Abstract：
:Ubiquitin targets proteins for attack by certain proteolytic enzymes, but the ubiquitinated cytoplasmic inclusions seen in some chronic neurodegenerative diseases may indicate the occurrence of reparative rather than destructive metabolic events. We have examined the production of ubiquitin in motor neurons of the rat's left hypoglossal nucleus after transection of their axons in circumstances that favour or prevent axonal regeneration. One week after axotomy, in situ hybridization with a radiolabelled cRNA probe revealed a twofold increase in the ubiquitin mRNA content of neurons with regenerating axons (nerve crushed) but not significant change when axonal regeneration had been prevented (nerve transected and ligated). After 2 weeks, ubiquitin mRNA was elevated to about 1.5 times the contralateral control level, regardless of the type of nerve injury, and by 4 weeks there were no longer any differences between the left and right sides. Despite the increased transcription, axotomy was not followed by any change in the quantity of ubiquitin-immunoreactive material in the nuclei or perikarya of hypoglossal neurons as measured by video image analysis of immunohistochemically stained sections. We suggest that ubiquitin is synthesized in neuronal cell bodies and transported into their axons, and that ubiquitin-mediated proteolysis is a metabolic process involved in the elongation of regenerating axons.
journal_name
Neuropathol Appl Neurobioljournal_title
Neuropathology and applied neurobiologyauthors
Savedia S,Kiernan JAdoi
10.1111/j.1365-2990.1994.tb01012.xsubject
Has Abstractpub_date
1994-12-01 00:00:00pages
577-86issue
6eissn
0305-1846issn
1365-2990journal_volume
20pub_type
杂志文章abstract：:The pathological findings in Alzheimer's disease (AD) are partly attributed to alterations in calcium-binding protein (CBP) functions. We showed previously that immunoreactivity of secretagogin, a recently cloned CBP, in the human hippocampus is restricted to pyramidal neurones and that the amount of immunoreactive ne...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.2007.00854.x
更新日期：2008-02-01 00:00:00
abstract：:Semliki Forest virus infections in mice produce an encephalitis with demyelination. If before giving the virus the mice are treated with muramyl dipeptide in Freund's incomplete adjuvant, there is a significant increase in demyelination. If ovalbumin is added to the above and then followed after an interval by a secon...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1988.tb01339.x
更新日期：1988-11-01 00:00:00
abstract：:Brains from human fetuses of 13 to 27 weeks gestation have been examined immunohistologically for the presence of macrophages using the marker alpha-1-anti-chymotrypsin. A preliminary study demonstrated this to be a satisfactory marker of brain macrophages, although macrophages were also weakly positive for the more s...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1991.tb00738.x
更新日期：1991-10-01 00:00:00
abstract：:The mechanisms underlying secondary or delayed cell death following traumatic brain injury (TBI) are poorly understood. Recent evidence from experimental models of TBI suggest that diffuse and widespread neuronal damage and loss is progressive and prolonged for months to years after the initial insult in selectively v...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2990.1998.00121.x
更新日期：1998-08-01 00:00:00
abstract：:Vascular endothelial growth factor (VEGF) has recently been implicated in several neurological disorders. Apart from its prominent role in angiogenesis, VEGF has been shown to have direct effects on neuronal and glial cells through activation of different VEGF receptor (VEGFR) types. In the present study the expressio...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.2003.00543.x
更新日期：2004-08-01 00:00:00
abstract：AIM:Recent studies indicate that tau pathology in Alzheimer's disease (AD) does not initially manifest in the cerebral cortex but in selected subcortical nuclei, in particular the locus ceruleus (LC). In this study we correlate both olfactory and brainstem tau pathology with neuritic Braak stages. METHODS:We examined ...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.2011.01244.x
更新日期：2012-10-01 00:00:00
abstract：:In a previous study, we described the inhibitory effects of the growth factor-antagonist, trapidil, on spontaneously occurring oligodendrocyte remyelination in the rat spinal cord following lysolecithin-induced demyelination [30]. The objective of the present study was to further investigate the mechanisms of trapidil...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1046/j.1365-2990.1998.00148.x
更新日期：1998-12-01 00:00:00
abstract：:Flow through the vasculature of an experimental rat glioma has been investigated during in situ perfusion of the brain, via the ascending aorta, with a simple saline solution. Using such a system, it has been shown previously that the blood-brain barrier will remain intact with an adequate cerebral perfusate flow rate...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1994.tb00995.x
更新日期：1994-10-01 00:00:00
abstract：:Mitochondrial abnormalities, in particular the accumulation of mitochondrial DNA mutations, have been proposed as a potential cause of normal ageing. One group of patients with mtDNA disorders have a nuclear DNA defect which accelerates the chronological accumulation of mitochondrial DNA mutations. These patients prov...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1046/j.1365-2990.2001.00315.x
更新日期：2001-06-01 00:00:00
abstract：:The effects of exposure to a cytotoxic agent, methylazoxymethanol acetate (MAM Ac), on the distribution, density and quantitative morphology of microglia in the rat forebrain have been examined with the aid of a peroxidase-conjugated lectin derived from Griffonia simplicifolia. Following exposure to MAM Ac (25 mg/kg m...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1992.tb00832.x
更新日期：1992-12-01 00:00:00
abstract：:Multiple system atrophy (MSA) is an unrelenting, sporadic, adult-onset, neurodegenerative disease of unknown aetiology. Its clinically progressive course is characterized by a variable combination of parkinsonism, cerebellar ataxia and/or autonomic dysfunction. Neuropathological examination often reveals gross abnorma...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2990.2011.01234.x
更新日期：2012-02-01 00:00:00
abstract：AIMS:Transition metals, oxidative stress and neuroinflammation have been proposed as part of a vicious cycle in central nervous system neurodegeneration. Our aim was to study the anti-inflammatory effect of pioglitazone, a peroxisome proliferative activated receptor-γ agonist, on iron-induced oxidative injury in rat br...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.2010.01107.x
更新日期：2010-12-01 00:00:00
abstract：:The avirulent demyelinating strain A7(74) of Semliki Forest virus after passage through mouse brain in vivo and mouse brain cell cultures has been shown to react immunologically with immune sera against galactocerebroside, glucocerebroside, total ganglioside and GT1b ganglioside but not against myelin or sulphatide . ...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：
更新日期：1984-03-01 00:00:00
abstract：:The causes of most neurological disorders are not fully understood. Inflammation and blood-brain barrier dysfunction appear to play major roles in the pathology of these diseases. Inflammatory insults that occur during brain development may have widespread effects later in life for a spectrum of neurological disorders...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2990.2008.01005.x
更新日期：2009-04-01 00:00:00
abstract：:Dementia with Lewy bodies (DLB) is characterized by the widespread presence of Lewy bodies (LBs) in the brain. alpha-Synuclein, the main component of LBs, is expressed as two main isoforms (112 and 140), but little is known about their differential expression in the brain. We compared alpha-synuclein 112 and alpha-syn...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.2004.00572.x
更新日期：2004-12-01 00:00:00
abstract：AIMS:Infection of the mouse central nervous system with wild type (WT) and vaccine strains of measles virus (MV) results in lack of clinical signs and limited antigen detection. It is considered that cell entry receptors for these viruses are not present on murine neural cells and infection is restricted at cell entry....
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.2009.01023.x
更新日期：2009-10-01 00:00:00
abstract：AIMS:Apolipoprotein A-I (apoA-I), the principal apolipoprotein associated with high-density lipoproteins in the periphery, is also found at high concentrations in the cerebrospinal fluid. Previous studies have reported either no impact or vascular-specific effects of apoA-I knockout (KO) on β-amyloid (Aβ) pathology. Ho...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/nan.12556
更新日期：2019-12-01 00:00:00
abstract：:The topography and cellular events in the experimental lesions caused by chlorosugars, 6-aminonicotinamide, dinitrobenzene and tribromoimidazole in animals are considered in relation to those features in human acute thiamine deficiency (Wernicke's) encephalopathy and for comparison in Leigh's disease. The topography a...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2990.1993.tb00474.x
更新日期：1993-12-01 00:00:00
abstract：AIMS:Brain oedema is a major contributing factor to the morbidity and mortality of a variety of brain disorders. Although there has been considerable progress in our understanding of pathophysiological and molecular mechanisms associated with brain oedema so far, more effective treatment is required and is still awaite...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/nan.12182
更新日期：2015-06-01 00:00:00
abstract：:Over the past few years, the traditional view of brain tumorigenesis has been revolutionized by advances in genomic medicine, molecular biology, stem cell biology and genetically engineered small-animal modelling. We now appreciate that paediatric brain tumours arise following specific genetic mutations in specialized...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2990.2011.01230.x
更新日期：2012-06-01 00:00:00
abstract：:The molecular genetic analysis of brain tumours has been the focus of considerable interest for a number of years. However, these studies have been largely directed towards understanding the fundamental biological processes involved in tumorigenesis and the techniques which have been used require considerable molecula...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2990.1997.tb01321.x
更新日期：1997-12-01 00:00:00
abstract：INTRODUCTION:Cerebral ischaemia is the defining pathophysiological abnormality in most forms of vascular dementia (VAD), but the pathogenesis of the dementia remains poorly understood. In Alzheimer's disease (AD), there is early loss of synaptic proteins, but these have been little studied in VAD. MATERIALS AND METHOD...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/nan.12215
更新日期：2015-06-01 00:00:00
abstract：:Existing techniques have been adapted and it has been possible to demonstrate acid phosphatase (APP) and myelin, lipid or astrocytic fibres in the same histological section. In normal controls APP was demonstrated in neurons, astrocytes, ependyma including choroid plexus epithelium and in pericytes, but not in oligode...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1979.tb00619.x
更新日期：1979-05-01 00:00:00
abstract：:The presence of histological variants of haemangioblastoma is well established, but data on the prognostic implications of histological subtyping are missing. We thus characterized clinical factors associated with histological subtypes, that is, of the cellular and reticular variant of haemangioblastoma, in a series o...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.2005.00669.x
更新日期：2005-12-01 00:00:00
abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is characterized by the deposition of granular osmiophilic material in association with vascular smooth muscle cells in many different organs. However, the cause of the subsequent destruction of smooth muscle cells tha...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1046/j.1365-2990.1998.00087.x
更新日期：1998-02-01 00:00:00
abstract：AIMS:post-haemorrhagic ventricular dilatation (PHVD) is a significant problem in neonatal care, with sequelae extending beyond childhood. Its management is important in determining outcome. Although rodent hydrocephalus models have been developed, PHVD, as a specific entity with a distinct pathophysiology, has not been...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.2010.01118.x
更新日期：2011-02-01 00:00:00
abstract：AIMS:Although telomere length (TL) and telomere maintenance proteins (shelterins) are markers of cellular senescence and peripheral blood biomarkers of Alzheimer's disease (AD), little information is available on telomeric alterations during the prodromal stage (MCI) of AD. We investigated TL in the default mode networ...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/nan.12672
更新日期：2020-10-26 00:00:00
abstract：:In babies of low birth weight dying in the first week of life, bilirubin encephalopathy involving the thalamus only or the thalamus and one or two other areas occurred in nineteen of 376 cases examined over a 10 year period. Although coexistent germinal layer haemorrhage was present in sixteen, this was not thought to...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1983.tb00114.x
更新日期：1983-07-01 00:00:00
abstract：:To confirm the intracellular accumulation of amyloid beta-protein (Abeta), we carefully performed immunohistochemistry using brains of cynomolgus monkeys of various ages. Cortical neurones and their large neurites were immunostained with antibodies against Abeta in young monkey brains. In aged monkey brains, intracell...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.2004.00624.x
更新日期：2005-04-01 00:00:00
abstract：:A few nanograms of tetanus toxin injected into a rat hippocampus causes a chronic epileptic syndrome characterized by brief seizures that recur intermittently for about 6 weeks. Cognitive and other behavioural impairments persist after the seizures and other epileptic electrographic activity have remitted, and may be ...
journal_title：Neuropathology and applied neurobiology
pub_type： 杂志文章
doi：10.1111/j.1365-2990.1992.tb00764.x
更新日期：1992-02-01 00:00:00
