1993-10-01 00:00:00

abstract：AIMS:The aim of this study was to describe the regional profiles of microglial activation in sporadic Creutzfeldt-Jakob disease (sCJD) subtypes and analyse the influence of prion strain, disease duration and codon 129 genotype. METHODS:We studied the amount/severity and distribution of activated microglia, protease-re...

journal_title：Neuropathology and applied neurobiology

authors： Franceschini A,Strammiello R,Capellari S,Giese A,Parchi P

更新日期：2018-10-01 00:00:00

abstract：:Mice and rats are found to be equally susceptible to developing symmetrical brain stem lesions on exposure to alpha-chlorohydrin and in both species the earliest neurotoxic changes are strictly confined to glial cells, particularly astrocytes; haemorrhages are not found in either species. Minimal evidence of increased...

journal_title：Neuropathology and applied neurobiology

authors： Cavanagh JB,Nolan CC,Seville MP

更新日期：1993-06-01 00:00:00

abstract：:Protein aggregation, mitochondrial impairment and oxidative stress are common to multiple neurodegenerative diseases. Homeostasis is regulated by a balanced set of anabolic and catabolic responses, which govern removal and repair of damaged proteins and organelles. Macroautophagy is an evolutionarily conserved pathway...

journal_title：Neuropathology and applied neurobiology

authors： Cherra SJ 3rd,Dagda RK,Chu CT

更新日期：2010-04-01 00:00:00

abstract：AIMS:Amyloid-β (Aβ) oligomers trigger synaptic degeneration that precedes plaque and tangle pathology. However, the signalling molecules that link Aβ oligomers to synaptic pathology remain unclear. Here, we addressed the potential role of RAPGEF2 as a novel signalling molecule in Aβ oligomer-induced synaptic and cognit...

journal_title：Neuropathology and applied neurobiology

authors： Jang YN,Jang H,Kim GH,Noh JE,Chang KA,Lee KJ

更新日期：2020-12-20 00:00:00

abstract：:The development of granule cells and the formation of synapses with mossy fibres were investigated in cerebella from jaundiced (j/j) Gunn rats with hereditary hyperbilirubinemia. The external granular layer was thinner than that in cerebella from heterozygous (+/j) Gunn rats without hyperbilirubinemia on days 12 and 1...

journal_title：Neuropathology and applied neurobiology

authors： Takagishi Y,Yamamura H

更新日期：1993-08-01 00:00:00

abstract：:Two cases are described, one with a multifocal cranial and limb neuropathy of adult onset associated with optic neuropathy, and the other with a diffuse demyelinating neuropathy characterized by congenital cataract, mental retardation and progressive lower limb paresis with an onset in childhood. Extensive investigati...

journal_title：Neuropathology and applied neurobiology

authors： Thomas PK,King RH,Workman JM,Schröder JM

更新日期：2000-12-01 00:00:00

abstract：AIMS:Glioblastomas are highly aggressive and treatment resistant. Increasing evidence suggests that tumour-associated macrophages/microglia (TAMs) facilitate tumour progression by acquiring a M2-like phenotype. Our objective was to investigate the prognostic value of TAMs in gliomas using automated quantitative double ...

journal_title：Neuropathology and applied neurobiology

authors： Sørensen MD,Dahlrot RH,Boldt HB,Hansen S,Kristensen BW

更新日期：2018-02-01 00:00:00

abstract：:Mitochondrial dysfunction leads to oxygen free radical (ROS) generation with consequent oxidative stress and cellular damage. Recently, activation of the cellular antioxidant system and apoptosis were demonstrated in skeletal muscle fibres from patients with mitochondrial diseases, but the underlying mechanisms remain...

journal_title：Neuropathology and applied neurobiology

authors： Filosto M,Tonin P,Vattemi G,Savio C,Rizzuto N,Tomelleri G

更新日期：2003-02-01 00:00:00

abstract：:The organization of astrocytes in myelinated culture of mouse spinal cord tissue was analysed ultrastructurally and compared with the pattern in vivo. Astrocyte cell bodies and their processes, connected by punctate adhesions and gap junctions, formed a continuous layer around the entire explant. Throughout the parenc...

journal_title：Neuropathology and applied neurobiology

authors： Kusaka H,Hirano A,Bornstein MB,Raine CS

更新日期：1984-11-01 00:00:00

abstract：UNLABELLED:It is well known that glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor for motoneurons. We have previously shown that it greatly enhanced motoneuron survival and axon regeneration after implantation of peripheral nerve graft following spinal root avulsion. AIMS:In the curre...

journal_title：Neuropathology and applied neurobiology

authors： Chu TH,Wang L,Guo A,Chan VW,Wong CW,Wu W

更新日期：2012-12-01 00:00:00

abstract：:Herpes simplex virus was injected into the vitreous of suckling and adult rabbits. In the suckling rabbits the infection caused an arrested myelination of the strip. Further, the infected strips showed degenerative changes with splitting and distension of myelin sheaths which then disintegrated. Ultrastructurally, her...

journal_title：Neuropathology and applied neurobiology

authors： Kristensson K,Wiśniewski HM

更新日期：1978-01-01 00:00:00

abstract：:We have examined the influence that axons may have on the expression of proteolipid protein (PLP), the major myelin protein of the CNS. Partial transections were made of the optic nerve of adult rats to produce approximately a 50% loss of axons. Twenty-eight days after lesioning, sections of the distal nerves were imm...

journal_title：Neuropathology and applied neurobiology

authors： McPhilemy K,Griffiths IR,Mitchell LS,Kennedy PG

更新日期：1991-08-01 00:00:00

abstract：:The role of Schwann cells (SC) in perineurial regeneration after nerve injury has not yet been resolved. It was hypothesized that SC alone are able to induce at least partial morphological restoration of the destroyed orthotopic perineureum (PN). To test the hypothesis, a permanently denervated segment of the rat scia...

journal_title：Neuropathology and applied neurobiology

authors： Popović M,Bresjanac M,Sketelj J

更新日期：2000-06-01 00:00:00

abstract：AIM:To understand the progression of CLN1 disease and develop effective therapies we need to characterize early sites of pathology. Therefore, we performed a comprehensive evaluation of the nature and timing of early CLN1 disease pathology in the spinal cord, which appears especially vulnerable, and how this may affect...

journal_title：Neuropathology and applied neurobiology

authors： Nelvagal HR,Dearborn JT,Ostergaard JR,Sands MS,Cooper JD

更新日期：2020-08-25 00:00:00

abstract：:Focal cortical dysplasia (FCD), which is often associated with intractable epilepsy, is a form of abnormal structure of the cerebral cortex caused by a disorder of normal neocortical development. In such cerebral lesions obtained from four patients (two male, two female; average age 32.3 years at operation), the immun...

journal_title：Neuropathology and applied neurobiology

authors： Nishio S,Morioka T,Hamada Y,Hisada K,Fukui M

更新日期：1999-06-01 00:00:00

abstract：AIMS:Insufficient oligodendroglial differentiation of oligodendroglial progenitor cells (OPCs) is suggested to be responsible for remyelination failure and astroglial scar formation in Theiler's murine encephalomyelitis (TME). The aim of the present study is to identify molecular key regulators of OPC differentiation i...

journal_title：Neuropathology and applied neurobiology

authors： Sun Y,Lehmbecker A,Kalkuhl A,Deschl U,Sun W,Rohn K,Tzvetanova ID,Nave KA,Baumgärtner W,Ulrich R

更新日期：2015-04-01 00:00:00